Entry |
|
Symbol |
PLCB2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
|
KO |
|
Organism |
ppam Pteronotus mesoamericanus (Parnell's mustached bat)
|
Pathway |
ppam04070 | Phosphatidylinositol signaling system |
ppam04261 | Adrenergic signaling in cardiomyocytes |
ppam04613 | Neutrophil extracellular trap formation |
ppam04621 | NOD-like receptor signaling pathway |
ppam04723 | Retrograde endocannabinoid signaling |
ppam04750 | Inflammatory mediator regulation of TRP channels |
ppam04925 | Aldosterone synthesis and secretion |
ppam04928 | Parathyroid hormone synthesis, secretion and action |
ppam04933 | AGE-RAGE signaling pathway in diabetic complications |
ppam04935 | Growth hormone synthesis, secretion and action |
ppam04961 | Endocrine and other factor-regulated calcium reabsorption |
ppam04973 | Carbohydrate digestion and absorption |
ppam05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
ppam_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:ppam00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
129064066 (PLCB2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
129064066 (PLCB2)
04310 Wnt signaling pathway
129064066 (PLCB2)
04371 Apelin signaling pathway
129064066 (PLCB2)
04020 Calcium signaling pathway
129064066 (PLCB2)
04070 Phosphatidylinositol signaling system
129064066 (PLCB2)
04072 Phospholipase D signaling pathway
129064066 (PLCB2)
04071 Sphingolipid signaling pathway
129064066 (PLCB2)
04022 cGMP-PKG signaling pathway
129064066 (PLCB2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
129064066 (PLCB2)
04081 Hormone signaling
129064066 (PLCB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
129064066 (PLCB2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
129064066 (PLCB2)
04613 Neutrophil extracellular trap formation
129064066 (PLCB2)
04621 NOD-like receptor signaling pathway
129064066 (PLCB2)
04062 Chemokine signaling pathway
129064066 (PLCB2)
09152 Endocrine system
04911 Insulin secretion
129064066 (PLCB2)
04922 Glucagon signaling pathway
129064066 (PLCB2)
04929 GnRH secretion
129064066 (PLCB2)
04912 GnRH signaling pathway
129064066 (PLCB2)
04915 Estrogen signaling pathway
129064066 (PLCB2)
04921 Oxytocin signaling pathway
129064066 (PLCB2)
04926 Relaxin signaling pathway
129064066 (PLCB2)
04935 Growth hormone synthesis, secretion and action
129064066 (PLCB2)
04918 Thyroid hormone synthesis
129064066 (PLCB2)
04919 Thyroid hormone signaling pathway
129064066 (PLCB2)
04928 Parathyroid hormone synthesis, secretion and action
129064066 (PLCB2)
04916 Melanogenesis
129064066 (PLCB2)
04924 Renin secretion
129064066 (PLCB2)
04925 Aldosterone synthesis and secretion
129064066 (PLCB2)
04927 Cortisol synthesis and secretion
129064066 (PLCB2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
129064066 (PLCB2)
04270 Vascular smooth muscle contraction
129064066 (PLCB2)
09154 Digestive system
04970 Salivary secretion
129064066 (PLCB2)
04971 Gastric acid secretion
129064066 (PLCB2)
04972 Pancreatic secretion
129064066 (PLCB2)
04973 Carbohydrate digestion and absorption
129064066 (PLCB2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
129064066 (PLCB2)
09156 Nervous system
04724 Glutamatergic synapse
129064066 (PLCB2)
04725 Cholinergic synapse
129064066 (PLCB2)
04728 Dopaminergic synapse
129064066 (PLCB2)
04726 Serotonergic synapse
129064066 (PLCB2)
04720 Long-term potentiation
129064066 (PLCB2)
04730 Long-term depression
129064066 (PLCB2)
04723 Retrograde endocannabinoid signaling
129064066 (PLCB2)
09157 Sensory system
04742 Taste transduction
129064066 (PLCB2)
04750 Inflammatory mediator regulation of TRP channels
129064066 (PLCB2)
09159 Environmental adaptation
04713 Circadian entrainment
129064066 (PLCB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
129064066 (PLCB2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
129064066 (PLCB2)
09174 Infectious disease: parasitic
05146 Amoebiasis
129064066 (PLCB2)
05142 Chagas disease
129064066 (PLCB2)
05143 African trypanosomiasis
129064066 (PLCB2)
09164 Neurodegenerative disease
05010 Alzheimer disease
129064066 (PLCB2)
05016 Huntington disease
129064066 (PLCB2)
05017 Spinocerebellar ataxia
129064066 (PLCB2)
05022 Pathways of neurodegeneration - multiple diseases
129064066 (PLCB2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
129064066 (PLCB2)
05415 Diabetic cardiomyopathy
129064066 (PLCB2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
129064066 (PLCB2)
04934 Cushing syndrome
129064066 (PLCB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:ppam04131]
129064066 (PLCB2)
Enzymes [BR:ppam01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
129064066 (PLCB2)
Membrane trafficking [BR:ppam04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
129064066 (PLCB2)
Endocytosis
Macropinocytosis
Phospholipase C
129064066 (PLCB2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
Unknown
|
AA seq |
1171 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAGDVLALVKHPLTANAPRTTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMNLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIEKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGDMLLTEPLEQFPLKPGTLLPSPEDLRGKILIKNKKNQFSGPASPGKEPGGE
AEGSGLPDTPVVGDTVWAGEEGAELEEEEEVEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKAAVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQTGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSIKVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPTTNSINPVWNEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLRSESNMALTMPALFIFLEMKDYVPDTWADLTVALANPIKFFSAHDKKSVKLKEAMGDL
PEKPFSLGSPAASQVNGATAPTSNGSAEPRTTSLEELQGLKGVVKLQRRHEKELRELERR
GARRWEELLQRGAAQLAELGPPGAGGGFGGRRLGPGKGSRKKRTLPCEETGWATLGEGPE
GAETLVRELRDRLELELLQQGEEKYECVLKRKQQQVAEQIAKMMDLAREKQVAELKTLKE
TSQSDTKEMKKKLEAKRLERIQAMIKVTTDKMAQERLKREINNSHIQEVVQVIKQMTESL
ERHQEKLEEKQAACLEQIREMEKQLQQEALAEYEARMKGLEAEVKEAVRTCLRPCFPSEA
EDKLERPCGTSREPCELDPPTAKKDIQESIL |
NT seq |
3516 nt +upstreamnt +downstreamnt
atgtctctgctcaaccctgtcctgctgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaacaacaatagcctccccggttatcctccgtgtg
gaccccaagggctactacttatactggacatatcagagtaaggagatggagtttctggat
atcaccagcatccgggacacccgctttgggaagtttgccaagattcccaagagccagaag
ctccgggatgtcttcaacatggactttcctgacaacaacttcctgctgaagacactcacc
gtggtgtctggccctgacatggtggacctgaccttccacaacttcgtctcctacaaggag
aatgtgggcaaggactgggctggagatgtgctggccctggtcaagcacccgctcacagcc
aacgccccccgcaccaccttcctagacaagatcctggtgaagctcaagatgcagctcaac
cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaagcgg
gtagaagcagctctcagtgcctgccacctcgccaaaggcaaaaacgacgccatcaatcct
gaggacttcccagaatctgtctacaagagtttcctcatgaacctctgtcctcggcctgaa
atagacgagatcttcacttcctaccacgccaaagccaaaccctacatgaccaaggagcac
ttgaccaaattcatcaaccagaaacagagggactcccgcctcaactccttactgttcccg
ccagcgcggcctgaccaggtgcagggcctcatcgaaaagtatgagcccagtggcatcaac
gtgcagaggggccagctgtcacccgagggcatggtgtggtttctctgtgggccggagaac
agcgtgctggcccaggacaagctgctgcttcaccacgacatgacacagccactcaatcat
tacttcatcaactcctcacacaacacgtacctgacagctggccagttctcaggcctctcc
tccgctgagatgtaccgccaggtactgctggctggctgccgctgtgtggaattggactgc
tggaaggggaagccccccgatgaggagcctatcatcacccatggctttaccatgaccaca
gacatctacttcaaagaagcaattgaagcaattgcagaaagtgcctttaagacctccccc
tatcctgtcatcttgtcatttgaaaaccacgtggactcaccccgccaacaggccaagatg
gctgagtactgccggacaatgtttggcgatatgctgctcacagagcccctggaacagttt
ccgctgaaaccaggcaccctcctgcccagccctgaggatctccgtggcaagatcctcatc
aaaaacaagaagaaccagttttctggcccagcatcccctggcaaggagccaggtggggag
gctgagggcagcggcctacctgatacccctgtggttggggacacagtgtgggctggtgag
gaaggggctgagctggaggaggaagaggaggtggaagaggaagaggaggagtcaggaaac
ctggatgaagaagagataaagaagatgcaatcagatgagggcacagcgggcctggaagtg
acagcttacgaggagatgtccagcctagtcaactacatccagcccaccaagttcatttcc
tttgagttctctgcccagaagaaccgaagttatgtcatctcctccttcacggagctcaag
gcttatgacctgctttccaaggccgcagtgcagtttgtggactacaacaagcgccagatg
agccgcatttaccccaagggcacccgcatggactcctccaactacatgccccagatgttc
tggaacgctggttgccagatggtcgccctcaacttccagacgatggacctgcccatgcag
cagaacatggcactatttgagttcaatgggcagaccggctacctcctcaagcatgaattc
atgcgtcggccagacaagcagttcaacccgttctcagtggaccgcatcgacgtggtggta
gccaccaccctttccattaaggtaatctctgggcagttcctgtcagaacgcagtgtgcgc
acctatgtggaagtggagctgtttggccttcctggggaccccaagaggcgctatcgcacc
aagctgtcacccactaccaactctatcaatcctgtctggaatgaggagccctttgtcttt
gagaagatcttgatgcctgagctggcctccctcagggtggccgtgatggaggaaggcaac
aagtttcttgggcaccgcatcatccccatcaatgccctaaattctggataccaccatctg
tgcctgcgcagtgagagcaacatggccctcaccatgccagcgctctttatcttcctggag
atgaaggactatgttcctgacacctgggcagatctcactgtggccctcgccaatcccatc
aagttcttcagtgcccatgataagaagtctgtgaagctcaaggaagccatgggagatctg
cctgagaagcccttctctctcgggagtccagctgccagccaggtcaacggagcaactgcc
ccaaccagcaatgggtcagcagagccgcggaccaccagtctggaggagctgcaggggctg
aagggcgtcgtgaagctgcagcggcggcacgagaaggagctgcgggagctggagcggcgc
ggcgcgcggcgctgggaggaactgctgcagcgcggcgcggcacagctggcggagctcggg
ccgccgggcgcggggggcggcttcgggggccgcaggctcggcccgggcaagggctcccgc
aagaaaaggacgctgccctgcgaggagaccggctgggccacgctgggcgagggccccgag
ggcgcggaaacgctcgtccgcgagctgagggaccggctggagctggagctgctgcagcag
ggcgaggagaagtacgaatgcgtcctgaagcgcaagcagcagcaagtggccgagcaaatc
gccaagatgatggacctggccagagagaaacaggttgcagagcttaagaccctcaaggag
acctcgcagagtgacaccaaggagatgaagaagaagctggaggccaagaggctggagcgg
atccaggccatgatcaaggtcaccaccgacaagatggcccaggagagattgaaaagagag
attaacaactcccacatccaagaggtagtacaggtcatcaagcagatgacagagagcctg
gagaggcaccaggagaagctggaggagaagcaggcagcctgcctggaacagatccgagag
atggaaaagcagctccagcaggaggcgctggcagagtacgaggccaggatgaagggcctg
gaggccgaggtgaaggaagcagtgaggacctgcctcaggccctgcttcccctcggaggct
gaggacaagcttgagaggccctgtgggacctccagggagccgtgtgagctggacccacct
acagccaagaaagacatccaggagagcatcctctga |