KEGG   Pteronotus mesoamericanus (Parnell's mustached bat): 129070855
Entry
129070855         CDS       T09558                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ppam  Pteronotus mesoamericanus (Parnell's mustached bat)
Pathway
ppam00562  Inositol phosphate metabolism
ppam01100  Metabolic pathways
ppam04015  Rap1 signaling pathway
ppam04020  Calcium signaling pathway
ppam04022  cGMP-PKG signaling pathway
ppam04062  Chemokine signaling pathway
ppam04070  Phosphatidylinositol signaling system
ppam04071  Sphingolipid signaling pathway
ppam04072  Phospholipase D signaling pathway
ppam04081  Hormone signaling
ppam04082  Neuroactive ligand signaling
ppam04261  Adrenergic signaling in cardiomyocytes
ppam04270  Vascular smooth muscle contraction
ppam04310  Wnt signaling pathway
ppam04371  Apelin signaling pathway
ppam04540  Gap junction
ppam04611  Platelet activation
ppam04613  Neutrophil extracellular trap formation
ppam04621  NOD-like receptor signaling pathway
ppam04713  Circadian entrainment
ppam04720  Long-term potentiation
ppam04723  Retrograde endocannabinoid signaling
ppam04724  Glutamatergic synapse
ppam04725  Cholinergic synapse
ppam04726  Serotonergic synapse
ppam04728  Dopaminergic synapse
ppam04730  Long-term depression
ppam04742  Taste transduction
ppam04750  Inflammatory mediator regulation of TRP channels
ppam04911  Insulin secretion
ppam04912  GnRH signaling pathway
ppam04915  Estrogen signaling pathway
ppam04916  Melanogenesis
ppam04918  Thyroid hormone synthesis
ppam04919  Thyroid hormone signaling pathway
ppam04921  Oxytocin signaling pathway
ppam04922  Glucagon signaling pathway
ppam04924  Renin secretion
ppam04925  Aldosterone synthesis and secretion
ppam04926  Relaxin signaling pathway
ppam04927  Cortisol synthesis and secretion
ppam04928  Parathyroid hormone synthesis, secretion and action
ppam04929  GnRH secretion
ppam04933  AGE-RAGE signaling pathway in diabetic complications
ppam04934  Cushing syndrome
ppam04935  Growth hormone synthesis, secretion and action
ppam04961  Endocrine and other factor-regulated calcium reabsorption
ppam04970  Salivary secretion
ppam04971  Gastric acid secretion
ppam04972  Pancreatic secretion
ppam04973  Carbohydrate digestion and absorption
ppam05010  Alzheimer disease
ppam05016  Huntington disease
ppam05017  Spinocerebellar ataxia
ppam05022  Pathways of neurodegeneration - multiple diseases
ppam05142  Chagas disease
ppam05143  African trypanosomiasis
ppam05146  Amoebiasis
ppam05163  Human cytomegalovirus infection
ppam05200  Pathways in cancer
ppam05415  Diabetic cardiomyopathy
ppam05417  Lipid and atherosclerosis
Module
ppam_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ppam00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129070855 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    129070855 (PLCB4)
   04310 Wnt signaling pathway
    129070855 (PLCB4)
   04371 Apelin signaling pathway
    129070855 (PLCB4)
   04020 Calcium signaling pathway
    129070855 (PLCB4)
   04070 Phosphatidylinositol signaling system
    129070855 (PLCB4)
   04072 Phospholipase D signaling pathway
    129070855 (PLCB4)
   04071 Sphingolipid signaling pathway
    129070855 (PLCB4)
   04022 cGMP-PKG signaling pathway
    129070855 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    129070855 (PLCB4)
   04081 Hormone signaling
    129070855 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    129070855 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129070855 (PLCB4)
   04613 Neutrophil extracellular trap formation
    129070855 (PLCB4)
   04621 NOD-like receptor signaling pathway
    129070855 (PLCB4)
   04062 Chemokine signaling pathway
    129070855 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    129070855 (PLCB4)
   04922 Glucagon signaling pathway
    129070855 (PLCB4)
   04929 GnRH secretion
    129070855 (PLCB4)
   04912 GnRH signaling pathway
    129070855 (PLCB4)
   04915 Estrogen signaling pathway
    129070855 (PLCB4)
   04921 Oxytocin signaling pathway
    129070855 (PLCB4)
   04926 Relaxin signaling pathway
    129070855 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    129070855 (PLCB4)
   04918 Thyroid hormone synthesis
    129070855 (PLCB4)
   04919 Thyroid hormone signaling pathway
    129070855 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    129070855 (PLCB4)
   04916 Melanogenesis
    129070855 (PLCB4)
   04924 Renin secretion
    129070855 (PLCB4)
   04925 Aldosterone synthesis and secretion
    129070855 (PLCB4)
   04927 Cortisol synthesis and secretion
    129070855 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    129070855 (PLCB4)
   04270 Vascular smooth muscle contraction
    129070855 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    129070855 (PLCB4)
   04971 Gastric acid secretion
    129070855 (PLCB4)
   04972 Pancreatic secretion
    129070855 (PLCB4)
   04973 Carbohydrate digestion and absorption
    129070855 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    129070855 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    129070855 (PLCB4)
   04725 Cholinergic synapse
    129070855 (PLCB4)
   04728 Dopaminergic synapse
    129070855 (PLCB4)
   04726 Serotonergic synapse
    129070855 (PLCB4)
   04720 Long-term potentiation
    129070855 (PLCB4)
   04730 Long-term depression
    129070855 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    129070855 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    129070855 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    129070855 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    129070855 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129070855 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    129070855 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    129070855 (PLCB4)
   05142 Chagas disease
    129070855 (PLCB4)
   05143 African trypanosomiasis
    129070855 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129070855 (PLCB4)
   05016 Huntington disease
    129070855 (PLCB4)
   05017 Spinocerebellar ataxia
    129070855 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    129070855 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129070855 (PLCB4)
   05415 Diabetic cardiomyopathy
    129070855 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    129070855 (PLCB4)
   04934 Cushing syndrome
    129070855 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppam04131]
    129070855 (PLCB4)
Enzymes [BR:ppam01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     129070855 (PLCB4)
Membrane trafficking [BR:ppam04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    129070855 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    129070855 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 129070855
NCBI-ProteinID: XP_054430009
LinkDB
Position
Unknown
AA seq 1236 aa
MKGKRKKKDNLCTYSMCMKKSFHRHVLNITMAKPYEFNWQKEVPSFLQEGAIFDRYEEES
FVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRLGATPKDPKILAALEAVGKSE
SDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVDGLRSIIHNFRANNVSPMTCLKKH
WMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTFEKFY
ELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQ
IIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNT
YLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQ
AIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPS
PNDLKRKILIKNKRLKPEVEQKQLEALKSMMEAGESAAPVNILEDYNEEETESADQEEEA
HPEYKYGNELSADDLGHKEAVANSVKKVSDDLEHEINKKGLVTVEDEQAWMASYKYVGAT
TNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQ
MSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPD
FMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEF
RTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRH
ISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIE
TSDIADVPSDTSKNDKKGKANTAKTNVTPQSSSELRPTTTAALGSGMEAKKGIELIPQVR
IEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKI
LEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEI
RDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIK
NKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKTC
HAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNTN
NT seq 3711 nt   +upstreamnt  +downstreamnt
atgaagggaaaaagaaagaaaaaagacaatttgtgtacttactccatgtgtatgaagaaa
agctttcacagacacgtcttgaatataaccatggccaaaccttacgaattcaactggcag
aaggaagttccttcctttttgcaagaaggagcaatttttgacagatatgaagaggaatcc
tttgtgtttgaacccaactgcctcttcaaagtggatgagtttggcttctttctgacctgg
aaaagtgaaggcaaggaaggacaagtgctagaatgctccctcatcaacagtattcggttg
ggagccacaccaaaggatcccaaaatcctggctgcccttgaagctgttggaaaatcagaa
agcgacctggaggggcggatagtttgtgtctgcagtggaacagacctggtgaacatcagt
ttcacttacatggtggctgaaaacccagaagtaactaagcaatgggtagatggtctaaga
tcaatcatacacaacttcagggccaacaacgtcagtccgatgacatgcctcaagaaacac
tggatgaaattggcgtttatgaccaacacaaatggtaaaattccagttaggagtattact
agaacctttgcatcagggaaaacagaaaaggtgatctttcaagcgctcaaggagttaggt
cttcccagtggaaagaatgatgaaattgagcctgcagcatttacttttgaaaagttctat
gaactgacacaaaagatttgtcctcggacagatatagaggatctttttaaaaaaatcaat
ggagacaaaactgattatttaacggtagaccaattagtgagctttctaaatgaacaccaa
cgagatcctcgactgaatgaaattttattcccattttatgatgctaaaagagcaatgcag
atcattgagatgtatgagcctgatgaggacttgaagaaaaaaggccttatatcaagtgat
ggattttgcagatatctgatgtcagatgaaaatgcacccgtcttcctagatcgtttagaa
ctctaccaagaaatggaccaccctctggctcactacttcatcagttcttcccacaacacc
tatctcactggccgacagtttggcgggaaatcttcagtagaaatgtacagacaggttctc
ctggctgggtgcaggtgtgtcgaacttgactgctgggatggaaaaggtgaagaccaagaa
ccgataataactcatggaaaagcaatgtgtacagatatcctttttaaggatgttattcaa
gccatcaaggaaactgcatttgtcacatctgaatatcctgtaattctctcctttgaaaat
cactgcagcaaatatcaacagtacaagatgtccaaatattgtgaagatctatttggggat
ctcctgttgaaacaagcacttgaatcacatccactcgaaccaggcaggcccttgccatcc
cccaatgacctcaaaagaaaaatactcatcaaaaataaacgactgaaacctgaggttgaa
caaaagcagctcgaagctttgaaaagcatgatggaagctggagaatccgctgctccagtt
aacatcttagaggattataatgaggaggaaacagagagtgctgaccaagaagaagaagct
caccctgaatataaatatggaaatgaactttctgctgatgacttgggtcacaaggaagct
gttgcaaatagcgtcaagaaggtttctgatgaccttgaacatgaaatcaacaaaaagggc
ctggttactgtagaagatgagcaggcatggatggcatcttataaatatgtaggtgctacc
actaatatccatccgtatttgtccacaatgatcaactatgcacagcctgtaaagtttcaa
ggtttccatgttgctgaagaacgcaatatccattataacatgtcttcttttaatgagtca
gtcggtctgggctacttgaagacacacgcgattgaatttgtgaattataacaaacggcaa
atgagtcgcatttaccccaagggaggccgagtcgattccagtaattacatgcctcagatt
ttctggaacgctggctgccagatggtttcactgaactatcaaaccccagatttagcgatg
caattgaatcagggaaaatttgagtataatggatcgtgtgggtaccttctcaaaccagat
ttcatgagacggcctgatcgaacatttgatcctttctctgaaactcctgttgacggggtt
attgcagccacttgctcagtgcaggtcatatcaggtcaattcttatcagataagaaaatc
ggcacatacgtggaagtggacatgtatgggttgcccactgacacgatacgtaaggaattc
cgaactcgcatggtgatgaacaacggactcaatccagtttacaatgaagaatcattcgta
tttcggaaggtgatcctccctgacctggcagtcttgagaatagcagtgtatgatgacaac
aacaagctcattggccagaggattctcccattggatggcctccaagccggctatcgacac
atttcccttcgaaacgagggaaataaaccattatcactgccaacgattttctgcaatatt
gttcttaaaacatatgtgcctgatggatttggagatattgtggatgctttatcagatcca
aagaagtttctttcaattacggaaaaaagagcagaccaaatgagagctatgggcatcgaa
accagtgacatagccgatgtgcccagcgacacttctaagaatgacaagaaaggaaaggcc
aacactgccaaaacaaatgtgactccacagagcagctctgaacttagaccaactaccacg
gctgccctggggtctggcatggaagccaagaaaggtattgaacttatccctcaagtgaga
atagaagatttaaagcagatgaaggcttatttgaagcatttaaagaaacagcagaaggag
ctgaattccttaaaaaagaaacatgcaaaggagcacagtaccatgcagaagttacactgc
acgcaagttgacaaaattgtggcacagtatgacaaagagaagtcgactcatgaaaaaatc
ctggagaaggcaatgaagaagaaagggggaagtaattgtcttgaaatgaaaaaagaaaca
gaaattaaaattcagacactgacatcagatcacaaatctaaggtcaaggagattgtggcg
cagcacacaaaagagtggtcagagatgatcaacacgcacagcgctgaggagcaggaaatc
cgggacctgcacctgagccagcagtgcgagctgctgaaaaagctcctgatcaacgcccac
gagcagcaaacccagcagctgaaactgtcccatgacagggaaagcaaggaaatgagagca
caccaggctaagatttctatggaaaatagcaaagctatcagccaagataaatctatcaag
aacaaagcggaacgggagaggcgagtcagggagttaaacagcagcaacactaaaaagttt
ctggaagaaagaaagagactcgcaatgaaacagtccaaagaaatggatcagctgaaaaaa
gtccagcttgaacacctagaattcctagagaagcagaatgagcagcttttgaaaacctgt
catgcagtgtcccaaactcaaggcgaaggagatgcagcagatggtgaaattggaagccga
gatggaccgcagaccagcaacagtagtatgaaactccagaacacaaactga

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