KEGG   Pteronotus mesoamericanus (Parnell's mustached bat): 129076577
Entry
129076577         CDS       T09558                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ppam  Pteronotus mesoamericanus (Parnell's mustached bat)
Pathway
ppam00562  Inositol phosphate metabolism
ppam01100  Metabolic pathways
ppam01521  EGFR tyrosine kinase inhibitor resistance
ppam01522  Endocrine resistance
ppam01524  Platinum drug resistance
ppam04012  ErbB signaling pathway
ppam04014  Ras signaling pathway
ppam04015  Rap1 signaling pathway
ppam04024  cAMP signaling pathway
ppam04062  Chemokine signaling pathway
ppam04066  HIF-1 signaling pathway
ppam04068  FoxO signaling pathway
ppam04070  Phosphatidylinositol signaling system
ppam04071  Sphingolipid signaling pathway
ppam04072  Phospholipase D signaling pathway
ppam04081  Hormone signaling
ppam04140  Autophagy - animal
ppam04145  Phagocytosis
ppam04150  mTOR signaling pathway
ppam04151  PI3K-Akt signaling pathway
ppam04152  AMPK signaling pathway
ppam04210  Apoptosis
ppam04211  Longevity regulating pathway
ppam04213  Longevity regulating pathway - multiple species
ppam04218  Cellular senescence
ppam04360  Axon guidance
ppam04370  VEGF signaling pathway
ppam04380  Osteoclast differentiation
ppam04510  Focal adhesion
ppam04517  IgSF CAM signaling
ppam04518  Integrin signaling
ppam04550  Signaling pathways regulating pluripotency of stem cells
ppam04611  Platelet activation
ppam04613  Neutrophil extracellular trap formation
ppam04620  Toll-like receptor signaling pathway
ppam04625  C-type lectin receptor signaling pathway
ppam04630  JAK-STAT signaling pathway
ppam04650  Natural killer cell mediated cytotoxicity
ppam04660  T cell receptor signaling pathway
ppam04662  B cell receptor signaling pathway
ppam04664  Fc epsilon RI signaling pathway
ppam04666  Fc gamma R-mediated phagosome formation
ppam04668  TNF signaling pathway
ppam04670  Leukocyte transendothelial migration
ppam04722  Neurotrophin signaling pathway
ppam04725  Cholinergic synapse
ppam04750  Inflammatory mediator regulation of TRP channels
ppam04810  Regulation of actin cytoskeleton
ppam04910  Insulin signaling pathway
ppam04914  Progesterone-mediated oocyte maturation
ppam04915  Estrogen signaling pathway
ppam04917  Prolactin signaling pathway
ppam04919  Thyroid hormone signaling pathway
ppam04923  Regulation of lipolysis in adipocytes
ppam04926  Relaxin signaling pathway
ppam04929  GnRH secretion
ppam04930  Type II diabetes mellitus
ppam04931  Insulin resistance
ppam04932  Non-alcoholic fatty liver disease
ppam04933  AGE-RAGE signaling pathway in diabetic complications
ppam04935  Growth hormone synthesis, secretion and action
ppam04960  Aldosterone-regulated sodium reabsorption
ppam04973  Carbohydrate digestion and absorption
ppam05010  Alzheimer disease
ppam05017  Spinocerebellar ataxia
ppam05020  Prion disease
ppam05100  Bacterial invasion of epithelial cells
ppam05132  Salmonella infection
ppam05135  Yersinia infection
ppam05142  Chagas disease
ppam05146  Amoebiasis
ppam05160  Hepatitis C
ppam05161  Hepatitis B
ppam05162  Measles
ppam05163  Human cytomegalovirus infection
ppam05164  Influenza A
ppam05165  Human papillomavirus infection
ppam05166  Human T-cell leukemia virus 1 infection
ppam05167  Kaposi sarcoma-associated herpesvirus infection
ppam05168  Herpes simplex virus 1 infection
ppam05169  Epstein-Barr virus infection
ppam05170  Human immunodeficiency virus 1 infection
ppam05171  Coronavirus disease
ppam05200  Pathways in cancer
ppam05203  Viral carcinogenesis
ppam05205  Proteoglycans in cancer
ppam05206  MicroRNAs in cancer
ppam05207  Chemical carcinogenesis - receptor activation
ppam05208  Chemical carcinogenesis - reactive oxygen species
ppam05210  Colorectal cancer
ppam05211  Renal cell carcinoma
ppam05212  Pancreatic cancer
ppam05213  Endometrial cancer
ppam05214  Glioma
ppam05215  Prostate cancer
ppam05218  Melanoma
ppam05220  Chronic myeloid leukemia
ppam05221  Acute myeloid leukemia
ppam05222  Small cell lung cancer
ppam05223  Non-small cell lung cancer
ppam05224  Breast cancer
ppam05225  Hepatocellular carcinoma
ppam05226  Gastric cancer
ppam05230  Central carbon metabolism in cancer
ppam05231  Choline metabolism in cancer
ppam05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppam05415  Diabetic cardiomyopathy
ppam05417  Lipid and atherosclerosis
ppam05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppam00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129076577 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    129076577 (PIK3CA)
   04014 Ras signaling pathway
    129076577 (PIK3CA)
   04015 Rap1 signaling pathway
    129076577 (PIK3CA)
   04370 VEGF signaling pathway
    129076577 (PIK3CA)
   04630 JAK-STAT signaling pathway
    129076577 (PIK3CA)
   04668 TNF signaling pathway
    129076577 (PIK3CA)
   04066 HIF-1 signaling pathway
    129076577 (PIK3CA)
   04068 FoxO signaling pathway
    129076577 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    129076577 (PIK3CA)
   04072 Phospholipase D signaling pathway
    129076577 (PIK3CA)
   04071 Sphingolipid signaling pathway
    129076577 (PIK3CA)
   04024 cAMP signaling pathway
    129076577 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    129076577 (PIK3CA)
   04152 AMPK signaling pathway
    129076577 (PIK3CA)
   04150 mTOR signaling pathway
    129076577 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    129076577 (PIK3CA)
   04517 IgSF CAM signaling
    129076577 (PIK3CA)
   04518 Integrin signaling
    129076577 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    129076577 (PIK3CA)
   04140 Autophagy - animal
    129076577 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    129076577 (PIK3CA)
   04218 Cellular senescence
    129076577 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129076577 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    129076577 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129076577 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129076577 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    129076577 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    129076577 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    129076577 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    129076577 (PIK3CA)
   04660 T cell receptor signaling pathway
    129076577 (PIK3CA)
   04662 B cell receptor signaling pathway
    129076577 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    129076577 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    129076577 (PIK3CA)
   04670 Leukocyte transendothelial migration
    129076577 (PIK3CA)
   04062 Chemokine signaling pathway
    129076577 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129076577 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    129076577 (PIK3CA)
   04929 GnRH secretion
    129076577 (PIK3CA)
   04915 Estrogen signaling pathway
    129076577 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    129076577 (PIK3CA)
   04917 Prolactin signaling pathway
    129076577 (PIK3CA)
   04926 Relaxin signaling pathway
    129076577 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    129076577 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    129076577 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    129076577 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    129076577 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    129076577 (PIK3CA)
   04722 Neurotrophin signaling pathway
    129076577 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129076577 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    129076577 (PIK3CA)
   04380 Osteoclast differentiation
    129076577 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    129076577 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    129076577 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129076577 (PIK3CA)
   05206 MicroRNAs in cancer
    129076577 (PIK3CA)
   05205 Proteoglycans in cancer
    129076577 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    129076577 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    129076577 (PIK3CA)
   05203 Viral carcinogenesis
    129076577 (PIK3CA)
   05230 Central carbon metabolism in cancer
    129076577 (PIK3CA)
   05231 Choline metabolism in cancer
    129076577 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129076577 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129076577 (PIK3CA)
   05212 Pancreatic cancer
    129076577 (PIK3CA)
   05225 Hepatocellular carcinoma
    129076577 (PIK3CA)
   05226 Gastric cancer
    129076577 (PIK3CA)
   05214 Glioma
    129076577 (PIK3CA)
   05221 Acute myeloid leukemia
    129076577 (PIK3CA)
   05220 Chronic myeloid leukemia
    129076577 (PIK3CA)
   05218 Melanoma
    129076577 (PIK3CA)
   05211 Renal cell carcinoma
    129076577 (PIK3CA)
   05215 Prostate cancer
    129076577 (PIK3CA)
   05213 Endometrial cancer
    129076577 (PIK3CA)
   05224 Breast cancer
    129076577 (PIK3CA)
   05222 Small cell lung cancer
    129076577 (PIK3CA)
   05223 Non-small cell lung cancer
    129076577 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129076577 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    129076577 (PIK3CA)
   05161 Hepatitis B
    129076577 (PIK3CA)
   05160 Hepatitis C
    129076577 (PIK3CA)
   05171 Coronavirus disease
    129076577 (PIK3CA)
   05164 Influenza A
    129076577 (PIK3CA)
   05162 Measles
    129076577 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    129076577 (PIK3CA)
   05163 Human cytomegalovirus infection
    129076577 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129076577 (PIK3CA)
   05169 Epstein-Barr virus infection
    129076577 (PIK3CA)
   05165 Human papillomavirus infection
    129076577 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129076577 (PIK3CA)
   05135 Yersinia infection
    129076577 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    129076577 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    129076577 (PIK3CA)
   05142 Chagas disease
    129076577 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129076577 (PIK3CA)
   05017 Spinocerebellar ataxia
    129076577 (PIK3CA)
   05020 Prion disease
    129076577 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129076577 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    129076577 (PIK3CA)
   05415 Diabetic cardiomyopathy
    129076577 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    129076577 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    129076577 (PIK3CA)
   04931 Insulin resistance
    129076577 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129076577 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129076577 (PIK3CA)
   01524 Platinum drug resistance
    129076577 (PIK3CA)
   01522 Endocrine resistance
    129076577 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppam04131]
    129076577 (PIK3CA)
Enzymes [BR:ppam01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     129076577 (PIK3CA)
Membrane trafficking [BR:ppam04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    129076577 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 129076577
NCBI-ProteinID: XP_054436689
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
SFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYTHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acgttaataactataaagcatgaactatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgtcacccaggaagcagaaagggaa
gaatttttcgacgaaacaagacgactttgtgatcttcggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtctgtaaagaagctgtggaccttagggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaacgtagaatcttcaccagaactgccaaagcac
atatacaataaattagataaaggacaaataattgtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctttgtgttttagaatatcagggcaaatacattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcaatataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaggaaagcctttactcacaactgccaatggac
tcttttacaatgccgtcttattccagacgcatctctaccgccacaccatatatgaatgga
gaaacttctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttgtgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggtcgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaatcctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagttatacccatgcaggactgagtaacagactagccagagac
aatgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaattacttctgtctgttaaatggaattctagagatgaagta
gcccagatgtactgcttggtgaaagattggcctccaatcaaacccgaacaggctatggag
cttttggactgcaactacccagatcctatggttcgaggttttgctgttcgatgcctagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcgttgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctactattggaatcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagttgaggctatggaaaagctcatcaacctaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaaccctgcacatcag
ttaggaaatctcaggcttgaagagtgtcgcattatgtcttctgcaaaaaggccactgtgg
ttgaattgggaaaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagacatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgagaaattctcacaccatcatgcagatt
cagtgcaaagggggcctgaaaggtgcgctgcagttcaacagccacacgctccatcagtgg
ctcaaggacaagaacaaaggagaaatatatgatgcggccattgatctgtttacacgttca
tgtgctggatattgtgtcgcgaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgggaacgtgtaccgtttgttttgacacaagatttc
ttaatagttattagtaaaggagcccaagaatgcacaaagacaagggaatttgagaggttt
caggagatgtgttacaaggcttatctagccattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacagtcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
accattaagcagcatgctttgaactga

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