KEGG   Pteronotus mesoamericanus (Parnell's mustached bat): 129088423
Entry
129088423         CDS       T09558                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ppam  Pteronotus mesoamericanus (Parnell's mustached bat)
Pathway
ppam01521  EGFR tyrosine kinase inhibitor resistance
ppam01522  Endocrine resistance
ppam04010  MAPK signaling pathway
ppam04012  ErbB signaling pathway
ppam04014  Ras signaling pathway
ppam04015  Rap1 signaling pathway
ppam04022  cGMP-PKG signaling pathway
ppam04024  cAMP signaling pathway
ppam04062  Chemokine signaling pathway
ppam04068  FoxO signaling pathway
ppam04071  Sphingolipid signaling pathway
ppam04072  Phospholipase D signaling pathway
ppam04140  Autophagy - animal
ppam04150  mTOR signaling pathway
ppam04151  PI3K-Akt signaling pathway
ppam04210  Apoptosis
ppam04218  Cellular senescence
ppam04270  Vascular smooth muscle contraction
ppam04360  Axon guidance
ppam04370  VEGF signaling pathway
ppam04371  Apelin signaling pathway
ppam04510  Focal adhesion
ppam04540  Gap junction
ppam04550  Signaling pathways regulating pluripotency of stem cells
ppam04613  Neutrophil extracellular trap formation
ppam04625  C-type lectin receptor signaling pathway
ppam04630  JAK-STAT signaling pathway
ppam04650  Natural killer cell mediated cytotoxicity
ppam04660  T cell receptor signaling pathway
ppam04662  B cell receptor signaling pathway
ppam04664  Fc epsilon RI signaling pathway
ppam04666  Fc gamma R-mediated phagocytosis
ppam04720  Long-term potentiation
ppam04722  Neurotrophin signaling pathway
ppam04726  Serotonergic synapse
ppam04730  Long-term depression
ppam04810  Regulation of actin cytoskeleton
ppam04910  Insulin signaling pathway
ppam04912  GnRH signaling pathway
ppam04914  Progesterone-mediated oocyte maturation
ppam04915  Estrogen signaling pathway
ppam04916  Melanogenesis
ppam04917  Prolactin signaling pathway
ppam04919  Thyroid hormone signaling pathway
ppam04921  Oxytocin signaling pathway
ppam04926  Relaxin signaling pathway
ppam04928  Parathyroid hormone synthesis, secretion and action
ppam04929  GnRH secretion
ppam04935  Growth hormone synthesis, secretion and action
ppam05010  Alzheimer disease
ppam05022  Pathways of neurodegeneration - multiple diseases
ppam05034  Alcoholism
ppam05132  Salmonella infection
ppam05152  Tuberculosis
ppam05160  Hepatitis C
ppam05161  Hepatitis B
ppam05163  Human cytomegalovirus infection
ppam05164  Influenza A
ppam05165  Human papillomavirus infection
ppam05167  Kaposi sarcoma-associated herpesvirus infection
ppam05170  Human immunodeficiency virus 1 infection
ppam05200  Pathways in cancer
ppam05205  Proteoglycans in cancer
ppam05206  MicroRNAs in cancer
ppam05207  Chemical carcinogenesis - receptor activation
ppam05208  Chemical carcinogenesis - reactive oxygen species
ppam05210  Colorectal cancer
ppam05211  Renal cell carcinoma
ppam05212  Pancreatic cancer
ppam05213  Endometrial cancer
ppam05214  Glioma
ppam05215  Prostate cancer
ppam05218  Melanoma
ppam05219  Bladder cancer
ppam05220  Chronic myeloid leukemia
ppam05221  Acute myeloid leukemia
ppam05223  Non-small cell lung cancer
ppam05224  Breast cancer
ppam05225  Hepatocellular carcinoma
ppam05226  Gastric cancer
ppam05230  Central carbon metabolism in cancer
ppam05231  Choline metabolism in cancer
ppam05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ppam00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129088423 (RAF1)
   04012 ErbB signaling pathway
    129088423 (RAF1)
   04014 Ras signaling pathway
    129088423 (RAF1)
   04015 Rap1 signaling pathway
    129088423 (RAF1)
   04370 VEGF signaling pathway
    129088423 (RAF1)
   04371 Apelin signaling pathway
    129088423 (RAF1)
   04630 JAK-STAT signaling pathway
    129088423 (RAF1)
   04068 FoxO signaling pathway
    129088423 (RAF1)
   04072 Phospholipase D signaling pathway
    129088423 (RAF1)
   04071 Sphingolipid signaling pathway
    129088423 (RAF1)
   04024 cAMP signaling pathway
    129088423 (RAF1)
   04022 cGMP-PKG signaling pathway
    129088423 (RAF1)
   04151 PI3K-Akt signaling pathway
    129088423 (RAF1)
   04150 mTOR signaling pathway
    129088423 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129088423 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    129088423 (RAF1)
   04218 Cellular senescence
    129088423 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129088423 (RAF1)
   04540 Gap junction
    129088423 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    129088423 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129088423 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    129088423 (RAF1)
   04625 C-type lectin receptor signaling pathway
    129088423 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    129088423 (RAF1)
   04660 T cell receptor signaling pathway
    129088423 (RAF1)
   04662 B cell receptor signaling pathway
    129088423 (RAF1)
   04664 Fc epsilon RI signaling pathway
    129088423 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    129088423 (RAF1)
   04062 Chemokine signaling pathway
    129088423 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129088423 (RAF1)
   04929 GnRH secretion
    129088423 (RAF1)
   04912 GnRH signaling pathway
    129088423 (RAF1)
   04915 Estrogen signaling pathway
    129088423 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    129088423 (RAF1)
   04917 Prolactin signaling pathway
    129088423 (RAF1)
   04921 Oxytocin signaling pathway
    129088423 (RAF1)
   04926 Relaxin signaling pathway
    129088423 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    129088423 (RAF1)
   04919 Thyroid hormone signaling pathway
    129088423 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    129088423 (RAF1)
   04916 Melanogenesis
    129088423 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    129088423 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    129088423 (RAF1)
   04720 Long-term potentiation
    129088423 (RAF1)
   04730 Long-term depression
    129088423 (RAF1)
   04722 Neurotrophin signaling pathway
    129088423 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    129088423 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129088423 (RAF1)
   05206 MicroRNAs in cancer
    129088423 (RAF1)
   05205 Proteoglycans in cancer
    129088423 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    129088423 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    129088423 (RAF1)
   05230 Central carbon metabolism in cancer
    129088423 (RAF1)
   05231 Choline metabolism in cancer
    129088423 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129088423 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129088423 (RAF1)
   05212 Pancreatic cancer
    129088423 (RAF1)
   05225 Hepatocellular carcinoma
    129088423 (RAF1)
   05226 Gastric cancer
    129088423 (RAF1)
   05214 Glioma
    129088423 (RAF1)
   05221 Acute myeloid leukemia
    129088423 (RAF1)
   05220 Chronic myeloid leukemia
    129088423 (RAF1)
   05218 Melanoma
    129088423 (RAF1)
   05211 Renal cell carcinoma
    129088423 (RAF1)
   05219 Bladder cancer
    129088423 (RAF1)
   05215 Prostate cancer
    129088423 (RAF1)
   05213 Endometrial cancer
    129088423 (RAF1)
   05224 Breast cancer
    129088423 (RAF1)
   05223 Non-small cell lung cancer
    129088423 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    129088423 (RAF1)
   05161 Hepatitis B
    129088423 (RAF1)
   05160 Hepatitis C
    129088423 (RAF1)
   05164 Influenza A
    129088423 (RAF1)
   05163 Human cytomegalovirus infection
    129088423 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129088423 (RAF1)
   05165 Human papillomavirus infection
    129088423 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129088423 (RAF1)
   05152 Tuberculosis
    129088423 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129088423 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    129088423 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    129088423 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129088423 (RAF1)
   01522 Endocrine resistance
    129088423 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppam01001]
    129088423 (RAF1)
Enzymes [BR:ppam01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     129088423 (RAF1)
Protein kinases [BR:ppam01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   129088423 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 129088423
NCBI-ProteinID: XP_054451777
LinkDB
Position
Unknown
AA seq 668 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVSVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDMCQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNVRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRGFCLRGRDA
IRSHSDSASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagacgca
gtgtttgatggccccagctgcatttccccgacaatagttcagcagtttggctatcagcgc
cgagcgtcagatgatggcaaacttacggactcatctaagacaagcaatacgattcgtgtt
ttcttgccaaacaagcaaagaacggtggtcagtgtacgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagaatgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgtttagattggaatactgatgctgcctcg
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagaccttcttgaagcttgccttctgtgacatgtgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatgtcaggcaactcttattgtttccaaattccact
attggtgacagtggagtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacgttc
aacacctccagcccctcctctgaaggttccctctctcagaggcagagatcgacgtccaca
cctaacgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagaggattttgtttgaggggaagagatgca
atccgaagtcacagtgactcagcctcaccttcagccttgtccagcagccccaacaatctg
agcccaacgggctggtcacagcccaaaacccctgtgccggcacagagagagcgggcacca
ggatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctctccactcggattgggtcaggctccttt
ggaactgtttataagggcaagtggcatggagatgttgcagtaaagatcctaaaggttgtt
gaccccacacctgagcagttccaagccttcaggaatgaggtggctgtccttcgcaaaaca
cggcacgtgaacatcttgctcttcatggggtacatgacaaaggacaatctggcgattgtg
acccagtggtgcgaaggcagcagcctctacaaacacctgcatgtccaagagaccaagttc
caaatgttccagttgattgacattgcccggcagacggctcagggaatggactatttgcat
gcgaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacccaccggctctatcctgtggatggccccagaagtgatccgaatgcag
gataataaccctttcagcttccagtctgacgtctactcctatggcattgtgctgtatgag
cttatgacaggggagctaccttattcccacatcaacaaccgagatcagatcatcttcatg
gtgggtcgagggtatgcctccccagatcttagtaaactgtacaagaactgccccaaagca
atgaagcggcttgtcgcagactgtgtgaagaaagttaaggaagagaggcctctttttccc
cagatcctgtcttccatcgagctgctccaacactctctaccgaaaatcaaccggagcgct
tctgagccatccctgcatcgggcggcccacaccgaggacatcaatgcctgcacgctgacc
acgtcccctagactgcctgtcttctag

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