KEGG   Phocoena phocoena (harbor porpoise): 136118632
Entry
136118632         CDS       T11058                                 
Symbol
AKT1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pphc  Phocoena phocoena (harbor porpoise)
Pathway
pphc01521  EGFR tyrosine kinase inhibitor resistance
pphc01522  Endocrine resistance
pphc01524  Platinum drug resistance
pphc04010  MAPK signaling pathway
pphc04012  ErbB signaling pathway
pphc04014  Ras signaling pathway
pphc04015  Rap1 signaling pathway
pphc04022  cGMP-PKG signaling pathway
pphc04024  cAMP signaling pathway
pphc04062  Chemokine signaling pathway
pphc04066  HIF-1 signaling pathway
pphc04068  FoxO signaling pathway
pphc04071  Sphingolipid signaling pathway
pphc04072  Phospholipase D signaling pathway
pphc04140  Autophagy - animal
pphc04150  mTOR signaling pathway
pphc04151  PI3K-Akt signaling pathway
pphc04152  AMPK signaling pathway
pphc04210  Apoptosis
pphc04211  Longevity regulating pathway
pphc04213  Longevity regulating pathway - multiple species
pphc04218  Cellular senescence
pphc04261  Adrenergic signaling in cardiomyocytes
pphc04370  VEGF signaling pathway
pphc04371  Apelin signaling pathway
pphc04380  Osteoclast differentiation
pphc04510  Focal adhesion
pphc04517  IgSF CAM signaling
pphc04518  Integrin signaling
pphc04550  Signaling pathways regulating pluripotency of stem cells
pphc04611  Platelet activation
pphc04613  Neutrophil extracellular trap formation
pphc04620  Toll-like receptor signaling pathway
pphc04625  C-type lectin receptor signaling pathway
pphc04630  JAK-STAT signaling pathway
pphc04660  T cell receptor signaling pathway
pphc04662  B cell receptor signaling pathway
pphc04664  Fc epsilon RI signaling pathway
pphc04666  Fc gamma R-mediated phagocytosis
pphc04668  TNF signaling pathway
pphc04722  Neurotrophin signaling pathway
pphc04725  Cholinergic synapse
pphc04728  Dopaminergic synapse
pphc04810  Regulation of actin cytoskeleton
pphc04910  Insulin signaling pathway
pphc04914  Progesterone-mediated oocyte maturation
pphc04915  Estrogen signaling pathway
pphc04917  Prolactin signaling pathway
pphc04919  Thyroid hormone signaling pathway
pphc04920  Adipocytokine signaling pathway
pphc04922  Glucagon signaling pathway
pphc04923  Regulation of lipolysis in adipocytes
pphc04926  Relaxin signaling pathway
pphc04929  GnRH secretion
pphc04931  Insulin resistance
pphc04932  Non-alcoholic fatty liver disease
pphc04933  AGE-RAGE signaling pathway in diabetic complications
pphc04935  Growth hormone synthesis, secretion and action
pphc04936  Alcoholic liver disease
pphc04973  Carbohydrate digestion and absorption
pphc05010  Alzheimer disease
pphc05017  Spinocerebellar ataxia
pphc05132  Salmonella infection
pphc05135  Yersinia infection
pphc05142  Chagas disease
pphc05145  Toxoplasmosis
pphc05152  Tuberculosis
pphc05160  Hepatitis C
pphc05161  Hepatitis B
pphc05162  Measles
pphc05163  Human cytomegalovirus infection
pphc05164  Influenza A
pphc05165  Human papillomavirus infection
pphc05166  Human T-cell leukemia virus 1 infection
pphc05167  Kaposi sarcoma-associated herpesvirus infection
pphc05168  Herpes simplex virus 1 infection
pphc05169  Epstein-Barr virus infection
pphc05170  Human immunodeficiency virus 1 infection
pphc05200  Pathways in cancer
pphc05205  Proteoglycans in cancer
pphc05207  Chemical carcinogenesis - receptor activation
pphc05208  Chemical carcinogenesis - reactive oxygen species
pphc05210  Colorectal cancer
pphc05211  Renal cell carcinoma
pphc05212  Pancreatic cancer
pphc05213  Endometrial cancer
pphc05214  Glioma
pphc05215  Prostate cancer
pphc05218  Melanoma
pphc05220  Chronic myeloid leukemia
pphc05221  Acute myeloid leukemia
pphc05222  Small cell lung cancer
pphc05223  Non-small cell lung cancer
pphc05224  Breast cancer
pphc05225  Hepatocellular carcinoma
pphc05226  Gastric cancer
pphc05230  Central carbon metabolism in cancer
pphc05231  Choline metabolism in cancer
pphc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pphc05415  Diabetic cardiomyopathy
pphc05417  Lipid and atherosclerosis
pphc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pphc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    136118632 (AKT1)
   04012 ErbB signaling pathway
    136118632 (AKT1)
   04014 Ras signaling pathway
    136118632 (AKT1)
   04015 Rap1 signaling pathway
    136118632 (AKT1)
   04370 VEGF signaling pathway
    136118632 (AKT1)
   04371 Apelin signaling pathway
    136118632 (AKT1)
   04630 JAK-STAT signaling pathway
    136118632 (AKT1)
   04668 TNF signaling pathway
    136118632 (AKT1)
   04066 HIF-1 signaling pathway
    136118632 (AKT1)
   04068 FoxO signaling pathway
    136118632 (AKT1)
   04072 Phospholipase D signaling pathway
    136118632 (AKT1)
   04071 Sphingolipid signaling pathway
    136118632 (AKT1)
   04024 cAMP signaling pathway
    136118632 (AKT1)
   04022 cGMP-PKG signaling pathway
    136118632 (AKT1)
   04151 PI3K-Akt signaling pathway
    136118632 (AKT1)
   04152 AMPK signaling pathway
    136118632 (AKT1)
   04150 mTOR signaling pathway
    136118632 (AKT1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    136118632 (AKT1)
   04518 Integrin signaling
    136118632 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    136118632 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    136118632 (AKT1)
   04218 Cellular senescence
    136118632 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    136118632 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    136118632 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    136118632 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    136118632 (AKT1)
   04613 Neutrophil extracellular trap formation
    136118632 (AKT1)
   04620 Toll-like receptor signaling pathway
    136118632 (AKT1)
   04625 C-type lectin receptor signaling pathway
    136118632 (AKT1)
   04660 T cell receptor signaling pathway
    136118632 (AKT1)
   04662 B cell receptor signaling pathway
    136118632 (AKT1)
   04664 Fc epsilon RI signaling pathway
    136118632 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    136118632 (AKT1)
   04062 Chemokine signaling pathway
    136118632 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    136118632 (AKT1)
   04922 Glucagon signaling pathway
    136118632 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    136118632 (AKT1)
   04920 Adipocytokine signaling pathway
    136118632 (AKT1)
   04929 GnRH secretion
    136118632 (AKT1)
   04915 Estrogen signaling pathway
    136118632 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    136118632 (AKT1)
   04917 Prolactin signaling pathway
    136118632 (AKT1)
   04926 Relaxin signaling pathway
    136118632 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    136118632 (AKT1)
   04919 Thyroid hormone signaling pathway
    136118632 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    136118632 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    136118632 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    136118632 (AKT1)
   04728 Dopaminergic synapse
    136118632 (AKT1)
   04722 Neurotrophin signaling pathway
    136118632 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    136118632 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    136118632 (AKT1)
   04213 Longevity regulating pathway - multiple species
    136118632 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    136118632 (AKT1)
   05205 Proteoglycans in cancer
    136118632 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    136118632 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    136118632 (AKT1)
   05230 Central carbon metabolism in cancer
    136118632 (AKT1)
   05231 Choline metabolism in cancer
    136118632 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    136118632 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    136118632 (AKT1)
   05212 Pancreatic cancer
    136118632 (AKT1)
   05225 Hepatocellular carcinoma
    136118632 (AKT1)
   05226 Gastric cancer
    136118632 (AKT1)
   05214 Glioma
    136118632 (AKT1)
   05221 Acute myeloid leukemia
    136118632 (AKT1)
   05220 Chronic myeloid leukemia
    136118632 (AKT1)
   05218 Melanoma
    136118632 (AKT1)
   05211 Renal cell carcinoma
    136118632 (AKT1)
   05215 Prostate cancer
    136118632 (AKT1)
   05213 Endometrial cancer
    136118632 (AKT1)
   05224 Breast cancer
    136118632 (AKT1)
   05222 Small cell lung cancer
    136118632 (AKT1)
   05223 Non-small cell lung cancer
    136118632 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    136118632 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    136118632 (AKT1)
   05161 Hepatitis B
    136118632 (AKT1)
   05160 Hepatitis C
    136118632 (AKT1)
   05164 Influenza A
    136118632 (AKT1)
   05162 Measles
    136118632 (AKT1)
   05168 Herpes simplex virus 1 infection
    136118632 (AKT1)
   05163 Human cytomegalovirus infection
    136118632 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    136118632 (AKT1)
   05169 Epstein-Barr virus infection
    136118632 (AKT1)
   05165 Human papillomavirus infection
    136118632 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    136118632 (AKT1)
   05135 Yersinia infection
    136118632 (AKT1)
   05152 Tuberculosis
    136118632 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    136118632 (AKT1)
   05142 Chagas disease
    136118632 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    136118632 (AKT1)
   05017 Spinocerebellar ataxia
    136118632 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    136118632 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    136118632 (AKT1)
   05415 Diabetic cardiomyopathy
    136118632 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    136118632 (AKT1)
   04932 Non-alcoholic fatty liver disease
    136118632 (AKT1)
   04931 Insulin resistance
    136118632 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    136118632 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    136118632 (AKT1)
   01524 Platinum drug resistance
    136118632 (AKT1)
   01522 Endocrine resistance
    136118632 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pphc01001]
    136118632 (AKT1)
Enzymes [BR:pphc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     136118632 (AKT1)
Protein kinases [BR:pphc01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   136118632 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 Seadorna_VP7
Other DBs
NCBI-GeneID: 136118632
NCBI-ProteinID: XP_065727940
LinkDB
Position
2:618076..637357
AA seq 480 aa
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEEMMDF
RSGSPGENSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFPEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLSPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFASIAWQDVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQIITITPPDRDDSMEGVDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaatgacgtggccatcgtgaaggagggctggctgcacaaacgaggtgagtacatcaaa
acctggcggccccggtacttcctcttgaagaacgacggcaccttcatcggctacaaggag
cggccgcaggacgtggagcagcgcgagtcgcccctgaacaacttctccgtggcgcaatgc
cagctgatgaagacggagcggccgcggcccaacaccttcatcatccgctgcctgcagtgg
accacggtcatcgagcgcacgttccatgtagagacccccgaggagcgggaggagtggaca
accgccatccagacggtggccgacgggctcaagaggcaggaggaggagatgatggacttc
cggtcgggctcgcctggcgagaactcaggggccgaggagatggaggtggcgctggccaag
cccaagcaccgcgtgaccatgaatgagtttgagtacctgaagctgctgggcaaaggcacc
ttcgggaaggtgatcctggtgaaggagaaggccacgggccgctactatgccatgaagatc
ctgaagaaggaggtcattgtggccaaggacgaggtggcccacacgcttacggagaaccgc
gtcctccagaactcccggcaccccttcctgacggccctgaagtactccttccagacccac
gaccgcctgtgcttcgtcatggagtacgccaacggaggcgagctcttcttccacctgtcc
cgggagcgggtgttccccgaggaccgggcccggttctacggcgccgagatcgtgtctgcc
ctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctc
atgctggacaaggacgggcacatcaagatcacggacttcgggctgtgcaaggagggcatc
aaggatggcgccaccatgaagaccttctgcgggacgcctgagtacctggcccccgaggtg
ctggaggacaacgactacggccgggcggtggactggtgggggctgggcgtggtcatgtac
gagatgatgtgcggccgcctgcccttctacaaccaggaccacgagaagcttttcgagctc
atcctcatggaggagatccgcttcccacgcacgctcagccctgaggccaagtccctgctc
tcagggctgctcaagaaggaccccaagcagcggctcggcggaggctccgaggacgccaag
gagatcatgcagcaccgcttcttcgccagcatcgcgtggcaggacgtgtatgagaagaag
ctcagcccacccttcaagcctcaggtcacgtccgagacggacaccaggtactttgacgaa
gagttcacagcccagattatcaccatcacgccgcccgaccgagacgacagcatggagggc
gtggacagcgagcggaggcctcacttcccccagttctcctactcggccagcggcacggcc
tga

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