Phocoena phocoena (harbor porpoise): 136118884
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Entry
136118884 CDS
T11058
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
pphc Phocoena phocoena (harbor porpoise)
Pathway
pphc00230
Purine metabolism
pphc01100
Metabolic pathways
pphc04927
Cortisol synthesis and secretion
pphc04934
Cushing syndrome
pphc05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
pphc00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
136118884 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
136118884 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
136118884 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
136118884 (PDE8A)
Enzymes [BR:
pphc01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
136118884 (PDE8A)
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Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PDE8
PAS
PAS_9
PAS_4
PAS_3
Response_reg
PAS_8
DUF5894
Band_7_C
Motif
Other DBs
NCBI-GeneID:
136118884
NCBI-ProteinID:
XP_065728306
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Position
2:140623714..140724582
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AA seq
837 aa
AA seq
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MGCAQSIHASESRAVYHGGNEAEDAPVPAAPPLQPGGPRLPPGQTTAASARSCGSSLVES
EPSGGSGSSIVAVADIQFGPMRFHPDQLQVLLVFPKEDKQCNGFCRACEKAGFKCTVIKE
AQTALACFLDKHHDIIIIDHRNPQQLDGEVLCRSIRSSELSENTVIVGVVRRAVREESSV
MSLIEAGFTRRYVENPSAMACYNELLQMEFGLVHPQLKLRACNSMFTALEKSQEAIEITS
EDHIVQYANPAFETTMGYESGELIGKDLAEVPVNEKKADLLETINSCIRIGKEWQGICSA
KEKNGDNVQQNVKILPVIGQGGKIRHYVSIVRACNGNNKATKIAECVQSDTHTDHQSGKH
NDRRKSSLDVRTAASRTSKVSSQRRRSSTARIHSMKIEAPITKAINIISAAQESSPMPVT
EALDRVLEILRTTELYSPQFDAKDDDPHAIDLVGGLMSDVFRRPSRNEYVLSTKNLQQAS
SSVITPTSLHDIPSQITQAMENEECWDFDIFELEAATHKRPLIYLGLKIFARFGVCEVLK
CSETTLRSWLQIIEANYHASNPYHNSTHSADVLHATAYFLCKERIKQTLDPLDEVTALIA
ATVHDLDHPGRTNSFLCNAGSELAILYNDTAVLERHHAALAFQLTTGDDKCNIFKNMERS
DYRSLRQSIIDMVLATEMTKHFEHVNKFVNSINKPLAALEEDGEADKNQEAIITMLRTPD
NRSLIKRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKRQDLPVVMPVFDRNTC
SIPKSQISFIDYFITDMFAAWDAFVDLPELMQHLDNNFKYWKGLDEMKLRSLRPPPE
NT seq
2514 nt
NT seq
+upstream
nt +downstream
nt
atgggctgtgcccagagcatccacgcttccgagagccgggcggtgtaccacggcggcaac
gaggccgaggacgcgccggtccccgcggcgccgccgttgcagcctggcgggccgcgcctc
ccacccggccagacgacggccgcctcggcccggtcctgcggctccagcctcgtggagtcc
gagccaagtggcggcagcggcagcagcatcgtagcagtagctgatatacaatttggcccc
atgagatttcatccagatcagctccaggtacttttagtgtttcccaaagaagataaacag
tgtaatggattctgtagggcatgtgaaaaagcagggtttaagtgtacagttatcaaggag
gctcagacggcccttgcctgtttcctggacaaacatcatgacatcatcatcattgaccac
agaaatccccaacagctggacggggaggtgctgtgcaggtctatcagatcatcagaactc
tcagaaaacacagttattgttggtgtagtacgcagggcggttagagaagagtcatctgta
atgtccctcattgaggctggctttacaaggaggtatgtagaaaaccccagcgccatggcc
tgttacaatgaactgctccagatggagtttggattggtgcacccacagctgaaactcagg
gcttgtaactcaatgttcactgcattagagaaaagtcaagaagcaattgaaattacaagt
gaagaccacattgtacagtatgcaaatccagcatttgaaacaacaatgggctatgagtca
ggtgaattaatagggaaggatttagcagaagtgcctgtaaatgaaaaaaaggctgatttg
ctcgagactataaattcatgcatcaggataggcaaggaatggcaaggaatttgctctgcc
aaagagaaaaacggagataatgtacaacaaaatgtgaagatactacctgtcatcggacag
ggaggaaaaattagacactatgtgtccattgtcagagcatgcaatggcaacaataaggct
acgaaaatagctgaatgtgttcagtctgacactcatacagatcatcagtcaggcaaacac
aacgacaggaggaaaagctcactagatgtcagaactgctgcctctcgaacaagcaaagtt
tccagccagagacgacgctcctccacggcccggatacattccatgaagatcgaggcgccc
atcaccaaggcaatcaatatcatcagtgctgcccaggaaagcagtcccatgcctgtgaca
gaagccttagatcgtgtgctggagattctgagaaccactgaattatattccccacaattc
gatgctaaggacgatgatcctcatgccatcgaccttgttgggggcttaatgtctgacgtt
tttcgaagaccatccaggaatgagtatgttctttcaacaaaaaaccttcaacaggcttcc
agcagtgtgatcacccccacctcccttcacgacatcccgtcacagataactcaggccatg
gaaaatgaggaatgctgggactttgatatttttgaactggaggctgccactcataaaagg
cctttgatttatcttggtctcaaaatatttgctcgctttggagtctgtgaagtcttaaaa
tgctctgagacaacgctgagatcgtggttgcaaattatcgaagccaattatcatgcttct
aacccctaccacaattctacacattctgccgacgtgcttcacgccactgcctattttctc
tgcaaggagaggataaagcaaactttagatccacttgatgaggtcactgccctcattgca
gccactgtccatgacctggaccaccccgggagaaccaactccttcctgtgcaatgctggg
agtgagctggccattctgtacaacgacactgctgtgctcgagagacaccacgcggccttg
gccttccagctgaccactggtgatgataagtgcaacatctttaaaaacatggagaggagt
gactaccggtcgctgcgccagagtattatcgacatggtcttagccacagagatgacaaag
cactttgagcacgtcaacaaatttgtcaacagcatcaacaagcccttggcagcattagag
gaagatggggaagctgataaaaatcaagaagccataatcactatgctcagaactccagac
aaccgcagtttgatcaaacgaatgctgattaagtgtgctgatgtgtccaatccctgccga
cccctggagcagtgcattgagtgggccgcacgtatctcagaagaatatttttctcagact
gatgaagagaagcgacaggacttgcctgtggtgatgccagtttttgacagaaatacctgc
agcatccccaaatcccaaatctctttcattgactacttcatcacagacatgtttgctgct
tgggacgcctttgtagacctgcctgagctaatgcagcatcttgacaacaattttaaatac
tggaagggactggacgaaatgaagctgcggagcctccgcccacctcctgaatag
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