Phocoena phocoena (harbor porpoise): 136120877
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Entry
136120877 CDS
T11058
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
pphc Phocoena phocoena (harbor porpoise)
Pathway
pphc00310
Lysine degradation
pphc01100
Metabolic pathways
pphc05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
pphc00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
136120877 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
136120877 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
pphc03036
]
136120877 (DOT1L)
Enzymes [BR:
pphc01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
136120877 (DOT1L)
Chromosome and associated proteins [BR:
pphc03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
136120877 (DOT1L)
HMT complexes
Dot1-containing complex
136120877 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
136120877
NCBI-ProteinID:
XP_065730615
LinkDB
All DBs
Position
3:complement(171946991..172000151)
Genome browser
AA seq
1728 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKTAMPADTPMDSGAEEEKAGATTVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTT
NPERKPKKTQSALDLLHAQTVSRAASPSPQESVTRCLPAGAPYQLPPSTQRRPPEQLLLA
PAPPALHRLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNARLLGAVQQLFGHCQA
QKEEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLR
LLKARCEELKLDWSTLSLEGLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQ
LKSCVPPDDALSLHLRGKGGLGRELEAEPGRPHLELDCARFSLPHLSNMSPELSMNGHAA
GYELCGTLSRPSPKQNTPQYLASPLDQEVVPCTPNHSGRPRLEKLSGLALPDYTRLSPAK
LVLRRHLSQDHTANSRATASELHSRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPAAL
QMTGEKGSEKGLKERTYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVR
STPSPVPQARESSSTLEKQMGAGTHGSGCSAAGSRSLALAPAGFAYAGSVAISGALAGSP
APLVSGAEPPTLDESSSSGSLFATVGSRSSTPQHPPLLAQPRNCGSASPAPQLCASPRLG
AQGPLPDTSKGDLPSEAGFSDPESEAKRRIVFTISAGSSSAKQSPSSKHSPLSSGARGDG
GQSHGQDSRKRGRRKRAAAGTPGFSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNIN
QPLEITAISSPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEP
SSARIERKIATISLESKSPPKTLENGGSLAGRKVPASEPVNSSKWKSTFSPISDLGLAKA
ADSPLQAASALSHNSLFAFRPGLEEPGTADAKLAAHPRKSFPGALPGAGGLSPSSHPASS
FALGGGLAADLSLHSFSDGASLSHKAPEAAGLGTPLSFPGPRGKEGGAADPGPFVNKRQL
DGLAPKGEGGPPVCGPADKASATHGKAGKGRDREPDVKNGHNLFMAAAAAAAAAAATPPG
GLLSGPGLAPAASSAGGTAPSVQTHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLFSS
VPAAGLVHVSTAATRLTNSHAMGSFSSGVAGGAVGGAFNHAVPPASAHPFGASFGSGAAC
RSATLSLTPLQAVASTPASSFQAPPPAEPRPPPPPPHLGRPPPGPPALHAPPPPNAALPP
PPALLPANSEPVLLQNLASLPANQAFLPASSAASVPPANASLSIKLASLPHKVSRPSFTV
HHPPLPGLALAQAAPVIPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq
5187 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggctgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atccggtgggtctgtgaagaaatcccagatctcaagctcgctatggagaattatgtttta
atcgactacgacaccaaaagcttcgaaagcatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggtaccacgcagcccatgaagctgaacaca
cggccgtccacggggctcctgcgccacatcctgcagcaggtctacaaccactcggtgacc
gaccccgagaaactcaacaactatgagcccttctccccggaggtgtacggggagacttcc
ttcgacctggtcgcccagatgatcgacgagatcaagatgaccgaagacgacctgtttgtg
gacctgggtagcggagtgggccaggttgtgctgcaggtcgctgcggctaccaactgcaaa
catcactatggtgtcgagaaagctgacatcccggccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagaga
ggagatttcctctcagaggagtggagagagcggatcgccaacacgagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggttcgcaaacatg
aaggaaggtggcagaattgtgtcctcgaagccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgcctctaaaa
ggctcggtgtcgtggacggggaagccggtgtcttactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacgaccacccccaccaaggtgccc
gagagcaagacggccatgcctgccgacacccccatggactctggtgctgaggaagagaaa
gccggggcaaccactgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggccggccggaagcgcggacgtcccaagaagatgagcaccacc
aaccccgagcgcaagcccaagaagacccagagcgcactggacctgctgcatgcccagacc
gtgtcgcgggcggcgtcaccctcgccgcaggagagcgtgacccgctgtctccccgcaggc
gccccctatcagctacctcccagcacgcagcgacgcccccctgagcagctgctgctggcg
cccgccccgcctgccctacaccggctgctagaatccttcaagattcagtacctacagttc
ctggcgtacacaaagacccctcagtacaaggccaacctgcagcagctgctggaccaggag
aaggagaagaacgcccggttgctgggtgccgtgcagcagctgttcggccactgccaagct
cagaaggaggagatcaagaggcttttccagcagaaactggatgagctgggagtgaaggcg
ctgacctacaacgacctgatccaagcgcagaaggagatctcggctcataaccagcagctg
agggagcagacggagcagctggagaagggcaaccgggagctgaggagccagagcctgcgg
ctgctcaaggcacggtgcgaggagctgaagctggactggtccacgctgtcccttgagggc
ctgctgaaggagaagcaggccctgaagagccagatctcggagaagcagaggcactgcctg
gagctgcagatcagcattgtggagctggagaagagccagaggcagcaggagctcctgcag
ctcaagtcctgcgtgccgcccgacgacgccctgtccctgcacctgcgcgggaagggtggc
ctgggccgagagctggaggccgagcccggccggccacacctggagctggactgtgccagg
ttctccctgccccacttgagcaacatgagcccggagctgtccatgaacggccatgcagcc
ggctatgagctctgcggcacgctgagccggccctcgcccaagcagaacaccccccagtac
ctggcctcccccctggaccaggaggtcgtgccctgcaccccgaaccacagtggccggccg
aggctcgagaagttgtccggcctggccctgcccgactacaccaggctctccccggccaag
ctggtgctgcggcgccacctgagccaggaccacacagccaacagcagggcgaccgccagc
gagctgcactcacgagctgagcatgccaaggagaacggcctcccgtaccagagccccggc
atcgccaacggcatcaaactgagcccacaggaccctcggccctcgtcccctgcggccttg
cagatgacgggagagaagggcagtgagaagggtttgaaggagcgcacctacgccagcagt
ggggaggccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcctagcaag
ctgcccgtcagcatccctctggccagcgtggtgctgcccagccgcgccgagaaggtgaga
agcacccccagccccgtgccacaggcccgagagtcctcgtccacactggagaagcagatg
ggtgctggcacccacggctccgggtgcagcgctgctgggagcagaagcctcgccctggcc
cctgcaggctttgcctacgccggctcagtggccatcagtggggccctggcaggcagcccg
gcaccactcgtctctggagccgagccccccaccctggacgagtcctccagctccggaagc
ctctttgccactgtggggtcccgcagctccacccctcagcacccccccctgctggcgcag
cctcgcaactgcggctcggcctcgcccgccccccagctctgcgccagtccccggcttggc
gcccagggcccgctccccgacaccagcaaaggagacctgccctctgaggccggcttctcg
gatcccgagagtgaagccaagagaaggatcgtcttcaccatctcggccggctctagcagc
gccaaacagtcaccttccagcaagcacagccctctgtcctcgggcgcccgcggtgacggc
ggccagagccacgggcaggacagccgcaagaggggcaggaggaagcgggcagcggcgggg
acccccggcttcagctcgggcgtgtcccccaagcgccgggccctgccgtccgtcgccggc
ctcttcacccagtcttcagggtcccccctgaacctcaactccatggtcagcaacatcaac
cagcccttggaaatcacggccatctcgtcccccgagagttccctgaagagctcgcctgtc
ccttaccaggacaacgaccagccgcccgtgctcaagaaggagaagcccctgagccagacc
aacggggcccactattccccgctgacctcggatgaggagcagggctctgaggacgagccc
agcagtgccagaattgagagaaaaattgcaaccatctccttagaaagcaaatctcctccg
aaaaccttggaaaatgggggcagcctggcgggaaggaaggtgccggccagcgagccggtc
aacagcagcaagtggaagtccaccttctcgcccatctccgacctcggcctggccaaggca
gccgacagcccgctgcaggccgcctccgctctgagccacaactccctgttcgctttccgg
cccggcctggaggaacctggcacggctgacgccaagctggctgcccaccccaggaagagc
ttcccaggcgcgctgccgggggcgggcgggctgagccccagcagccatcccgccagcagc
ttcgccctgggcgggggcctggcggctgacctcagtttacacagcttcagcgatggtgct
tctctctcccacaaggcccccgaggcggccggcctgggcacccccctgagctttcccggc
ccgcggggcaaggagggcggcgccgcagaccccggccccttcgtgaacaagaggcagctg
gacggactggccccgaagggcgaggggggcccacctgtgtgcggacccgcggacaaggcc
tcagcgacgcacggcaaggcgggcaagggccgtgaccgcgagcccgatgtcaagaacggc
cacaacctcttcatggccgctgctgctgctgccgccgccgccgctgccaccccccccggg
ggcctcctcagcggcccgggccttgccccggcggcgtcctcggcagggggcacggccccg
tccgtccagacccaccgccccttcctgggcgccttcgcccccggcccgcagttcgcactg
ggccccatgtccctgcaggccaacctgggcccgtccgtgctgcagtccctgttcagctcc
gtgcccgccgccggcctggtgcacgtctcaaccgctgccaccagactgaccaactcgcac
gccatgggcagcttctcctccggggtggccggcggtgcagtcggaggtgcctttaaccac
gcggtgcctcccgcctccgctcatccgtttggagccagtttcggcagtggggctgcatgt
cgcagcgccacgctgagcctaaccccgctgcaggcggtggccagcaccccggcctcttcc
tttcaggccccgccccctgcggagccgaggccgcccccgccccctccgcacctgggccgg
ccccctccggggccgcccgccctccacgccccgccccctcctaacgccgccttgcctccg
ccccccgcgctgctcccggctaactctgagcccgtgctcctgcagaacctcgcgtccctc
ccagctaaccaagctttcttacctgcctcctctgctgcctctgtgccgcctgctaacgcc
tctctgtccatcaagctcgcctcacttccgcacaaggtgtcccgcccctccttcacggtg
caccacccgcccctgcccgggctggccctggcccaggccgcgcccgtgatcccgcaggcc
agctccacggggccgcccgccgtgtgggtttcccttggcatgccacctccgtatgccgcg
cgccttgcgggggttaagccgcgataa
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