KEGG   Phocoena phocoena (harbor porpoise): 136121894
Entry
136121894         CDS       T11058                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pphc  Phocoena phocoena (harbor porpoise)
Pathway
pphc00562  Inositol phosphate metabolism
pphc01100  Metabolic pathways
pphc01521  EGFR tyrosine kinase inhibitor resistance
pphc01522  Endocrine resistance
pphc01524  Platinum drug resistance
pphc04012  ErbB signaling pathway
pphc04014  Ras signaling pathway
pphc04015  Rap1 signaling pathway
pphc04024  cAMP signaling pathway
pphc04062  Chemokine signaling pathway
pphc04066  HIF-1 signaling pathway
pphc04068  FoxO signaling pathway
pphc04070  Phosphatidylinositol signaling system
pphc04071  Sphingolipid signaling pathway
pphc04072  Phospholipase D signaling pathway
pphc04081  Hormone signaling
pphc04140  Autophagy - animal
pphc04150  mTOR signaling pathway
pphc04151  PI3K-Akt signaling pathway
pphc04152  AMPK signaling pathway
pphc04210  Apoptosis
pphc04211  Longevity regulating pathway
pphc04213  Longevity regulating pathway - multiple species
pphc04218  Cellular senescence
pphc04360  Axon guidance
pphc04370  VEGF signaling pathway
pphc04380  Osteoclast differentiation
pphc04510  Focal adhesion
pphc04550  Signaling pathways regulating pluripotency of stem cells
pphc04611  Platelet activation
pphc04613  Neutrophil extracellular trap formation
pphc04620  Toll-like receptor signaling pathway
pphc04625  C-type lectin receptor signaling pathway
pphc04630  JAK-STAT signaling pathway
pphc04650  Natural killer cell mediated cytotoxicity
pphc04660  T cell receptor signaling pathway
pphc04662  B cell receptor signaling pathway
pphc04664  Fc epsilon RI signaling pathway
pphc04666  Fc gamma R-mediated phagocytosis
pphc04668  TNF signaling pathway
pphc04670  Leukocyte transendothelial migration
pphc04722  Neurotrophin signaling pathway
pphc04725  Cholinergic synapse
pphc04750  Inflammatory mediator regulation of TRP channels
pphc04810  Regulation of actin cytoskeleton
pphc04910  Insulin signaling pathway
pphc04914  Progesterone-mediated oocyte maturation
pphc04915  Estrogen signaling pathway
pphc04917  Prolactin signaling pathway
pphc04919  Thyroid hormone signaling pathway
pphc04923  Regulation of lipolysis in adipocytes
pphc04926  Relaxin signaling pathway
pphc04929  GnRH secretion
pphc04930  Type II diabetes mellitus
pphc04931  Insulin resistance
pphc04932  Non-alcoholic fatty liver disease
pphc04933  AGE-RAGE signaling pathway in diabetic complications
pphc04935  Growth hormone synthesis, secretion and action
pphc04960  Aldosterone-regulated sodium reabsorption
pphc04973  Carbohydrate digestion and absorption
pphc05010  Alzheimer disease
pphc05017  Spinocerebellar ataxia
pphc05020  Prion disease
pphc05100  Bacterial invasion of epithelial cells
pphc05132  Salmonella infection
pphc05135  Yersinia infection
pphc05142  Chagas disease
pphc05146  Amoebiasis
pphc05160  Hepatitis C
pphc05161  Hepatitis B
pphc05162  Measles
pphc05163  Human cytomegalovirus infection
pphc05164  Influenza A
pphc05165  Human papillomavirus infection
pphc05166  Human T-cell leukemia virus 1 infection
pphc05167  Kaposi sarcoma-associated herpesvirus infection
pphc05168  Herpes simplex virus 1 infection
pphc05169  Epstein-Barr virus infection
pphc05170  Human immunodeficiency virus 1 infection
pphc05171  Coronavirus disease - COVID-19
pphc05200  Pathways in cancer
pphc05203  Viral carcinogenesis
pphc05205  Proteoglycans in cancer
pphc05206  MicroRNAs in cancer
pphc05207  Chemical carcinogenesis - receptor activation
pphc05208  Chemical carcinogenesis - reactive oxygen species
pphc05210  Colorectal cancer
pphc05211  Renal cell carcinoma
pphc05212  Pancreatic cancer
pphc05213  Endometrial cancer
pphc05214  Glioma
pphc05215  Prostate cancer
pphc05218  Melanoma
pphc05220  Chronic myeloid leukemia
pphc05221  Acute myeloid leukemia
pphc05222  Small cell lung cancer
pphc05223  Non-small cell lung cancer
pphc05224  Breast cancer
pphc05225  Hepatocellular carcinoma
pphc05226  Gastric cancer
pphc05230  Central carbon metabolism in cancer
pphc05231  Choline metabolism in cancer
pphc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pphc05415  Diabetic cardiomyopathy
pphc05417  Lipid and atherosclerosis
pphc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pphc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    136121894 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    136121894 (PIK3CB)
   04014 Ras signaling pathway
    136121894 (PIK3CB)
   04015 Rap1 signaling pathway
    136121894 (PIK3CB)
   04370 VEGF signaling pathway
    136121894 (PIK3CB)
   04630 JAK-STAT signaling pathway
    136121894 (PIK3CB)
   04668 TNF signaling pathway
    136121894 (PIK3CB)
   04066 HIF-1 signaling pathway
    136121894 (PIK3CB)
   04068 FoxO signaling pathway
    136121894 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    136121894 (PIK3CB)
   04072 Phospholipase D signaling pathway
    136121894 (PIK3CB)
   04071 Sphingolipid signaling pathway
    136121894 (PIK3CB)
   04024 cAMP signaling pathway
    136121894 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    136121894 (PIK3CB)
   04152 AMPK signaling pathway
    136121894 (PIK3CB)
   04150 mTOR signaling pathway
    136121894 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    136121894 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    136121894 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    136121894 (PIK3CB)
   04218 Cellular senescence
    136121894 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    136121894 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    136121894 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    136121894 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    136121894 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    136121894 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    136121894 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    136121894 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    136121894 (PIK3CB)
   04660 T cell receptor signaling pathway
    136121894 (PIK3CB)
   04662 B cell receptor signaling pathway
    136121894 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    136121894 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    136121894 (PIK3CB)
   04670 Leukocyte transendothelial migration
    136121894 (PIK3CB)
   04062 Chemokine signaling pathway
    136121894 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    136121894 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    136121894 (PIK3CB)
   04929 GnRH secretion
    136121894 (PIK3CB)
   04915 Estrogen signaling pathway
    136121894 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    136121894 (PIK3CB)
   04917 Prolactin signaling pathway
    136121894 (PIK3CB)
   04926 Relaxin signaling pathway
    136121894 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    136121894 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    136121894 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    136121894 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    136121894 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    136121894 (PIK3CB)
   04722 Neurotrophin signaling pathway
    136121894 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    136121894 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    136121894 (PIK3CB)
   04380 Osteoclast differentiation
    136121894 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    136121894 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    136121894 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    136121894 (PIK3CB)
   05206 MicroRNAs in cancer
    136121894 (PIK3CB)
   05205 Proteoglycans in cancer
    136121894 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    136121894 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    136121894 (PIK3CB)
   05203 Viral carcinogenesis
    136121894 (PIK3CB)
   05230 Central carbon metabolism in cancer
    136121894 (PIK3CB)
   05231 Choline metabolism in cancer
    136121894 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    136121894 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    136121894 (PIK3CB)
   05212 Pancreatic cancer
    136121894 (PIK3CB)
   05225 Hepatocellular carcinoma
    136121894 (PIK3CB)
   05226 Gastric cancer
    136121894 (PIK3CB)
   05214 Glioma
    136121894 (PIK3CB)
   05221 Acute myeloid leukemia
    136121894 (PIK3CB)
   05220 Chronic myeloid leukemia
    136121894 (PIK3CB)
   05218 Melanoma
    136121894 (PIK3CB)
   05211 Renal cell carcinoma
    136121894 (PIK3CB)
   05215 Prostate cancer
    136121894 (PIK3CB)
   05213 Endometrial cancer
    136121894 (PIK3CB)
   05224 Breast cancer
    136121894 (PIK3CB)
   05222 Small cell lung cancer
    136121894 (PIK3CB)
   05223 Non-small cell lung cancer
    136121894 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    136121894 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    136121894 (PIK3CB)
   05161 Hepatitis B
    136121894 (PIK3CB)
   05160 Hepatitis C
    136121894 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    136121894 (PIK3CB)
   05164 Influenza A
    136121894 (PIK3CB)
   05162 Measles
    136121894 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    136121894 (PIK3CB)
   05163 Human cytomegalovirus infection
    136121894 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    136121894 (PIK3CB)
   05169 Epstein-Barr virus infection
    136121894 (PIK3CB)
   05165 Human papillomavirus infection
    136121894 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    136121894 (PIK3CB)
   05135 Yersinia infection
    136121894 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    136121894 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    136121894 (PIK3CB)
   05142 Chagas disease
    136121894 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    136121894 (PIK3CB)
   05017 Spinocerebellar ataxia
    136121894 (PIK3CB)
   05020 Prion disease
    136121894 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    136121894 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    136121894 (PIK3CB)
   05415 Diabetic cardiomyopathy
    136121894 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    136121894 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    136121894 (PIK3CB)
   04931 Insulin resistance
    136121894 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    136121894 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    136121894 (PIK3CB)
   01524 Platinum drug resistance
    136121894 (PIK3CB)
   01522 Endocrine resistance
    136121894 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pphc04131]
    136121894 (PIK3CB)
Enzymes [BR:pphc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     136121894 (PIK3CB)
Membrane trafficking [BR:pphc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    136121894 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 Tom37_C
Other DBs
NCBI-GeneID: 136121894
NCBI-ProteinID: XP_065731785
LinkDB
Position
4:complement(21252042..21446686)
AA seq 1064 aa
MPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNY
PMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKI
GVLIGRGLHEFDALKDPEVNEFRIKMRRFSEEKIQSLVGLSWMDWLKQTYPPEHEPSIPE
NLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHGKEDEVSPYDY
VLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKLYEQEMIAIEAAINR
NSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCK
TVVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKAINPSKYQ
TIRKSGKVDYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQTNPYTE
NATALHIRFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKEILDRDP
LSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREA
LELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALA
NRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKALSKQVEALNKLKTLNSLI
KLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYIEKCKYMDSKMKPL
WLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGD
HSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCA
GYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIH
VIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKD
SLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3195 nt   +upstreamnt  +downstreamnt
atgcctcctgctatggcagacatccttgacatctgggcagtggattcacagatagcatct
gatggctccatacccgtggatttccttttgcccactgggatttatatccagttggaggta
cctcgggaagctaccatttcctatattaaacagatgttatggaaacaagttcataattac
ccaatgtttaacctccttatggaaattgactcctatatgtttgcatgtgtgaatcaaact
gctgtatatgaggagcttgaagatgaaacaagaagactctgtgatgtcagaccttttctt
ccagttctcaaattagtgacaagaagttgtgacccaggcgaaaaattagactcaaaaatt
ggagtccttataggaagaggtttgcatgaatttgatgccttgaaggatcctgaggtgaat
gaattccgaataaaaatgcgcagattcagtgaggaaaagattcagtcacttgtgggattg
tcttggatggattggctaaagcaaacctatccaccagagcatgaaccatccattcctgaa
aatttagaagataaactttacggaggaaagctcattgtggctgttcattttgaaaattgt
caggatgtgtttagctttcaagtatctcctaatatgaatcctatcaaaataaatgaattg
gcaatccaaaaacgtttgactattcatgggaaagaagatgaagttagcccctatgactat
gtgttgcaagtcagtgggagagtagaatatgtgtttggtgatcacccactaattcagttc
cagtatatccggaactgtgtaatgaatagaaccttgccccattttatacttgtggaatgt
tgcaagatcaagaagctgtatgaacaggaaatgattgccatagaggctgccataaatcga
aattcatctaaccttcctcttcctttaccaccaaagaaaactcgaattatttctcatgtt
tgggaaaataacaaccctttccaaattgtcttggttaagggaaataaacttaacacagaa
gaaactgtaaaagttcacgtcagggctggcctttttcatggtaccgaactcctgtgtaaa
accgtcgtaagctcagagatatcagggaaaaacgatcatatttggaatgaaccactggaa
tttgatatcaatacttgtgacctgccacgaatggctcgattatgtttcgctgtttatgca
gttttggataaagtgaaaacgaagaaatcaactaaagctattaatccctctaaatatcag
accatcaggaaatctggaaaagtggattatcctgtagcctgggtaaatacgatggttttt
gactttaaaggacagttgagatctggagatataatattacacagctggtcttcatttcct
gatgaacttgaagaaatgttgaatccaatgggaactgttcaaacaaatccatatactgaa
aatgcaacagctttgcacatcagattcccagagaataaaaaacaaccttattactatcct
ccctttgataagattattgaaaaggcagctgagattgcaagcagtgatagtgctaatgta
tcaagtcgaggtggaaagaagtttcttgctgtactgaaagaaatcttggacagggatccg
ttgtctcaactgtgtgagaatgaaatggatcttatttggactttgcgacaagactgcaga
gagaatttcccacagtcattgccaaaattactgctgtcaatcaagtggaataaacttgag
gatgttgctcagcttcaggcactacttcagatttggcctaaactgcccccccgggaggcc
ctggagcttctagatttcaactatccagatcagtacgtgcgagaatatgctgtgggctgt
ctgcaacagatgagtgatgaagaactctctcaatatcttttacagttggtgcaagtttta
aaatatgagccttttcttgattgtgccctctctagattcctactagaaagagcacttgct
aatcggaggatagggcagtttttattttggcaccttaggtcagaagtgcacattcctgct
gtttcagtacaatttggtgtcatccttgaagcatactgccggggaagcgtaggtcacatg
aaagcgctttccaagcaggttgaagcactcaataaattaaaaactttaaatagtttaatc
aaactgaatgcaatgaagctaaatagagccaaagggaaagaagcaatgcacacttgttta
aaacagaatgcttatcgggaagccctctctgacctgcaatcacctctgaacccatgtgtt
atcctctcagaactctatattgaaaagtgtaaatacatggattccaaaatgaagcctttg
tggctggtgtacaacaacaaggtgtttggtgaggattcagttggagtgatttttaaaaat
ggtgatgatttacggcaggatatgttgacactccaaatgctgcgcttgatggatttactc
tggaaagaagctggtctggatcttaggatgctgccttatggctgtttagcaacaggagac
cactctggcctcattgaagttgtgagcacctctgagacaattgctgacattcagctgaac
agtagcaatgtggctgcagcagcagccttcaacaaagatgcccttctgaactggcttaaa
gaatacaattctggggatgacctggaccgagccattgaggagtttaccctgtcctgtgcc
ggctactgtgtagcttcttatgtccttgggattggtgacagacatagtgataacatcatg
gtcaaaaaaactggccagctcttccacattgactttggacatattcttggaaatttcaag
tctaaatttggcattaaaagggagagagtgccttttattcttacttatgatttcattcat
gtgattcaacaaggaaaaacaggaaacacggaaaagtttggccggttccgccagtgttgt
gaggatgcatatctgattttacgacggcatgggaatctcttcatcactctctttgcactg
atgttgactgcagggcttcctgagctcacatcagtcaaggatatacagtatcttaaggac
tctcttgccttagggaagagtgaagaagaagcactcaagcaatttaagcaaaaatttgat
gaggcactcagggaaagctggactactaaagtgaactggatggcccacacagttcggaaa
gactacagatcttaa

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