Phocoena phocoena (harbor porpoise): 136124397
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Entry
136124397 CDS
T11058
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
pphc Phocoena phocoena (harbor porpoise)
Pathway
pphc00790
Folate biosynthesis
pphc01100
Metabolic pathways
pphc01240
Biosynthesis of cofactors
pphc01523
Antifolate resistance
pphc04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
pphc00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
136124397 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
136124397 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
136124397 (FPGS)
Enzymes [BR:
pphc01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
136124397 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
136124397
NCBI-ProteinID:
XP_065735146
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Position
6:107638993..107647501
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AA seq
580 aa
AA seq
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MSRARCHLRAALFLAAVSSRGATTGVAARRVLSAWPAPQEPGMEYQDAVRTLNTLQTNAN
YLEQVKRQRGDPQTQLEAMRLYLARSGLQVEDLDQLNIIHITGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWRLYHRLEETKDDSSCVSMPGYFR
FLTLMAFHIFLQEKVDLAVMEVGIGGAYDCTNIVKKPVVCGVSSLGIDHTGLLGDTMEKI
AWQKGGIFKSGVPAFTVLQPDGPLAVLRDRAQQISCPLYLCPPLEALEEGGPLLTLGLEG
EHQQANAALALQLARCWLQQKGYRDTGELKASRPSLPGQLPLAPVFQPTSHMQHGLRDTE
WPGRTQLLRRGPLTWYLDGAHTTSSMQACVRWFRQALQSRERLGGGSEVRVLLFNSTGDR
DSAALLKLLQPCQFDYTVFCPNLTEVSSTDNADQQNFTVTLDQVLLRCLAHQQHWSRLHE
DQASPEPGGPAPLLLAPRPAHTHSASSLVFSCISHALQWISQGRDPVFQPPSPPRVLFAH
PVAGSGAVVLQEAAAIHVLVTGSLHLVGGVLKLLEPSLSQ
NT seq
1743 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcgggcacgctgccacctgcgcgcggctctcttcctggcagcggtttcttcgcgt
ggtgcaacaaccggggtcgcagcgaggcgagtattgagcgcgtggcctgcgccgcaggag
cccggcatggagtatcaggatgccgtgcgcacactcaacaccctgcagaccaatgccaac
tacttggagcaggtgaagcgccagcggggtgacccccagacacaactggaagccatgagg
ctgtacttggcacggagtgggctgcaggtggaggacttggaccaactgaacatcattcac
atcactgggaccaaggggaagggctccacctgtgccttcactgaacgtatcctccgaagc
tatggcctgaagacgggattctttagctctccccacctggtgcaggtgcgtgagcggatc
cgaatcaatgggcagcccataagccccgagctcttcaccaagcacttctggcgcctctac
caccggctggaggagaccaaggatgacagcagctgtgtctccatgcctggctacttccgc
ttcctcacactcatggccttccacatcttcctccaagagaaggtggacctggcagtgatg
gaagtgggcatcggcggtgcttacgactgcaccaacatcgtcaagaagcctgtggtgtgt
ggggtctcctctcttggcatcgaccacactggccttctgggggacacgatggagaagatc
gcatggcagaaagggggcatttttaagagtggcgtccccgccttcactgtgctccagcct
gacgggcccctggcagtgctgagggaccgcgctcagcagatctcatgtcccctctacctg
tgcccaccactagaagccctggaggaaggggggccgctgctgaccctgggcctggagggg
gaacaccagcaggccaatgccgccttggccttgcagctggctcgctgctggctgcagcag
aagggctaccgggatactggagagctgaaggcgtccaggccaagcctcccggggcagctg
cccctggcacctgtgttccagcccacgtcccacatgcagcatgggcttcgggatacggag
tggccgggccggacgcagttgctgcggcggggcccccttacttggtacctggacggcgcg
cacaccaccagcagcatgcaggcctgcgtgcgctggttccgccaggcgctgcaaagccgc
gagaggctgggcggcgggtctgaggtccgtgtcttgctcttcaactccactggggaccgg
gattccgcggccctgctgaagctgctgcagccctgccagtttgactataccgttttctgc
cctaacctgacagaggtgtcatccacagacaacgcagaccaacagaacttcacagtgacc
ctggaccaggtgctgctccgctgcctggcgcaccagcagcactggagccgcctgcacgag
gaccaggccagcccggagcctggtgggcctgcacccctgctgctggcaccccgcccagcc
cacacccacagcgccagctccctcgtcttcagctgcatttcccacgccttgcagtggatc
agtcaaggccgggaccctgtctttcagccacccagtcccccacgggtcctctttgcccac
cctgtggcaggcagtggggccgtcgtcctccaggaggctgctgccatccacgtgctggtc
acaggcagcctgcacctggtgggcggcgtgctgaagctgctggagccctccctgtcccag
tag
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