KEGG   Phocoena phocoena (harbor porpoise): 136127414
Entry
136127414         CDS       T11058                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pphc  Phocoena phocoena (harbor porpoise)
Pathway
pphc00562  Inositol phosphate metabolism
pphc01100  Metabolic pathways
pphc04015  Rap1 signaling pathway
pphc04020  Calcium signaling pathway
pphc04022  cGMP-PKG signaling pathway
pphc04062  Chemokine signaling pathway
pphc04070  Phosphatidylinositol signaling system
pphc04071  Sphingolipid signaling pathway
pphc04072  Phospholipase D signaling pathway
pphc04081  Hormone signaling
pphc04082  Neuroactive ligand signaling
pphc04261  Adrenergic signaling in cardiomyocytes
pphc04270  Vascular smooth muscle contraction
pphc04310  Wnt signaling pathway
pphc04371  Apelin signaling pathway
pphc04540  Gap junction
pphc04611  Platelet activation
pphc04613  Neutrophil extracellular trap formation
pphc04621  NOD-like receptor signaling pathway
pphc04713  Circadian entrainment
pphc04720  Long-term potentiation
pphc04723  Retrograde endocannabinoid signaling
pphc04724  Glutamatergic synapse
pphc04725  Cholinergic synapse
pphc04726  Serotonergic synapse
pphc04728  Dopaminergic synapse
pphc04730  Long-term depression
pphc04742  Taste transduction
pphc04750  Inflammatory mediator regulation of TRP channels
pphc04911  Insulin secretion
pphc04912  GnRH signaling pathway
pphc04915  Estrogen signaling pathway
pphc04916  Melanogenesis
pphc04918  Thyroid hormone synthesis
pphc04919  Thyroid hormone signaling pathway
pphc04921  Oxytocin signaling pathway
pphc04922  Glucagon signaling pathway
pphc04924  Renin secretion
pphc04925  Aldosterone synthesis and secretion
pphc04926  Relaxin signaling pathway
pphc04927  Cortisol synthesis and secretion
pphc04928  Parathyroid hormone synthesis, secretion and action
pphc04929  GnRH secretion
pphc04933  AGE-RAGE signaling pathway in diabetic complications
pphc04934  Cushing syndrome
pphc04935  Growth hormone synthesis, secretion and action
pphc04961  Endocrine and other factor-regulated calcium reabsorption
pphc04970  Salivary secretion
pphc04971  Gastric acid secretion
pphc04972  Pancreatic secretion
pphc04973  Carbohydrate digestion and absorption
pphc05010  Alzheimer disease
pphc05016  Huntington disease
pphc05017  Spinocerebellar ataxia
pphc05022  Pathways of neurodegeneration - multiple diseases
pphc05142  Chagas disease
pphc05143  African trypanosomiasis
pphc05146  Amoebiasis
pphc05163  Human cytomegalovirus infection
pphc05200  Pathways in cancer
pphc05415  Diabetic cardiomyopathy
pphc05417  Lipid and atherosclerosis
Module
pphc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pphc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    136127414 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    136127414 (PLCB3)
   04310 Wnt signaling pathway
    136127414 (PLCB3)
   04371 Apelin signaling pathway
    136127414 (PLCB3)
   04020 Calcium signaling pathway
    136127414 (PLCB3)
   04070 Phosphatidylinositol signaling system
    136127414 (PLCB3)
   04072 Phospholipase D signaling pathway
    136127414 (PLCB3)
   04071 Sphingolipid signaling pathway
    136127414 (PLCB3)
   04022 cGMP-PKG signaling pathway
    136127414 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    136127414 (PLCB3)
   04081 Hormone signaling
    136127414 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    136127414 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    136127414 (PLCB3)
   04613 Neutrophil extracellular trap formation
    136127414 (PLCB3)
   04621 NOD-like receptor signaling pathway
    136127414 (PLCB3)
   04062 Chemokine signaling pathway
    136127414 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    136127414 (PLCB3)
   04922 Glucagon signaling pathway
    136127414 (PLCB3)
   04929 GnRH secretion
    136127414 (PLCB3)
   04912 GnRH signaling pathway
    136127414 (PLCB3)
   04915 Estrogen signaling pathway
    136127414 (PLCB3)
   04921 Oxytocin signaling pathway
    136127414 (PLCB3)
   04926 Relaxin signaling pathway
    136127414 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    136127414 (PLCB3)
   04918 Thyroid hormone synthesis
    136127414 (PLCB3)
   04919 Thyroid hormone signaling pathway
    136127414 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    136127414 (PLCB3)
   04916 Melanogenesis
    136127414 (PLCB3)
   04924 Renin secretion
    136127414 (PLCB3)
   04925 Aldosterone synthesis and secretion
    136127414 (PLCB3)
   04927 Cortisol synthesis and secretion
    136127414 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    136127414 (PLCB3)
   04270 Vascular smooth muscle contraction
    136127414 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    136127414 (PLCB3)
   04971 Gastric acid secretion
    136127414 (PLCB3)
   04972 Pancreatic secretion
    136127414 (PLCB3)
   04973 Carbohydrate digestion and absorption
    136127414 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    136127414 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    136127414 (PLCB3)
   04725 Cholinergic synapse
    136127414 (PLCB3)
   04728 Dopaminergic synapse
    136127414 (PLCB3)
   04726 Serotonergic synapse
    136127414 (PLCB3)
   04720 Long-term potentiation
    136127414 (PLCB3)
   04730 Long-term depression
    136127414 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    136127414 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    136127414 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    136127414 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    136127414 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    136127414 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    136127414 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    136127414 (PLCB3)
   05142 Chagas disease
    136127414 (PLCB3)
   05143 African trypanosomiasis
    136127414 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    136127414 (PLCB3)
   05016 Huntington disease
    136127414 (PLCB3)
   05017 Spinocerebellar ataxia
    136127414 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    136127414 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    136127414 (PLCB3)
   05415 Diabetic cardiomyopathy
    136127414 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    136127414 (PLCB3)
   04934 Cushing syndrome
    136127414 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pphc04131]
    136127414 (PLCB3)
Enzymes [BR:pphc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     136127414 (PLCB3)
Membrane trafficking [BR:pphc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    136127414 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    136127414 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 136127414
NCBI-ProteinID: XP_065739008
LinkDB
Position
8:102174898..102191297
AA seq 1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPSGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLITVVAGPDPVNTSFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGVPDS
SVRKRPLEQSNSALSESSAVTEPSSPQLGSPSSDSCPGLSNGEEAGLEKPSLEPQKSLGE
ESLQRGPDALGSAYREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANAVRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLALLRVAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLV
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGLETSQETQSQQP
GSQLTPNPTPSPLDASPRRAPGPITSPTSTSLSSPGQRDDLIASVLSEVAPAPLDELRGH
KALLKLQSRQERDFRELHKKHQRKAVALTRRLLDSLAQAQAESRCRHRPGVLGGEDEREE
EEEVKRYQEFQKKQVQCLLELREAQMDTEAQRRLEHLRQAQQRLREIVMDAHATQFKRLK
EMNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRQERLVAAQQQILQQLTEEEPKLLAQLAQECQEQRERLPQEIRRSLLGETPEGLGDGHL
VACASNGHAPGSSGHLSGADSESQEETTKL
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtcgtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaactctgcgcgtggaccccagtggcttcttcctgtactggacagggcccaacatggag
gtggacacactggacatcagttccatcagggacacgaggacaggccgttatgcccgccta
cccaaggaccccaagattcgggaggtgttgggctttgggggccctgatgcccggttggag
gagaagttgataacagtggtggccgggccagacccggtgaatacatcgtttttgaacttc
atggccgtgcaggatgacacagccaaggtctggtccgaggagctgttcaagctggccatg
aacatcctggctcagaacgcctcccggaacaccttcttgcgcaaagcgtacacgaagctg
aaactgcaggtgaaccaggatggacggatcccggtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtagaaactgcgctggaatcctgtggcctcaatttcaaccggagc
gagtccatccggcctgacgagttttccttggaaatcttcgagcggttcttgaacaagctt
tgtctgcggccggacattgacaagatcctgctggagataggcgccaagggcaaaccatac
ctgacactggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaat
gaagtgctgtacccacctctgcggccctcccaggcccggctgcttatcgagaagtatgag
cccaaccagcaattcctggagagagaccagatgtccatggagggcttcagccgctacctg
ggaggtgaggagaatggcatcctgcccctagaggctctggatctgagcgcagacatgacc
cagccgctcagtgcctacttcatcaactcctcacacaacacctatctcactgcggggcag
ctggcgggaacatcgtcggtggagatgtaccggcaggcactgctgtggggctgccgctgc
gtggagctggacgtgtggaaagggcggccgcctgaggaggagcccttcatcacccacggc
ttcaccatgaccacggaggtgccgctgcgagatgtgctggaggccattgcggagaccgcc
ttcaagacctcgccctaccctgtcatcctctcctttgagaaccatgtggactcggcaaag
cagcaggccaagatggctgagtactgccgctccatctttggggacgcgctgctcatcgac
cccctggacaagtacccgctggccccgggcgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcggcaccggcccagcactggcgttcccgacagc
tctgtgcgcaagcggccgctagagcagagcaactcggccctgagcgagagctccgccgtc
accgagccctcctcgccccagctcgggtcccccagctctgacagctgcccaggcctgagc
aatggggaggaggcgggccttgagaagcccagcctggagcctcagaagtctctgggtgag
gagagtttgcagcggggccctgatgcccttggatctgcctaccgtgaggatgaggaagag
gatgaggaagaggaggaacagacggaccccaaaaagccgaccaccgacgagggcactgcc
agcagtgaggtcaatgccactgaggaaatgtcgacgcttgtcaactacatcgagcccgtc
aagttcaagtccttcgaggctgctcgaaagaggaacaagtgctttgagatgtcatccttt
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacacgtgtggactcgtccaactacatg
ccccagctcttctggaatgtgggctgccagctcgtcgcgctcaacttccagaccctggac
gtggccatgcagctcaacgcgggcgtgttcgagtacaacgggcgcagtggctacctactc
aagcccgagttcatgcggcggccagacaagtcctttgaccccttcaccgaggtcatcgtg
gatggcatcgtggccaatgccgtgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggatatgttcggcctccctgtcgacacgcggcgc
aagtaccgcactcggacctctcaggggaactcgttcaaccccgtgtgggatgaggagccc
ttcgacttccccaaagtggtgctgcccacgctggctttgctgcgcgtcgcggcctttgag
gagggtggcaagttcgtggggcaccgcatcctgcctgtctctgccatccgctcagggtac
cactacatctgcctgcggaacgaggccaaccagccgctgtgcctgccggccctgcttgtc
tacactgaggcctctgactacattcccgatgaccaccaagactacgcagaggccctgatc
aatcccatcaagcacgtcagcctgatggaccagagggccaagcagctggccgccctcatt
ggggagagtgaggctcaggctggcctggagacaagccaggagacccagtctcagcagcca
gggtcccaactgaccccaaaccccacacccagcccactggacgcctccccccgccgggcc
ccaggccccatcacctcccccaccagcacctccctcagcagcccaggtcagcgtgatgac
ctcattgccagcgtcctctcagaggtggccccggccccgctggatgagctccgaggccac
aaggccctgttgaagctccagagccggcaagagcgagactttcgagagctacacaagaag
catcagcggaaggcggttgccctcacacgccggttgctcgacagcctggcccaggcccag
gccgagagcaggtgccggcaccggccgggtgtcctaggcggggaggacgagagggaggag
gaggaagaggtgaagaggtatcaagagttccaaaagaagcaggtgcagtgtctgctggag
ctgagggaagcccagatggacacagaggcccagcggaggctggagcacctgagacaggct
cagcagaggctcagggagattgtcatggatgctcacgccactcagttcaagagactgaag
gagatgaacgagagggagaagaaggaactgcagaagatcctggacaggaagcgccacaac
agtatctcagaggcaaagaccagggagaaacataagaaggaggcggaactgacagagatt
aaccgtcgacacatcactgagtcggtcaactccatccgtcggctggaggaggcccaaaag
cagcggcaggaacgccttgtggccgcgcagcagcagattctccaacagctgacagaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgggagaggctgccc
caggagatccgccggagcctgctgggcgagacaccggagggactgggggacgggcatctg
gtggcctgtgccagcaatggtcacgcgcctgggagcagtgggcacctgtccggcgctgat
tcggagagccaagaggagactacgaagctctga

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