KEGG   Phocoena phocoena (harbor porpoise): 136129277
Entry
136129277         CDS       T11058                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pphc  Phocoena phocoena (harbor porpoise)
Pathway
pphc01521  EGFR tyrosine kinase inhibitor resistance
pphc01522  Endocrine resistance
pphc04010  MAPK signaling pathway
pphc04012  ErbB signaling pathway
pphc04014  Ras signaling pathway
pphc04015  Rap1 signaling pathway
pphc04022  cGMP-PKG signaling pathway
pphc04024  cAMP signaling pathway
pphc04062  Chemokine signaling pathway
pphc04068  FoxO signaling pathway
pphc04071  Sphingolipid signaling pathway
pphc04072  Phospholipase D signaling pathway
pphc04140  Autophagy - animal
pphc04150  mTOR signaling pathway
pphc04151  PI3K-Akt signaling pathway
pphc04210  Apoptosis
pphc04218  Cellular senescence
pphc04270  Vascular smooth muscle contraction
pphc04360  Axon guidance
pphc04370  VEGF signaling pathway
pphc04371  Apelin signaling pathway
pphc04510  Focal adhesion
pphc04519  Cadherin signaling
pphc04540  Gap junction
pphc04550  Signaling pathways regulating pluripotency of stem cells
pphc04613  Neutrophil extracellular trap formation
pphc04625  C-type lectin receptor signaling pathway
pphc04630  JAK-STAT signaling pathway
pphc04650  Natural killer cell mediated cytotoxicity
pphc04660  T cell receptor signaling pathway
pphc04662  B cell receptor signaling pathway
pphc04664  Fc epsilon RI signaling pathway
pphc04666  Fc gamma R-mediated phagocytosis
pphc04720  Long-term potentiation
pphc04722  Neurotrophin signaling pathway
pphc04726  Serotonergic synapse
pphc04730  Long-term depression
pphc04810  Regulation of actin cytoskeleton
pphc04910  Insulin signaling pathway
pphc04912  GnRH signaling pathway
pphc04914  Progesterone-mediated oocyte maturation
pphc04915  Estrogen signaling pathway
pphc04916  Melanogenesis
pphc04917  Prolactin signaling pathway
pphc04919  Thyroid hormone signaling pathway
pphc04921  Oxytocin signaling pathway
pphc04926  Relaxin signaling pathway
pphc04928  Parathyroid hormone synthesis, secretion and action
pphc04929  GnRH secretion
pphc04935  Growth hormone synthesis, secretion and action
pphc05010  Alzheimer disease
pphc05022  Pathways of neurodegeneration - multiple diseases
pphc05034  Alcoholism
pphc05132  Salmonella infection
pphc05152  Tuberculosis
pphc05160  Hepatitis C
pphc05161  Hepatitis B
pphc05163  Human cytomegalovirus infection
pphc05164  Influenza A
pphc05165  Human papillomavirus infection
pphc05167  Kaposi sarcoma-associated herpesvirus infection
pphc05170  Human immunodeficiency virus 1 infection
pphc05200  Pathways in cancer
pphc05205  Proteoglycans in cancer
pphc05206  MicroRNAs in cancer
pphc05207  Chemical carcinogenesis - receptor activation
pphc05208  Chemical carcinogenesis - reactive oxygen species
pphc05210  Colorectal cancer
pphc05211  Renal cell carcinoma
pphc05212  Pancreatic cancer
pphc05213  Endometrial cancer
pphc05214  Glioma
pphc05215  Prostate cancer
pphc05218  Melanoma
pphc05219  Bladder cancer
pphc05220  Chronic myeloid leukemia
pphc05221  Acute myeloid leukemia
pphc05223  Non-small cell lung cancer
pphc05224  Breast cancer
pphc05225  Hepatocellular carcinoma
pphc05226  Gastric cancer
pphc05230  Central carbon metabolism in cancer
pphc05231  Choline metabolism in cancer
pphc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pphc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    136129277 (RAF1)
   04012 ErbB signaling pathway
    136129277 (RAF1)
   04014 Ras signaling pathway
    136129277 (RAF1)
   04015 Rap1 signaling pathway
    136129277 (RAF1)
   04370 VEGF signaling pathway
    136129277 (RAF1)
   04371 Apelin signaling pathway
    136129277 (RAF1)
   04630 JAK-STAT signaling pathway
    136129277 (RAF1)
   04068 FoxO signaling pathway
    136129277 (RAF1)
   04072 Phospholipase D signaling pathway
    136129277 (RAF1)
   04071 Sphingolipid signaling pathway
    136129277 (RAF1)
   04024 cAMP signaling pathway
    136129277 (RAF1)
   04022 cGMP-PKG signaling pathway
    136129277 (RAF1)
   04151 PI3K-Akt signaling pathway
    136129277 (RAF1)
   04150 mTOR signaling pathway
    136129277 (RAF1)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    136129277 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    136129277 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    136129277 (RAF1)
   04218 Cellular senescence
    136129277 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    136129277 (RAF1)
   04540 Gap junction
    136129277 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    136129277 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    136129277 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    136129277 (RAF1)
   04625 C-type lectin receptor signaling pathway
    136129277 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    136129277 (RAF1)
   04660 T cell receptor signaling pathway
    136129277 (RAF1)
   04662 B cell receptor signaling pathway
    136129277 (RAF1)
   04664 Fc epsilon RI signaling pathway
    136129277 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    136129277 (RAF1)
   04062 Chemokine signaling pathway
    136129277 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    136129277 (RAF1)
   04929 GnRH secretion
    136129277 (RAF1)
   04912 GnRH signaling pathway
    136129277 (RAF1)
   04915 Estrogen signaling pathway
    136129277 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    136129277 (RAF1)
   04917 Prolactin signaling pathway
    136129277 (RAF1)
   04921 Oxytocin signaling pathway
    136129277 (RAF1)
   04926 Relaxin signaling pathway
    136129277 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    136129277 (RAF1)
   04919 Thyroid hormone signaling pathway
    136129277 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    136129277 (RAF1)
   04916 Melanogenesis
    136129277 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    136129277 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    136129277 (RAF1)
   04720 Long-term potentiation
    136129277 (RAF1)
   04730 Long-term depression
    136129277 (RAF1)
   04722 Neurotrophin signaling pathway
    136129277 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    136129277 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    136129277 (RAF1)
   05206 MicroRNAs in cancer
    136129277 (RAF1)
   05205 Proteoglycans in cancer
    136129277 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    136129277 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    136129277 (RAF1)
   05230 Central carbon metabolism in cancer
    136129277 (RAF1)
   05231 Choline metabolism in cancer
    136129277 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    136129277 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    136129277 (RAF1)
   05212 Pancreatic cancer
    136129277 (RAF1)
   05225 Hepatocellular carcinoma
    136129277 (RAF1)
   05226 Gastric cancer
    136129277 (RAF1)
   05214 Glioma
    136129277 (RAF1)
   05221 Acute myeloid leukemia
    136129277 (RAF1)
   05220 Chronic myeloid leukemia
    136129277 (RAF1)
   05218 Melanoma
    136129277 (RAF1)
   05211 Renal cell carcinoma
    136129277 (RAF1)
   05219 Bladder cancer
    136129277 (RAF1)
   05215 Prostate cancer
    136129277 (RAF1)
   05213 Endometrial cancer
    136129277 (RAF1)
   05224 Breast cancer
    136129277 (RAF1)
   05223 Non-small cell lung cancer
    136129277 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    136129277 (RAF1)
   05161 Hepatitis B
    136129277 (RAF1)
   05160 Hepatitis C
    136129277 (RAF1)
   05164 Influenza A
    136129277 (RAF1)
   05163 Human cytomegalovirus infection
    136129277 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    136129277 (RAF1)
   05165 Human papillomavirus infection
    136129277 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    136129277 (RAF1)
   05152 Tuberculosis
    136129277 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    136129277 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    136129277 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    136129277 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    136129277 (RAF1)
   01522 Endocrine resistance
    136129277 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pphc01001]
    136129277 (RAF1)
Enzymes [BR:pphc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     136129277 (RAF1)
Protein kinases [BR:pphc01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   136129277 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 136129277
NCBI-ProteinID: XP_065741548
LinkDB
Position
10:4802263..4831720
AA seq 668 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLQDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSIVGDSGFPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHGESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSSTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHISNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagacgct
gtgtttgatggccccagctgcatctcccctacaatagttcagcagtttggctatcagcgt
cgggcatcagatgatggcaaacttacggacccttctaagacaagcaacactatccgtgtt
tttttgccaaacaagcaaagaacagtggtcaatgtgcggaatggaatgagcttgcaagac
tgccttatgaaagctctcaaggtgaggggcctgcaaccagagtgctgtgcagttttcaga
cttctccacgaacacaagggtaaaaaagcacgtttagattggaatactgatgctgcctcg
ttgattggagaggaacttcaagtagatttcctggatcatgttccactcacaacacacaac
tttgctcggaagaccttcctgaaacttgccttctgtgacatctgtcagaagttcctgcta
aatgggtttagatgtcagacttgtggctacaagtttcacgagcattgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttgctgttcccaaattccatt
gttggtgatagtgggttcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtctcccggatgcctgttagttcccagcacagatactccacaccccacgctttcacattc
aacacctccagcccctcctctgaaggttccctctctcagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccttgcccgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagtcacggtgaatcagcctcaccttcagccttgtccagcagtcccaacaatctg
agcccaacaggctggtcacagcccaaaacccctgtgccggcacagagagagcgggcaccg
ggatccagcacccaggagaaaaataaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctctccactcggattgggtcaggctccttt
gggactgtttataagggcaagtggcatggagacgttgcagtaaagattctaaaggttgtt
gaccccacaccagagcagttccaggccttcaggaatgaagtggctgtccttcgcaaaacc
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctataaacacctgcacgtccaggagaccaagttc
cagatgttccagttgattgacattgcccggcagacggctcagggaatggactacttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagactttggtttggcaacagtgaagtcgcgctggagtggttctcag
caggttgaacaacccaccggctccatcttgtggatggccccagaggtgattcgaatgcag
gacaataacccgttcagcttccagtctgacgtctactcttacggcatcgtgctgtatgag
cttatgacgggggaactgccctactcccacatcagcaaccgcgatcagatcatcttcatg
gtaggccgagggtacgcctccccagaccttagtaagctgtacaagaactgccccaaagca
atgaagaggctggtagccgactgtgtgaagaaagttaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaaaatcaaccggagcgct
tctgagccatccctgcaccgggcggcccataccgaggacatcaatgcctgcacgctgacc
acatcccctagattgcctgtcttctag

DBGET integrated database retrieval system