Phocoena phocoena (harbor porpoise): 136136063 Help Entry 136136063         CDS       T11058                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism pphc  Phocoena phocoena (harbor porpoise) Pathway pphc04020   Calcium signaling pathway pphc04024   cAMP signaling pathway pphc04260   Cardiac muscle contraction pphc04261   Adrenergic signaling in cardiomyocytes pphc04371   Apelin signaling pathway pphc04713   Circadian entrainment pphc04911   Insulin secretion pphc04921   Oxytocin signaling pathway pphc04972   Pancreatic secretion pphc05020   Prion disease pphc05022   Pathways of neurodegeneration - multiple diseases pphc05410   Hypertrophic cardiomyopathy pphc05412   Arrhythmogenic right ventricular cardiomyopathy pphc05414   Dilated cardiomyopathy pphc05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pphc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     136136063 (RYR2)    04020 Calcium signaling pathway     136136063 (RYR2)    04024 cAMP signaling pathway     136136063 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     136136063 (RYR2)    04921 Oxytocin signaling pathway     136136063 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     136136063 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     136136063 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     136136063 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     136136063 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     136136063 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     136136063 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     136136063 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     136136063 (RYR2)    05414 Dilated cardiomyopathy     136136063 (RYR2)    05415 Diabetic cardiomyopathy     136136063 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pphc04040]     136136063 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pphc04990]     136136063 (RYR2) Ion channels [BR:pphc04040]  Voltage-gated cation channels   Ryanodine receptor    136136063 (RYR2) Domain-containing proteins not elsewhere classified [BR:pphc04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    136136063 (RYR2) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  136136063 NCBI-ProteinID:  XP_065750005 LinkDB All DBs Position 16:complement(75811255..76326310) Genome browser AA seq 4971 aa AA seqDB search MIFQVDLNPEALLLTCFPVSVLERCDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLES TSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSQGAIDVKKWKFMMKTAQGGGHR TLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSE GEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGG DVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRW GQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGT SEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHE ESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLE HEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILN SLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKE GHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNH VSSMRPNIFLGVSEGSAQYRKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGE EWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRIN GQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEK LKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHE LWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLSALGCHVG ISDEHTEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDR IRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDH AARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSD ERAFAFDGFKAQRWHQGSEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELA FKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWL SKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDLMFYRLSMPIECA EVFSKTAAGGIPGAGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRVDKDKEATKPEFN NHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVR IFPGQEPANVWVGWITSDFQQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAG ESLSPGQGRNNNGLEIGCVVDTASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPN VFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRI SERQGWLVQCVEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHR VAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTE ETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSINNEGYQYSPEFPLDILKAKT IQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHSEDLKHILQLIEPSVF KEAAGPEEEGESPEKEPCAEDSKLEGAAEEENKGGKRSKEGLLQMKLPEPVKLQMCLLLQ YLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQE QINMLLNFKDDKSECPCPEEIQDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLS LVEKVTYLKKKQAEKPIESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQ YDGIGGLVRALPKTYTINGISVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMN NKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQ KAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVVRYLA GCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPEC FGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTPDTEEEEDDTIHMGNAIMT FYAALIDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGN VVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSAT DMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIE VCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNF GAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMME KQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDS SKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQT SQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPL LVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLI RYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPL CSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGL ESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFE HIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAF LETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVDLAESGIRYTQ MPHVMEVILPMLCSYMSHWWEHGPENNPGRAEMCCTALNSEHMNTLLGNILKIIYNNLGI DEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEVRGDMSE AELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSH NFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAAL KRLLPIGLNICAPGDQELIALAKTRFSLKDTEDEVRDIIRSNIHLQGKVEDPAIRWQMAL YKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVAC FRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVD PLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRS KEKEMEKQKLLYQQARLHDRDAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQ QKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDGE FTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSG KDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHM QMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMIL KFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCTETDE NETLDYEGFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLG RIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCE DTIFEMQLAAQISESDLNERSANKEESGKEKPEEQGPRTGFFSIVTVTSALFALRYNILT LMRMLSLKSLKKQMKKVKKMTVKDMVTAFFTSYWGFFMSLLHFVASVFRGFSRIVGSLLL GGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEDGERKAMEGALPSEDLTDLKELTEESD LLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKAKEEKEEKEES KSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYF ARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVSSLDSSPRIIA VHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLY ITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAA LDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMAMSVLGHYNN FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS EDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIV ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA NYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14916 nt NT seq  +upstreamnt  +downstreamnt atgatttttcaggttgatttgaacccagaagctctgttattgacctgttttcctgtgtca gttttggaacgatgtgatgatgaagtggttctgcagtgtactgcaaccatccacaaagaa cagcagaaactgtgtttggccgcagaagggtttggcaacagactttgcttcttggagtcc acttcgaattccaagaatgttcccccagacctctccatctgcacctttgtgctggaacag tccctctctgtccgggccctgcaggagatgctggctaacactgtggagaagtcacaaggg gcaattgatgtgaaaaaatggaaattcatgatgaagaccgctcaaggtggtggccaccga acgctcctctatggacatgccatattgctgcgccattcctacagcggcatgtatctgtgc tgcctgtccacctctcggtcttcaactgataaactggcttttgatgttggcttgcaagag gacacaacaggtgaagcttgttggtggaccatccatcctgcctccaagcagcgctcagaa ggagaaaaagtacgggttggagatgacctcatcttagttagtgtgtcctccgaaaggtac ttgcacttgtcttatggcaacggcagcctgcacgtggacgccgctttccagcagaccctc tggagcgtggccccaatcagctcaggaagtgaagcagcccaagggtatctgattggtggt gacgtcctcaggttgcttcatggacacatggatgaatgcctcacggtcccttcaggagaa cacggtgaagagcagcgaagaactgttcattacgaaggtggtgctgtatctgttcacgca cgttccctgtggagactagagacgctaagagttgcgtggagtggaagccacataagatgg ggccagcctttccgactacgccatgtcacaacaggaaaatacttgagcctcatggaagac aaaagccttctactcatggacaaagaaaaagctgatgtcaaatcaacagcatttaccttc cgatcttccaaggaaaaattggatgtaggagtgagaaaagaagttgatggcatgggaacc tctgaaataaaatatggagactcagtatgctatatacagcatatcaatacgggcttgtgg ctaacttaccagtctgtggatgtgaaatctgtgagaatgggatccatacaacgtaaggct attatgcatcatgaaggtcacatggatgatggcctaaatttgtccagatctcagcatgaa gaatcacggacagcacgtgtcatccggagcacagtcttccttttcaatagatttattagg ggccttgatgctctcagcaaaaaagcgaaggcttccactgtagacttacctatagagtct gtaagtctaagtctgcaggacctgattggctacttccacccaccagatgagcacttagag catgaagataagcagaacagattacgagctctaaaaaatcggcagaatctcttccaggaa gagggaatgatcaaccttgtgctcgagtgtatagacaggctgcacgtgtacagcagcgct gcacactttgcggatgtcgctgggagagaagcaggggaatcttggaaatcgattctgaat tctctgtatgagttgctggcggctctaattagaggaaatcgtaaaaactgtgctcaattt tctggctccctcgactggttaatcagccgattggaaagactggaagcttcttctggtatt cttgaagttttacactgtgtgttagtagaaagtccagaagctctaaatattattaaagaa ggccatattaaatccattatctcacttttagacaagcatggaagaaatcacaaggttctg gacgtcttatgctccctctgtgtttgccatggggtagcagtccgttctaaccagcatctc atctgcgacaatcttctgccaggaagagacctgttactgcagacacgccttgtgaaccac gtcagcagcatgaggcccaatatttttctgggtgtcagcgaagggtctgcgcagtatagg aaatggtactatgagttgatggtggaccacaccgagccatttgtgaccgccgaagccact cacctgcgagtgggctgggcttcaacggaggggtactctccctaccctggagggggcgag gagtggggtggaaatggtgtcggagatgacctcttctcctatggatttgatggccttcac ctttggtcaggttgtattgcccgtactgtcagctcaccaaaccagcatctgttgagaact gatgatgtcatcagttgctgtttagatctaagtgccccaagcatctccttccgaattaac ggacaacctgttcaaggcatgtttgagaatttcaacattgatggcctcttctttccagtt gtcagtttctctgcaggaatcaaggtacgctttctgcttggggggagacatggagaattt aagttccttcctccgcccgggtatgctccttgttatgaagctgttctgccaaaagaaaag ttgaaagtggaacacagccgagagtacaagcaagaaaggacatatacacgggacctcctg ggacccacagtttccctgacacaagccgccttcacaccgatccccgtggataccagccag attgtgttgcctccccacctggagaggataagagaaaagctggcagagaatatccatgaa ctctgggttatgaataaaattgaacttggctggcagtatggtccggttagagatgacaat aagagacagcacccgtgtctggtggagttctgcaagctgcctgaacaggaacgcaattac aacttacagatgtcgcttgagaccctgaagactttgtcggcattaggatgtcatgtgggt atatcagatgaacacaccgaagaaaaggtgaaaaaaatgaagctgccgaagaattaccag ctgacaagtggatacaagcctgccccgatggacctgagctttatcaagctcaccccatct caggaagcgatggtggacaagttggcggaaaatgctcataacgtgtgggcccgggatcga atccggcagggctggacctatggcatccaacaggatgtaaagaacagaagaaaccctcgc ctggttccctatgcccttctagatgaccgaactaagaaatccaacaaggacagcctccgt gaggccgtgcgcacactgctggggtatggctacaacctggaggctcccgatcaagatcat gctgccagagctgaagtgtgcagcggcacaggagaaaggttccgaatcttccgcgctgag aaaacttacgctgtgaaggcaggaaggtggtattttgaatttgaggctgtcactgctgga gacatgagagttggctggagcagaccaggctgtcaacccgatcaggagcttggctcggat gaacgtgcctttgctttcgatggcttcaaggcccagcggtggcaccagggcagtgagcac tatgggcgctcttggcaagcaggcgatgttgtggggtgtatggttgacatgacagaacat accatgatgttcacactgaacggcgaaatccttctggatgattcgggttcagaattggct ttcaaggactttgatgttggtgatggattcatacctgtatgtagccttggagtggctcaa gtgggcaggatgaactttggaaaggatgtcagcaccttgaaatatttcaccatctgtggc ttacaagagggctatgaaccatttgccgttaacacgaacagggatattaccatgtggcta agcaagaggcttcctcagtttctccaagttccatcaaaccatgaacatattgaggtgacc agaattgacggcaccatcgacagttccccgtgtttaaaggtcactcagaagtcctttggc tctcagaacagcagcacggatctcatgttttatcgtctgagcatgcccatcgagtgcgcg gaggtcttctccaagactgcggctggagggatccctggcgccggtctctttgggcccaag aatgatttggaggattatgatgtggattcggactttgaggttctcatgaagacagctcat ggccatctggtgccagatcgagtggacaaagacaaagaagctacaaaaccagagtttaac aaccacaaagattatgctcaggaaaagccctctcgtctgaaacaaagatttttgcttaga aggacaaagccagattacagcaccagccactctgcaagactcacagaagatgtcctggca gatgagagggacgactatgattacttgatgcaaacgtccacgtactattactcagtgaga atctttcctggacaagaacctgccaacgtctgggtgggctggatcacatccgatttccaa cagtatgatacaggctttgacctggacagagttcgtacagtgaccgtgactctaggagat gaaaaaggaaaggtgcacgaaagcatcaaacgcagcaactgctatatggtgtgtgcgggt gagagcctgagccccgggcaaggacgcaacaacaacggcctggagattggctgcgtggtg gacaccgccagtgggctgctcaccttcacggccaacggcaaggagctgagcacatactat caggtggaaccaagtacaaaattatttcctgcagtttttgcgcaagctacaagtcccaac gtttttcagtttgagttgggacgaataaagaatgtgatgcctctctcagcgggattattc aagagcgagcacaaaaaccccgtgccgcagtgtccccctcgtctccatgtgcagttcctc tcacatgtcctctggagcagaatgcccaaccagttcttgaaggtagacgtgtctcgaata agtgaacgccaaggctggctggtgcagtgtgtggaacctctgcagttcatgtctctccat atcccagaggagaacagatctgtggacatcctggaactgacggagcaggaagaactgctg aaattccactaccatactctccggctctactcggccgtctgcgcgcttgggaatcaccgg gtggcccacgccttgtgcagccacgtggacgaaccgcagctgctctacgccatcgagaat aagtacatgcccggcttgctgcgcgccggctactatgacctgctgattgacatccacctc agctcctacgccaccgccaggctcatgatgaacagtgagttcatcgtccccatgacggag gagacaaagagcatcaccctcttccccgatgagaacaaaaagcacggcctcccgggcatt ggcctcagcacctccctcaggccacggatgcagttttcctccccgagttttgtcagcatt aacaacgagggttaccagtacagccctgagttcccgctggacatcctgaaggccaagacc atacagatgctgacggaggccgtgaaagagggcagccttcacgcccgggaccctgtcggg gggaccactgagttcctcttcgtccctctcatcaagttgttctataccctgctcatcatg ggcatcttccacagcgaggacttgaaacacatcttgcagttgattgagcccagcgtgttc aaggaagctgccggtcccgaggaagagggagagtcgccagagaaggagccctgtgcggaa gactccaagctggaaggagccgctgaggaagaaaacaaaggcggtaagaggtccaaggaa ggcctgctccaaatgaaactgcccgagccagttaaattgcagatgtgcctgctacttcag tacctctgtgactgccaggtccggcaccggatagaagccattgtggccttttcagatgac tttgtagccaagctccaagacaatcaacgattccgctataacgaagttatgcaagccttg aacatgtcggctgcactcacagccaggaaaaccaaggaattcagatcaccgcctcaagag cagatcaatatgcttctcaattttaaggatgacaaaagcgaatgtccatgtcccgaagaa atccaagaccaactcttagattttcatgaagatttgatgacacattgtgggattgagctg gatgaagatgggtctctggatggaaacagtgatttaacaattagaggacgcctgctgtcc ttggtagaaaaggtgacatacctaaagaagaagcaagctgaaaagcccattgagagtgac tccaagaagtcgtccactcttcagcagttgatttctgagaccatggtccgatgggcccaa gagtctgttattgaagaccctgagttggtgagggccatgttcgtgttgctccatcgacag tacgatggcattgggggtctggtccgggctctgccaaagacctacactataaatggtatt tccgtggaggataccatcaacctgctggcatctcttggtcagattcgttctctgctgagt gtgagaatgggcaaagaagaagagaaacttatgatccgtggattaggggatatcatgaat aataaagtgttttaccagcaccctaatctcatgagggcacttgggatgcacgagacagtg atggaggtcatggtgaatgtccttggaggtggggagtccaaggaaatcacttttcccaag atggtggccaactgttgccgttttctctgttacttctgtcgtataagtaggcagaatcag aaagcaatgttcgatcatctcagttatttactggaaaacagcagtgttggtcttgcctca ccagctatgagaggttcaacgccactggacgtggcagcagcctcggtgatggataataat gaactagccttagctttgcgggagccagatctggaaaaggtagtagtgcgatatttggct ggttgtggactgcaaagttgtcagatgctggtgtcgaagggttatccagacattgggtgg aatccagttgaaggagagagataccttgactttctcagatttgctgtcttctgtaatggg gaaagcgtggaggagaatgcaaatgtcgtggtgagattgctcatccggaggcctgagtgt ttcggtcctgccttgaggggggaaggtgggaatggtctgctcgcagccatggaagaagcc ataaaaatagctgaggatccttctcgagatggtccctcaccaactagtggatccagcaaa acccctgatacagaagaggaggaagatgataccatccacatggggaatgccatcatgaca ttttatgcagctttgattgacctgttaggacgctgtgctcccgaaatgcatttgattcat gctgctaagggagaagccatcagaatcaggtctattttgagatccctgattccactggga gatttggtgggagtaatcagcattgcttttcagatgccaacgatagccaaagatgggaat gtggtggagcctgacatgtctgcggggttttgcccagatcacaaggcagccatggttttg ttccttgacagggtctatggaattgaggttcaagatttcctcctccatcttctcgaggtt ggctttctgccagatctgcgggctgctgcttctttagatacggctgctttgagcgctaca gacatggccctggccctcaatcggtacctttgcacggccgtgttgcctttgttaacaaga tgtgctcctctttttgctggcactgagcaccatgcttccctcattgactcattacttcac accgtgtacagactttctaagggctgctcacttaccaaagctcaacgagattccatagaa gtgtgtttactctccatttgtggccaattgagaccttctatgatgcagcacttactcaga agattagtatttgatgtcccattattaaatgaacatgcaaagatgcctcttaagctgctg acaaatcattatgaaagatgctggaaatactactgcctgcctggagggtggggaaacttt ggagctgcctcagaagaagaacttcatttatccagaaagttgttctggggcatttttgat gccctgtctcaaaagaaatatgaacaagaacttttcaaactggcactgccttgcctgagt gcagttgcgggagctttgcctccagactacatggagtcaaattatgtcagtatgatggaa aaacagtcatcaatggattctgaagggaactttaacccacaacctgttgatacctcaaat attacaattcctgagaagttggaatacttcattaacaaatatgcagaacattcccatgac aagtggtcaatggacaagttggcaaatggatggatttatggagaaatatattcagactcg tctaaagttcaaccattaatgaagccatataaactattatctgaaaaggaaaaagaaatt tatcgctggccaatcaaagaatctttaaaaactatgctggcctgggggtggagaattgaa aggacacgggagggagacagcatggccctttataaccggactcgtcgtatttcccagaca agccaggtttctgtagatgccgcccatggttatagcccccgagccattgacatgagcaac gttacactatccagagatctgcatgctatggcagaaatgatggctgaaaactaccataat atatgggcaaagaaaaagaaactggaactggagtccaaaggaggtggaaaccatcccctg ctggtaccctatgatacactgacggccaaagagaaagccaaggatagggaaaaagcacag gacatcctcaagttcctgcagatcaatggctatgctgtatccagaggattcaaggacctg gaattggacactccttctattgagaaacgatttgcctatagtttccttcagcaactcatt cgctatgtggacgaagcccaccagtatatcctggagtttgatggtggcagcagaagcaaa ggagaacatttcccttatgaacaagaaatcaagttctttgctaaagttgttcttccttta attgatcagtatttcaaaaaccatcgtttatacttcttatctgcagcaagccgacctctc tgttctggaggacatgcatcaaacaaagagaaagaaatggtgactagcctattctgcaaa cttggagttcttgtcaggcataggatttcactatttggaaatgatgcaacatcaattgtc aactgtcttcatattttgggtcagactttggatgcaaggactgtgatgaagactggcctg gaaagtgttaaaagtgcactcagagctttcctggacaatgccgcagaggatctggagaag acgatggaaaatcttaagcagggccagttcacccacacccgaaaccaacccaaaggtgtt actcagattatcaattataccacggtggcactgttgccaatgctgtcatcattatttgag catattggccagcatcagttcggagaagatctaatattggaagatgtacaggtatcatgt tatagaattctgactagcttgtatgcattgggaaccagcaagagtatttatgtggaaagg caacgttctgcattaggagagtgtctggctgcctttgctggtgcctttcctgtagcattt ttggaaactcatctcgacaaacacaatatttactccatctacaatactaagtcttctcga gagagagcagctcttaatttgccaactaatgtcgaagatgtttgtccaaatataccatct ttggagaaactcatggaagaaattgtggacttagctgagtccggtattcgctacacacaa atgccacatgtgatggaagttatcctgcccatgctgtgtagctacatgtctcattggtgg gagcacggacccgagaataatccaggaagggctgagatgtgctgcacggctctgaactca gagcacatgaacacgctgctgggaaatatcctgaaaatcatatataataacttgggaatt gatgagggagcctggatgaaaaggttagcagtattttcccagcctattataaataaagtg aaacctcagctcttgaaaactcatttcttgccattaatggagaaactcaagaaaaaggca gctatggtggtatcagaggaagaccatctgaaatccgaggtcaggggggatatgtccgag gctgaacttctcattctagacgagttcaccacgctggccagagatctctatgccttctac ccgctcttgattagatttgtggactataacagggcaaagtggctaaaagagcctaaccca gaagcagaagaccttttccgcatggttgcagaggtgtttatctactggtcaaaatcccac aatttcaagagagaagagcagaacttcgtggtacaaaatgaaatcaacaatatgtctttc cttattacggacaccaagtcaaagatgtccaaggcagctgtttctgatcaggaaaggaag aaaatgaagcgcaaaggagaccggtattccatgcagacctctcttatcgtggcagctctg aagcgattactgcccattggcttgaacatctgtgcccctggggaccaggagctcattgct ctggccaaaactcgatttagtctgaaagacactgaggatgaagttcgagatataatccgc agtaatattcacttacaaggcaaggtggaggatcctgctattagatggcagatggctctt tacaaagatttacccaacaggacagaagacacttcagatcctgagaagacagtggaaagg gtcttggatatagcaaatgtgctttttcatcttgaacaggtcgagcatcctcagagatca aaaaaggctgtgtggcacaaactgctctctaagcagaggaaacgggcagtggttgcctgc tttcggatggctcctttgtataatctgccaaggcatcgggctgtcaatctctttcttcag ggatatgaaaaatcttggattgagacagaagaacattactttgaagataaactgatagaa gatttagcgaaacctggagcagaacctccggaagaagatgaagggactaagcgggttgat cctctccatcagctgatacttctgttcagtcgaacggctttaacggagaaatgcaaactg gaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcatgacgag gaagacgatgatggggaagaggaagtgaagagttttgaagtcacaggatcccaacgcagc aaggaaaaagaaatggaaaagcaaaagcttctgtaccaacaagccaggctccacgaccgt gatgcagctgagatggtgctgcagaccatcagtgccagcaaaggtgaaactggacccatg gtggctgctactttgaaactcggaattgctatcttaaatggcgggaactctacagtacag cagaaaatgcttgactatctcaaggagaaaaaggatgtgggcttctttcagagccttgct ggcctgatgcagtcatgcagtgtccttgacctaaacgcatttgagcgccaaaacaaagct gaaggacttgggatggtgaccgaggaaggatcaggagaaaaggttctgcaggatggcgaa ttcacctgtgacctcttccgcttcttgcagctgctttgtgagggacacaactcagatttt caaaattatctgagaactcagactggcaataatacgactgtcaacataatcatctctacc gtagactacctactgagagttcaggaatcaatcagtgacttctattggtattactctggg aaagatgtcattgatgaacagggacaaaggaatttctccaaagcgattcaagtagcaaaa caagtctttaacacgcttacagagtatattcagggtccttgcactggcaaccagcagagt ttggctcatagcaggctctgggatgcggtggtgggttttcttcatgtgtttgcccacatg cagatgaagctgtctcaggattccagtcaaattgagctgctgaaagaattgatggatctt cagaaggacatggtggtcatgttgctgtccatgttggaaggcaatgtcgttaatggcacc atcggcaaacagatggttgatatgctcgtggaatcttccaacaacgtggagatgattctc aaattttttgacatgttcttaaaactcaaggacttgacgtcttctgatacctttaaagag tatgacccagacggtaagggagtcatttccaagagggacttccacaaagcgatggagagc cataagcactacacccagtccgagactgaatttctgctgtcctgcacagagacggatgaa aacgaaactctggactacgagggatttgtcaagcggttccacgagcctgccaaggacatc ggcttcaacgtggcagtgcttctgacaaacctttctgaacacatgcccaacgacacccgg ctgcagaccttcctggaattggccgagagcgtcctgaattacttccagccgtttctgggc cgcatcgagatcatgggcagtgccaagcgcatcgagagggtttactttgaaatcagtgag tccagccgaacccagtgggagaagccccaggtcaaggagtccaaaaggcaatttatattt gatgtggtcaacgaagggggagaaaaagagaagatggagctcttcgtgaacttctgtgag gacaccatatttgagatgcagctcgcagctcagatctcagagtcggacttgaacgagagg tcagcaaataaagaggagagcgggaaggagaagccagaggagcaggggccgaggacgggt ttcttttccatcgtgacggtcacgtcggccctgtttgccctcaggtataatatcttgacc cttatgcggatgctcagcttaaagagcctgaagaagcagatgaagaaggtgaagaagatg acggtgaaggacatggtcacggccttctttacgtcctactgggggttttttatgagcctc ctgcacttcgtagcgagcgttttcagaggcttctcccgcatcgtcggcagcctcctcctg ggaggaagcctggtggaaggtgcaaagaagatcaaggtggcggagctcttggccaacatg ccggaccccacgcaggatgaggttcgaggagacggggaggacggagagaggaaagccatg gaaggcgccctgcccagcgaagatctgacggacttaaaggaactgacagaggagagtgac ctgctttccgacatctttggcctggacctgaagcgagaaggcgggcagtacaaactgatt cctcataatcccaatgctggcctgagcgacctcatgagcaaccccgtccctatccccgag gtgcaagaaaagttccaggaacagaaggcaaaagaagaaaaggaagaaaaagaagaaagc aaatccgaacctgagaaagccgagggagaagatggagaaaaagaagaaaaagccaaagaa gataagggtaaacaaaaattaaggcagctccacacacacagatatggagagccagaagtt cctgagtcagcattctggaagaaaatcatagcctatcaacagaaacttctaaactatttt gctcgcaacttttacaacatgagaatgttagccttatttgtcgcgtttgcaatcaatttc atcttgctcttttataaggtctccacttcttctgtggttgaaggaaaggagctccccact cgcagttcaagtgaaaatgccaaagttagcagcctggacagctcgcctagaatcattgca gttcactatgtgctggaggagagcagcggctacatggagcccacgctgcgtatcttagcc attttgcacacggttatctctttcttctgcatcattggatactactgcttgaaagtccca ctggttatttttaagcgagaaaaagaagtagctcgaaaattggaatttgatgggctttat attacagaacagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaac acacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaa tatggagagttctatggccgagacagaatcagcgagttacttggcatggacaaagctgcc ctggacttcagcgatgcccgggaaaagaagaagccaaagaaagacagctccctgtcggcc gtgctgaactctattgatgtgaagtatcagatgtggaaactaggagtcgttttcactgac aattccttcctctaccttgcctggtatatggccatgtccgttctcggacactataacaac tttttttttgccgctcatcttcttgacattgctatgggattcaagacgttaagaaccatc ttgtcatcagtaacacacaatggcaaacagcttgtattaaccgttggcttattagctgtt gtcgtatacctatatactgtcgtggcattcaattttttccgaaaattctacaataaaagt gaagatggcgatacaccggacatgaaatgtgatgacatgctaacgtgctatatgttccac atgtatgttggggtacgtgccggagggggtatcggtgatgaaatcgaagacccagccggc gacgagtatgagatctatcgaatcatctttgatatcaccttcttcttctttgtaattgtc attctcttggccataatacaaggtttaattatcgatgcttttggggaactaagagaccaa caggaacaggtcaaagaagacatggagaccaagtgcttcatctgtgggataggcaatgat tacttcgacaccgtgccccatggctttgaaacccacactttacaggaacacaacttggcc aattatctgttttttctgatgtatctcataaacaaagatgaaacagagcacacaggacag gaatcttatgtttggaagatgtatcaagaaaggtgctgggaatttttccccgctggggat tgtttccggaaacagtacgaagaccagctaaattaa

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