Paenibacillus polymyxa SC2: PPSC2_22060 Help Entry PPSC2_22060       CDS       T01335                                  Symbol pmxE Name (GenBank) polymyxin synthetase Organism ppm  Paenibacillus polymyxa SC2 SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Condensation AMP-binding PP-binding AMP-binding_C AATase PapA_C Motif Other DBs NCBI-ProteinID:  AKA44313 UniProt:  A0A0D5ZCE2 LinkDB All DBs Position complement(4930633..4949571) Genome browser AA seq 6312 aa AA seqDB search MRENTNEKYGLTQAQRRIWFMEIMNPGTSITMLSATYQITGEINAQLLEQAAAEIVKTYD VFRIRISGDLQNPTQWFEEPENVQARISRLEIGTTEQFYAWVKEVSEKPASVFDEHLHQF TIIHFANGQVWLNLTVNHIIADGLSVNALLHAVMEKYLELRKGTYSSYQAPSYLDYISAE REYEQSQRYQKGKEYWLTKYNTLPETTGIKSYPPFSIGSESNKLAITLDGSRYERILAFS EQYQVSLYTLFLSAMYVLLYKLTDSTDVPVGTVFANRTSKKEKETIGMFVSTVATRIRLN PDKHVLSLIQTVSKENTADLRYQKYPYNQLIQDLREQHGRNDLSGLFRTSLEYLPLKIVE YEEIKVRLEAHFARHEMDDLLLRFDHMLNEGHVILHASYRTGLFETAEIDRIMEQYVTVL DQFLQTPELPVREISLLSDEERHRILNVFNPPVAGLSEGEAFHRYVEKFAREIPDHPAVV YMDKQLTYGELNERAERLASLLREQGVGRETITGIWAERSVELLVGVLAVWKAGGAYVPL DPDYPAERIEYMLSDSDASVLLTQRHLLERARGWLADDRLKLQAVYAMDDEQIYNGDALA VEFESAGSAPQDLAYVIYTSGTTGRPKGVMIEHGSLVNTADAYRREYRLDQFPVRLLQLA SFSFDVFVGDIARTLYNGGTMVIVPKDDRIDPNLLYGWIRDQNITVFESTPALILPFMQH IYEEGLDVSSMQLLITSSDACSVTDYRLLQERFGGQFRIINSYGVTEAAIDSSFYGEPLD KLPPSGHVPIGKAWLNARFYIVDAALKPVPVGVPGELVIGGAGVARGYWNRPDLTAEKFV DSPFVPGERLYRTGDLARWLEDGNVDFIGRIDYQVKIRGFRIELGEIETALLRFPGVKQA VVTDRTDEQGQKYLCGYVTADASLQLSDLLSQLKQELPAHMVPARLVSLDKLPLTPNGKI DRKALPEPTGEVEADREYVAPRTTLETRLALIWQQVLGIARVGVQDDFFDLGGHSLRAST LVSKIRKELQVEVPLREVFRYTTIEQLAQRIGGLRQQETYEITKAAEAEYYPVSSEQKRL YILRQLDGAERSYNMSAALLLEGKLDRTRVEHAFRALIQRHETLRTGIEQVQGELVQRIY DEVEFAVDYFQASEREVDQVVEAYYHPFDVTKPPLLRIGLIEVAEDRHILLFDMHHIVSD GISTALLFDEFSRLYRGEELVPLRIQYKDYAVWQHSEAYGQMLQPQKEYWLEQLSGELPV LELPTDFPRPAVQSFDGRTVKFYIGKERTEKLKELAARTGTTLYMVLLSAYSILMHKYSG QEDLIVGTPIAGRTQEEVQPIVGMFVNTLAIRSRPERSKPYLSYLEEIKDITLGAFEHPN YLFEDLVESLHIPRATGRNPLFDTFFALQNTENEQIVIEGLEQSFYPLENRTSKFELLLD ISELDGQLECRLDYATALYKQETAERFARHYDKLLETIAAAPDGDIASLEMLTEEEIREL VGGFNDSEADYPRQQTIHGLFEEQAELYPDNVAAVMNERQLTYRELNERSNRLARKLRET GVEADQLVAILAERSLDMVVGILAILKAGGAYVPVDPDYPEERIRFMIEDSGAPLLLIQK HLHEKTDFAGTRLELDDYVWGDRGADSADALDASNLEPISGPGNLAYVIYTSGTTGRPKG TLIEHKNVVRLLFNDKNLFDFGPSDTWTLFHSFCFDFSVWEMYGALLYGGKLVIVPPLTA KNPADFLALLGREQVTILNQTPTYFYQLLREVLADHPYDLRIRNVIFGGEALSPLLLKGF KTKYPETKLINMYGITETTVHVTYKEITWVEMEAAKSNIGKPIPTLRVYVLDENRRPVPI GVAGEMYVAGEGLARGYLNRPDLTAEKFVDSPFAEGEKLYRSGDLAAWLPDGNIEYLGRI DHQVKIRGYRIELDEIETQLLNVEGVEEAVVLARQDGGGEKALVAYFVADRTLTVSEMRT SLAQGMPGYMIPSYFVQLERMPLTTNGKVDRKALPEPQGGLQTGVEYVAPRNRTESQLVK IWEEVLGYSGIGVLDNFFELGGHSLRATNLVSKIRKEMNVELPLRDVFRCMTVESMAGAI ASLEETRHSSIPKAEEKAYYPVSSAQKRLYVLHQLDGSELNYNLPSALQLEGALNEAKVE KALTTLVARHDMLRTGFEIVNGEPVQRIHPLVAFKVEKLQASEDQVAAILEGFIQPFDLT QPPLLRALLIELEKEKFLLALDIHHIGSDGLSMDVLLREFVRLYNGEELPELRIQYKDYA VWQQSEEQRQRIKRQEEYWRGVFSSELPVLELPLDFSRPAVQQFDGQTLTFTLDAEKSEA LKRLAGDSGATLYMLLLAAYSVLLHKYAGQEDIVVGTPIAARSHADLQPIIGMFVNTLAL RLAPVAERTFLDYLQEVKETTLGAYEHQDYPFEELVEALQVSRDLSRNPLFDTMFSLQKH ESLDLPLEGLKWSLFDIEEKTAKFDLSFDIVEADNELVCKIEYATSLFRQETMVRLAGHY EQLLASILAQPGARISDLDILTDSEKHDLLVGFDVSSSALAKQPAAEGTGLEADESWRER TFHELFEEQAERTPGALAVVYEDSKLTYAELNAKANRLAFALRERGVKPEQVVGILAGRS AELLIGVLAVWKAGGAYVPLDPDYPAERIEYMLADSGASVLLTQTRLLEQAEAWCSDGAL VLQTVLALDDAATYSLGASEAAVGVQALGEAGAEAEALAQAETAAAETSATAEAEKNVLA ADLASNPANVNKPRDLAYVIYTSGTTGKPKGVMIEHRSLVNTAAGYRREYRLDQFPIRLL QLASFSFDVFVGDIARTLYNGGTMVIVPKDDRIDPTRLYGWIRDYAVTVFESTPALIVPF MEHVHAEGLDLSSMQLLITSSDACSVADYRTLQERFGSQFRIINSYGVTEAAIDSSFYDE PLKKLPKTGSVPIGKAWLNAKFYIVDANLKPVPIGVLGELVIGGAGVGRGYLNRPDLTAE KFVDSPFAAGERLYRTGDLARWMPDGNVDFIGRIDNQVKIRGYRIELGEIEAAMKNFAGV RQALVIDRTDERGQKYLCGYVVADSSFDLEGLVAHLDAALPSHMVPSRIMRLDQLPLTPN GKIDRKALPVPEGSIRAEAAYTAPRTPAEQALASVWQSVLGVDQVGTMDNFFALGGDSIK ALQVSSRLLQTGYKLVMKDLFHYPTISALSLQLQTAERTASQAEVTGEVILTPIQRWFFE QNPADVHHSNQAFMQFSKQGFDEEALRQAVRQLVVHHDALRTVYRQTENGYIAWNRGAGE NEALFDLEFVDFKGVGDVKEAVEAKANDIQASIDLENGPLVKLGLFRCDDGDHLLIAIHH LVVDGVSWRILLEDFAAGYEQALQGQPIRLPLKTDSFQTWAKQLADYANGPAMESEREYW QHIEQLTYEPLPKDFEQGRSKLKDSGLVTVRLTAEETEQLLKQAHRAYHTEMNDLLLAAL GLAIQAWSGRERVLVNLEGHGREDILPDVDITRTVGWFTSQFPVVLEPGHAQALGHQVKQ VKESLRRIPNKGIGYGILRYLSAPRDGERFALEPEISFNYLGQFDQDYESSGSRPSPFSP GSDSSPNAVMDYVLDINGMVSEGVQELTIRYGETQYKRETIERLGTLLHSSLREVISHCV SKERPELTPSDVLLQDVTVEELERLAEHTAALGELENVYTLTPLQKGMLFHSLLDADSEA YFEQVTFDLCGSLNVEAFTQGLDTLVQRNEALRTNFITGWRDEPIQVVFRERKCEVYFED IRSVSDEDPEKTIADFVSADKANKFDLARGSLMRVTVLRTGDESYHVIWSHHHILMDGWC MSFMIKEVFDTYFAFQEKQTLELPPVTSYSRYIEWLEAQDAAKASRYWSEYLAGYDQQTK LPQEKTQLKQGHFEAAEIDVELSKELTGQIERVARQQQVTLNTFMQTVWGLVLQVYNNSE DVVFGSVVSGRPAEIPGIESMIGLFINTIPVRIQGKAGETVADILRKTQDQALASGAYET FPLFEIQSLSEQKRDLINHIMVFENYPMEEQIEQVVGGDQEALKIANIQSPEQTNYDLDI TVIPEEHILLRFTYNALTFREEDIRLIHGHFAQALEKVAANPNIRVNQLELLTAAEKEQI LGAFNPAQPEAAPAAAFHRLFEEQAERTPEEAAVVYENDRLTYAELNERANRLAATLRAS GIGRETIVGILAERSVDLLVAVLAVWKAGGAYVPLDPDYPAERVRFMLEDSGAKVLLTQT PLRERAEAWLGEEELALAAVLYLDDEASYSEERANAPIGSGIVSGKLTDAVDDGDESHQN IGTDSFHEARPEELAYVIYTSGTTGKPKGVMIEHRSLVNTAAGYRREYRLNQFPVRLLQL ASFSFDVFVGDIARTLYNGGTMVIVPKDDRIDPSRLHYWIEREQVTIFESTPALIVPFLE YVHEQRLDMSWMELLITSSDSCSVADYRTLQERFDSLFRIINAYGVTEAAIDSSFYDEEL TKLPQTGNVPIGKAWLNAKFYIVDAHLNPVPVGVLGELVIGGVGVARGYLNRPELTEEKF VDSPFAAGERLYRTGDLARWMEDGNVDFIGRIDNQAKIRGYRIETGEVEAKLLSVGGVKE AVVVVREDQEGQKALCAYYTAEEGLTALDLKRAIASELPGYMIPSYFVEMERLPLTPNGK IDRKALPAPEGGASAGREYVAPRTELEAKLAAIWQDVLVREKAVGVTDNFFDLGGHSLRA TTLVSKMHKELGVEFPLRDVFRYSTVEEMAAAMERLEIGSFTAIPAAEPSEYYPLSSAQK RLYILNQLEGAELSYNIPGAMLLEGGLDRQRFEEAFRGLVARHETLRTGFEMVKGEAVQR IYEEVAFQVEYVQISGEQAEETVRQFVRPFDLAKPPLLRVGLAELAPDRHILMFDTHHIV SDGVSIDVLIEEFVRLYSGEQLEPLRIQYKDYAVWQQSDEQKAQLAKQEAYWLDMFRGEL PVLELPTDYPRPSMQSYEGRTLQLFMDSKKSEGLKRLAAENGATLYMVLLAGYTILLHKY TGQEDVVVGTPIAGRNHSDVQPLIGMFVNTLAIRSYPAAGKTFLDYLKEIKETTLGAFEH QNYPFEELVDKVNVARDLRRNPLFDTMFALQNTENLEIQLPGLHLSTYASEEIVSKFDLS LDVTEIEEGLEYLFEYATALYKTETVEKLAAHYLQLLESILRNPTATIAELGILTPAEKE QILGAFNPAQPEATPAAAFHRLFEEQVERTPEEAAVVYENDRLTYAELNERANRLAATLR ASGIGRETIVGILAERSVDLLVAVLAVWKAGGAYVPLDPDYPAERVRFMLEDSGAKVLLT QTPLRERAEAWLGEEELALATVLYLDDEASYSEERANAPIGSGRVSGKLTDAVDDGDESH QNIGTDSFHEARPEELAYVIYTSGTTGKPKGVMIEHRSLVNTAAGYRREYRLDQFPVRLL QLASFSFDVFVGDIARTLYNGGTMVIVPKDDRIDPSRLHHWIEREQVTIFESTPALIVPF LEYVHEQGLDMSWMELLITSSDSCSVADYRTLQERFGSLFRIINAYGVTEAAIDSSFYDE ELTKLPQTGNVPIGKAWLNAKFYIVDAHLNPVPVGVLGELVIGGVGVARGYLNRPKLTEE KFVDSPFAAGERLYRTGDLARWMEDGNVDFIGRIDNQAKIRGYRIETGEVEAKLLSVGGV KEAVVVVREDQEGQKALCAYYTAEEGLTAADLKRAIASELPGYMIPSYFVEMERLPLTPN GKIDRKALPAPEGGASAGREYVAPRTQLEAKLVAIWQDVLGSVTIGVTDNFFDLGGHSLR ATTLVSKVHKELSVDLPLRDVFRHSTIEAMAEAISQLERQEHLSIPVLDKRDYYPLSSVQ KRLYIQQQMEGAELSYNMSGMTVLVGRLERNQFEAALKGLIARHEILRTGFEMVDGEPVQ RIYPDLKFAVEYTKATESETKSIVDGFVRVFDLERPPLLRVGLVEWEAERHLLMLDIHHI VTDGMSMGIFVEELLRLYNGETLEPLRIQYKEFAAWQQSEPVKERLKRQEAYWLDVLEGE LPTLELPTDFVRPAARSFEGDVLPFSIDKQMTDSLQRIADENGATLYMVLLAAYSILLSK YSGQEDFIVGTPASGRTHADLEPLIGMFVNTLAIRHYPSGEKTFLAYLNEVKETMLGAYD HQDYPFEELVKKLQAPRDQSRNPVFDVMFVLETKEDNVQSFGDIKIESYPETHTVSQFDL TLVISLLDEGMNGQFEYATKLFTRNLIDNFAQDLLVIITQICEQPSVLLKDISLNGQSEQ EQDVLEAIDIIF NT seq 18939 nt NT seq  +upstreamnt  +downstreamnt gtgagagagaataccaacgagaaatatggattaacgcaagcccagcgccgaatatggttc atggaaattatgaatccgggaacgtccatcacgatgctttccgcgacctaccagattacg ggcgagatcaacgcacagcttctggagcaagcggcggcagagatcgtcaaaacctatgac gttttccgaatccgcattagcggggatttgcaaaatccaacgcagtggttcgaagagccg gagaatgtccaagctaggataagccgcctcgaaataggcacaaccgaacaattctatgct tgggtgaaagaagtaagcgaaaaaccggccagcgtgttcgacgaacacctccaccaattt acgattatccattttgcgaacggccaagtatggctcaatttgacggtaaatcatattatc gccgacggcttgtccgtcaatgctttgctgcatgcggtgatggaaaaatacctggaactg cgcaaaggcacctacagcagttaccaggccccttcctatctggattatatttctgcggag cgtgaatatgagcaatcgcagcgttatcaaaaaggcaaggaatactggctgacgaagtac aacactttgcctgaaacgaccggcattaaatcgtatccgccattctcgatcggcagcgaa tccaataaactggccatcactttggacggttcccggtatgaacgcattctggccttcagc gaacaatatcaggtcagcttatatacgttatttctgtccgctatgtacgtcttattgtac aagctgaccgacagcaccgatgttccggtcggcacggttttcgccaatcgcaccagcaag aaggaaaaagaaacgatcggcatgttcgtcagcaccgtggctacgcggattcgtctgaat ccagacaagcacgtgctttccttgatccaaacggtttccaaggaaaatacggcggatctg cggtatcagaaatacccttataaccaattgatccaggatttacgcgaacaacacggccgc aacgatctttcggggctgttccgtacgtctctagaatatctgcctttgaaaatcgtggag tacgaagaaatcaaggtacgcctggaggctcacttcgctaggcacgagatggacgatttg ctgctgcgcttcgatcatatgttgaatgaaggccatgtaattctccatgcttcctatcgt accggcctgttcgagacggccgagattgatcggattatggaacagtatgtaaccgttctg gaccagtttcttcagactcccgaactgccggtacgcgagatttctctgctgagcgatgag gagagacaccgcattctcaacgtttttaacccgccggtggcagggcttagcgagggagaa gcgtttcatcggtatgttgaaaagtttgcccgggaaattccagatcatccggcagtcgtc tacatggacaaacagctgacctacggcgaattgaacgaacgcgccgagcggctggcttct ctccttcgcgaacagggcgtgggaagggagacgattacggggatctgggcagagcgttcg gtggaactgctggtcggggtgctcgccgtttggaaagccggcggagcctatgtaccgctg gaccccgattatccggcggagcggattgagtacatgctcagcgatagcgatgcatcggtg ctgcttacgcagcgtcatctgttggagcgggccagaggttggttggccgatgaccggctg aagcttcaagctgtctatgccatggacgatgaacagatttataacggggatgccttagcc gtggaatttgaatctgccggcagcgccccgcaagacttggcttatgtgatttacacctcg ggtacgacgggacgcccgaaaggcgtcatgatcgagcacggtagtctcgtgaatacggcg gatgcgtaccgtcgcgagtaccggttggatcagtttccggtgcggctgctgcagctggcc agcttctcgtttgacgtgttcgtcggagacatcgcgcggacgctgtataacggaggcacg atggtgattgtgccgaaggatgaccggattgatccgaacctcttatacggctggattcgg gaccaaaacattacggtattcgaatcgacgcctgcgctcatcctgccgttcatgcagcat atttatgaagaagggctggacgttagctccatgcagttgctgattaccagctcggatgct tgcagtgtcaccgattaccgattgctgcaggaaagattcggcggacaattccgcatcatc aacagctatggcgttaccgaagcggccattgacagcagcttttacggtgagccgctggat aagctgccgccgtcaggtcatgtgccgatcggaaaagcttggctaaacgcccggttttac attgtcgatgccgcattaaagccggttcctgtaggggttccgggcgagcttgtcatcggc ggcgccggggtggcgcgcgggtactggaaccgtccggacctaaccgccgagaagtttgtg gacagcccgtttgtgccgggcgaacgtctgtaccggacaggcgatttggcccgctggctg gaagacggcaacgtcgacttcatcggccggatcgactatcaggtgaaaattcgcgggttc cggatcgaactcggcgaaattgaaacggccctgctgcgttttccgggcgtcaagcaggct gtggtgaccgaccgtacggatgagcaggggcagaagtatttgtgcggctacgtgacggcg gatgcttccttgcagctgagcgatctgctgtcccaattgaagcaagagctgccggcccat atggtcccggcccggttggtgtctcttgataagcttccgctcacgccgaacggcaaaatt gaccgtaaagcgctgcctgaaccgaccggagaggtagaagcagaccgtgagtatgtggct cctcgcacaacgcttgaaacaagacttgctctcatttggcagcaggtgctgggtattgcg cgagttggagtccaagacgatttctttgacttgggtggtcattccttgcgggcctccacg ctggtttccaagattcggaaagagctgcaagtcgaggttccgctgcgggaagttttccgc tacaccacgatcgaacagctggcccaaagaatcggcggtttaaggcagcaggagacgtat gagattacaaaggcggctgaggctgagtactatccggtttcatccgagcaaaagcgtctg tacatcctacgccagcttgacggggccgagcgcagctacaatatgtcggcggcgcttctt ctcgaaggcaagctggaccgcacgcgcgtcgagcacgcgttccgggcgctgattcagcgc catgagacgctgcgtaccgggatcgagcaggttcaaggcgagcttgttcagcgcatctat gatgaggtggagtttgctgtcgattatttccaggcgagcgagcgggaagtggaccaagtg gtggaagcttactatcacccgtttgatgtaaccaagccgccacttctccgcatcggcctg atcgaagtcgccgaggatcgccacattctgctgttcgatatgcaccatattgtctcggac ggcatttcgacagcgctgctcttcgacgagttcagccgcctgtatcggggcgaggagctg gtcccgctgcgcattcaatacaaagattatgccgtttggcagcattccgaagcttacggg cagatgctccagccgcagaaggagtactggctggaacagctgtcgggcgagctgccggtc ttggaactgccgacggacttcccgcggcctgcggtgcaaagctttgacggccggaccgtg aagttttatatcgggaaagagcggacggagaagctgaaagagctggcggcgcggacgggg acgaccctgtacatggtgctgctgtcggcttactccatccttatgcataaatattcgggt caggaagatctgattgtcggaacgccgattgccggaagaacgcaggaagaagtgcagccg atcgtggggatgtttgtcaacacgctggccattcgcagccgtccggagcgttccaagccg tacctttcgtacctggaagaaatcaaggacatcacgctcggggctttcgaacacccaaat tatttgttcgaagacttggtggaaagtcttcacattccacgcgcgaccggccggaatccg ctctttgatacgttcttcgccctgcaaaatacggaaaacgagcaaattgtcatcgagggg ctggagcaatcgttttatccgctggaaaaccgaacatccaagttcgagctgctcctggac atttcggagctggacggtcagctcgaatgccggttggattacgctacggctttgtataaa caggagaccgcggagcggttcgccagacattatgacaagctgctggaaaccatcgcagca gcgccggacggggatattgcctcgctggaaatgctcacagaggaggaaatccgcgagttg gtgggcggtttcaacgattcggaggcggactacccgcggcagcagacgattcacggcttg ttcgaagagcaggcggagctttacccggacaacgtagccgccgtcatgaacgagcggcag ctgacataccgcgagctgaacgagcgatccaaccgccttgcgcggaagctgcgggagacg ggagtagaagcggaccaactggtagcgattctggccgaacgctcgctcgatatggtcgtc ggcattctggcgattctcaaagcgggcggagcatacgtgcctgtcgatcccgactacccg gaggagcgtatccgcttcatgatcgaggattcgggcgcgccgttattgctgattcaaaag catctgcacgagaagaccgacttcgcaggaacgcgcctcgaattggacgattacgtttgg ggtgacagaggggcggactccgccgatgcactggacgcttcgaacctggagccgatttcc ggaccgggcaacctggcctatgtcatctacacgtcgggaacgaccggcagaccgaaagga acgctgatcgagcataagaacgtcgtgcggctcctgttcaacgacaagaacctgttcgac ttcgggccgtccgacacgtggacgctgttccactcgttctgcttcgatttctccgtctgg gaaatgtacggagcgctgctgtacggaggcaagctggtcatcgtaccgccgctcacggcg aaaaatccggccgatttcctggcgctactgggccgcgaacaggtcacgattttgaaccag acaccaacgtacttctaccagctgctgcgtgaggtcttggcggaccatccgtacgatctg cggattcgcaacgtcatcttcgggggcgaagcgctgagtccgctgctgctcaagggcttc aagacgaagtacccggagacaaagctgatcaatatgtacggcattaccgagacgacggtt cacgtgacgtataaggaaatcacgtgggtcgaaatggaggcggcgaagagcaatatcggc aagccgatcccgacgctgagggtgtacgtcctggatgaaaaccgccgccctgtgccgatc ggtgtagcgggcgaaatgtacgtggccggggaaggccttgcgagaggatacctgaaccgt ccggatctgacggcggagaagttcgtcgattccccgtttgcggagggggagaagctgtac cgctcgggcgacttggcagcttggctgccggacggcaacatcgaatacctaggccggatc gatcatcaggtgaaaatccgcgggtaccggatcgagttggacgaaatcgagacgcagctt ctgaacgtcgagggcgtggaagaagcggtggtgctcgcccgtcaggacggcgggggagag aaggcgcttgtcgcctactttgtggcggaccggacgctgacggtcagtgaaatgagaacc tcgctggcccagggaatgccggggtacatgatcccttcgtacttcgtgcagttggagcgc atgccgctgacgaccaacggcaaagtggaccgcaaagcgctgccggagccgcaaggtggc ttacaaacgggcgtcgaatacgtagcgccgcgtaaccggacggagtcccagcttgtgaag atctgggaggaagtgctgggctactccggcattggagtcttggacaatttcttcgagctc ggcggccactccttgcgggcgacgaaccttgtcagcaagattcggaaggaaatgaacgtc gaacttccgctgcgcgatgtgttccgctgtatgacggtagagtcgatggccggggctatt gccagcttggaagaaacgcggcacagctcgattccgaaagcggaagagaaagcgtactat ccggtttcctccgcgcaaaaaaggctgtacgtcctgcaccaactggatggctcagagctg aattacaacctcccaagcgccttgcaattggaaggggctttgaacgaggccaaagtggaa aaggcgctgactactttggtggcccggcacgatatgctgcgtaccggttttgaaatcgtg aatggggagccggttcagcgtattcatccgctcgtagctttcaaagtcgagaagcttcaa gcaagcgaagatcaggttgcggccattcttgaaggcttcattcagccttttgacttgacc cagccgcctttgctgcgcgccctactgatcgaactggagaaagagaaatttctgctcgcg ctggatattcatcatattggttccgacggcctttccatggacgtgctgctgcgcgaattc gtgcggctttacaatggggaggaattgccggagctgcggattcaatacaaggattacgcc gtttggcagcaatccgaggagcagcgccagcgcatcaaacggcaggaggaatactggcgc ggggtattcagctccgagcttccggttcttgagctgcctctcgacttctcccgcccggcc gttcagcagtttgacggtcaaacgctcacgtttacgctggatgcggagaaaagcgaagct ctcaaacggcttgccggcgattcgggggcgacgctgtacatgcttctgctagctgcgtac tccgtattgcttcataaatacgcgggacaggaagatatagtggttggcactccgattgcc gcccgttctcacgccgacctgcagccgattatcggcatgttcgtcaatacgctggccctt cgcttggccccggtggcggagcggacgttcctggattacttgcaggaagtgaaggaaacg acgcttggagcctacgagcaccaggactatccgttcgaggagctggtggaagctcttcag gtgagccgggatttaagccggaatcctctgtttgacaccatgttttctttgcaaaagcac gaaagcttggatttacccctggaaggtttgaaatggtcgctgttcgacatcgaggaaaag acggcaaagtttgatcttagctttgatatcgtggaagctgataacgagctggtttgcaag atcgagtacgctacctcgttgtttagacaggaaacgatggtacggctggcgggtcattac gagcagcttttggcgtcgatcctggctcagccgggtgcgcggatttcggatttggatatc ttgacggacagcgaaaagcatgatttgctggtcgggtttgacgtgtcgtcttcggctctt gcgaagcaacccgccgcagagggtacaggtttggaagcggatgagtcgtggagagagaga acgttccacgagctgttcgaggagcaggcggagcgcactccgggagcgctggcggttgtc tacgaagacagcaagctgacgtatgcggagctgaacgccaaagcgaatcgtctggcgttt gcactgcgggagcgcggggtgaagccggagcaggtggtcggcattctggccggccgttcg gcggagctgttgatcggggtgctcgccgtatggaaagcgggtggcgcttatgtgccgctc gacccggactatccggcggagcggatcgagtatatgctcgcggacagcggggcgtcggtg ctgctcacgcagacccgcctgctggagcaggcggaagcttggtgcagcgacggagctcta gtgctgcaaacggtgcttgcgcttgacgacgccgcgacgtacagcctcggcgcgtcggaa gcggctgtgggcgtacaagctttgggcgaagcaggcgcagaggcggaggctttggcgcaa gcggaaacggctgctgccgaaacgtccgccacggcagaagccgagaagaacgtactagcg gcggatctcgcatcgaatccggcgaatgtgaacaagccgcgcgatttggcttacgtgatc tatacgtcgggaacgacgggcaagccgaagggcgtgatgatcgagcaccgcagcctggtg aacacggcggcgggctaccggcgggaataccgcctggatcagttcccgatccggctgctg cagctcgccagcttctcgttcgacgtgttcgtcggcgacattgcgcggacgctgtacaac gggggcaccatggtcatcgtgccgaaggacgaccggattgatccaacccgcctctacggc tggattcgcgactacgccgtgacggtgttcgaatcgactccggcgctgatcgtgccgttc atggagcatgtgcatgccgagggtctggacctcagctcgatgcagctgctgatcacaagc tcggatgcgtgcagcgtagcggattaccgcaccttgcaggagcgcttcggctcgcagttc cgtattattaacagctacggcgtaacggaagcggcgattgactccagcttctatgacgag ccgctgaagaagctgccgaagacgggtagcgtgccgatcggcaaagcttggctgaacgcc aagttctacatcgtggatgcgaatctgaagccggtgccgatcggggtgttgggcgagctg gttatcggcggagcgggtgtgggccgcggttacttgaatcgcccggatttgacggcggag aaattcgtagacagcccgttcgccgctggggagcggctgtaccggacgggcgacctggcg cgctggatgccggacggcaacgtggacttcatcggccggatcgacaaccaggtgaaaatt cgcggctatcggatcgagcttggtgaaattgaagcggccatgaaaaattttgccggcgtg cgtcaagcgcttgtcatcgaccggacggacgagcgggggcagaaatatttgtgcgggtat gtcgtagcggattccagcttcgatctggaagggcttgtggcccatctggacgccgcgctg ccttcccatatggtgccttcgcgcatcatgcgcctggatcaattgccgcttacgccgaac gggaagatcgaccgtaaagcgctgcctgtaccggaaggaagcattcgtgccgaggctgca tacacggcacctcgtactcctgccgagcaagcacttgcgtcggtctggcagtcggtgctg ggcgtggatcaggtcggcacgatggacaatttctttgcgctcggcggcgattcgatcaag gccttgcaggtatcgtcccgtcttttgcaaacggggtacaagctggtcatgaaagatttg ttccattacccgacgatttccgcccttagtttgcagctgcaaacggcggagagaacggca agccaggccgaagtgacgggagaggtcatcttgaccccgattcagcgctggttctttgaa caaaatccggccgacgtgcatcacagcaaccaggcgttcatgcagttctccaagcaaggc tttgacgaagaagctttacgtcaagcggtgcgtcagcttgtcgtgcatcacgatgctctc cgtacggtttaccgccaaaccgagaatggctatatcgcctggaaccgcggcgccggggag aacgaagcgctgttcgatctggaatttgtcgatttcaagggagtcggcgacgtgaaagaa gcggtagaggctaaggcaaatgacattcaagcgagcatcgatctggaaaacggtccgctg gtgaagctcggcttgttccgctgcgacgacggcgaccacctgctcatcgcgatccatcac ttggtcgtagacggcgtatcctggcggattctgcttgaggattttgctgccggctatgag caggcgctgcaagggcagccgatccgtctgccgctcaaaacggattcattccaaacgtgg gcgaaacagctcgctgattatgcgaacggtccggcgatggaaagcgagagagagtactgg cagcatatcgagcaattgacctatgagccgcttccgaaagattttgaacaaggcagatcc aagctgaaggacagcgggctcgtgaccgttcgcttgacggcggaggaaaccgaacagctg ctgaagcaggcacaccgtgcttaccatacggaaatgaacgatttgctgcttgccgcgctt ggcctcgcgatacaagcttggagcggccgggaacgcgtgctggtgaatctcgaaggccac ggccgggaagatattttgccggatgtggacattacgcgcacggtaggctggtttacaagc caattccctgtcgttctggagccgggtcacgcccaggcgctcggtcatcaggtgaaacag gttaaagaaagcttgcgccgcattccgaacaaaggaatcggctacggcatcctgcgttat ttgtcggcgccgcgtgacggcgagcgcttcgctttggagccggagatcagctttaactat ttgggtcagttcgaccaggattacgaaagcagcggctcgcggccgtctccgttcagcccg ggctccgattcaagtccgaatgcagtgatggattatgtcctcgatatcaacggtatggtg tcggaaggagtgcaggaactcacgatccgttatggggaaacccagtataaacgggaaacg atagagcgcctgggtaccctgcttcattcgagcttgcgtgaagtcatcagccattgcgta tcgaaagagcggccggagcttacgcctagcgacgtactgcttcaagatgtgacggtggag gaactggagcggctggccgaacatacggcggcgctcggcgaactggagaatgtatacacc ctgactccgctgcaaaaagggatgttgttccacagcctgctggatgccgattcggaagct tacttcgaacaggtgaccttcgatctgtgcggaagcctgaatgtcgaagccttcacccaa ggattggatacgctggtgcagcggaatgaggcgctgcggaccaactttattaccggctgg agagacgagccgattcaagtggtattccgcgagcggaagtgtgaagtgtacttcgaagat attcgctcggtaagcgatgaagacccggagaagacgatagccgatttcgtcagcgcggat aaagcgaacaagttcgatttggcccgaggctctcttatgcgcgtgacagttttgcgcacg ggcgacgagtcctaccatgtgatctggagtcaccatcacattttgatggacggctggtgc atgtccttcatgatcaaggaagtgttcgacacctacttcgcgttccaagagaagcagacg ctggagcttcctccggttacctcgtactcccggtatatcgaatggctggaagctcaagat gccgcgaaagcttcgcgttactggtccgagtatttggcgggttacgatcagcagaccaag ctgccccaggagaaaacgcagctgaagcagggccattttgaagcggctgaaatcgatgtg gaactcagcaaggaactgaccgggcaaatcgagcgggtggcgcgccagcagcaggtgacg ctcaatacgttcatgcagaccgtatggggactggttttgcaggtatacaacaacagcgag gatgtcgtattcggctccgtcgtatccgggcgtccagcggaaattccgggcatcgaaagc atgatcggcctgtttattaatacgatcccggtccgtattcaaggcaaagccggggagacg gtagccgatatcttgagaaaaacccaggatcaagcgctggcatcgggagcttacgaaacg ttcccgctgttcgaaattcagtcgctgagcgagcaaaagcgagacttgatcaaccatatc atggtctttgaaaattatccgatggaagaacagattgagcaggtcgtcggcggagaccaa gaagcgctgaaaatcgctaatatccagtcgccggagcaaacgaactacgacctagacatt accgtcattccggaagagcatattttgctgcggtttacgtacaatgcgctgacgttcaga gaggaagacatcaggctgatccacggacattttgcccaagcactggagaaggttgcggct aacccgaacatccgcgtgaatcagttggagcttttgacggcggcggaaaaagagcaaatt cttggcgcgtttaatccggcgcagccggaagcggctcctgcggccgcgttccaccggctg tttgaggaacaggcggagcgcacgccggaagaggcggccgtcgtgtacgagaacgaccgg ctgacgtatgcggagctgaacgagcgggcgaaccgcttggcggctacgctgcgcgcaagt ggcatcggccgggagacgatcgtcggcattctcgccgagcgttcggtggacttgctggtg gccgtgctggccgtctggaaagcgggcggggcgtatgtgccgctggacccggattatccg gcggagcgcgtgcggttcatgcttgaagacagcggagcgaaggtactgctgacgcaaacg ccgctgcgagagcgtgctgaagcctggcttggcgaagaggagctggcgctggcggcggtg ctgtacctggacgacgaagcgtcgtacagcgaggagcgggcgaatgcgccgattggctcc ggcatagtctccggcaagctgacggatgctgtggacgacggcgatgagagccatcagaat attggcaccgacagcttccatgaagcccgtccggaggaactggcgtacgtgatctatacg tcgggaacgacgggcaagccgaagggcgtgatgatcgagcaccgcagcctggtgaacacg gcggcgggctaccggcgggaataccggttgaaccagttcccggtgcggctgctgcagctc gcaagcttctcgttcgacgtgttcgtgggagatatcgcgcggacgctgtacaacggaggc acgatggtgatcgtgccgaaggacgaccggatcgatccgtctcgtctgcactactggatt gagcgggagcaggtcaccatcttcgaatcgacgccggcgctgatcgtgccgttcctggag tacgtgcacgagcagcggctggatatgagctggatggagctgttgatcacgagctcggac agctgcagcgtggcggattaccggaccttgcaggaacgcttcgactcgttgttccggatc atcaacgcatacggcgtgacggaagcggcgatcgactccagcttctacgacgaggagctg acgaagctaccgcagacaggtaatgtgccgatcggtaaagcgtggctgaatgcgaaattc tacatcgtggatgcgcatctgaatccggtgccggtcggggtgctgggcgagctggtcatc ggcggagtcggagtggcgcgcgggtacttgaaccgtccggagctgacggaagaaaagttc gtagacagtccgttcgccgcgggcgagcggctgtaccgcacgggagacttggcgcgatgg atggaggacggcaacgtggacttcatcggccggatcgacaaccaggcgaaaatccggggg taccggattgagacgggcgaagtcgaagcgaagctgctgagtgtaggtggcgtgaaggaa gcggtcgtcgtcgtcagggaagatcaagaaggtcagaaagctttgtgcgcttattataca gcggaagaaggcttgacggcgttggacctgaagcgggcgattgccagcgagctgccgggg tacatgatcccgtcgtacttcgtggagatggagcgcctgcctctgacgccgaacggaaag atcgaccggaaggcgctgccagcaccggaagggggagcaagcgcaggccgcgaatacgtg gcgccgcgcaccgaacttgaggcgaagctggccgccatttggcaggatgtacttgttcgg gagaaggcggtaggcgtaacggacaacttcttcgacctcggcggacactccctgcgggcg acgacgcttgtcagcaaaatgcataaggagctaggcgttgaattcccgcttcgcgacgta ttccgctactcgacggttgaggaaatggccgcggctatggagcggctggagatcggctcg ttcacggctattccggctgcggaacctagcgagtattatccgctctcttccgctcagaaa cgtctctatatcttgaaccagctggaaggagccgagctgagttacaacataccgggagct atgctactcgaaggagggctcgaccggcagcggtttgaagaagcgttccgcgggctcgta gctcgtcatgaaacgctgcgtaccggctttgagatggtaaaaggcgaagcggttcagcgg atttacgaagaagtcgccttccaggtggaatatgtgcagatcagcggggagcaggcggaa gaaacggtgcgccaattcgttcgtccgtttgatctagcgaagccgccacttctgcgggta ggccttgccgaactggcgccggaccggcacattctaatgttcgatacgcatcatatcgta tccgacggcgtttcgattgacgtactgatcgaagagttcgtccgcttgtacagcggggaa cagttggagccgctccgcattcaatacaaagattatgcggtatggcagcaatcggacgag cagaaagctcagcttgccaagcaggaagcctactggctcgacatgttccgcggagagctg ccggttttggaattgccgacggactatccgcgcccgtctatgcagagctacgagggccgc acgctgcaattgtttatggatagcaagaaaagcgagggtctgaaacggcttgcagccgag aacggcgcaacgctttacatggttctgcttgctggttatacaatattattgcataagtat acagggcaagaagacgtggtggtcggtacgccgattgcgggaagaaatcacagcgacgtt cagccgctgatcgggatgttcgtcaataccctggccatccgcagttatccggctgccggt aagacgttccttgactacttgaaggaaatcaaggagacgacgctgggcgcttttgaacat cagaattatccgtttgaggaactggtggataaagtgaacgtggctcgcgatttacgccgc aatccgctattcgatacaatgtttgctttgcagaatacagagaatttggaaatccagctt cccggactccatttgtcgacgtatgccagcgaagaaattgtttctaaattcgatctcagc ttggacgtcacggagatcgaggaaggcttggaatatctgtttgaatatgctactgctctt tataaaaccgaaacggtggagaaattggccgctcactacttgcagctgcttgaatccatt ctccgcaacccgacggcgactattgccgagctgggcattttgacaccggcggaaaaagag cagattctcggcgcgtttaacccggcgcagccggaagcgactcctgcggccgcgttccac cggctgttcgaggaacaggtggagcgcacgccggaagaggcagccgtcgtgtacgagaac gaccggctgacgtatgcggagctgaacgagcgggcgaaccgcttggcggctacgctgcgc gcaagcggcatcggccgggagacgatcgtcggcattctcgccgagcgttcggtggacttg ctggtggccgtgctggccgtctggaaagcgggcggggcgtatgtgccgctggacccggat tatccggcggagcgcgtgcggttcatgcttgaagacagcggagcgaaggtgctgctgacg caaacgccgctgcgagagcgcgccgaagcctggctcggcgaagaggagctggcgctggcc acggtgctgtacctggatgacgaagcgtcgtacagcgaggagcgggcgaatgcgccgatt ggctcgggcagggtctccggcaagctgacggatgctgtggacgacggcgatgagagccat cagaatattggcaccgacagcttccatgaagcccgtccggaggaactggcgtacgtgatc tatacgtcgggaacgacgggcaagccgaagggcgtgatgatcgagcaccgcagcctggtg aacacagcggcgggctaccggcgggaataccggttggatcagttcccggtgcggctgctg cagctcgcaagcttctcattcgacgtgttcgtgggagatatcgcgcggacgctgtacaac ggaggcacgatggtgatcgtgccgaaggacgaccggattgatccgtctcgtctgcaccac tggattgagcgggagcaggtcaccatcttcgaatcgacgccggcgctgatcgtgccgttc ctggagtacgtgcacgagcaggggctggatatgagctggatggagctgttgatcacgagc tcggacagctgcagcgtggcggattaccggaccttgcaggaacgcttcggctcgttgttc cggatcatcaacgcatacggcgtgacggaagcggcgatcgactccagcttctacgacgag gagctgacgaagctaccgcagacaggtaatgtgccgatcggtaaagcgtggctgaatgcg aaattctacatcgtggatgcgcatctgaatccggtgccggtcggggtgctgggcgagctg gtcatcggcggagtcggagtggcgcgcgggtacttgaaccgtccgaagctgacggaagaa aagttcgtagacagtccgttcgccgcgggcgagcggctgtaccgcacgggagacttggcg cggtggatggaggacggcaacgtggacttcatcggccggatcgacaaccaggcgaaaatc cgggggtaccggattgagacgggcgaagtcgaagcgaagctgctgagtgtaggtggcgtg aaggaagcggtcgtcgtcgtcagggaagatcaagagggtcagaaagctttgtgcgcttat tatacagcggaagaaggcttgacggcggcggacctgaagcgggcgattgccagcgagctg ccggggtacatgatcccgtcgtacttcgtggagatggagcgcctgcctctgacgccgaac ggaaagatcgaccggaaggcgctgccggcgccggaagggggagcaagcgcaggccgcgaa tatgtggcgccgcgcacccaactggaggcgaaactggtcgccatctggcaggacgtgctc gggtcggtcacgattggcgtgacggacaacttcttcgacctcggcgggcactccctgcgg gcgacgacgctggtcagcaaggtgcacaaggagctgagcgtggacctgccgctgcgcgat gtgttccggcactcgaccatcgaagcgatggccgaagcgatcagccaattggagcggcag gaacacctctccattccggttctggataagagggattactatccgctttcctccgtgcaa aaacggctgtacatccagcagcagatggaaggcgccgagcttagctacaacatgtccggc atgacggttctcgtcgggcgcttggaacggaatcaattcgaggcggcgctcaaaggattg atagctcgtcacgaaattttgcgaaccggcttcgaaatggtcgacggcgaaccggtacaa cggatttatccggacttgaagtttgccgtcgagtatacgaaagcgacggaaagtgaaacg aagagcatcgtagatggctttgtgcgcgtctttgatttggagcggccgccgctgctacgt gtgggcttagtcgaatgggaagcggaacggcatctgctcatgctggacattcatcatatc gtcacagatggcatgtcgatgggcatcttcgtcgaagagctgctgcgcctgtataacggc gagactctggaaccgcttcggattcaatacaaggaattcgccgcttggcagcagtccgaa cctgtaaaagagcggctgaaacgtcaggaagcctactggctggacgtgctggaaggcgaa ctgccgacgcttgaactgcctacggactttgtcagacctgccgctcgcagctttgaggga gatgtgctgcctttcagcatcgacaagcagatgaccgacagcttgcagcgcatcgccgat gagaacggtgccaccctttatatggtgttattggcggcctattcaatcttgctcagcaag tactcgggacaagaagacttcattgtaggcacgccggcttcgggccgcacacatgccgac ctggagccgctcatcggaatgtttgtcaacactttggcgattcgccattatccgtccggg gagaagacgttcctcgcttacttgaacgaagtcaaagaaacgatgctgggggcctacgac caccaggattatccgttcgaggagcttgtgaaaaagctgcaggcgccgcgagatcaaagc cgcaatcctgtattcgatgtcatgtttgttctggaaaccaaggaagataacgttcaaagc ttcggggatatcaagatcgaatcttatccggaaactcatacggtttcccaatttgatctt accttggtcatttcgttgctggatgagggaatgaacgggcagtttgaatatgcaaccaag ttgtttacgcgcaatctgatcgacaatttcgctcaggacctgctcgtgatcatcacccaa atttgcgaacagccttcggtgctgttgaaggatatttccctgaacgggcaatccgaacag gagcaagatgtgctagaggccattgatattattttctaa

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