Pimephales promelas (fathead minnow): 120492983 Help Entry 120492983         CDS       T08155                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism pprm  Pimephales promelas (fathead minnow) Pathway pprm04020   Calcium signaling pathway pprm04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pprm00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120492983    04020 Calcium signaling pathway     120492983  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pprm04040]     120492983 Ion channels [BR:pprm04040]  Voltage-gated cation channels   Ryanodine receptor    120492983 SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc EF-hand_7 EF-hand_1 Ago_Mid EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  120492983 NCBI-ProteinID:  XP_039547266 LinkDB All DBs Position Unknown AA seq 4457 aa AA seqDB search MLAGQNGEGNPDHERWAAQGGGHRTLLYGHAILLRHSFSGMYLTCLKTSRSLTDKLSFDV GLEEDSIGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERFLHLSISNGSIQVDASF MQTLWNVQPTCSRSNVAVGFLLGGQVMRLFHGHDESLTIPGSEQSEAQQRVVNYETGKGG SKARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGHYLGQTEDQGLILLDREKSDTTATA FCFRPSKEKIDSGPKRDIDGMGVAEIKYGDSFCFIMHVSTGLWLSYQAPDAKSSRLGPLK RRAVLSLEGHMDDGLTLQLCQHEESRAARIIRNTTHLFTQFIRGLDGLNGEKATEVTLPV CEVLQTLNDLIVYFQQPDSELEHEEKQRQLRSLIKRQDLFKEEGMLTLVSHCIDRLNVYN SATEFEELAGEEAGEAWKDILNLLYELLAALIRGNRTNCTQFSRKLDWLVSKLERLESSS GILEVLHCVLIESPESLNIIQKAHIKSIISLLYKHGRNHKILDVLCSLCVCNGVAVRANQ NFICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGMSEGSAQYKKWYFELIIDQVDHYVTSE PTHLRVGWATTKGYAPYPGGGEGWGGNGVGDDLYSYSFDGLHLWSGRIPRAVASINQHLL NSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNVDGFFFPVVSFSAGVKVRFLLGGRHG DFKFLPPAGYASCYEALLPKEKMRVEPVKEYKRDLEGVRDLLGTTEFLSQASFIPVPVNT SQIVLPPHLENVRDKLAENIHELWGMNKIELGWMYGKVRDDNKRQHPCLVDFSKLPETEK NYNLQMSSETLKTLLALGCHVAQVNIDAEEDLKKMKLPKNYMMANGYKPTPLDLSEVKLT PGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNRRNPRLVPYALLDERTKKSNRDS LREAIRTLVGYGYFIDPPDQESSHQAEEGVESIRVFRVEKTYAVKTGKWYFEFEALTGGD MRVGWARPGCRPDIELGLDDQAFVFDGCRGRRMHMGSHFFGRSWNKGDVVGCMINMDDKS MIFTLNGELLITNKGSELCFADFDTEDGFIPVCSLGLSQIGRMNLGKDASTFKYYTMCGL QEGFEPFAVNMNREVTMWFSKRLPTFVNVPEEHPHIEVTRIDGSVDTPPCLKVTHKTFGT QTSNDDMVCCRLSMPVDFHSGPRKITDINEGIADGQRAKKDDGGKIEYGSITKYFYSVRV FAGQDPSSVWVGWVTPDYHYYSKHFSLNTVRTVTVTLGDERGRVHESVRRSNCYMVCAGD IVSNSAGRSNTDLEIGCSIDLASGLVSFTANGRELPNAYQVEPNTKLFPAVFVQPTSPNL FQFEFPKIPDAMPLSSAIFKSLQKNPEPQCPPRLNVQTIVSVLWSRMPNTFLSVETARVS ERHGWVVQCLEPLQMMGVHIPEENRCIDIMELSENEGLRQFHYHTLKLFCALCALGNTRV AHALCSHLDQSQLLYTIDNQYLTGQLREGFYNVLISIHLETAKEAHLMMNNEFIIPVTEE TRSIRLFPDDSKRHSLPGVGLSTSLTTRLNFSPPCFITTKRDQPLFSPQIPLGILKEKAI SMLTEAVQGGGTHIRDPVGGSVEYQFVPILKLIGTLLIMGALTSEEVRIILLLIDPIVFG DSKEEEKQIAVAEQGAEKEEATSNEEKAVEAGEEESKEAKQPPKGLLEKSLPESVKRQMC ELLHYFCDCELKQRIEAIVAFSDDFVSKLQYNQKFRYNELMQAFNMSAAVTAKKTREFRS PPQEQINMLLNFSAGEDCTCPEELQEELQGFHDDLRLHCGIPMEEEEEEQDTSLKGRLMS LVYKIKGRPQKTEEEPTEQEQAAPTNLKELISQTMVCWAQECKIQDPELVRSMFSLLRRQ YDGIGELLRALRKSYTISAKSVGDAINLLASLGQIRSLLSVRMGEEEGQLMIDGLGDIMN NKVFYQHPNLMRVLGMHETVMQVMVNVLGGDKNKEIAFPKMVASCCRFLCYFCRISRQNQ KSMFDHLSYLLENSSVGLACPTMRGSTPLDVAASSVMDNNSLALALEEPDLEKVVTYLAG CGLQNCPMLIAKGYPDIGWNPIEGERYLSFLRFAVFVNGESVEENANVVVKLLIRRPECF GPALRGEGGQGLLAAMKEAIKISEDPALDLPNLPEGVAPTVGKDKEEEEEVPHMGNSIMS FYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTKDLVGIISIPLKMPVVNKDGT VTEPDMNASFCPEHKAPMVLFLDRVYGIDDQSFLLHLLEVGFLPDLRASASLDSEVLRTT ETALAMNRYIGSAVLPLLTRCAHLFAHTEHHAMLVDSTLHTIYRLSKGRSLTKAQRDAID ECLMAICMHLRPSMLQQLLRRLVFDVPQLTEYCKMPINLLTNHYEQNWKYYCLPTGLGSY GMASEEELHLTKKLFWGLFDSLSQKKYDAELFKMAMPCLSAIAGALPPDYVDSSPGSTLV KQASVDAQGNFDPQPVSTANILLPEKLDYIASKFAEHTHEKWSSEKIALGWSAGDKLDDN AKTHPLLKPYKALSEKERETYRYPVKETIKSMLAMGWNIERTREGEAKLQQKETEKQRKV SESSQGEFNPAPQDLENVILSRELQAMVETVAENYHNIWAKKKKKELDSKGGGSHPLLVP YDTLTAKEKYRDREKAQELFKFLQVNGYAISRGLKDLEQDSSSMEKRIAYKFLKRLLSYV DSAQEFIAHLEAMASSGKTDKSPHDQEIKFFAKILLPLIDQYFKNHSMYFLSTPNINLSS SGYASNKEKEMITSIFCKLAALVRHRISLFGSDSTTMVSCLHILSRSIDFRTLMKSGSEL VKAGVRTFFENAAEDLEKTLENLKLGKLGQSRSQMKGVTQIINYTTVALLPILTVVFQHI TQHQFGSVLLLDDIQLSCYRILTSLYSLGSGKNIYVEKQLPSLGECLSTLVGAMPVAFLE PHLNMHNPLSVFNTKTPRERAILSMPDTVDEMCNEMPQLDGLMKDIGEISESGARYTEMP QVIEVILPMLCNYLSYWWAKGPDNSPADANCCTTVTSEHLSLILGNILKILNNNLGIDNA PWMKRLAVYTQPIISRAGPDLLRGHFLPTLEKLKKKTVKIVTEEEMLKAESRLDTQEAEL QILDEFSVLCRDLYAFYPMLIRYVDNNRSKWLKEPDSDSTELFNMVSEIFILWCKSHNFK REEQNFVVQNEINNLAFLTGDSKTKMSKSGGQDQERRGKKRRGELYSIQTSLIVAAHKKM MPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKDYLRKNLHLQEKSADPAVQWQLNLYKD VVVKSEGAPDPEQNVERVQAISAAVYHLDQVELPLRNKKMVFQKLLSKQRKRAVVACFRM APLYNLPRHRSINLFLSGYQRLWIETEEYSFEEKLVQDLAKTPMAVVEEEEEEEAEVQPD PLHQLILHFSHNALTERSFLEEDPLFIAYADMMAKSCAENEEEEEEEEGKEKTFEEKEME KQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTGTLKLGISILNGGNVLVQQKMLDY LKEKRDAGFFKSLSGLMMSCSVLDLNAFERQNKAESLGMMTEEGSANMRERGSKVLQNDD FTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSG KDVMDEAGQLNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANM QMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMIL KFFDMFLKLKDLTTSDNFKEYDPDCKGVISKKEFQKSMESQKQYTQSEIEFLLSCVEADE NDIFNYEEFVERFHEPAKDIGFNVVVLLTNLSEHMPHDTRLSTFLDLAESVLNYFEPYLG RIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMEMFVNFCE DTIFEMQLASQISESDAAERPEEDEDEELHSLLEGLSEEEDASLESASAFTAACVSVKKS MSNFRQMLTFKSMRKQFKKFKKLTIREMITGFFSFFWMLFTGFFKGIFGIIFGFFHIIWS SMFGGGFVEGAKNMKVTDILGNMPDPTQFGIHGDVLEAEKTESSELVVPADMVQMTGAGA EKLEPDMIMDLLNTGGKKEGKHGAEPGLGDVCEVLTEVSAPAEKKTQKVAAEKPESEPEK ADTENQEKEDKVKEQTPEEPAAEKPAPKAKRGSSKESAPAFMASFFVVLEVYKTKTLNYL ARNFYNLRFLALFVAFAINFILLFYKVTGGFDDEEEEEGSWGGEEEEGDEDDEGLEYFIL QESTGYMAPTLTFLAITHTIISLLCVFGYYCLKVPLVVFKREKEIARKLEFDGLYITEQP SDDDIKGQWDRLVIATP NT seq 13374 nt NT seq  +upstreamnt  +downstreamnt atgcttgcagggcagaatggtgaaggaaatcctgatcatgagcgatgggcagcacaagga gggggacatcggacactgctctacggtcacgctatcctccttaggcattccttcagtgga atgtatctgacatgtctgaagacttccaggtctctaacagacaaactgtcttttgatgtt ggcctagaagaggattcaattggggaagcttgttggtggacaattcacccggcatccaag cagaggtcagagggtgagaaagtgcgcattggggatgacctcatattggtcagtgtttct tctgagaggttcctgcacctctccatctccaatggaagtattcaagtggatgcttctttc atgcaaacactgtggaatgttcagcctacctgctccagaagcaatgtggcagtgggattt cttctgggtgggcaagtgatgcgcttgttccatgggcacgatgagagtctcactatacca ggatctgaacaaagtgaagcgcaacagagagtggtgaactatgagactggtaaaggaggg tccaaggccaggtctttatggagattggagcctcttcggataagctggagtggtagccac atcagatggggtcaacccttccgcctgcgccatctctccactggtcactacctgggccag acagaggaccaggggctgatactgttagacagagagaagtcggacaccactgcaactgcc ttttgtttccggccaagcaaggaaaagattgactctggcccaaagcgtgatattgatggg atgggggttgcagagatcaaatatggtgattcgttctgcttcattatgcacgtgtccacg ggcctgtggctgtcctaccaagcgcctgatgcaaaatcttctcgcctgggaccactgaag agaagggctgtcctgtctcttgagggtcatatggatgatgggctgactctgcagctctgc cagcacgaggagtccagggcggctcgcatcattcgtaataccacccacctcttcactcag ttcatcaggggtctggatggtttgaatggagaaaaggctacagaggtgactctgcctgtg tgtgaagtgctgcagaccctcaacgacctcattgtgtacttccaacagccagactctgag ctggaacatgaggagaaacagaggcagcttcgatctctcattaaacgccaagatctcttc aaagaggagggaatgctaaccttggtctcacactgcatcgatcggctaaacgtatacaac agtgccactgagtttgaggagctagctggcgaggaggccggagaggcatggaaggacatt ctcaacctcctctatgagcttctggccgctctgattcgaggcaacagaaccaactgcaca cagttctctcgcaagctggattggctagtcagcaagctagagcgattggagtcctcatca ggcattttagaggtgcttcattgtgtcctaatcgagagtccagaatctctgaacatcatc cagaaggcccacatcaaatccattatttctctgctgtacaagcatgggcgcaaccacaag attcttgatgttctctgttccctgtgtgtctgcaatggtgtggctgtgagagccaatcag aatttcatctgtgatcacctgcttcccaagagagatctgctgctccagacacgtctggtc aatgatgtccaaagtatgagacccaacatcttcctgggcatgagtgagggctctgcgcag tataagaaatggtactttgagctgatcatcgatcaagtagaccactatgtaaccagtgag cccacccaccttcgagttggctgggccaccaccaaaggctacgccccctatcctgggggt ggagagggttggggaggaaatggtgtgggtgacgatctttactcctacagttttgatggt cttcatctgtggtcagggcgaatcccacgggccgtggcctcaatcaaccagcacttgctg aattcagatgatgtggtgagctgctgtctggatcttggagcccctagcatgtctttccga attaacggtcagcctgttcaaggcatgtttgaagacttcaacgtagatggcttcttcttt cccgtcgtcagtttctctgcaggggtcaaggtccgtttcttgttgggtggtcgtcatgga gactttaagttccttcctccagcgggctatgcatcatgttatgaagccttgctccccaaa gaaaagatgcgtgtggagcctgtgaaggagtataaaagagacctggaaggagtgagagat ctgttgggcaccacagagttcctgtcccaggcttccttcattcctgttcctgtcaacacc agccagattgtcctgcctccacatcttgaaaatgtgcgggacaagttggctgagaacatc catgagctctggggcatgaacaaaatagagcttggttggatgtacggcaaggttcgagat gacaacaagagacagcacccttgtcttgtcgacttttctaaactgccagaaacagaaaag aattataacctgcaaatgtcctctgaaactttgaagaccctacttgctttgggctgccat gttgcacaagtcaatatagatgctgaggaagacttgaaaaagatgaaactccccaagaac tacatgatggcaaatggttataagcctacaccactagacctttctgaagtgaaactgaca cctggtcaagaggttctagttgataaacttgctgaaaacgctcataatgtttgggccaaa gatcgcatcaaacaaggatggacctatggtattcagcaggatttgaaaaaccgtcgtaat ccacggttggtgccatatgctttactagatgaacgcactaagaaatcgaacagagacagt cttcgtgaggccatccgtactctggttggatatggatatttcattgatccacctgatcaa gagtcttctcaccaggcagaggagggtgttgaatccatccgtgtcttccgcgtggagaag acctacgctgtgaagacagggaagtggtattttgagttcgaggcgctcactggaggtgac atgcgggtgggctgggcacggcctggatgcagacctgatatagaattgggactagatgac caagccttcgtctttgatggctgcaggggccgccggatgcatatgggcagtcatttcttt gggcggtcatggaataaaggagatgtggtcggctgcatgatcaacatggacgacaaatct atgatattcaccctgaatggagagctcttaatcaccaacaagggctctgagctctgcttt gctgactttgacacggaagatgggttcattccagtgtgcagcctgggtctttcccaaatt ggtcgcatgaacttggggaaagatgctagtacttttaagtactacactatgtgtggcctt caagagggctttgaaccctttgctgtcaacatgaatcgagaggtcaccatgtggttcagc aaacgcctgccaacatttgtgaatgtgccagaggagcacccacatattgaggttacaaga atagatgggtctgtggacacacctccatgtctaaaggtgacacacaagacatttggtacc cagaccagcaatgacgacatggtctgttgtcgcctgagcatgcctgttgatttccactct ggccctcggaagatcactgatatcaatgaggggattgctgatggccaaagagccaagaag gacgatggaggcaagattgaatatggcagcattacaaagtacttctactctgtgagagtg tttgccggacaagatccatcatcagtttgggtgggctgggtaacaccagactaccattac tacagcaaacatttcagcctcaacacagttcgcaccgtcacagtaacactgggagacgag aggggacgtgttcatgagagtgtgaggagaagtaactgttacatggtctgtgctggtgac attgtgagcaactctgcaggccgtagtaacactgatcttgagattggttgctccatagat cttgcctcaggcctggtctcattcaccgccaatggcagagagctgcctaacgcataccag gttgagcctaacactaagctcttccctgctgtgtttgttcaacccacgagtcccaacctc ttccagttcgagtttccaaaaatcccagatgcaatgcccctgtcttcagccatcttcaaa agtttacaaaaaaacccagagccccagtgtcctcctcggctgaatgtccagacaattgtg tccgtgctgtggagcagaatgcccaacaccttcctgtcggtggagacggcccgtgtgagt gagaggcatggctgggtggtgcaatgtctggagcccctgcagatgatgggcgtgcatatc ccagaggagaacaggtgtatcgacatcatggagctgtcggaaaatgaaggtctgcggcag ttccactatcacactttaaagcttttttgcgccctttgtgccctgggcaacactcgcgta gctcacgccctctgcagccatctcgaccaatcgcagctcctgtacaccattgataaccaa tacctgactggtcagctacgtgaaggcttttacaatgtcctcattagcattcacctggag acagccaaagaggcccatctaatgatgaacaacgagttcataatcccagtgacggaggag acaaggagcatccgcctcttccctgacgactcaaagcgtcactctcttcctggagtgggc ctgagcacctcacttaccactcgcctcaacttctcccctccgtgtttcattaccaccaag cgtgatcagcctctcttcagcccccagatccctctgggtatcctgaaggagaaagccatc agtatgctgacggaagctgtgcagggcggtggcacccacattcgagatcctgtgggcgga agcgtcgagtatcagtttgttccgattctcaagttgattggcacactgctgataatgggg gcgttgaccagcgaggaggtgagaatcattctgctcctcatcgaccccattgtttttggg gacagtaaggaggaggagaaacagatagctgttgcagaacaaggagccgagaaagaggag gccaccagtaatgaagagaaggctgtggaggcgggagaggaagagagtaaagaggccaag cagcctcccaaaggtcttctggagaagagcttgccagaatcggtcaaacgtcagatgtgt gagctactgcactatttctgtgactgtgagctgaagcagcgcattgaggctatcgtggcc ttctcagatgatttcgtctccaagctgcagtacaatcagaagttccgctacaacgagttg atgcaagccttcaacatgtcagctgctgtcacggccaaaaagactagagagttccgctca cctccccaagagcagataaacatgctgttgaactttagtgctggtgaggattgcacttgt cccgaggagcttcaagaggaacttcaaggcttccatgatgaccttcgactacattgtggc ataccaatggaagaggaggaggaggagcaagacacatctcttaaaggccgcctgatgtcc ctggtatacaagattaaaggtcgtcctcaaaaaactgaggaagaaccaactgagcaagag caggctgctcctaccaatctgaaggagctgatatctcagactatggtctgctgggctcag gagtgcaaaatccaagacccggaactggttcgcagcatgtttagccttttgaggaggcag tatgatggcatcggagagctgctcagagctttgaggaagagctacaccatcagtgccaag tctgtaggggacgcgatcaacctgctggcctcactgggccagatccgttcactacttagc gtccgcatgggcgaagaggagggccagctcatgattgatggcctgggggacatcatgaac aacaaagtgttttaccaacatccaaatctgatgcgtgttctcggcatgcacgagacagta atgcaagtcatggtcaatgtgctgggtggagacaagaataaggagattgccttccccaag atggtggccagctgttgtcgctttctgtgctacttttgtcgcatcagccgtcagaaccag aagtctatgtttgaccacctgagctacctcctggagaacagcagcgtggggctggcatgc ccaaccatgagaggctccacacctttagacgtggctgcgtcctctgtgatggacaacaac agtttggctctggcactagaggaacctgatcttgagaaggtggttacatatctggcaggc tgtgggttacagaactgcccaatgctcattgccaagggatacccagacattggctggaac ccaatagaaggagaacgctatttgtccttcttacggtttgctgtttttgtcaatggtgaa agtgttgaagagaacgctaatgtcgttgtgaagcttttgatcaggcgtcctgagtgcttt ggacctgctcttagaggagagggaggtcaaggtttactcgctgccatgaaggaagccatc aagatctcagaagatcctgctttagacctgcccaacttacctgaaggggttgcaccaacg gttgggaaggataaagaggaggaggaggaggttccccacatgggcaactctattatgtcc ttctactcagcccttattgatcttctgggccgatgtgcacctgagatgcaccttataaac aaaggaaaaggtgaagcattgcgtatccgtgccatcctccgttccctagtacccactaaa gatttggttggaataatcagtattcctctcaaaatgccggtcgtcaataaagatggcact gtgacggagccagatatgaatgccagcttttgtccagagcacaaggcgcccatggtgctt ttcctggaccgtgtctatggcattgacgaccaaagcttcttgttgcacctgcttgaggtt ggcttcctgccagacctgcgagcttcagcctccctggactcggaggtgctcaggactact gagacagccctggccatgaaccggtacattggatcagcagtgctgcctctgttgacccgc tgtgctcatctgttcgcgcacactgagcaccatgcaatgctcgttgactccacgcttcac accatctatcgcctctcaaagggccgatcactcaccaaggcccagagagatgctattgat gaatgtctaatggccatctgcatgcatctgcggccatcaatgctacagcaacttttgcgt cgtcttgtgtttgatgtcccacagcttacagagtactgcaagatgcccattaatcttttg acaaatcactatgagcagaattggaagtactattgtctgccaacgggcctgggcagctat ggaatggcatcagaggaggaactccacctcaccaagaaactcttctggggactttttgac tctctatctcaaaagaaatatgatgcagagcttttcaaaatggccatgccgtgtctgagt gccatagccggtgcattaccacctgactacgtggactccagtccaggttccacattagtt aagcaggcctctgtggatgcacaaggcaacttcgacccccagcctgttagcactgctaac atcttgctccctgaaaaactagattacattgcaagcaagtttgcggagcatactcacgag aaatggtcctctgagaagatcgctcttggctggtctgcgggggataaattagatgacaac gctaaaactcatccgcttctgaaaccatacaaagcactaagtgaaaaggaaagggagact tatcgctatcctgtgaaagagactataaagagcatgttggcaatgggatggaacattgag aggaccagagaaggagaggccaagttgcagcaaaaggaaacagaaaaacaacgcaaagta tcagagtcctcacagggtgagtttaatccagccccacaagatttggaaaatgttattcta tcaagggaactacaggcaatggttgaaacagttgcagaaaattaccacaacatttgggca aagaagaagaagaaggaacttgacagtaaaggaggaggaagtcatccattgttggtaccg tacgacacactgacggcaaaggagaagtacagagacagagagaaggcccaggagctcttt aaatttctacaggtcaatggatatgccattagcagaggtctgaaggacctggagcaagat tcctcttctatggaaaaaaggattgcctacaagtttctcaagaggctcttgagttatgtt gattctgcgcaggagtttatcgctcatcttgaggctatggcttccagtgggaagacagac aaatctccccatgatcaagagatcaagttctttgctaagatcctgctgcccctcatagac cagtacttcaagaaccacagcatgtacttcctgtcaacccccaacatcaaccttagcagc agtggctacgcatccaacaaagaaaaggagatgatcactagtattttctgtaagctggca gcccttgtcagacataggatttcactctttggaagtgactccaccaccatggtgagctgc ttacacatcctgtcacgctcaattgacttcaggactttaatgaagtctggctcagaactg gtgaaggctggtgtcaggactttcttcgagaatgcagcagaagacctggagaaaactctg gagaacttgaagctggggaagttgggtcagtcgcgctctcagatgaagggagttacccag atcatcaactacaccacagtggccctgctgcccatcctgacggttgtctttcagcatatt acccaacaccagtttggatcagtgttgctattggatgacattcaactgtcctgctaccgc atcctgaccagcctgtactcactgggcagtggcaagaacatctatgtggaaaaacagctg ccctcgctgggtgaatgtttatctaccctggttggagccatgcctgttgctttcctggaa ccccacctaaatatgcacaatcccctatctgtcttcaacaccaagacaccaagagaacga gctattttgagcatgccagacaccgtggatgagatgtgtaatgagatgcctcaacttgac ggcctaatgaaggacattggggaaatttctgaatctggagcacgctatacagagatgcca caggtcatcgaggtcatccttcccatgttgtgtaactacctgtcttactggtgggctaaa ggtccagataactcgccagctgatgccaattgctgcacaactgtcacatctgagcatctc agcctcatcctgggcaatatcctaaagattctaaacaacaaccttggcattgataacgcc ccctggatgaaaagacttgcagtatacacccagccgatcattagcagggctggcccagat ctcctgagagggcacttcctgccaacgctggagaaactgaagaagaaaacagtgaagata gtgactgaggaggagatgctgaaggctgaaagcagattagacactcaggaagctgaactg cagattctggatgagttttctgttctctgcagggatctgtatgccttctatccgatgctc attcgttatgtggacaacaacagatccaaatggttgaaggaaccagattcagattcaact gaacttttcaatatggtgtcggagattttcattctatggtgtaaatctcataactttaaa agggaagagcaaaattttgtggtgcaaaatgaaattaacaacctggcattccttactgga gacagcaagacgaagatgtcaaagtctggaggtcaggaccaagagagaagagggaaaaaa agaagaggagagttgtactccatccagacttcccttatcgtagcagctcacaagaagatg atgcccattggcctgaacatgtgcactcctggagaccaggagctcatttccctcgccaag atccgttacagtctgaaagacacagatgatgaggttaaggattacctgaggaagaacctc catcttcaggagaagtcggcagatccagcagtgcagtggcagctgaacctctataaagat gttgtggtgaagagtgagggagctccagacccagagcaaaatgtggagagagttcaggcc atctctgctgctgtctaccaccttgatcaggttgagctgcctcttaggaacaagaagatg gtgtttcagaagctgctgtcaaagcaacgaaagcgtgccgtagtggcctgtttccgaatg gcaccactctacaacttaccaaggcatcgctcaattaacctcttcctcagtggctatcag agactttggatagagacagaggagtactcctttgaggagaagctagtgcaggacctggca aaaactcctatggctgtggtagaggaagaagaggaagaggaagctgaagttcagccagac cctcttcatcagctcatccttcacttcagtcacaatgctctgacggaaagaagtttccta gaagaagatcctctctttattgcatatgctgacatgatggcaaaaagctgtgctgagaat gaggaagaagaagaagaagaggaaggaaaagaaaaaacttttgaggaaaaagaaatggag aagcagaagattctgtaccagcaggccagacttcatgcccgtggggctgctgaaatggtg ctacagatgatcagtgccagtaaaggccgacttggtcctatggtgactggcacccttaaa cttggtatttccatcctaaacggaggcaacgttctcgtccagcagaaaatgctggattat ttgaaggaaaagcgagatgccggcttctttaaaagtttatctggactaatgatgtcttgt agtgtgctggatttgaatgcgtttgaaaggcaaaataaagcagagagtcttggaatgatg actgaagagggatcagccaacatgagagagcggggttccaaagtactacaaaatgatgac tttacaaaggatctattcaggtttttgcaacttctgtgcgagggccacaataatgatttc caaaacttcttgcggacccagactggaaacactactacagtcaacatcatcattagcact gtggactacctattacgtcttcaagaatccataagcgatttctactggtattactctggg aaagacgtcatggatgaggctgggcaacttaacttttccaaagctttggcagtagccaaa caaatctttaactcactcactgagtacattcagggcccttgtatcgggaatcagcagagt ttggcacacagcaggttgtgggacgcagtggttgggtttctgcatgttttcgcaaacatg caaatgaaactgtcacaggattctagtcagatagagttattgaaggaactgatggatttg cagaaggatatggtggttatgatgttatctcttcttgagggtaatgtggtgaatggaact attggtaagcagatggtcgacactttagtggagtcctccagcaatgtggaaatgattctc aagttcttcgacatgttcctcaaactgaaggacctcaccacatctgataacttcaaggag tatgacccagattgcaaaggcgttatatctaagaaagagttccagaagtctatggagagc cagaagcaatacacccagtctgaaatcgagtttcttctctcctgcgtggaggcagatgaa aatgacatattcaactacgaggagtttgtggaacgctttcacgaaccagccaaggacatc ggcttcaacgtggttgtgcttctcactaacctttcggaacatatgcctcacgacacgcgc ctatccaccttcttagacctggctgaaagcgtgctcaattactttgagccgtacctgggc cgtattgagatcatggggggtgccaagaggattgagagggtttacttcgagatcagcgag tctagcagaacccagtgggagaagccacaagtcaaagagtccaaacgacagttcatcttc gatgtggtcaacgaaggcggtgagagcgagaagatggagatgttcgtaaacttctgtgag gacaccatttttgaaatgcagttggcctctcagatctccgagtcagatgccgcagaacga cctgaggaggacgaagatgaggagttgcacagtctgcttgaaggcttgtctgaggaggaa gacgcatctcttgaatctgcctcggccttcacggctgcctgcgtctctgtgaagaagagc atgtctaatttccgtcagatgctgacatttaagagtatgaggaagcagtttaagaaattc aagaagctgaccatcagagaaatgatcacagggttcttctccttcttctggatgctcttc accgggttcttcaaaggcattttcggcatcatcttcgggttcttccatataatttggtcc tccatgtttggagggggttttgtagagggagctaaaaacatgaaagtgacagatattttg ggtaatatgcctgatccaacacagtttgggatccatggcgatgtactggaagcagaaaaa actgagagcagtgagctggtggtgccggcagatatggtgcagatgaccggtgctggtgct gagaagctggagccggatatgatcatggatctactcaatactggtggaaagaaagaaggc aagcatggagcagaacccggtctgggcgatgtctgtgaagtcctgactgaagttagtgcc cctgctgagaagaaaacccagaaagtagcagcagagaagccagaatctgagccagagaaa gccgacaccgagaatcaggagaaagaagacaaggttaaagagcaaacgcctgaggaacca gcagcagaaaaaccagctccaaaagccaaacgtggctcatcaaaagaaagcgctccagca ttcatggccagtttctttgtagtgcttgaagtctacaaaaccaaaactctaaactacctg gctcgtaatttctacaaccttcgttttctggctctgtttgtggccttcgccatcaacttc atcctgctcttctacaaggtgactggaggtttcgatgacgaggaagaggaggagggatcc tggggtggagaagaggaggagggtgatgaagatgacgaaggattggaatacttcattctt caggagagcactggctacatggctcccactttgactttcttggctataacgcacacaatc atctccttgctctgtgtctttggatattactgccttaaggttcctttagtcgtgttcaag cgagagaaggagatcgctaggaagcttgagtttgatggtttgtatattaccgagcagccg tctgatgatgacatcaaaggacagtgggatcgtttggtcattgcaactccgtaa

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