KEGG   Pan paniscus (bonobo): 100969444
Entry
100969444         CDS       T02283                                 
Symbol
AKT1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04010  MAPK signaling pathway
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04022  cGMP-PKG signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04261  Adrenergic signaling in cardiomyocytes
pps04370  VEGF signaling pathway
pps04371  Apelin signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04613  Neutrophil extracellular trap formation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04728  Dopaminergic synapse
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04920  Adipocytokine signaling pathway
pps04922  Glucagon signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04936  Alcoholic liver disease
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05132  Salmonella infection
pps05135  Yersinia infection
pps05142  Chagas disease
pps05145  Toxoplasmosis
pps05152  Tuberculosis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05200  Pathways in cancer
pps05205  Proteoglycans in cancer
pps05207  Chemical carcinogenesis - receptor activation
pps05208  Chemical carcinogenesis - reactive oxygen species
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05415  Diabetic cardiomyopathy
pps05417  Lipid and atherosclerosis
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100969444 (AKT1)
   04015 Rap1 signaling pathway
    100969444 (AKT1)
   04630 JAK-STAT signaling pathway
    100969444 (AKT1)
   04668 TNF signaling pathway
    100969444 (AKT1)
   04066 HIF-1 signaling pathway
    100969444 (AKT1)
   04068 FoxO signaling pathway
    100969444 (AKT1)
   04072 Phospholipase D signaling pathway
    100969444 (AKT1)
   04071 Sphingolipid signaling pathway
    100969444 (AKT1)
   04024 cAMP signaling pathway
    100969444 (AKT1)
   04022 cGMP-PKG signaling pathway
    100969444 (AKT1)
   04151 PI3K-Akt signaling pathway
    100969444 (AKT1)
   04152 AMPK signaling pathway
    100969444 (AKT1)
   04150 mTOR signaling pathway
    100969444 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100969444 (AKT1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100969444 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100969444 (AKT1)
   04613 Neutrophil extracellular trap formation
    100969444 (AKT1)
   04620 Toll-like receptor signaling pathway
    100969444 (AKT1)
   04660 T cell receptor signaling pathway
    100969444 (AKT1)
   04662 B cell receptor signaling pathway
    100969444 (AKT1)
   04664 Fc epsilon RI signaling pathway
    100969444 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    100969444 (AKT1)
   04062 Chemokine signaling pathway
    100969444 (AKT1)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    100969444 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    100969444 (AKT1)
   04929 GnRH secretion
    100969444 (AKT1)
   04915 Estrogen signaling pathway
    100969444 (AKT1)
   04917 Prolactin signaling pathway
    100969444 (AKT1)
   04926 Relaxin signaling pathway
    100969444 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    100969444 (AKT1)
   04919 Thyroid hormone signaling pathway
    100969444 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100969444 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    100969444 (AKT1)
   04728 Dopaminergic synapse
    100969444 (AKT1)
   04722 Neurotrophin signaling pathway
    100969444 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100969444 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    100969444 (AKT1)
   04213 Longevity regulating pathway - multiple species
    100969444 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100969444 (AKT1)
   05205 Proteoglycans in cancer
    100969444 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    100969444 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100969444 (AKT1)
   05230 Central carbon metabolism in cancer
    100969444 (AKT1)
   05231 Choline metabolism in cancer
    100969444 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100969444 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100969444 (AKT1)
   05212 Pancreatic cancer
    100969444 (AKT1)
   05225 Hepatocellular carcinoma
    100969444 (AKT1)
   05226 Gastric cancer
    100969444 (AKT1)
   05214 Glioma
    100969444 (AKT1)
   05221 Acute myeloid leukemia
    100969444 (AKT1)
   05220 Chronic myeloid leukemia
    100969444 (AKT1)
   05218 Melanoma
    100969444 (AKT1)
   05211 Renal cell carcinoma
    100969444 (AKT1)
   05215 Prostate cancer
    100969444 (AKT1)
   05213 Endometrial cancer
    100969444 (AKT1)
   05224 Breast cancer
    100969444 (AKT1)
   05222 Small cell lung cancer
    100969444 (AKT1)
   05223 Non-small cell lung cancer
    100969444 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100969444 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    100969444 (AKT1)
   05161 Hepatitis B
    100969444 (AKT1)
   05160 Hepatitis C
    100969444 (AKT1)
   05164 Influenza A
    100969444 (AKT1)
   05162 Measles
    100969444 (AKT1)
   05163 Human cytomegalovirus infection
    100969444 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100969444 (AKT1)
   05169 Epstein-Barr virus infection
    100969444 (AKT1)
   05165 Human papillomavirus infection
    100969444 (AKT1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100969444 (AKT1)
   05152 Tuberculosis
    100969444 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100969444 (AKT1)
   05142 Chagas disease
    100969444 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100969444 (AKT1)
   05017 Spinocerebellar ataxia
    100969444 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100969444 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    100969444 (AKT1)
   05415 Diabetic cardiomyopathy
    100969444 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100969444 (AKT1)
   04932 Non-alcoholic fatty liver disease
    100969444 (AKT1)
   04931 Insulin resistance
    100969444 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100969444 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100969444 (AKT1)
   01524 Platinum drug resistance
    100969444 (AKT1)
   01522 Endocrine resistance
    100969444 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pps01001]
    100969444 (AKT1)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100969444 (AKT1)
Protein kinases [BR:pps01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   100969444 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_11 PH_20 Seadorna_VP7 ABC1
Other DBs
NCBI-GeneID: 100969444
NCBI-ProteinID: XP_034794161
Ensembl: ENSPPAG00000040270
LinkDB
Position
15:complement(105950803..105978465)
AA seq 480 aa
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgagcgacgtggctattgtgaaggagggctggctgcacaaacgaggggagtacatcaag
acctggcggccacgctacttcctcctcaagaatgatggcaccttcattggctacaaggag
cggccgcaggatgtggaccaacgtgaggcccccctcaacaacttctctgtggcgcagtgc
cagctgatgaagacggagcggcctcggcccaacaccttcatcatccgctgcctgcagtgg
accactgtcatcgaacgcaccttccatgtggagactcctgaggagcgggaggagtggaca
accgccatccagactgtggccgacggcctcaagaagcaggaggaggaggagatggacttc
cggtcgggctcacccagtgacaactcaggggctgaagagatggaggtgtccctggccaag
cccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcact
ttcggcaaggtgatcctggtgaaggagaaggccacaggccgctactacgccatgaagatc
ctcaagaaggaagtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgc
gtcctgcagaactccaggcaccccttcctcacagccctgaagtactctttccagacccac
gaccgcctctgcttcgtcatggagtacgccaacgggggcgagctgttcttccacctgtcc
cgggagcgtgtgttctccgaggaccgggcccgcttctatggcgctgagatcgtgtcagcc
ctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctc
atgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatc
aaggacggtgccaccatgaagaccttttgtggcacacccgagtacctggcccccgaggtg
ctggaggacaatgactacggccgtgcagtggactggtgggggctgggcgtggtcatgtac
gagatgatgtgcggccgcctgcccttctacaaccaggaccatgagaagctttttgagctc
atcctcatggaggagatccgcttcccgcgcacgcttggtcccgaggccaagtccttgctt
tcggggctgctcaagaaggaccccaagcagaggcttggcgggggctccgaggacgccaag
gagatcatgcagcatcgcttctttgccggtatcgtgtggcagcacgtgtacgagaagaag
ctcagcccacccttcaagccccaggtcacatcggagactgacaccaggtattttgatgag
gagttcacggcccagatgatcaccatcacaccacctgaccaagatgacagcatggagtgt
gtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcc
tga

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