Pan paniscus (bonobo): 100969544 Help Entry 100969544         CDS       T02283                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism pps  Pan paniscus (bonobo) Pathway pps04020   Calcium signaling pathway pps04371   Apelin signaling pathway pps04713   Circadian entrainment pps04921   Oxytocin signaling pathway pps04970   Salivary secretion pps05010   Alzheimer disease pps05012   Parkinson disease pps05020   Prion disease pps05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pps00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100969544 (RYR3)    04020 Calcium signaling pathway     100969544 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100969544 (RYR3)   09154 Digestive system    04970 Salivary secretion     100969544 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     100969544 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100969544 (RYR3)    05012 Parkinson disease     100969544 (RYR3)    05020 Prion disease     100969544 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     100969544 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pps04040]     100969544 (RYR3) Ion channels [BR:pps04040]  Voltage-gated cation channels   Ryanodine receptor    100969544 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  100969544 NCBI-ProteinID:  XP_034794365 Ensembl:  ENSPPAG00000030728 LinkDB All DBs Position 16:22089131..22652150 Genome browser AA seq 4870 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPPTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGT TQFLSQASFIPCPVDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFSKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPVLW SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED TSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVR MMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTVNLLAALGQIRSLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDDEEEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKIFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKF LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADG KGDTQEAELLILDEFAVLCRDLYAFYPMLLRYVDNNRSNWLKSPDADSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKS DDPAVKWQLNLYKNVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDK EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNDEFTCDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID FLLSCAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPAS AFAMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLF TILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGI TTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQ KKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQK VEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKV PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC FRKQYEDQLG NT seq 14613 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgaggactgaggatgaa gtggtactccagtgcatcgccaccattcataaggagcagaggaagttctgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagccaagtacattcct ccagatctctgcgtctgcaattttgtgctggaacagtccctatctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaaggaggtggccac aggaccctgttatacggccatgcagttctcctgaggcactctttcagcggaatgtatcta acatgcttgactacatcaagatcccagacagacaaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggactatacatcctgcttccaaacagaggtcc gaaggagagaaagttcgaattggcgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatggtaacatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgtcttttccatggtcatgatgaatgtttgacgataccacctacagac cagaatgattcccagcacaggaggatattctacgaagctgggggagctgggactcgagcc aggtctctgtggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggccaggctttccgactccggcatctcaccacaggccactacctggccttgacagaagac caaggccttatactgcaagaccgggcaaagtcagacaccaagtccacagctttctctttc cgggcatcaaaggaactcaaggagaaattagactccagtcacaagcgagacatagaaggc atgggagttccagaaatcaagtatggagattctgtctgctttgtgcagcatatagccagt ggtctgtgggtgacctacaaagcacaagacgccaaaacttcccgcctgggacctctaaaa agaaaggtcatactccatcaggaaggccacatggatgatggattaacactgcagagatgc cagcgtgaggagtcccaggctgctcggatcatccggaacactacagccttattcagccag tttgtcagcggaaacaatcgcacagctgcccccatcaccctgcctatagaagaagtcctg cagaccctacaggacttgatcgcctacttccagcccccggaggaggagatgcgacatgaa gacaagcagaacaagctccgctcactcaaaaacagacaaaatcttttcaaggaagaggga atgttggcccttgtcttaaattgcattgaccgcttaaatatctacaatagcgtagcacac tttgcagggattgcaagggaagagagtggcatggcctggaaagaaattctgaacctcctc tacaaattgctggctgctctcattcgcggaaacagaaacaattgcgctcaattctccaat aaccttgattggctcatcagtaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttaactgaaagcccagaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgttggataagcacgggcggaatcacaaggttctggatatc ctgtgctccctctgtctctgcaatggggttgcagtgagagccaaccagaatctgatctgt gacaacttgctgccccggagaaacctactcctgcagacacgactgattaacgatgtaacc agtatccggccaaacatcttcctgggagttgcggagggctcagcccagtacaagaagtgg tacttcgagctgattatcgaccaggtggaccccttcctaacagcagagcccacacatctg cgggtgggctgggcctcttcttcaggctatgccccatacccaggaggtggagaaggatgg ggaggcaatggtgttggtgatgacctgtactcctatggctttgatggacttcacctttgg tcaggccggatacccagagctgtggcttccatcaaccagcacctcctgagatcggatgac gtggtaagctgctgcctggacctcggggtgcccagcatctcattccgcatcaatgggcaa cccgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtgatgagc ttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagagtttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaagagaagatgaga ttggagcctgtcaaagaatataaacgtgatgctgatggcattagagatctcttgggtacc acccagttcctctcccaagcctctttcatcccatgccccgtagacaccagtcaggttgtt ttgccacctcacctagaaaagatccgagacagactagctgaaaacatccatgagctttgg ggaatgaataaaatagaacttggctggactttcagcaagatacgagatgacaataaaaga caacacccttgccttgtggagttttcaaagctccccgaaactgagaagaattataacctg caaatgtcaactgaaaccttaaaaaccctcctggccctggggtgccacattgctcatgtt aacccagctgctgaggaggatctcaagaaggtcaaactgcccaaaaactatatgatgtcc aacggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcacacaatgtttgggcaaaagacagaataaaa caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccgtctggtg ccatatgcattactggatgagcgtaccaagaagtcaaacagggacagcctgcgggaagct gtgcgcacttttgttggttacgggtataacattgagccatcagaccaagaactagctgac tcggctgtggagaaggtcagcatagacaagatccgatttttccgggtagagcgatcttac gcagtgagatctggaaagtggtattttgagtttgaggtggtgactggaggagacatgcga gtcggctgggccaggccaggctgtcggcctgatgtcgagctgggggccgatgaccaagcc tttgtgtttgaaggcaacaggggccagcgttggcatcaaggaagtgggtattttgggcgt acctggcagccaggggatgtggtcggatgtatgattaacctggatgatgcttcaatgatc ttcacactgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgac tacgagattgagaatggcttcgtgcccatctgctgtctggggctatctcagattggccgc atgaatctcgggacagatgccagtaccttcaagttttataccatgtgcggtctccaagag ggctttgagccttttgctgtcaacatgaacagagatgttgctatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccaaaggatcatccacacatagaggtcatgaggattgat ggcaccatggacagccctccgtgtctcaaggtgacccataagacatttggcacacagaat agcaatgccgacatgatctattgccgcttgagcatgccggtcgagtgccactcctccttc agccacagcccctgtctggacagtgaagctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactatgccatccgcatctttgctggacaggatcca tcctgtgtctgggtcggatgggtgactccagactatcacttgtacagtgaaaagtttgac ctgaataaaaactgcacagtgactgtcaccctaggggatgaaagaggccgggtccatgaa agtgtgaagcgcagcaactgctacatggtctggggtggggacattgtagccagttcccag agatcaaatcggagcaatgtggacctggagatcggctgtctcgtggatctggccatgggc atgttgtccttctcagccaatggaaaggaactgggcacctgctaccaggtggagcctaat accaaagtgtttccagcagtcttcctgcagcctacaagtacttctttgtttcagtttgaa cttggaaagctgaagaatgcaatgcccctgtcagcggccatattcaggagtgaagagaag aacccagtcccacagtgtccacctcggctggatgtccaaaccatccagcccgtgctctgg agccgcatgcccaacagcttcctgaaggtggagaccgagcgtgtgagcgagcgccacggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatccccgaggagaac aggtgtgtggatatcctggagctctgtgagcaggaggacctgatgcggttccattaccac acgctgaggctctacagcgcggtgtgcgccctgggaaacagccgcgtggcctacgccctg tgcagccacgtggacctctcccagctcttctatgccattgacaacaagtacctccccggc ctccttcgatctggtttctatgacctgctcatcagcatccacctggccaacgccaaggag aggaagctgatgatgaagaacgagtacatcatccccattaccagcaccaccaggaatatc cgcctcttcccggacgagtccaagaggcatggactgcctggggtgggcctgagaacatgt ctcaagcccgggttcaggttctccaccccttgctttgttgtgactggtgaggatcaccaa aagcagagccccgagattcccttggagagtctcaggacgaaggctctgagtatgctgaca gaggcagtgcagtgcagcggggcccacatccgagaccccgtaggggggtctgtggagttc cagtttgtgcctgtgctgaaactcattggaaccctgctggtcatgggcgtgtttgatgat gatgatgttcggcagatcctcctcctgattgatccctctgtgtttggggagcatagtgcg gggacagaggagggagcagaaaaggaggaagtgacccaggtggaggagaaggctgtggag gctggggagaaggccggcaaggaggctcctgtcaaaggcttgttgcagactcgattaccc gaatctgtcaagctgcagatgtgtgagctcctcagctatctctgcgactgtgagctgcag caccgagtggaggccattgtggcatttggtgacatttatgtctccaagctgcaggcaaat cagaagttccgctacaatgagctcatgcaggccctgaacatgtctgcggccctgactgcc cggaagaccaaggagttccgctcacccccacaggagcagatcaacatgctacttaacttt caactgggagagaactgcccctgcccagaggagattcgggaggagctgtatgatttccat gaggaccttctccttcactgtggggttcctttggaagaagaggaagaggaggaggaggac acctcctggacaggaaaactctgtgccttggtttacaaaatcaaaggcccacccaagcca gagaaggagcagccgacggaggaggaggagagatgccccacaacattgaaggaactcatc tcacagacgatgatctgctgggcccaggaggaccagatccaggattcagagctggtccga atgatgttcaacctcctccggaggcagtatgacagcatcggggagctgctgcaggcactg cggaagacctacaccatcagccacacctctgtaagcgacaccgtcaacctgctggctgcc ctgggccaaatccgctccctcctcagtgtcaggatgggcaaggaagaggagttgctcatg atcaatgggctgggagacataatgaacaacaaggtgttttaccagcatcccaacctcatg agagtcctgggcatgcacgagacggtgatggaggtgatggtgaacgtgttgggtacagag aaatctcagattgcatttccaaagatggttgctagctgctgccgtttcctttgctatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagttatcttctggag aatagcagtgttggcctagcttccccgtcgatgaggggatccaccccactggatgtggca gcttcctctgtgatggacaacaatgagttagcgctgagcttagaggaaccagacctcgag aaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttctggccaaa ggataccctgatgtcggctggaaccccattgaaggggaacgctacctgtccttcctgagg tttgctgtcttcgtgaacagtgagagtgtggaagaaaacgccagcgttgtggtcaagctg ctcatcagacgcccagagtgcttcggcccggccctgcggggtgaggggggaaacgggctc ttggcggccatgcagggtgccattaagatctctgagaacccagcgctcgacctcccctct caaggatacaaaagagaagtcagcacggaggacgatgaagaggaagaagaaatcgtgcat atgggcaatgcaatcatgtcattttattcggcccttatagatctactgggccgctgtgct cctgaaatgcacctcatccagacaggaaagggggaagccatccgcatcaggtccatcctg cgctccctggtccccacagaagacctggttgggatcatcagcatccccttgaaactgccc tccctcaacaaagatgggtcggtcagtgagccagatatggcggccaacttctgccctgac cacaaggcacctatggtgctgttcttggaccgcgtttatggcattaaggatcaaactttt ctgctccacttgctggaggttggatttttacctgacctaagagcttctgcctctctagat acagtttccctaagcaccacagaggctgcgcttgcactaaataggtatatatgttctgct gtgctcccgctcctcacaagatgtgcccctctctttgccggaacagaacactgcacctct ctgattgattccacactgcagacaatatacaggctatccaagggacgttccctcaccaaa gcacaaagggacactatagaagaatgtttgcttgccatttgcaatcacttgaggccttcc atgttacagcaactcctgcgacgcctcgtttttgatgtgccgcaactcaatgaatactgc aaaatgcctctcaagcttctgacgaatcactatgaacagtgttggaagtattactgcctg ccttcaggatgggggagctacgggctagctgtggaagaagagctgcacctaacggagaag attttctgggggatttttgactcgctgtcccataagaaatatgacccagatcttttccga atggccctgccttgtctcagtgctatagctggggccttgccaccagattatttagatacc agaatcacagccacattggagaaacagatctcagtggatgcagatggcaactttgaccca aaacctatcaacaccatgaatttttccttgcctgaaaaattggaatacatcgtcaccaag tatgctgagcattcacatgataaatgggcctgtgacaagagtcagagtggatggaaatat gggatttccctggatgaaaatgtgaagacccacccactgataaggcctttcaagacatta acggagaaggagaaggaaatttatcgctggcctgcccgagagtccctgaaaaccatgctg gctgtgggctggactgtggagaggaccaaagagggagaagctttggttcaacagcgggaa aatgagaagcttcgaagtgtgtcccaggccaaccagggcaacagctacagtcctgctccc ctcgacctctcaaacgttgtgctctccagagagctccagggaatggtggaggtcgtggct gagaactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggt ggcagtcaccctcttctggtaccatatgacaccttgactgccaaggaaaagttcaaggac cgggagaaggcacaggacctgtttaagttcctccaagtgaatggcatcatagtttccagg ggtatgaaggatatggagctggatgcctcctccatggagaagaggtttgcctataagttc ttgaagaagatcctgaaatacgttgattctgctcaagaatttattgcccatttagaagcc attgtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttctcctcccgctggttgaccagtacttcaccaatcattgcctctacttcttgtca tcccctctgaagccccttagcagcagcggatatgcctcccataaggagaaagaaatggtg gccagcctgttctgcaaacttgccgcccttgttagacacagaatttccctctttggtagt gattctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggact gtcatgaagtcaggctcagagctggtgaaggctgggttacgagcattctttgaaaatgct gcagaagatttggagaagacttcagaaaacctgaaacttgggaagttcacccattcccga acgcagattaaaggcgtttctcagaatattaactacactacagtggctctgctccccatc ctgacgtccatctttgagcacgtcactcagcatcagtttggaatggatctactcttgggt gatgtgcagatttcatgctaccacatactgtgcagcctctactcccttgggacgggaaag aacatttatgttgaaaggcaacgccctgcccttggagaatgtcttgcctcgctggcagct gccataccagtggcattcctggagcccacccttaatcgctacaatccactctcggtcttc aacaccaaaacccccagggagaggtctattctggggatgccagacacggtagaagacatg tgtcctgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggccgagtca ggggcccggtacacagagatgccccatgtcatcgaggtgatcttacccatgctctgcaac tacctgtcctactggtgggagcgggggcctgagaacctgccccccagcacagggccatgc tgcaccaaggtcacctctgaacacctcagtctcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgatgaggcctcctggatgaagcgcattgcagtgtatgcacag cccatcatcagcaaagccaggcccgacctgctgagaagccacttcatcccaactctggag aagctgaagaaaaaggccgtcaagacggtgcaggaggaggagcagttgaaagccgatggc aaaggggacacccaggaggcagaactcctcatcctggacgagttcgcggtcctctgcaga gatctctatgccttctaccccatgctgctccgctacgtggacaacaacagatctaactgg ctgaagagtcctgatgctgattctgaccagctcttccgcatggtggcagaagtcttcatt ctgtggtgtaaatctcataacttcaagagggaagagcaaaattttgtgattcagaatgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaa gtaaagtctggaggacaagaccaggagcggaagaagacaaagcggcggggagacttgtat tccatccagacctccctcatcgtggctgcactcaagaaaatgctgcccattggtttgaat atgtgtactccaggcgaccaggagctgatctccctcgcaaaatcacgatacagccatagg gacacagatgaagaggtcagagaacatctgcggaacaacttgcacttgcaggaaaagtct gatgacccagctgtaaaatggcaactgaacctctacaagaatgttctgaagagtgaagaa cctttcaatccggaaaagacagtggagcgtgtgcagagaatttcagcagctgtcttccac ctggaacaggtggaacagcctttgaggtccaagaaggccgtctggcacaaactgttatca aagcaacggaaacgggcagtggtggcctgtttcaggatggcccctctctacaacctgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gagtattcctttgaagagaaactagtacaggatttggctaaatctccaaaggtggaagag gaggaggaggaagagacagaaaaacaacctgacccactacatcagatcattctctatttt agccgcaacgctctcacggagaggagcaaattggaagacgaccctttgtacacctcctat tccagcatgatggccaagagttgtcaaagtggtgaggatgaagaagaagatgaagacaag gaaaaaacatttgaagagaaagagatggagaagcaaaaaaccctctatcagcaagctcgg ctgcatgagcgtggtgctgcggagatggtccttcagatgataagcgctagcaaaggtgag atgagccccatggtggttgagacgctgaagctggggatcgccattctgaacggaggcaat gctggtgtgcaacagaaaatgctagattacctaaaggagaaaaaggatgctggattcttt caaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagagg cagaataaagctgaaggcctggggatggtgactgaagaaggaacactcattgttcgtgaa cgtggtgaaaaagtactccagaatgacgagttcacgtgtgatctctttagattcctacag ttactttgtgaaggacataacagtgactttcagaacttcctgcggactcagatgggcaac accaccaccgtgaatgtcatcatcagcactgtggactaccttctgcgtctgcaggaatca atcagtgatttctactggtattattcagggaaggacatcattgatgaatctggacagcac aatttttcgaaagctctggcagtcaccaagcagattttcaattctcttacagaatacatc cagggcccttgcattggcaatcaacagagcctggctcacagcaggctgtgggacgcagtg gttggcttcctccatgtctttgctaatatgcagatgaaactctctcaggattccagtcag atcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctcctggaagggaatgtggtaaatggcaccattggcaagcagatggttgacacactggta gaatcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaa gacttaaccagctcagacaccttcaaagaatatgacccagatggtaaaggaattatctcc aaaaaagaattccagaaggccatggaagggcaaaaacagtacacgcagtcagagattgac tttctcctgtcgtgtgcagaagctgatgagaatgacatgtttaattacgttgattttgta gaccggttccatgagccagccaaggacatagggtttaatgtggctgtgttattgacaaat ctttctgaacacatgccaaacgattcccgcctgaagtgtctgttggacccagcagaaagt gtgctaaattacttcgaaccctacctaggacgcatcgagatcatgggtggggccaagaag attgagcgtgtttattttgagatcagtgaatccagtcgcactcagtgggagaagccccag gtgaaggaatctaagcgacagttcatttttgatgttgtcaatgaaggtggggaacaggaa aagatggagctgtttgtgaacttctgtgaggacaccatctttgaaatgcagttagcatct cagatctctgaatccgattcagctgacaggccagaagaggaggaagaagatgaagattct tcttacgtgttagaaattgcgggtgaagaggaagaagacgggtctcttgagccggcctct gcatttgctatggcctgtgcctctgtgaagaggaatgtcaccgacttcctgaagagagca accctgaagaacctcaggaagcagtacaggaacgtgaaaaagatgactgcgaaggagctg gtgaaggtgctcttctcctttttctggatgctgttcgtggggctattccagttgctcttc accatcctgggaggaatctttcagatcctctggagcacagtgtttggagggggcctggta gaaggggcaaagaacatcagagtgaccaagatcctgggtgacatgcctgacccaacccaa tttggtatccatgatgacactatggaggctgagagggcagaggtgatggagccaggtatc accactgaactagtacacttcataaagggggagaagggagatacagatatcatgtcagac ctctttggactccacccaaagaaagagggcagcttaaagcatgggcctgaagtaggtttg ggtgacctctcagaaattattggcaaggatgaaccccctacattagagagtactgtacag aagaagaggaaagctcaggcagcagaaatgaaagcagcaaatgaagcagaaggaaaagta gaatccgagaaggcagacatggaagatggagagaaggaagacaaagacaaagaagaggag caagctgagtacctgtggacagaagtgacaaaaaagaagaagcggcggtgtggtcagaag gttgagaagccggaagctttcacagccaatttctttaaagggctggaaatctatcagacc aagttactgcattacctggccaggaatttctacaacctgaggttccttgctctgtttgta gccttcgctatcaacttcatcctgcttttttataaggtcactgaagagcctttagaagaa gagacagaggatgttgcaaacctatggaattcctttaatgacgaggaagaggaagaagcg atggtattctttgtccttcaggagagcaccgggtatatggcaccaacgctgcgggccctg gccatcatccacaccatcatctctctagtctgtgtggtgggctactactgcctgaaggtg cctttggtggttttcaaaagggaaaaagaaatcgccaggaagctggagtttgatggccta tatatcaccgaacagccatctgaagatgacatcaaggggcagtgggaccgcttggtgatc aacacaccatcttttcctaataactactgggacaagtttgtaaagagaaaggtgatcaac aagtatggagatctctacggagcagaacgcattgctgaacttctgggtttggacaaaaat gctcttgactttagcccagtagaagagaccaaagcagaagcggcttctctggtgtcatgg ctaagttccatagacatgaagtaccatatctggaagcttggagttgtttttactgacaac tcctttctctaccttgcctggtatacaaccatgtcagtcctgggccactacaataacttc ttctttgctgctcacctattggacatcgcaatgggcttcaagacactgaggaccattctg tcatctgtaactcacaatggcaaacagttggttctgactgtcggtctcctggccgtggtg gtttatctctatactgtggtggctttcaacttcttccgcaagttctacaacaaaagcgaa gacgatgacgagcccgatatgaagtgcgacgacatgatgacgtgttaccttttccacatg tacgtgggagtgagagcaggaggtggcattggtgatgaaattgaagaccctgctggtgat ccttatgaaatgtatcgcattgtctttgacattacctttttcttctttgtcattgtcatc ctgctggccatcattcaaggtcttattattgatgctttcggagagctaagagaccagcag gaacaagtgcgagaagatatggagactaaatgtttcatctgtgggattggcaatgactac tttgacacgacccctcatggttttgaaacacatacattacaagagcacaacttagccaac tacttgttctttctgatgtatttgattaataaagatgaaacagagcacacgggtcaggaa tcttatgtctggaagatgtaccaagaaaggtgttgggatttcttcccagccggtgactgc tttcgtaaacaatatgaagatcagcttggataa

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