Pan paniscus (bonobo): 100974705 Help Entry 100974705         CDS       T02283                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X4   KO K04962   ryanodine receptor 2 Organism pps  Pan paniscus (bonobo) Pathway pps04020   Calcium signaling pathway pps04024   cAMP signaling pathway pps04260   Cardiac muscle contraction pps04261   Adrenergic signaling in cardiomyocytes pps04371   Apelin signaling pathway pps04713   Circadian entrainment pps04911   Insulin secretion pps04921   Oxytocin signaling pathway pps04972   Pancreatic secretion pps05020   Prion disease pps05022   Pathways of neurodegeneration - multiple diseases pps05410   Hypertrophic cardiomyopathy pps05412   Arrhythmogenic right ventricular cardiomyopathy pps05414   Dilated cardiomyopathy pps05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pps00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100974705 (RYR2)    04020 Calcium signaling pathway     100974705 (RYR2)    04024 cAMP signaling pathway     100974705 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     100974705 (RYR2)    04921 Oxytocin signaling pathway     100974705 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     100974705 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     100974705 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     100974705 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     100974705 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     100974705 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     100974705 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     100974705 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     100974705 (RYR2)    05414 Dilated cardiomyopathy     100974705 (RYR2)    05415 Diabetic cardiomyopathy     100974705 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pps04040]     100974705 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pps04990]     100974705 (RYR2) Ion channels [BR:pps04040]  Voltage-gated cation channels   Ryanodine receptor    100974705 (RYR2) Domain-containing proteins not elsewhere classified [BR:pps04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100974705 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  100974705 NCBI-ProteinID:  XP_034805477 Ensembl:  ENSPPAG00000043978 LinkDB All DBs Position 1:complement(11327556..12116058) Genome browser AA seq 4956 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSYSG MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS LMEDKNLLLMDKEKADVKSTALTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVD TGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFN RFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQN LFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGS AQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGF DGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYT RDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV RDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLP KNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR RNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRI FRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQ GNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSL GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEH IEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGL FGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQR FLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVWVGWIT SDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEI GCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLS AGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQF MSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLY AIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHG LPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHAR DPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKE LSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVA FSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECP CPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKP VESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYT INGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSV GLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPD IGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAM EEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMH LIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAA MVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPL LTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQH LLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWG IFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVD TSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKE KEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAID MSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDRE KAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGS RGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSL FCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAED LEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQ VSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTK SSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMS RWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPII NKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLY AFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINN MSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQE LIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKT VERVLDIANVLFHLEQVEHSQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNL FLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEK CKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARL HDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQ SLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHN SDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQ VAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKEL MDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDT FKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPA KDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFE ISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDL NGRSANKEESEKERPEEQGPRMAFFSVLTVKSALFALRYNILTLMRMLSLKSLKKQMKKV KKMTVKDMVTAFFSSYWSIFVTLLHFVASVFRGFSRIICSLLLGGSLVEGAKKIKVAELL ANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQY KLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEE KAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAF AINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYVLEESSGYMEPT LRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWD RLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKD SSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFK TLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLT CYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFG ELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDET EHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14871 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaagacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcaccgcaaccatccacaaagaacaacagaagctatgcttggcagcagaa ggatttggcaacagactttgtttcttggagtccacttccaattccaagaatgtgccccca gacctctccatctgcacctttgtgctggagcagtccctctctgtccgggcgctgcaggag atgctggctaacaccgtggagaaatcagaagggaaattcatgatgaagactgctcaaggt ggtggtcatcgaacactcctctacggacatgccatattgctgcgccattcctatagtggc atgtatctgtgctgcctgtccacctcccggtcttcaactgataagctggcttttgatgtt ggcttgcaagaggacaccacaggtgaggcttgttggtggaccatacaccctgcctctaag cagcgatcagaaggagaaaaagtacgagttggagatgacctcatcttagttagcgtgtcc tctgaaaggtacttgcacttgtcttatggcaacggcagcttacacgtggatgccgctttc cagcagactctctggagcgtggccccaatcagctcaggaagtgaggcagcccaagggtat ctcattggtggtgatgtcctcaggttgctgcatggacacatggacgagtgtctcactgtc ccttcaggagaacatggtgaagagcagcggagaactgttcattatgaaggtggcgctgtg tctgttcatgcacgttccctttggagactagagacgctaagagttgcgtggagtggaagc cacataaggtggggacagccgttccgactacgccacgtcacaacaggaaaatacttgagt ctcatggaagacaaaaaccttctactcatggacaaagagaaagctgatgtaaaatcaaca gcccttaccttccggtcttccaaggaaaaattggatgtaggggtgagaaaagaagtcgac ggcatgggaacatctgaaataaaatacggtgactcagtatgctatatacaacatgtagac acaggcctatggcttacttaccagtctgtggacgtgaaatccgtgagaatgggatctata caacgtaaggctattatgcatcatgaaggccacatggatgatggcataagtttatcgaga tcccagcatgaagaatcacgcacagcacgagttatccggagcacagtcttccttttcaat agatttataaggggccttgatgctctcagcaagaaagcgaaggcttccacagtcgatttg cctatagagtccgtaagtctaagtctgcaggatctcattggctacttccaccccccagat gagcatttagagcatgaagacaaacagaacagactacgagccctgaagaatcggcaaaat ctcttccaggaagagggaatgatcaacctcgtgcttgagtgcatagaccgtttgcacgtc tacagcagtgcagcacactttgctgatgttgctgggcgagaagcaggagagtcttggaaa tccattctgaattctctgtatgagttgctggcggctctaattagaggaaatcgtaaaaac tgtgctcaattttccggctccctcgactggttgatcagcagattggaaagactggaagct tcttcgggcattctggaagttttacactgtgttttagtagaaagtccagaagctctaaat attattaaagaaggacatattaaatctattatctcacttttagacaaacatggaagaaat cacaaggttctggatgttttgtgctcactctgtgtttgccacggggttgcggtccgttct aaccagcatctcatctgtgacaatctcttaccaggaagagacttgttattgcagacacgt cttgtgaaccatgtcagcagcatgagacccaatatttttctgggcgtcagtgaaggttct gctcagtataagaaatggtactatgaattgatggtggaccacacagagccctttgtgaca gctgaagcgactcacctgcgagtgggctgggcttccactgaagggtattctccctaccct ggagggggcgaagagtggggtggaaatggtgttggagatgatctcttctcctatggattt gatggccttcatctctggtcaggttgtattgctcgtactgtaagctcaccaaaccaacat ctgttaagaactgatgatgtcatcagttgctgtttagatctgagtgccccaagcatctcg ttccgaattaatggacaacctgttcaaggaatgtttgagaatttcaacatcgatggcctc ttctttccagtcgttagtttctctgcaggaataaaagtacgctttctgcttggagggcga catggagaattcaaatttcttcctccacctgggtatgctccttgttatgaagctgttctg ccaaaagaaaagttgaaagtggaacacagccgagagtacaagcaagaaagaacgtacaca cgcgacctgctgggccccacagtttccctgacgcaagctgccttcacacccatccctgtg gataccagccagatcgtgttgcctcctcatctagaaagaataagagaaaaactggcagag aatatccatgaactctgggttatgaataaaattgagcttggctggcagtatggtccggtt agagatgacaacaagagacaacacccatgcctggtggagttctgcaagctgcctgaacag gagcgcaattacaacttacaaatgtcgcttgagaccctgaagactttgttggcattagga tgtcatgtgggtatatcagatgaacatgctgaagacaaggtgaaaaaaatgaagctaccc aagaattaccagctgacaagtggatacaagcctgcacctatggacctgagctttatcaaa ctcaccccatcgcaagaagcaatggtggacaagttggcagaaaatgcgcataatgtgtgg gcgcgggatcgaatccggcagggctggacttatggcatccaacaggacgtaaagaacaga agaaatcctcgccttgttccctacactcttctggatgaccgaaccaagaaatccaacaag gacagcctccgcgaggctgtgcgcacgctgctggggtacggctacaacttggaagcacca gatcaagatcatgcagccagagccgaagtgtgcagcggcactggggaaaggttccgaatc ttccgtgccgagaagacctatgcagtgaaggccggacggtggtattttgaatttgagacg gtcactgctggagacatgagggttggttggagtcggcctggttgtcagccggatcaggag cttggctcagatgaacgtgcctttgcctttgatggcttcaaggcccagcggtggcatcag ggcaatgaacactatgggcgctcttggcaagcaggcgatgttgtggggtgtatggttgac atgaacgaacacaccatgatgttcacactgaatggtgaaatccttcttgatgattcaggc tcagaactggctttcaaggactttgatgtgggcgatggattcatacctgtgtgtagcctt ggagtggctcaagtgggtaggatgaactttggaaaggatgtcagcaccttgaaatatttc accatctgtggcttacaagagggctatgaaccatttgccgttaatacaaacagggatatt accatgtggctgagcaagaggcttcctcagtttcttcaagttccatcaaaccatgaacat atagaggtgaccagaatagacggcaccatagacagttccccatgtttaaaggtcactcag aagtcttttggttctcagaacagcaacactgatatcatgttttatcgcctgagcatgccg atcgagtgcgcggaggtcttctccaagacggtggctggagggctccctggggctggcctt ttcgggcccaagaatgacttggaagattatgatgctgattctgactttgaggttctgatg aagacagctcatggccatctagtgcccgatcgtgttgacaaagacaaagaagctactaaa ccagagtttaacaaccacaaagattatgcccaggaaaagccctctcgtctgaaacaaaga tttttgcttagaagaacaaagccagattacagcacaagccattctgcaagactcaccgaa gatgtccttgctgatgatcgggatgactatgatttcttgatgcaaacgtccacgtactat tactcagtgagaatctttcctggacaagaacctgctaatgtctgggtgggctggattaca tcagatttccatcagtatgacacaggctttgacttggacagagttcgcacagtaacagtt actctaggagatgaaaaaggaaaagtgcatgaaagcatcaaacgcagcaactgctatatg gtatgtgcgggtgagagcatgagccccgggcaaggacgcaacaataatggactggagatt ggctgtgtggtggatgctgccagcgggctgctcacattcattgccaatggcaaggaactg agcacatactatcaggtggaaccgagtacaaaattatttcctgcggtttttgcacaagct acaagtcccaatgttttccagtttgagttgggaagaataaagaatgtgatgcctctctcg gcgggattattcaagagtgaacacaagaaccccgtgccgcagtgccccccgcgcctccac gtgcagttcctgtcacacgtcctgtggagcagaatgcccaaccagtttttgaaggtagat gtgtctcgaataagtgaacgccaaggctggttggtgcagtgtttggatcctctgcagttc atgtctcttcatatccctgaggaaaacagatctgttgacatcttagagttgacagagcag gaggaattgctgaaatttcactatcacaccctccggctctactcagccgtctgtgctctt gggaaccaccgggtggcccatgccctgtgcagccatgtggatgaacctcagctcctctat gccattgagaacaagtacatgcctggtttgctgcgtgctggctactatgacctgctgatt gacatccacctgagctcctatgccactgccaggctcatgatgaacaacgagtacattgtc cccatgacggaggagacgaagagcatcaccctgttccctgatgagaacaaaaagcacggc cttccagggatcggcctcagcacctccctcaggccacggatgcagttttcctcccccagt tttgtaagcattagtaatgaatgttaccagtacagtccagagttcccactggacatcctc aagtccaaaaccatacagatgctgacagaagctgttaaagagggcagtcttcatgcccgg gacccagttggagggactactgaattcctctttgtacctctcatcaagcttttctatacg ctgctgatcatgggcatctttcacaacgaggacttgaagcacatcttgcagttgattgag cccagtgtgtttaaagaagctgccactccggaggaggagagtgacacgctggagaaagag ctcagtgtggatgatgcaaagctgcaaggagctggtgaggaagaagccaaggggggcaag cggcccaaggaaggcctgctccaaatgaaactgccagagccagttaaattgcagatgtgc ctactgcttcagtacctctgtgactgccaggtccggcaccggatagaagccattgtagcc ttttcagatgattttgtggctaagctccaagacaatcaacgtttccgatataacgaagtc atgcaagccttaaacatgtcagctgcactcacagccaggaaaacaaaggaatttagatca ccacctcaagaacagatcaatatgcttctcaattttaaggatgacaaaagtgaatgtcca tgtccagaagaaattcgtgaccaactattggatttccatgaagatttgatgacacactgt ggaattgagctggatgaagatgggtctctggatggaaacagtgatttaacaattagaggg cgtctgctatccctggtagaaaaggtgacatatctgaagaagaagcaagcagaaaaacca gttgagagtgactccaaaaagtcctccactctgcagcagctgatctctgagaccatggtc cgatgggctcaggagtctgtcattgaagaccccgagctggtgagggccatgttcgtgttg ctccatcggcagtatgacggcattgggggtcttgttcgggccctgccaaagacctacacg ataaatggtgtgtccgtggaggacaccatcaacctgctggcatcccttggtcagattcgg tccctgctgagtgtgagaatgggcaaagaagaagagaagcttatgattcgtggattaggg gatattatgaataacaaagtgttttaccagcaccctaatctcatgagggcactggggatg cacgagactgtgatggaggtcatggtgaacgtccttggaggtggagagtccaaggaaatc acctttcccaagatggtggccaactgttgccgttttctctgttacttctgtcgtataagt aggcagaatcaaaaagctatgtttgatcatctcagttatttactggaaaacagtagtgtt ggtcttgcctccccagctatgagaggttcaacaccactggatgtggctgcagcttcggtg atggataataatgaactagcattagctctgcgtgagccggatctagaaaaggtagttcgt tatttggctggttgtggactgcaaagttgccagatgctggtgtctaagggctatccagac attgggtggaacccagttgaaggagagagatatcttgactttctcagatttgctgtcttc tgtaatggggagagtgtggaggaaaatgcaaatgtcgtggtgagattgctcattcggagg cctgagtgttttggtcctgctttgagaggagaaggtgggaatgggcttcttgcagcaatg gaagaagccatcaaaatcgccgaggatccttcccgagatggtccctcaccaaatagcgga tccagtaaaacacttgatacagaggaggaggaagatgacactatccacatggggaacgcg atcatgaccttctattcagctttgattgacctcttgggacgctgtgctcctgagatgcat ttgattcatgctgggaagggagaagccatcagaattaggtccattttgagatccctaatt cccctgggagatttggtgggcgttatcagcatcgcttttcagatgccaacaatagccaaa gatgggaatgtggtggaacctgacatgtctgcggggttttgcccagatcacaaggcagcc atggttttattccttgacagggtctatggaattgaggttcaagacttcctcctccatctt cttgaggttggctttctgccagatctccgggcagctgcttctttagatacggcagctttg agtgctacagacatggccttggccctcaatcggtacctttgcacagccgtcttgccattg ttaacaagatgtgctcctctctttgctggcacagagcaccacgcttctctcattgactca ttacttcatactgtgtatagactttctaagggctgttcacttaccaaagctcagcgggat tccatagaagtttgtttactctctatttgtggacaactgagaccttctatgatgcagcac ttactcagaagattagtatttgatgttccattattaaatgaacacgcaaagatgcctctt aaactgctgacaaatcattatgaaagatgctggaaatattactgcctgcctggagggtgg ggaaactttggtgctgcctcagaagaagaacttcatttatcaagaaagttgttctggggc atttttgatgccctgtctcaaaagaaatatgaacaagaacttttcaaactggcactgcct tgcctgagtgcagttgcgggagctttgcctccagactacatggagtcaaattatgtcagt atgatggaaaaacagtcatcaatggattctgaagggaactttaacccacaacctgttgat acctcaaatattacaattcctgagaagttggaatacttcattaacaaatatgcagaacac tcccatgacaaatggtcaatggacaagttggcaaatggatggatttatggagaaatatat tcagactcttctaaggttcagccattaatgaagccatataagctattgtctgaaaaggaa aaagaaatttaccgctggccaatcaaagaatctttaaaaactatgctggcttggggctgg agaattgaaagaactcgggagggagacagcatggccctttacaaccggactcgtcgtatt tctcagacaagccaggtttctgtagacgctgcccatggttacagtccccgggccattgac atgagcaatgttacgctatctagagacctgcatgctatggcagaaatgatggctgaaaac taccataatatatgggcaaagaaaaagaaaatggagttggagtccaaaggaggaggaaac catcctctgctggtgccctatgatacactgacagccaaagagaaagccaaggatagagaa aaagcacaggacatcctcaagttcttgcagatcaatggatatgctgtatccagaggattt aaggacctggaactggacacgccttctattgagaaacgatttgcctatagtttcctccaa caactcattcgctatgtggatgaagcccatcagtatatcctggagtttgatggtggcagc agaggcaaaggagaacatttcccttatgaacaagaaatcaagttctttgcaaaagtcgtt cttcctttaattgatcagtatttcaaaaaccatcgtttatacttcttatctgcagcaagc agacctctctgctctggaggacatgcttccaacaaagagaaagaaatggtgactagccta ttctgcaaacttggagttcttgtcaggcataggatttcactatttggcaatgatgcaaca tcaattgtcaactgtcttcatattttgggtcagactttggatgcaaggacagtgatgaag actggcctggagagtgttaaaagtgcactcagagcttttctggacaacgctgcagaggat ctggagaagaccatggaaaacctcaagcagggccagttcactcacacccgaaaccagccc aaaggggttactcagattatcaattacaccacagtggccctgctgccaatgctgtcttca ttatttgaacatattggccagcatcagttcggagaagacctaatattggaagatgtccag gtgtcttgttatagaattctgactagcttatatgctttgggaaccagcaagagtatttac gtggagaggcaacgttctgcattaggagaatgtctagctgcctttgctggtgctttccct gtagcatttttggaaactcatctggacaaacataatatttactccatctacaataccaag tcttcacgagaaagagcagctctcagtttgccaactaatgtggaagatgtttgtccaaac ataccgtctttggagaaactcatggaagaaatcgtggaattagccgagtccggcattcgc tacactcaaatgccacatgtcatggaagtcatactgcccatgctttgcagctacatgtct cgttggtgggagcatggacctgagaacaatccagaacgggccgagatgtgctgcacagcc ctgaactcagagcacatgaacacacttctagggaacatattgaaaatcatatataataac ttggggattgatgagggagcctggatgaagaggctagcagtgttttcccagcctataata aataaagtgaaacctcagctcttgaaaactcatttcttgccattaatggagaaactcaag aaaaaggcagctacggtggtgtctgaggaagaccacctgaaagccgaggccaggggggac atgtcggaggctgaactcctgatcctagatgagttcaccacactggccagagatctctat gccttctaccctctcttgattagatttgtggactataacagggcaaagtggctaaaggag cctaacccagaagcagaggagctcttccgcatggtggctgaagtgtttatctactggtcc aagtcccataatttcaaaagagaagagcagaacttcgttgtacagaatgaaatcaacaat atgtctttccttattactgataccaagtcaaagatgtcaaaggcagctgtttctgatcag gaaaggaagaaaatgaagcgcaaaggagatcggtattccatgcagacctctctgattgta gcagctctgaagcggttactgcccattgggttgaacatctgtgcccctggggaccaggag ctcattgctctggccaaaaatcgatttagcctgaaagatactgaggatgaagtacgagat ataatccgcagcaatattcatttacaaggcaagttggaggatcctgctattagatggcaa atggctctttacaaagacttaccaaacaggactgatgatacctcagatccagagaagacg gtagaaagagtattggatatagcaaatgtgctttttcatcttgaacaggtggaacattct cagagatctaaaaaggctgtatggcataaactactctctaagcagaggaaaagggctgtt gtagcctgcttccggatggcccccttatataatctgccaaggcatcgggctgtcaatctc tttcttcagggatatgaaaagtcttggattgaaacagaagaacattactttgaagataaa ctgatagaagatttagcaaaacctggggctgaacctccagaagaagatgaaggcactaag agagttgatcctctacatcagctgatccttctgtttagtcggacagctttaacagagaaa tgcaaactggaggaagattttttatatatggcctatgcagatattatggcaaagagttgt catgatgaggaagatgacgatggtgaagaggaagtgaagagttttgaagtcacaggatcc caacgcagcaaggaaaaagaaatggaaaaacaaaagcttctataccagcaagcccgactc cacgatcgtggcgcggctgagatggtgctacagacaatcagtgccagcaaaggtgaaact ggaccaatggtagcagctactctgaaacttggaattgctattttaaatggtgggaactcc acagtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggcttctttcag agcctggccggcctgatgcagtcatgtagtgtccttgacctaaatgcatttgagcgacaa aacaaagctgaaggtcttgggatggtgacagaggaaggatcaggagaaaaggttctgcag gacgatgagttcacctgtgacctcttccgattcctgcaactactctgtgagggacacaac tcagattttcagaattatctgagaactcagactggcaataatacaactgtcaacataatt atctccactgtagactacctactgagagttcaggaatcaattagtgacttttattggtat tactctgggaaagatgttattgatgaacaaggacaacggaatttctccaaagctatccaa gtggcaaaacaagtctttaacactcttacagagtatattcagggtccttgcactgggaat caacagagtttggcacacagcaggctgtgggatgctgtggtcggctttcttcatgtgttt gcccatatgcagatgaagctgtcgcaggattccagtcaaattgagctattaaaagaatta atggatctgcagaaggatatggtggtcatgttgctgtccatgttagaaggtaatgttgtt aatggaacgattggcaaacagatggtggatatgcttgtggaatcttccaacaatgtggag atgattctcaaattttttgacatgttcttaaaactaaaggatttgacgtcgtctgatact tttaaagaatatgaccccgatggcaagggagtcatttccaagagggacttccacaaagcg atggagagccataagcactacacgcagtcagaaacggaatttcttctgtcttgtgcggag acggatgagaatgaaaccctcgactacgaagagttcgtcaaacgcttccacgaacctgcg aaggacatcggcttcaatgtcgccgtccttctgacaaacctctccgagcacatgcccaac gatacccgacttcagacttttctggaattagcagagagcgtcctgaattatttccagccc tttctgggccgcatcgaaatcatgggaagcgccaaacgcatcgagagagtctattttgaa atcagcgagtccagccgaacccagtgggagaagccccaggtcaaggagtccaaaagacag ttcatatttgacgtggtcaacgaaggaggagagaaagagaagatggaactcttcgtgaac ttctgcgaggacaccatctttgaaatgcagctggcggctcagatctcggagtcggacttg aacgggaggtcagcgaacaaggaagagagcgagaaggagaggccggaagagcagggcccg aggatggcgttcttctccgtcctgacggtcaagtcggccctgtttgcgctcaggtacaat atcttgacccttatgcgaatgctcagtctgaagagcctgaagaagcagatgaaaaaagta aaaaagatgaccgtgaaggacatggtcacggccttcttttcgtcctactggagtattttc gtgaccctcttgcacttcgtggccagcgttttcagaggcttttcccgcatcatttgcagc ctgctgcttgggggaagcctcgtcgaaggtgctaaaaagatcaaagttgcagaactgtta gccaacatgccagaccccactcaggatgaggttagaggagatggggaggagggagagagg aaacccctggaagccgccctgccctccgaggatctgaccgacttaaaggagctgacagag gaaagtgaccttctttcggacatctttggcctggatctgaagagagaaggaggacagtac aaactgattcctcataatccaaatgctgggctcagtgacctcatgagcaacccagtcccc atgcctgaggtgcaggaaaaatttcaggaacagaaggcaaaagaagaagaaaaggaagaa aaagaagaaaccaaatctgaacctgaaaaagccgagggagaagatggagaaaaagaagag aaagccaaggaagacaagggcaaacaaaagttgaggcagcttcacacacacagatacgga gaaccagaagtgccagagtcagcattctggaagaaaatcatagcatatcaacagaaactt ctaaactattttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcattt gctatcaatttcatcttgctcttctataaggtctccacttcttctgtggttgaaggaaag gagctccccacgagaagttcaagtgaaaatgccaaagtgaccagcctggacagcagctcc catagaatcatcgcagttcactatgtactagaggagagcagcggctacatggagcccacg ttgcgtatcttagctattctgcacacggtcatttctttcttctgcatcattggatactac tgcttgaaagtcccattggttatttttaagcgagaaaaggaagtggcacggaaattggaa tttgatgggctttatattacagaacagccttcagaagatgatattaaaggccagtgggat agactcgtaatcaacacacagtcatttcccaacaactactgggacaaatttgttaaaaga aaggttatggataagtatggagagttctacggccgagacagaatcagtgaattacttggc atggacaaggcagctctggacttcagtgatgccagagaaaagaagaagccaaagaaagac agctccttatcagctgtactgaactccattgatgtgaagtatcagatgtggaaactagga gtcgttttcactgacaattccttcctctacctagcctggtatatgactatgtctgttctt ggacactataacaactttttttttgccgctcaccttctcgacattgctatgggattcaag acattaagaaccatcttgtcctcagtaactcacaatggcaaacagctcgtattaaccgtt ggcttattagctgttgttgtatacctatacactgtggtggcattcaattttttccgaaaa ttctacaataaaagtgaagatggtgatacaccagatatgaaatgtgatgatatgctaaca tgctatatgttccacatgtatgttggagttcgtgctggaggagggatcggggatgaaatc gaagacccagcaggagatgaatatgagatctatcgaatcatctttgacatcactttcttc ttctttgttattgtcattctcttggccataatacaaggtctaattatcgatgcttttgga gaactaagagaccaacaggaacaagtcaaagaagacatggagaccaaatgcttcatctgt gggataggcaatgattacttcgacacagtgccacatggctttgaaacccacactttacag gagcacaacttggctaattacttgttttttctgatgtatcttataaacaaagatgaaaca gaacacacaggacaggaatcttatgtctggaagatgtatcaagaaaggtgttgggaattt ttcccagcaggggattgcttccggaaacagtatgaagaccagctaaattaa

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