KEGG   Pan paniscus (bonobo): 100975618
Entry
100975618         CDS       T02283                                 
Symbol
PRKAA1
Name
(RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2
  KO
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps04068  FoxO signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04371  Apelin signaling pathway
pps04530  Tight junction
pps04710  Circadian rhythm
pps04714  Thermogenesis
pps04910  Insulin signaling pathway
pps04920  Adipocytokine signaling pathway
pps04921  Oxytocin signaling pathway
pps04922  Glucagon signaling pathway
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04936  Alcoholic liver disease
pps05410  Hypertrophic cardiomyopathy
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    100975618 (PRKAA1)
   04068 FoxO signaling pathway
    100975618 (PRKAA1)
   04151 PI3K-Akt signaling pathway
    100975618 (PRKAA1)
   04152 AMPK signaling pathway
    100975618 (PRKAA1)
   04150 mTOR signaling pathway
    100975618 (PRKAA1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100975618 (PRKAA1)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    100975618 (PRKAA1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100975618 (PRKAA1)
   04922 Glucagon signaling pathway
    100975618 (PRKAA1)
   04920 Adipocytokine signaling pathway
    100975618 (PRKAA1)
   04921 Oxytocin signaling pathway
    100975618 (PRKAA1)
  09149 Aging
   04211 Longevity regulating pathway
    100975618 (PRKAA1)
   04213 Longevity regulating pathway - multiple species
    100975618 (PRKAA1)
  09159 Environmental adaptation
   04710 Circadian rhythm
    100975618 (PRKAA1)
   04714 Thermogenesis
    100975618 (PRKAA1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100975618 (PRKAA1)
   05410 Hypertrophic cardiomyopathy
    100975618 (PRKAA1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100975618 (PRKAA1)
   04932 Non-alcoholic fatty liver disease
    100975618 (PRKAA1)
   04931 Insulin resistance
    100975618 (PRKAA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pps01001]
    100975618 (PRKAA1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pps04131]
    100975618 (PRKAA1)
   03029 Mitochondrial biogenesis [BR:pps03029]
    100975618 (PRKAA1)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.31  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
     100975618 (PRKAA1)
Protein kinases [BR:pps01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   100975618 (PRKAA1)
Membrane trafficking [BR:pps04131]
 Autophagy
  Other autophagy associated proteins
   Others
    100975618 (PRKAA1)
Mitochondrial biogenesis [BR:pps03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    100975618 (PRKAA1)
  Mitophagy factors
   Other mitophagy factors
    100975618 (PRKAA1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr AMPK_alpha_AID AdenylateSensor ABC1 Kinase-like Kdo APH
Other DBs
NCBI-GeneID: 100975618
NCBI-ProteinID: XP_003811017
Ensembl: ENSPPAG00000035948
UniProt: A0A2R9B7U6
LinkDB
Position
4:69533595..69577363
AA seq 559 aa
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSCSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ
NT seq 1680 nt   +upstreamnt  +downstreamnt
atgcgcagactcagttcctggagaaagatggcgacagccgagaagcagaaacacgacggg
cgggtgaagatcggccactacattctgggtgacacgctgggggtcggcaccttcggcaaa
gtgaaggttggcaaacatgaattgactgggcataaagtagctgtgaagatactcaatcga
cagaagattcggagccttgatgtggtaggaaaaatccgcagagaaattcagaacctcaag
cttttcaggcatcctcatataattaaactgtaccaggtcatcagtacaccatctgatatt
ttcatggtgatggaatatgtctcaggaggagagctatttgattatatctgtaagaatgga
aggctggatgaaaaagaaagtcggcgtctgttccaacagatcctttctggtgtggattat
tgtcacaggcatatggtggtccatagagatttgaaacctgaaaatgtcctgcttgatgca
cacatgaatgcaaaaatagctgattttggtctttcaaacatgatgtcagatggtgaattt
ttaagaacaagttgtggctcacccaactatgctgcaccagaagtaatttcaggaagattg
tatgcaggcccagaggtagatatatggagcagtggggttattctctatgctttattatgt
ggaacccttccatttgatgatgaccatgtgccaactctttttaagaagatatgtgatggg
atcttctatacccctcaatatttaaatccttctgtgattagccttttgaaacatatgctg
caggtggatcccatgaagagggccacaatcaaagatatcagggaacatgaatggtttaaa
caggaccttccaaaatatctctttcctgaggatccatcatgtagttcaaccatgattgat
gatgaagccttaaaagaagtatgtgaaaagtttgagtgctcagaagaggaagttctcagc
tgtctttacaacagaaatcaccaggatcctttggcagttgcctaccatctcataatagat
aacaggagaataatgaatgaagccaaagatttctatttggcgacaagcccacctgattct
tttcttgatgatcatcacctgactcggccccatcctgaaagagtaccattcttggttgct
gaaacaccaagggcacgccatacccttgatgaattaaatccacagaaatccaaacaccaa
ggtgtaaggaaagcaaaatggcatttaggaattagaagtcaaagtcgaccaaatgatatt
atggcagaagtatgtagagcaatcaaacaattggattatgaatggaaggttgtaaaccca
tattatttgcgtgtacgaaggaagaatcctgtgacaagcacttactccaaaatgagtcta
cagttataccaagtggatagtagaacttatctactggatttccgtagtattgatgatgaa
attacagaagccaaatcagggactgctactccacagagatcgggatcagttagcaactat
cgatcttgccaaaggagtgattcagatgctgaggctcaaggaaaatcctcagaagtttct
cttacctcatctgtgacctcacttgactcttctcctgttgacctaactccaagacctgga
agtcacacaatagaattttttgagatgtgtgcaaatctaattaaaattcttgcacaataa

DBGET integrated database retrieval system