KEGG   Pan paniscus (bonobo): 100978643
Entry
100978643         CDS       T02283                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00562  Inositol phosphate metabolism
pps01100  Metabolic pathways
pps04015  Rap1 signaling pathway
pps04020  Calcium signaling pathway
pps04022  cGMP-PKG signaling pathway
pps04062  Chemokine signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04081  Hormone signaling
pps04082  Neuroactive ligand signaling
pps04261  Adrenergic signaling in cardiomyocytes
pps04270  Vascular smooth muscle contraction
pps04310  Wnt signaling pathway
pps04371  Apelin signaling pathway
pps04540  Gap junction
pps04611  Platelet activation
pps04613  Neutrophil extracellular trap formation
pps04621  NOD-like receptor signaling pathway
pps04713  Circadian entrainment
pps04720  Long-term potentiation
pps04723  Retrograde endocannabinoid signaling
pps04724  Glutamatergic synapse
pps04725  Cholinergic synapse
pps04726  Serotonergic synapse
pps04728  Dopaminergic synapse
pps04730  Long-term depression
pps04742  Taste transduction
pps04750  Inflammatory mediator regulation of TRP channels
pps04911  Insulin secretion
pps04912  GnRH signaling pathway
pps04915  Estrogen signaling pathway
pps04916  Melanogenesis
pps04918  Thyroid hormone synthesis
pps04919  Thyroid hormone signaling pathway
pps04921  Oxytocin signaling pathway
pps04922  Glucagon signaling pathway
pps04924  Renin secretion
pps04925  Aldosterone synthesis and secretion
pps04926  Relaxin signaling pathway
pps04927  Cortisol synthesis and secretion
pps04928  Parathyroid hormone synthesis, secretion and action
pps04929  GnRH secretion
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04934  Cushing syndrome
pps04935  Growth hormone synthesis, secretion and action
pps04961  Endocrine and other factor-regulated calcium reabsorption
pps04970  Salivary secretion
pps04971  Gastric acid secretion
pps04972  Pancreatic secretion
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05016  Huntington disease
pps05017  Spinocerebellar ataxia
pps05022  Pathways of neurodegeneration - multiple diseases
pps05142  Chagas disease
pps05143  African trypanosomiasis
pps05146  Amoebiasis
pps05163  Human cytomegalovirus infection
pps05200  Pathways in cancer
pps05415  Diabetic cardiomyopathy
pps05417  Lipid and atherosclerosis
Module
pps_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100978643 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100978643 (PLCB4)
   04310 Wnt signaling pathway
    100978643 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100978643 (PLCB4)
   04072 Phospholipase D signaling pathway
    100978643 (PLCB4)
   04071 Sphingolipid signaling pathway
    100978643 (PLCB4)
   04022 cGMP-PKG signaling pathway
    100978643 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100978643 (PLCB4)
   04081 Hormone signaling
    100978643 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100978643 (PLCB4)
   04613 Neutrophil extracellular trap formation
    100978643 (PLCB4)
   04062 Chemokine signaling pathway
    100978643 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    100978643 (PLCB4)
   04922 Glucagon signaling pathway
    100978643 (PLCB4)
   04929 GnRH secretion
    100978643 (PLCB4)
   04915 Estrogen signaling pathway
    100978643 (PLCB4)
   04921 Oxytocin signaling pathway
    100978643 (PLCB4)
   04926 Relaxin signaling pathway
    100978643 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    100978643 (PLCB4)
   04918 Thyroid hormone synthesis
    100978643 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100978643 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    100978643 (PLCB4)
   04924 Renin secretion
    100978643 (PLCB4)
   04925 Aldosterone synthesis and secretion
    100978643 (PLCB4)
   04927 Cortisol synthesis and secretion
    100978643 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    100978643 (PLCB4)
   04971 Gastric acid secretion
    100978643 (PLCB4)
   04972 Pancreatic secretion
    100978643 (PLCB4)
   04973 Carbohydrate digestion and absorption
    100978643 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100978643 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    100978643 (PLCB4)
   04725 Cholinergic synapse
    100978643 (PLCB4)
   04728 Dopaminergic synapse
    100978643 (PLCB4)
   04726 Serotonergic synapse
    100978643 (PLCB4)
   04720 Long-term potentiation
    100978643 (PLCB4)
   04730 Long-term depression
    100978643 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100978643 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    100978643 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    100978643 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100978643 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100978643 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100978643 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100978643 (PLCB4)
   05142 Chagas disease
    100978643 (PLCB4)
   05143 African trypanosomiasis
    100978643 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100978643 (PLCB4)
   05016 Huntington disease
    100978643 (PLCB4)
   05017 Spinocerebellar ataxia
    100978643 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    100978643 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100978643 (PLCB4)
   05415 Diabetic cardiomyopathy
    100978643 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100978643 (PLCB4)
   04934 Cushing syndrome
    100978643 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pps04131]
    100978643 (PLCB4)
Enzymes [BR:pps01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100978643 (PLCB4)
Membrane trafficking [BR:pps04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100978643 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100978643 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 100978643
NCBI-ProteinID: XP_034803165
Ensembl: ENSPPAG00000024031
LinkDB
Position
21:9967849..10403434
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPSCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPVAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSM
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccagctgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaac
gtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacatttgcatcgggaaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccgtggcattttcttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgacgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aacgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttatctcactggcagacagttcggcgggaag
tcttcggtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcagggctttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagcggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggacgataatgaagaggaa
atcgaaagtgctgaccaagaggaggaagctcaccctgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggtcactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatatt
cattataacatgtcgtcttttaatgaatcagtcggtcttggctacttgaagacacatgca
attgaatttgtcaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgac
cccttctctgaaactcctgttgatggtgttattgcagccacttgctcagtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctacgtagaggtggatatgtatggg
ttgcccactgacaccatacgtaaggaattccgaactcgcatggttatgaataatggactc
aatccagtttacaatgaagagtcatttgtatttcggaaggtgatcctgccagacctggct
gtcttgagaatagctgtgtatgatgataacaacaagctgattggccagaggatcctcccg
cttgatggcctccaagccggatatcgacacatttcccttcgaaatgagggaaataaacca
ttatcactaccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatatcgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagccgacgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaacaccgccaaagcaaatgtgacccctcag
agtagctctgagctcagaccaaccaccacggctgccctggcctctggtgtggaagccaag
aaaggtattgaacttatccctcaagtaaggatagaagacttgaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaggagctaaattctttaaagaagaaacatgcaaag
gaacacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaatcaaaattcagacgctgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctactcatcaatgcccacgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagacttgccatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaatgcaaactga

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