| Entry |
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| Symbol |
ARHGEF12
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| Name |
(RefSeq) rho guanine nucleotide exchange factor 12 isoform X1
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| KO |
| K07532 | Rho guanine nucleotide exchange factor 12 |
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| Organism |
pps Pan paniscus (bonobo)
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| Pathway |
| pps04270 | Vascular smooth muscle contraction |
| pps04625 | C-type lectin receptor signaling pathway |
| pps04810 | Regulation of actin cytoskeleton |
| pps05163 | Human cytomegalovirus infection |
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| Brite |
KEGG Orthology (KO) [BR:pps00001]
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100981550 (ARHGEF12)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100981550 (ARHGEF12)
04625 C-type lectin receptor signaling pathway
100981550 (ARHGEF12)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100981550 (ARHGEF12)
09158 Development and regeneration
04360 Axon guidance
100981550 (ARHGEF12)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100981550 (ARHGEF12)
05205 Proteoglycans in cancer
100981550 (ARHGEF12)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
100981550 (ARHGEF12)
09171 Infectious disease: bacterial
05135 Yersinia infection
100981550 (ARHGEF12)
05152 Tuberculosis
100981550 (ARHGEF12)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:pps04131]
100981550 (ARHGEF12)
Membrane trafficking [BR:pps04131]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
100981550 (ARHGEF12)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
9:121040732..121193474
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| AA seq |
1544 aa
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEE
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ
EAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDVS
RPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGT
EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRR
IFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL
EDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDK
SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSI
LGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGY
LPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ
VQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ
LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKS
RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKV
KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKM
IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
KLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSAK
PIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTS
GKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLK
QLLVQQLGLTEKSVQEDWQHFPRYRAASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTG
DIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEH
FFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQ
PMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQ
SQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS |
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| NT seq |
4635 nt +upstreamnt +downstreamnt
atgagtggcacacagtctactatcaccgacaggtttcccctcaaaaaacctataaggcat
ggaagtattttgaaccgagagtcaccaacagataagaagcagaaagttgagcgcattgca
tcacatgattttgaccccacagatagctcctccaagaagacaaagtctagttcagaggag
agtagatccgagatatatggtcttgttcagcgttgcgtaatcatccagaaagatgacaat
ggatttgggctgacggtcagtggagacaatccagtcttcgtacagtctgtcaaagaagat
ggagcagccatgcgggctggagtacagacaggtgatcgaatcatcaaggtgaatggaact
ctggtgactcactcaaatcatctggaggtggtgaagctaatcaaatctggttcctatgta
gctctcactgttcagggacgcccacctgggtcgccccagattccacttgccgactctgaa
gtagagccgtcagtcattggacatatgtctcccatcatgacatctcctcattcacctgga
gcatctgggaatatggagagaatcactagtcctgtgctcatgggggaggaaaacaatgtg
gttcataaccagaaagtagaaattctcagaaaaatgttacagaaagaacaggaacggcta
cagttattgcaggaagattacaaccgaacacctgcccaaagattgctaaaagagatccaa
gaggccaagaaacacattcctcagctgcaagagcagttatccaaagccacaggctctgct
caggatggagctgtagttacaccctccagacctttaggggacaccctaacagtcagtgag
gcagaaacagatcctggagatgtactgggcaggactgactgtagcagtggagatgtttct
cggcccagtagtgacaatgcagatagtcccaagagtggcccaaaagagagaatttatcta
gaggaaaacccagagaaaagtgaaacaattcaggacactgacactcaatcacttgtcgga
agtccctcaacccgtatagcacctcatattattggagcagaagatgatgattttggtact
gaacatgaacagatcaatggacagtgcagctgtttccagagcattgaattactaaaatct
cgcccggctcatttggctgttttcttacaccatgtagtttcacaatttgaccctgcgact
ttgctctgttatctctattcagacctgtataaacataccaattccaaagaaactcgtcgc
atcttccttgagtttcatcagttctttctagatcgatcagcacacctgaaagtttctgtt
cctgatgaaatgtctgcagatctagaaaagagaagacctgagctcattcctgaggatctg
catcgccactatatccaaactatgcaagaaagagtccatccagaagttcaaaggcactta
gaagattttcggcagaaacgtagtatgggactgaccttggctgaaagcgagctgactaaa
cttgatgcagagcgagacaaggaccgattgactttggagaaggagcggacatgtgcagaa
cagattgttgccaaaattgaagaagtattgatgactgctcaggctgtagaggaagataag
agctccaccatgcagtatgttattctcatgtatatgaagcatttgggagtaaaagtgaaa
gagcctcgaaatttggagcacaaacggggtcggattggatttcttcccaaaatcaagcaa
agtatgaagaaagataaagaaggggaagaaaaagggaagcgaagaggattccccagcatc
ctgggacccccacggagaccaagccgtcatgacaacagtgcaattggcagagccatggaa
ctacagaaggcgcgccaccctaagcacttatccacaccctcatctgtgagtcctgaacct
caggactctgccaagttgcgccagagtgggttagcaaatgaaggaacagacgctggatac
ctgcctgccaattccatgtcttctgtagcttcaggggcctctttttcccaggaaggaggg
aaagagaatgatacaggatcaaagcaagttggagaaacatcagcacctggagacacctta
gatggcacacctcgtactctcaatactgtctttgatttcccaccacctccattagaccaa
gtgcaggaggaggaatgtgaagtagaaagggtgacagaacatgggacaccaaagcccttt
cgaaagtttgacagtgtagcttttggagaaagtcaaagtgaggatgaacaatttgaaaat
gacttagagacagatccacccaactggcagcagcttgttagtcgagaagtgttactggga
ctaaaaccttgtgaaatcaaaagacaggaagtgattaatgaattgttctacactgaaaga
gctcatgttcgaacactgaaggttcttgatcaagtgttctatcagcgagtatccagagaa
ggaattctgtcaccctcagagctacggaaaattttttcaaacttggaagatattcttcaa
cttcatattggattgaatgaacaaatgaaggctgttcgaaagagaaatgagacctctgtt
atcgatcagattggggaagatttgctgacatggttcagcggaccaggagaggagaaattg
aaacatgctgctgctaccttttgcagtaaccaacctttcgccctggaaatgatcaagtct
cgtcagaaaaaggattctcgatttcagacttttgtgcaagatgctgaaagtaatccactg
tgtcgtcgtcttcaactgaaggatattattcccactcaaatgcaaaggcttactaagtac
ccacttctgttggataatattgccaaatacacagaatggccaacagaaagggagaaggtg
aagaaagctgcagatcactgtcgtcagatcttaaattatgtaaatcaggccgtcaaggag
gcagaaaacaagcagcgcctagaagattatcagcgtcgccttgatacctccagcctgaag
ttgtcagagtacccaaatgttgaagagctcaggaatttggatttaacaaaaaggaagatg
attcatgaagggccactggtttggaaggtgaatagagataaaactattgatttatacaca
ttgctgctggaagacattcttgtattgttacaaaagcaggatgatagactggttttaagg
tgtcatagtaagattctggcatctacagctgatagcaaacacacgtttagccctgtcatt
aagttgagtacagtgttggttcgacaagtggcaacagataacaaagctttattcgtcatt
tccatgtcagacaatggcgctcagatttatgaactggtggcacagacagtttctgaaaag
actgtctggcaggacctaatctgtcggatggctgcatcagtgaaggagcaatccgcaaag
ccaattccattaccacagtcaacacctggcgaaggagataatgatgaagaagatccttca
aaattaaaagaggagcagcatggcatttcagtcactggtttgcagagtccagacagagat
ttgggattagaatctaccttaatatcgtcaaaacctcagtctcattcactgagtacctct
gggaaatcagaggtacgtgatctgtttgtggctgagagacagtttgcaaaggaacaacat
acagatgggacactaaaggaagttggagaagattatcaaatcgcaatcccagattcacac
ctgcctgtctcagaagaacggtgggcattggatgcactaagaaatttgggtttgttgaag
cagttgctggtgcaacagctaggtttgactgagaagagcgttcaggaagactggcaacat
ttcccaagatacagagcagcctctcaggggccgcagacagacagtgtcatccagaactct
gaaaatattaaggcctatcattctggtgaaggacatatgccctttagaactggaactggt
gacattgcaacgtgttacagtccacggacttcaactgaatcttttgctccacgggattca
gtgggactggcaccccaggatagccaggcaagtaacattttagtaatggaccacatgatt
atgaccccagagatgcctaccatggagccagaagggggtcttgatgacagtggagagcac
ttttttgatgcccgtgaagcacatagtgatgagaatccatcagaaggtgatggagcagtt
aacaaggaagagaaggatgttaatttacgcatctcaggaaactatttgatccttgatggc
tatgacccagtgcaggagagttccacagatgaggaggttgcttcctcacttaccctgcag
cccatgacaggcatccctgctgtggaatccacccaccagcagcaacattctcctcagaat
actcactccgatggggcaatttcaccattcacccccgaatttctggtccagcagcgctgg
ggagctatggagtattcctgttttgagatccagagtccctcctcttgtgcagattcacag
agccagatcatggagtacattcataagatagaggctgaccttgaacacttaaagaaggtg
gaggaaagttacaccattctttgccaaaggctggctggatcagccctcacagacaagcac
tcagataaaagttag |
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