KEGG   Pongo pygmaeus (Bornean orangutan): 129016682
Entry
129016682         CDS       T10128                                 
Symbol
MAP2K4
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 4 isoform X1
  KO
K04430  mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Organism
ppyg  Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg04010  MAPK signaling pathway
ppyg04012  ErbB signaling pathway
ppyg04620  Toll-like receptor signaling pathway
ppyg04664  Fc epsilon RI signaling pathway
ppyg04668  TNF signaling pathway
ppyg04912  GnRH signaling pathway
ppyg04926  Relaxin signaling pathway
ppyg04935  Growth hormone synthesis, secretion and action
ppyg04936  Alcoholic liver disease
ppyg05132  Salmonella infection
ppyg05135  Yersinia infection
ppyg05142  Chagas disease
ppyg05161  Hepatitis B
ppyg05166  Human T-cell leukemia virus 1 infection
ppyg05167  Kaposi sarcoma-associated herpesvirus infection
ppyg05169  Epstein-Barr virus infection
ppyg05208  Chemical carcinogenesis - reactive oxygen species
ppyg05417  Lipid and atherosclerosis
ppyg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppyg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129016682 (MAP2K4)
   04012 ErbB signaling pathway
    129016682 (MAP2K4)
   04668 TNF signaling pathway
    129016682 (MAP2K4)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    129016682 (MAP2K4)
   04664 Fc epsilon RI signaling pathway
    129016682 (MAP2K4)
  09152 Endocrine system
   04912 GnRH signaling pathway
    129016682 (MAP2K4)
   04926 Relaxin signaling pathway
    129016682 (MAP2K4)
   04935 Growth hormone synthesis, secretion and action
    129016682 (MAP2K4)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    129016682 (MAP2K4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129016682 (MAP2K4)
   05161 Hepatitis B
    129016682 (MAP2K4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129016682 (MAP2K4)
   05169 Epstein-Barr virus infection
    129016682 (MAP2K4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129016682 (MAP2K4)
   05135 Yersinia infection
    129016682 (MAP2K4)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    129016682 (MAP2K4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129016682 (MAP2K4)
   05418 Fluid shear stress and atherosclerosis
    129016682 (MAP2K4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    129016682 (MAP2K4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppyg01001]
    129016682 (MAP2K4)
Enzymes [BR:ppyg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     129016682 (MAP2K4)
Protein kinases [BR:ppyg01001]
 Serine/threonine kinases: STE group
  STE7 family
   129016682 (MAP2K4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like Seadorna_VP7 Pkinase_fungal ABC1 Haspin_kinase Choline_kinase APH
Other DBs
NCBI-GeneID: 129016682
NCBI-ProteinID: XP_054312233
LinkDB
Position
19:11991724..12112763
AA seq 399 aa
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
NT seq 1200 nt   +upstreamnt  +downstreamnt
atggcggctccgagcccgagcggcggcggcggctccgggggcggcagcggcagcggcacc
ccgggccccgtagggtccccggcgccgggccacccggccgtcagcagcatgcagggtaaa
cgcaaagcactgaagttgaattttgcaaatccacctttcaaatctacagcaaggtttact
ctgaatcccaatcctacaggagttcaaaacccacacatagagagactgagaacacacagc
attgagtcatcaggaaaactgaagatctcccctgaacaacactgggatttcactgcagag
gacttgaaagaccttggagaaattggacgaggagcttatggttctgtcaacaaaatggtc
cacaaaccaagtgggcaaataatggcagttaaaagaattcggtcaacagtggatgaaaaa
gaacaaaaacaacttcttatggatttggatgtagtaatgcggagtagtgattgcccatac
attgttcagttttatggtgcactcttcagagagggtgactgttggatctgtatggaactc
atgtctacctcgtttgacaagttttacaaatatgtatatagtgtattagatgatgttatt
ccagaagaaattttaggcaaaatcactttagcaactgtgaaagcactaaaccacttaaaa
gaaaacttgaaaattattcacagagatatcaaaccttccaatattcttctggacagaagt
ggaaatattaagctctgtgacttcggcatcagtggacagcttgtggactctattgccaag
acaagagatgctggctgtaggccatacatggcacctgaaagaatagacccaagcgcatca
cgacaaggatatgatgtccgctctgatgtctggagtttggggatcacattgtatgagttg
gccacgggccgatttccttatccaaagtggaatagtgtatttgatcaactaacacaagtc
gtgaaaggagatcctccgcagctgagtaattctgaggaaagggaattctccccgagtttc
atcaactttgtcaacttgtgccttacgaaggatgaatccaaaaggccaaagtataaagag
cttctgaaacatccctttattttgatgtatgaagaacgtgccgttgaggtcgcatgctat
gtttgtaaaatcctggatcaaatgccagctactcccagctctcccatgtatgtcgattga

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