Pongo pygmaeus (Bornean orangutan): 129022833
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Entry
129022833 CDS
T10128
Symbol
MAPK1
Name
(RefSeq) mitogen-activated protein kinase 1
KO
K04371
mitogen-activated protein kinase 1/3 [EC:
2.7.11.24
]
Organism
ppyg Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg01521
EGFR tyrosine kinase inhibitor resistance
ppyg01522
Endocrine resistance
ppyg01524
Platinum drug resistance
ppyg04010
MAPK signaling pathway
ppyg04012
ErbB signaling pathway
ppyg04014
Ras signaling pathway
ppyg04015
Rap1 signaling pathway
ppyg04022
cGMP-PKG signaling pathway
ppyg04024
cAMP signaling pathway
ppyg04062
Chemokine signaling pathway
ppyg04066
HIF-1 signaling pathway
ppyg04068
FoxO signaling pathway
ppyg04071
Sphingolipid signaling pathway
ppyg04072
Phospholipase D signaling pathway
ppyg04114
Oocyte meiosis
ppyg04140
Autophagy - animal
ppyg04148
Efferocytosis
ppyg04150
mTOR signaling pathway
ppyg04151
PI3K-Akt signaling pathway
ppyg04210
Apoptosis
ppyg04218
Cellular senescence
ppyg04261
Adrenergic signaling in cardiomyocytes
ppyg04270
Vascular smooth muscle contraction
ppyg04350
TGF-beta signaling pathway
ppyg04360
Axon guidance
ppyg04370
VEGF signaling pathway
ppyg04371
Apelin signaling pathway
ppyg04380
Osteoclast differentiation
ppyg04510
Focal adhesion
ppyg04520
Adherens junction
ppyg04540
Gap junction
ppyg04550
Signaling pathways regulating pluripotency of stem cells
ppyg04611
Platelet activation
ppyg04613
Neutrophil extracellular trap formation
ppyg04620
Toll-like receptor signaling pathway
ppyg04621
NOD-like receptor signaling pathway
ppyg04625
C-type lectin receptor signaling pathway
ppyg04650
Natural killer cell mediated cytotoxicity
ppyg04657
IL-17 signaling pathway
ppyg04658
Th1 and Th2 cell differentiation
ppyg04659
Th17 cell differentiation
ppyg04660
T cell receptor signaling pathway
ppyg04662
B cell receptor signaling pathway
ppyg04664
Fc epsilon RI signaling pathway
ppyg04666
Fc gamma R-mediated phagocytosis
ppyg04668
TNF signaling pathway
ppyg04713
Circadian entrainment
ppyg04720
Long-term potentiation
ppyg04722
Neurotrophin signaling pathway
ppyg04723
Retrograde endocannabinoid signaling
ppyg04724
Glutamatergic synapse
ppyg04725
Cholinergic synapse
ppyg04726
Serotonergic synapse
ppyg04730
Long-term depression
ppyg04810
Regulation of actin cytoskeleton
ppyg04910
Insulin signaling pathway
ppyg04912
GnRH signaling pathway
ppyg04914
Progesterone-mediated oocyte maturation
ppyg04915
Estrogen signaling pathway
ppyg04916
Melanogenesis
ppyg04917
Prolactin signaling pathway
ppyg04919
Thyroid hormone signaling pathway
ppyg04921
Oxytocin signaling pathway
ppyg04926
Relaxin signaling pathway
ppyg04928
Parathyroid hormone synthesis, secretion and action
ppyg04929
GnRH secretion
ppyg04930
Type II diabetes mellitus
ppyg04933
AGE-RAGE signaling pathway in diabetic complications
ppyg04934
Cushing syndrome
ppyg04935
Growth hormone synthesis, secretion and action
ppyg04960
Aldosterone-regulated sodium reabsorption
ppyg05010
Alzheimer disease
ppyg05020
Prion disease
ppyg05022
Pathways of neurodegeneration - multiple diseases
ppyg05034
Alcoholism
ppyg05132
Salmonella infection
ppyg05133
Pertussis
ppyg05135
Yersinia infection
ppyg05140
Leishmaniasis
ppyg05142
Chagas disease
ppyg05145
Toxoplasmosis
ppyg05152
Tuberculosis
ppyg05160
Hepatitis C
ppyg05161
Hepatitis B
ppyg05163
Human cytomegalovirus infection
ppyg05164
Influenza A
ppyg05165
Human papillomavirus infection
ppyg05166
Human T-cell leukemia virus 1 infection
ppyg05167
Kaposi sarcoma-associated herpesvirus infection
ppyg05170
Human immunodeficiency virus 1 infection
ppyg05171
Coronavirus disease - COVID-19
ppyg05200
Pathways in cancer
ppyg05203
Viral carcinogenesis
ppyg05205
Proteoglycans in cancer
ppyg05206
MicroRNAs in cancer
ppyg05207
Chemical carcinogenesis - receptor activation
ppyg05208
Chemical carcinogenesis - reactive oxygen species
ppyg05210
Colorectal cancer
ppyg05211
Renal cell carcinoma
ppyg05212
Pancreatic cancer
ppyg05213
Endometrial cancer
ppyg05214
Glioma
ppyg05215
Prostate cancer
ppyg05216
Thyroid cancer
ppyg05218
Melanoma
ppyg05219
Bladder cancer
ppyg05220
Chronic myeloid leukemia
ppyg05221
Acute myeloid leukemia
ppyg05223
Non-small cell lung cancer
ppyg05224
Breast cancer
ppyg05225
Hepatocellular carcinoma
ppyg05226
Gastric cancer
ppyg05230
Central carbon metabolism in cancer
ppyg05231
Choline metabolism in cancer
ppyg05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
ppyg05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
ppyg00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
129022833 (MAPK1)
04012 ErbB signaling pathway
129022833 (MAPK1)
04014 Ras signaling pathway
129022833 (MAPK1)
04015 Rap1 signaling pathway
129022833 (MAPK1)
04350 TGF-beta signaling pathway
129022833 (MAPK1)
04370 VEGF signaling pathway
129022833 (MAPK1)
04371 Apelin signaling pathway
129022833 (MAPK1)
04668 TNF signaling pathway
129022833 (MAPK1)
04066 HIF-1 signaling pathway
129022833 (MAPK1)
04068 FoxO signaling pathway
129022833 (MAPK1)
04072 Phospholipase D signaling pathway
129022833 (MAPK1)
04071 Sphingolipid signaling pathway
129022833 (MAPK1)
04024 cAMP signaling pathway
129022833 (MAPK1)
04022 cGMP-PKG signaling pathway
129022833 (MAPK1)
04151 PI3K-Akt signaling pathway
129022833 (MAPK1)
04150 mTOR signaling pathway
129022833 (MAPK1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
129022833 (MAPK1)
04148 Efferocytosis
129022833 (MAPK1)
09143 Cell growth and death
04114 Oocyte meiosis
129022833 (MAPK1)
04210 Apoptosis
129022833 (MAPK1)
04218 Cellular senescence
129022833 (MAPK1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
129022833 (MAPK1)
04520 Adherens junction
129022833 (MAPK1)
04540 Gap junction
129022833 (MAPK1)
04550 Signaling pathways regulating pluripotency of stem cells
129022833 (MAPK1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
129022833 (MAPK1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
129022833 (MAPK1)
04613 Neutrophil extracellular trap formation
129022833 (MAPK1)
04620 Toll-like receptor signaling pathway
129022833 (MAPK1)
04621 NOD-like receptor signaling pathway
129022833 (MAPK1)
04625 C-type lectin receptor signaling pathway
129022833 (MAPK1)
04650 Natural killer cell mediated cytotoxicity
129022833 (MAPK1)
04660 T cell receptor signaling pathway
129022833 (MAPK1)
04658 Th1 and Th2 cell differentiation
129022833 (MAPK1)
04659 Th17 cell differentiation
129022833 (MAPK1)
04657 IL-17 signaling pathway
129022833 (MAPK1)
04662 B cell receptor signaling pathway
129022833 (MAPK1)
04664 Fc epsilon RI signaling pathway
129022833 (MAPK1)
04666 Fc gamma R-mediated phagocytosis
129022833 (MAPK1)
04062 Chemokine signaling pathway
129022833 (MAPK1)
09152 Endocrine system
04910 Insulin signaling pathway
129022833 (MAPK1)
04929 GnRH secretion
129022833 (MAPK1)
04912 GnRH signaling pathway
129022833 (MAPK1)
04915 Estrogen signaling pathway
129022833 (MAPK1)
04914 Progesterone-mediated oocyte maturation
129022833 (MAPK1)
04917 Prolactin signaling pathway
129022833 (MAPK1)
04921 Oxytocin signaling pathway
129022833 (MAPK1)
04926 Relaxin signaling pathway
129022833 (MAPK1)
04935 Growth hormone synthesis, secretion and action
129022833 (MAPK1)
04919 Thyroid hormone signaling pathway
129022833 (MAPK1)
04928 Parathyroid hormone synthesis, secretion and action
129022833 (MAPK1)
04916 Melanogenesis
129022833 (MAPK1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
129022833 (MAPK1)
04270 Vascular smooth muscle contraction
129022833 (MAPK1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
129022833 (MAPK1)
09156 Nervous system
04724 Glutamatergic synapse
129022833 (MAPK1)
04725 Cholinergic synapse
129022833 (MAPK1)
04726 Serotonergic synapse
129022833 (MAPK1)
04720 Long-term potentiation
129022833 (MAPK1)
04730 Long-term depression
129022833 (MAPK1)
04723 Retrograde endocannabinoid signaling
129022833 (MAPK1)
04722 Neurotrophin signaling pathway
129022833 (MAPK1)
09158 Development and regeneration
04360 Axon guidance
129022833 (MAPK1)
04380 Osteoclast differentiation
129022833 (MAPK1)
09159 Environmental adaptation
04713 Circadian entrainment
129022833 (MAPK1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
129022833 (MAPK1)
05206 MicroRNAs in cancer
129022833 (MAPK1)
05205 Proteoglycans in cancer
129022833 (MAPK1)
05207 Chemical carcinogenesis - receptor activation
129022833 (MAPK1)
05208 Chemical carcinogenesis - reactive oxygen species
129022833 (MAPK1)
05203 Viral carcinogenesis
129022833 (MAPK1)
05230 Central carbon metabolism in cancer
129022833 (MAPK1)
05231 Choline metabolism in cancer
129022833 (MAPK1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
129022833 (MAPK1)
09162 Cancer: specific types
05210 Colorectal cancer
129022833 (MAPK1)
05212 Pancreatic cancer
129022833 (MAPK1)
05225 Hepatocellular carcinoma
129022833 (MAPK1)
05226 Gastric cancer
129022833 (MAPK1)
05214 Glioma
129022833 (MAPK1)
05216 Thyroid cancer
129022833 (MAPK1)
05221 Acute myeloid leukemia
129022833 (MAPK1)
05220 Chronic myeloid leukemia
129022833 (MAPK1)
05218 Melanoma
129022833 (MAPK1)
05211 Renal cell carcinoma
129022833 (MAPK1)
05219 Bladder cancer
129022833 (MAPK1)
05215 Prostate cancer
129022833 (MAPK1)
05213 Endometrial cancer
129022833 (MAPK1)
05224 Breast cancer
129022833 (MAPK1)
05223 Non-small cell lung cancer
129022833 (MAPK1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
129022833 (MAPK1)
05170 Human immunodeficiency virus 1 infection
129022833 (MAPK1)
05161 Hepatitis B
129022833 (MAPK1)
05160 Hepatitis C
129022833 (MAPK1)
05171 Coronavirus disease - COVID-19
129022833 (MAPK1)
05164 Influenza A
129022833 (MAPK1)
05163 Human cytomegalovirus infection
129022833 (MAPK1)
05167 Kaposi sarcoma-associated herpesvirus infection
129022833 (MAPK1)
05165 Human papillomavirus infection
129022833 (MAPK1)
09171 Infectious disease: bacterial
05132 Salmonella infection
129022833 (MAPK1)
05135 Yersinia infection
129022833 (MAPK1)
05133 Pertussis
129022833 (MAPK1)
05152 Tuberculosis
129022833 (MAPK1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
129022833 (MAPK1)
05140 Leishmaniasis
129022833 (MAPK1)
05142 Chagas disease
129022833 (MAPK1)
09164 Neurodegenerative disease
05010 Alzheimer disease
129022833 (MAPK1)
05020 Prion disease
129022833 (MAPK1)
05022 Pathways of neurodegeneration - multiple diseases
129022833 (MAPK1)
09165 Substance dependence
05034 Alcoholism
129022833 (MAPK1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
129022833 (MAPK1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
129022833 (MAPK1)
04933 AGE-RAGE signaling pathway in diabetic complications
129022833 (MAPK1)
04934 Cushing syndrome
129022833 (MAPK1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
129022833 (MAPK1)
01524 Platinum drug resistance
129022833 (MAPK1)
01522 Endocrine resistance
129022833 (MAPK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ppyg01001
]
129022833 (MAPK1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
ppyg03036
]
129022833 (MAPK1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ppyg04147
]
129022833 (MAPK1)
Enzymes [BR:
ppyg01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
129022833 (MAPK1)
Protein kinases [BR:
ppyg01001
]
Serine/threonine kinases: CMGC group
MAPK family [OT]
129022833 (MAPK1)
Chromosome and associated proteins [BR:
ppyg03036
]
Eukaryotic type
Centromeric chromatin formation proteins
SAC (spindle assembly checkpoint) factors
Protein kinases
129022833 (MAPK1)
Exosome [BR:
ppyg04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
129022833 (MAPK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
APH
STATB_N
Haspin_kinase
FTA2
Kdo
Motif
Other DBs
NCBI-GeneID:
129022833
NCBI-ProteinID:
XP_054325037
LinkDB
All DBs
Position
23:31071347..31178173
Genome browser
AA seq
364 aa
AA seq
DB search
MAAAAAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI
SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLL
KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP
DHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ
LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTF
NPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP
GYRS
NT seq
1095 nt
NT seq
+upstream
nt +downstream
nt
atggcggcggcggcggcggcggcggcggcggcgggcgcgggcccggagatggtccgcggg
caggtgttcgacgtggggccgcgctacaccaacctctcgtacatcggcgaaggcgcctac
ggcatggtgtgctctgcttatgataatgtcaacaaagttcgagtagctatcaagaaaatc
agcccctttgagcaccagacctactgccagagaaccctgagggagataaaaatcttactg
cgcttcagacatgagaacatcattggaatcaatgacattattcgagcaccaaccatcgag
caaatgaaagatgtatatatagtacaggacctcatggaaacagatctttacaagctcttg
aagacacaacacctcagcaacgaccatatctgctattttctttaccagatcctcagaggg
ttaaaatatatccattcagctaatgttctgcaccgtgacctcaagccttccaacctgctg
ctcaataccacctgtgatctcaagatctgtgactttggcctggcccgtgttgcagatcca
gaccatgatcacacagggttcctgacagaatatgtggccacacgttggtacagggctcca
gaaattatgttgaattccaagggctacaccaagtccattgatatttggtctgtaggctgc
attctggcagaaatgctttctaacaggcccatctttccagggaagcattatcttgaccag
ctgaaccacattctgggtattcttggatccccatcacaagaagacctgaactgtataata
aatttaaaagctaggaactatttgctttctcttccacacaaaaataaggtgccatggaac
aggctgttcccaaatgctgactccaaagctctggacttactggacaaaatgttgacattc
aacccacacaagaggattgaagtagaacaggctctggcccacccatatctggagcagtat
tacgacccgagtgacgagcccatcgccgaagcaccattcaagttcgacatggaattggat
gacttgcctaaggaaaagctcaaagaactaatttttgaagagactgctagattccagcca
ggatacagatcttaa
DBGET
integrated database retrieval system