Pongo pygmaeus (Bornean orangutan): 129024644
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Entry
129024644 CDS
T10128
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
ppyg Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg00010
Glycolysis / Gluconeogenesis
ppyg00020
Citrate cycle (TCA cycle)
ppyg00620
Pyruvate metabolism
ppyg00785
Lipoic acid metabolism
ppyg01100
Metabolic pathways
ppyg01200
Carbon metabolism
ppyg01210
2-Oxocarboxylic acid metabolism
ppyg04066
HIF-1 signaling pathway
ppyg04922
Glucagon signaling pathway
ppyg05230
Central carbon metabolism in cancer
ppyg05415
Diabetic cardiomyopathy
Module
ppyg_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
ppyg00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
129024644 (PDHA1)
00020 Citrate cycle (TCA cycle)
129024644 (PDHA1)
00620 Pyruvate metabolism
129024644 (PDHA1)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
129024644 (PDHA1)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
129024644 (PDHA1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
129024644 (PDHA1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
129024644 (PDHA1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
129024644 (PDHA1)
Enzymes [BR:
ppyg01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
129024644 (PDHA1)
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GFIT
Motif
Pfam:
E1_dh
DXP_synthase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID:
129024644
NCBI-ProteinID:
XP_054327780
LinkDB
All DBs
Position
X:19860306..19876271
Genome browser
AA seq
463 aa
AA seq
DB search
MGSRRSLERAGHPLDAVLVGPRPGAAHDVITTLSRRGATEAWRLLGHLKETWGYPRRASW
AVRSRRCRHCLCFMRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLE
EGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAG
INPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIV
GAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRY
GMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTY
RYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIE
DAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS
NT seq
1392 nt
NT seq
+upstream
nt +downstream
nt
atgggcagccgcaggtctttagagagggcggggcaccccctggacgccgttctggttggc
ccgcggcccggcgcagcgcatgacgttattacgactctgtcacgtcgcggtgcgactgag
gcgtggcgtctgctggggcacctgaaggagacttgggggtacccgcgtcgtgcctcttgg
gctgtgaggagtcgccgctgccgccactgcctgtgcttcatgaggaagatgctcgccgcc
gtctcccgcgtgttgtctggcgcttctcagaagccggcaagcagagtgctggtagcatcc
cgtaattttgcaaatgatgctacatttgaaattaagaaatgtgaccttcaccggctggaa
gaaggccctcctgtcacaacagtgctcaccagggaggatgggctcaaatactacaggatg
atgcagactgtgcgccgaatggagttgaaagcagatcagctgtataaacagaaaattatt
cgtggtttctgtcacttgtgtgatggtcaggaagcttgctgtgtgggcctggaggccggc
atcaaccccacagaccatctcatcacagcctaccgggctcatggctttactttcacccgg
ggcctttctgtccgagaaattctcgcagagcttacaggacgaaaaggaggttgtgctaaa
gggaaaggaggatcgatgcacatgtatgccaagaacttctacgggggcaatggcatcgtg
ggagcgcaggtgcccctgggcgctgggattgctctagcctgtaagtataatggaaaagat
gaggtctgcctgactttatatggcgatggtgctgctaaccagggccagatattcgaagct
tacaacatggcagctttgtggaaattaccttgtattttcatctgtgagaataatcgctat
ggaatgggaacgtctgttgagagagcagcagccagcactgattactacaagagaggcgat
ttcattcctgggctgagagtggatggaatggatatcctatgcgtccgagaggcgacaagg
tttgctgctgcctattgtagatctgggaaggggcccatcctgatggagctgcagacttac
cgttaccacggacacagtatgagtgatcctggagtcagttaccgtacacgagaagaaatt
caggaagtaagaagtaagagtgaccctattatgcttctcaaggacaggatggtgaacagc
aatcttgccagtgtggaagaactaaaggaaattgatgtggaagtgaggaaggagattgag
gatgctgcccagtttgccacggccgatcctgagccacctttggaagagctgggctaccac
atctactccagcgacccaccttttgaagttcgtggtgccaatcagtggatcaagtttaag
tcagtcagttaa
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