Pongo pygmaeus (Bornean orangutan): 129034648
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Entry
129034648 CDS
T10128
Symbol
JAK1
Name
(RefSeq) tyrosine-protein kinase JAK1 isoform X1
KO
K11217
Janus kinase 1 [EC:
2.7.10.2
]
Organism
ppyg Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg01521
EGFR tyrosine kinase inhibitor resistance
ppyg04151
PI3K-Akt signaling pathway
ppyg04217
Necroptosis
ppyg04380
Osteoclast differentiation
ppyg04550
Signaling pathways regulating pluripotency of stem cells
ppyg04620
Toll-like receptor signaling pathway
ppyg04621
NOD-like receptor signaling pathway
ppyg04630
JAK-STAT signaling pathway
ppyg04658
Th1 and Th2 cell differentiation
ppyg04659
Th17 cell differentiation
ppyg05140
Leishmaniasis
ppyg05145
Toxoplasmosis
ppyg05152
Tuberculosis
ppyg05160
Hepatitis C
ppyg05161
Hepatitis B
ppyg05162
Measles
ppyg05163
Human cytomegalovirus infection
ppyg05164
Influenza A
ppyg05165
Human papillomavirus infection
ppyg05166
Human T-cell leukemia virus 1 infection
ppyg05167
Kaposi sarcoma-associated herpesvirus infection
ppyg05168
Herpes simplex virus 1 infection
ppyg05169
Epstein-Barr virus infection
ppyg05171
Coronavirus disease
ppyg05200
Pathways in cancer
ppyg05203
Viral carcinogenesis
ppyg05212
Pancreatic cancer
ppyg05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ppyg00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
129034648 (JAK1)
04151 PI3K-Akt signaling pathway
129034648 (JAK1)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
129034648 (JAK1)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
129034648 (JAK1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
129034648 (JAK1)
04621 NOD-like receptor signaling pathway
129034648 (JAK1)
04658 Th1 and Th2 cell differentiation
129034648 (JAK1)
04659 Th17 cell differentiation
129034648 (JAK1)
09158 Development and regeneration
04380 Osteoclast differentiation
129034648 (JAK1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
129034648 (JAK1)
05203 Viral carcinogenesis
129034648 (JAK1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
129034648 (JAK1)
09162 Cancer: specific types
05212 Pancreatic cancer
129034648 (JAK1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
129034648 (JAK1)
05161 Hepatitis B
129034648 (JAK1)
05160 Hepatitis C
129034648 (JAK1)
05171 Coronavirus disease
129034648 (JAK1)
05164 Influenza A
129034648 (JAK1)
05162 Measles
129034648 (JAK1)
05168 Herpes simplex virus 1 infection
129034648 (JAK1)
05163 Human cytomegalovirus infection
129034648 (JAK1)
05167 Kaposi sarcoma-associated herpesvirus infection
129034648 (JAK1)
05169 Epstein-Barr virus infection
129034648 (JAK1)
05165 Human papillomavirus infection
129034648 (JAK1)
09171 Infectious disease: bacterial
05152 Tuberculosis
129034648 (JAK1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
129034648 (JAK1)
05140 Leishmaniasis
129034648 (JAK1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
129034648 (JAK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ppyg01001
]
129034648 (JAK1)
Enzymes [BR:
ppyg01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
129034648 (JAK1)
Protein kinases [BR:
ppyg01001
]
Non-receptor tyrosine kinases
JAK family [OT]
129034648 (JAK1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Jak1_Phl
FERM_F2
SH2_1
FERM_F1
ABC1
SH2
FERM_C_FAK1
Motif
Other DBs
NCBI-GeneID:
129034648
NCBI-ProteinID:
XP_054340072
LinkDB
All DBs
Position
1:165210600..165446063
Genome browser
AA seq
1154 aa
AA seq
DB search
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDIGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK
NT seq
3465 nt
NT seq
+upstream
nt +downstream
nt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagactgaggtgaacctggaggcccctgagccaggggtggaagtgatcttc
tatctgtcggacagggagcccctccggctgggcagtggagagtacacagcagaggaactg
tgcatcagggctgcacaggcatgccgtatctctcctctttgtcacaacctctttgccctg
tatgacgagaacaccaagctctggtatgctccaaatcgcaccatcaccgttgatgacaag
atgtccctccggctccactaccggatgaggttctatttcaccaattggcatggaaccaac
gacaatgagcagtcagtgtggcgtcattctccaaagaagcagaaaaatggctacgagaaa
aaaaaggttccagatgcaacccctctccttgatgccagctcactggagtatctgtttgct
cagggacagtatgatttggtgaaatgcctggctcctattcgagaccccaagaccgagcag
gatggacatgatattgagaatgagtgtctagggatggctgtcctggccatctcacactat
gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgaggata
aataatgttttcaaggatttcctaaaggaatttaacaacaagaccatttgtgacagcagc
gtgtccacgcatgacctgaaggtgaaatacttggctactttggaaactttgacaaaacat
tacggtgctgaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat
tggtttcattcgaatgacattggaaacgttctgtactacgaagtgatggtgactgggaat
cttggaatccagtggaggcataaaccaaatgttgtttctgttgaaaaggaaaaaaataaa
ctgaagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaagatccgg
gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct
gtggtcagcattaacaagcaggacaacaagaaaatggaactgaagctctcttcccacgag
gaggccttgtcctttgtgtccctggtagatggctacttccggctcacagcagacgcccat
cattacctctgcaccgacgtggcccccccgttgatcgtccacaacatacagaatggctgt
catggtccaatctgtacagaatacgccatcaataaattgcggcaagaaggaagcgaggag
gggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgaccgtcacc
tgctttgagaagtctgagcaggtgcagggtgcccagaagcagttcaagaactttcaaatc
gaggtgcagaagggccgctacagtctgcacggttcggaccgcagcttccccagcttggga
gacctcatgagccacctcaagaagcagatcctgcgcacggataacatcagcttcatgcta
aaacgctgctgccagcccaagccccgagaaatctccaacctgctggtggctactaagaaa
gctcaggagtggcagcccgtctaccccatgagccagctgagtttcgatcggatcctcaag
aaggatctggtgcagggcgagcaccttgggagaggcacaagaacacacatctactctggg
accctgatggattacaaggatgacgaaggaacttctgaagagaagaagataaaagtgatc
ctcaaagtcttagaccccagccacagggatatttccctggccttcttcgaggcagccagc
atgatgagacaggtctcccacaaacacatcgtgtacctctacggagtctgtgtccgcgac
gtggagaatatcatggtggaagagtttgtggaagggggtcctctggatctcttcatgcac
cggaaaagcgatgtccttaccacaccatggaaattcaaagttgccaaacagctggccagt
gccctgagctacttggaggataaagacctggtccatggaaatgtgtgtactaaaaacctc
ctcctggcccgtgaaggcatcgacagtgagtgtggcccgttcatcaagctcagtgacccc
ggcatccccattacggtgctgtctaggcaagagtgcattgaacgaatcccatggattgct
cccgagtgtgttgaggactccaagaacctgagtgtggctgctgacaagtggagctttgga
accacgctctgggaaatctgctacaatggcgagatccccttgaaagacaagacgctgatt
gagaaagagagattctatgaaagccggtgcaggccggtgacaccatcgtgtaaggagctg
gctgacctcatgacccgctgcatgaactacgaccccaatcagaggcctttcttccgagct
atcatgagagacattaataagcttgaagagcagaatccagatattgtttcagaaaaaaaa
ccagcaactgaagtggaccccacacattttgaaaagcgcttcctaaagaggatccgtgac
ttgggagagggccactttgggaaggttgagctctgcaggtatgaccccgaaggggacaat
acaggggagcaggtggctgttaagtctctgaagcctgagagtggaggtaaccacatagct
gatctgaaaaaggaaatcgagatcttaaggaacctctatcatgagaacattgtgaagtac
aaaggaatctgcacagaagacggaggaaatggtattaagctcatcatggaatttctgcct
tcgggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcag
ctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcggcaatacgtt
caccgggacttggcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattgga
gacttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgtcaaggatgac
cgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaaattttatatt
gcctctgacgtctggtcttttggagtcactctgcatgagctgctgacttactgtgattca
gattctagtcccatggctttgttcctgaaaatgataggcccaacccatggccagatgaca
gtcacaagacttgtgaatacattaaaagaaggaaaacgcctgccgtgcccacctaactgt
ccagatgaggtttatcaacttatgaggaaatgctgggaattccaaccatccaatcggaca
agctttcagaaccttattgaaggatttgaagcacttttaaaataa
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