KEGG   Pongo pygmaeus (Bornean orangutan): 129040721
Entry
129040721         CDS       T10128                                 
Symbol
MET
Name
(RefSeq) hepatocyte growth factor receptor isoform X1
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
ppyg  Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg01521  EGFR tyrosine kinase inhibitor resistance
ppyg04010  MAPK signaling pathway
ppyg04014  Ras signaling pathway
ppyg04015  Rap1 signaling pathway
ppyg04020  Calcium signaling pathway
ppyg04151  PI3K-Akt signaling pathway
ppyg04360  Axon guidance
ppyg04510  Focal adhesion
ppyg04520  Adherens junction
ppyg05100  Bacterial invasion of epithelial cells
ppyg05144  Malaria
ppyg05200  Pathways in cancer
ppyg05202  Transcriptional misregulation in cancer
ppyg05205  Proteoglycans in cancer
ppyg05206  MicroRNAs in cancer
ppyg05208  Chemical carcinogenesis - reactive oxygen species
ppyg05211  Renal cell carcinoma
ppyg05218  Melanoma
ppyg05223  Non-small cell lung cancer
ppyg05225  Hepatocellular carcinoma
ppyg05226  Gastric cancer
ppyg05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ppyg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129040721 (MET)
   04014 Ras signaling pathway
    129040721 (MET)
   04015 Rap1 signaling pathway
    129040721 (MET)
   04020 Calcium signaling pathway
    129040721 (MET)
   04151 PI3K-Akt signaling pathway
    129040721 (MET)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129040721 (MET)
   04520 Adherens junction
    129040721 (MET)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    129040721 (MET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129040721 (MET)
   05202 Transcriptional misregulation in cancer
    129040721 (MET)
   05206 MicroRNAs in cancer
    129040721 (MET)
   05205 Proteoglycans in cancer
    129040721 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    129040721 (MET)
   05230 Central carbon metabolism in cancer
    129040721 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    129040721 (MET)
   05226 Gastric cancer
    129040721 (MET)
   05218 Melanoma
    129040721 (MET)
   05211 Renal cell carcinoma
    129040721 (MET)
   05223 Non-small cell lung cancer
    129040721 (MET)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    129040721 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    129040721 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129040721 (MET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppyg01001]
    129040721 (MET)
Enzymes [BR:ppyg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     129040721 (MET)
Protein kinases [BR:ppyg01001]
 Receptor tyrosine kinases (RTK)
  MET family
   129040721 (MET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal Linker_histone
Other DBs
NCBI-GeneID: 129040721
NCBI-ProteinID: XP_054351496
LinkDB
Position
6:115373525..115496746
AA seq 1409 aa
MKSKSKSLAECLAQDKPLIMKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKY
QLPNFTAETLIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDC
SSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCI
FSPQIEEPSQCPDCVVSALGAKVLSSIKDRFINFFVGNTINSSYFPDHPLHSISVRRLKE
TKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRF
CSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDI
LFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRT
LLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGR
FMQVVVSRSGPSTPHVNFLLDSHLVSPEVIVEHPLNQNGYTLVVTGKKITKIPLNGLGCR
HFQSCSQCLSAPPFVQCGWCHDKCVRSEECSSGTWTQQICLPAIYKVFPSSAPLEGGTRL
TICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSDSTMNILKCTVGPAMNKHFNMSIIIS
NGHGTTQYSTFSYVDPVITGISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKS
VSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTIT
GVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFF
MLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKS
CENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSI
SIALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESV
DYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPE
LVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEV
SQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDL
IGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKT
GAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRR
LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKC
VAPYPSLLSSEDNADDEVDTRPASFWETS
NT seq 4230 nt   +upstreamnt  +downstreamnt
atgaagagtaaatccaagagtttagcagaatgcctcgcacaggataaacctctcataatg
aaggcccccgctgtgcttgcacctggcatcctcgtgctcctgtttaccttggtgcagagg
agcaatggggagtgtaaagaggcactagcaaagtccgagatgaatgtgaatatgaagtat
cagcttcccaacttcaccgcggaaacactcatccagaatgtcattctacatgagcatcac
attttccttggtgccactaactacatttatgttttaaatgaggaagaccttcagaaggtt
gctgagtacaagaccgggcctgtgttggaacacccagattgtttcccatgtcaggactgc
agcagcaaagccaatttatcaggaggcgtttggaaagataacatcaacatggctctagtt
gtcgacacctactatgatgatcaactcattagctgtggcagcgtcaacagagggacctgc
cagcgacatgtctttccccacaatcatactgctgacatacagtcggaggttcactgcata
ttctccccacagatagaagagcccagccagtgtcctgactgtgtggtgagcgccctggga
gccaaagtcctttcatctataaaggaccggttcatcaacttctttgtaggtaataccata
aattcttcttatttcccagatcatccattgcattcaatatcagtgagaaggctaaaggaa
acgaaagatggttttatgtttttgacggaccagtcctacattgatgttttacctgagttc
agagattcttaccccattaagtatgtccatgcctttgaaagcaacaattttatttacttc
ttgacggtccaaagggaaactctagatgctcagacttttcacacaagaataatcaggttc
tgttccataaactctggattgcattcctacatggaaatgcctctggagtgtattcttaca
gaaaagagaaaaaagagatccacaaagaaggaagtgtttaatatccttcaggctgcgtat
gtcagcaagcctggggcccaacttgctagacaaataggagccagcctgaatgatgacatt
ctctttggggtgttcgcacaaagcaagccagattctgccgaaccaatggatcgatctgcc
atgtgtgcattccctatcaaatatgtcaacgacttcttcaacaagatcgtcaacaaaaac
aatgtgagatgtctccagcatttttacggacccaatcatgagcactgttttaataggaca
cttctgagaaattcatcaggctgtgaagcgcgccgtgatgaatatcgaacagagtttacc
acagctttgcagcgcgttgacttattcatgggtcaattcagcgaagtcctcttaacatct
atatccaccttcattaaaggagacctcaccatagctaatcttgggacatcagagggtcgc
ttcatgcaggttgtggtttctcgatcaggaccatcaacccctcatgtgaattttctcctg
gactcccatctggtgtctccagaagtgattgtggagcatccattaaaccagaatggctac
acactggttgtcactgggaagaagatcacgaagatcccattgaatggcttgggctgcaga
catttccagtcctgcagtcagtgcctctctgccccaccctttgttcagtgtggctggtgc
catgacaaatgtgtgcgatcggaggaatgctcgagcgggacatggactcaacagatctgt
ctgcctgcaatctacaaggttttcccaagtagtgcaccccttgaaggagggacaaggctg
accatatgtggctgggactttggatttcggaggaataataaatttgatttaaagaaaact
agagttctccttggaaatgagagctgcaccttgactttaagtgacagcacgatgaatata
ttgaaatgcacagttggtcctgccatgaataagcatttcaatatgtccataattatttca
aatggccacgggacaacacaatacagtacattctcctatgtggatcctgtaataacaggt
atttcgccgaaatatggtcctatggctggtggcactttacttactttaactggaaattac
ctaaacagtgggaattccagacacatttcaattggtggaaaaacatgtactttaaaaagt
gtgtcaaacagtattcttgaatgttataccccagcccaaaccatttcaactgagtttgct
gttaaattgaaaattgacttagccaaccgagagacaagcatcttcagttaccgggaagat
cccattgtctacgaaattcatccaaccaaatcttttattagtggtgggagcacaataaca
ggtgttgggaaaaacctgaattcagttagtgtcccgaggatggtcataaatgtgcatgaa
gcaggaaggaactttacagtggcatgtcaacatcgctctaattcagagataatctgctgt
accactccttccctgcaacagctgaatctgcaactccccctgaaaaccaaagcctttttc
atgttagatgggatcctttccaaatactttgatctcatttatgtacataatcctgtgttt
aagccttttgaaaagccagtgatgatctcaatgggcaatgaaaatgtactggaaattaag
ggaaatgatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaataagagc
tgtgagaatatacacttacattctgaagccgttttatgcacggtccccaatgacctgctg
aaattgaacagcgagctaaatatagagtggaagcaagcaatttcttcaaccgtccttgga
aaagtaatagttcaaccagatcagaatttcacaggattgattgctggtgttgtctcaata
tcaatagcactgttattactacttgggtttttcctgtggctgaaaaagagaaagcaaatt
aaagatctgggcagtgaattagttcgctatgatgcaagagtacacactcctcatttggat
aggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaatctgta
gactaccgagctacttttccagaagatcagtttcctaattcatctcagaacggttcatgc
cgacaagtgcagtatcctctgacagacatgtcccccatcctaactagtggggactctgat
atatccagtccattactgcaaaatactgtccacattgacctcagtgccctaaatccagag
ctggtccaggcagtgcaacatgtagtgattgggcccagtagcctgattgtgcatttcaat
gaagtcataggaagagggcattttggttgtgtatatcatgggactttgttggacaatgat
ggcaagaaaattcactgtgctgtgaaatccttgaacagaatcactgacataggagaagtt
tcccaatttctgaccgagggaatcatcatgaaagattttagtcatcccaatgtcctctcg
ctcctgggaatctgcctgcgaagtgaagggtctccactggtggtcctaccatacatgaaa
catggagatcttcgaaatttcattcgaaatgagactcataatccaactgtaaaagatctt
attggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaagtttgtc
cacagagacttggctgcaagaaactgtatgctggatgaaaaattcacagtcaaggttgct
gattttggtcttgccagagacatgtatgataaagaatactatagtgtacacaacaaaaca
ggtgcaaagctgccagtgaagtggatggctttggaaagtctgcaaactcaaaagtttacc
accaagtcagatgtgtggtcctttggcgtgctcctctgggagctgatgacaagaggagcc
ccaccttatcctgacgtgaacacctttgatataactgtttacttgttgcaagggagaagg
ctcctacaacccgaatactgcccagaccccttatatgaagtaatgctaaaatgctggcac
cctaaagccgaaatgcgcccatccttttctgaactggtgtcccggatatcagcgatcttc
tctactttcattggggagcactatgtccatgtgaacgctacttatgtgaacgtaaaatgt
gtcgctccatatccttctctgttgtcatcagaagataacgctgatgatgaggtggacaca
cgaccagcctccttctgggagacatcatag

DBGET integrated database retrieval system