Pongo pygmaeus (Bornean orangutan): 129043958
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Entry
129043958 CDS
T10128
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
ppyg Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg00790
Folate biosynthesis
ppyg01100
Metabolic pathways
ppyg01240
Biosynthesis of cofactors
ppyg01523
Antifolate resistance
ppyg04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
ppyg00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
129043958 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
129043958 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
129043958 (FPGS)
Enzymes [BR:
ppyg01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
129043958 (FPGS)
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GFIT
Motif
Pfam:
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
129043958
NCBI-ProteinID:
XP_054357355
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Position
13:118488071..118499867
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AA seq
587 aa
AA seq
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MSRARSHLRAALFLAAASARGVTTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWHLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDHHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSVQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSTSLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQSPSP
PKGLLTHPVAHSGAGVLREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq
1764 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcgtgcgcggagccacctgcgcgccgctctattcctggcagcggcgtctgcgcgc
ggcgtaacgacccaggtcgcggcgcggcggggcttgagcgcgtggccggtgccgcaggag
cccagcatggagtaccaggatgccgtgcgcatgctcaataccctacagaccaatgccggc
tacctggagcaggtgaagcgccagcggggtgacccccagacacagctggaagccatggaa
ctgtacctggcacggagtgggctgcaggtggaggacttggatcggctgaacatcatccac
gtcactgggacgaaggggaagggctccacctgtgccttcacggaatgtatcctccgaagc
tatggcctgaagacgggattctttagctctccccacctggtgcaggttcgggagcggatc
cgcatcaatgggcagcccatcagtcctgagctcttcaccaagtacttctggcacctctac
caccggctggaagagaccaaggatggcagctgtgtctccatgcccccctacttccgcttc
ctgacactcatggccttccacgtcttcctccaagagaaggtggacctggcagtggtggag
gtgggcattggcggggcttatgactgcaccaacatcatcaggaagcctgtggtgtgcgga
gtctcctctcttggcatcgaccacaccagcctcctgggggatacggtggagaagatcgca
tggcagaaagggggcatctttaagcaaggtgtccctgccttcactgtgctccaacctgaa
ggtcccctggcagtgctgagggaccgagcccagcagatctcatgtcctctatacctgtgt
ccgatgctggaggccctggaggaaggggggccgccgctgactctgggcctggagggggag
caccagcggtccaacgctgccttggccttgcagctggcccactgctggctgcagcggcag
gaccaccatggtgctggggagccgaaggcatccaggccagggcttctgtggcagctgccc
ctggcacctgtgttccagcccacatcccacatgcggctcgggcttcggaacacggagtgg
ccgggccggacgcaggtgctgcggcgcgggcccctcacctggtacctggacggtgcgcac
accgccagcagcgtgcaggcctgcgttcgctggttccgccaggcgctgcagggccgcgag
cggccgagcggtggccccgaggttcgagtcttgctcttcaatgctaccggggaccgggac
ccggcggccctgctgaagctgctgcagccttgccagtttgactatgccgtcttctgccct
aacctgacagaggtgtcatccacaggcaacgcagaccaacagaacttcacggtgacactg
gaccaggtcctgctccgctgcctggaacaccagcagcactggaaccacctggacgaagag
caggccagcccggacctctggagtgcccccagcccagagcctggtgggtccacatccctg
cttctggcgccccacccaccccacacctgcagtgccagctccctcgtcttcagctgcatt
tcacatgccttgcaatggatcagccaaggccgagaccccatcttccagtcccccagtccc
ccaaagggcctcctcacccaccccgtggctcacagtggggccggcgtactccgtgaggct
gctgccatccatgtgctagtcactggcagcctgcacctggtgggtggtgtcctgaagctg
ctggagcccgcactgtcccagtag
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