Pieris rapae (cabbage white): 111001605 Help Entry 111001605         CDS       T05162                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism prap  Pieris rapae (cabbage white) Brite KEGG Orthology (KO) [BR:prap00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:prap04040]     111001605    04990 Domain-containing proteins not elsewhere classified [BR:prap04990]     111001605 Ion channels [BR:prap04040]  Voltage-gated cation channels   Ryanodine receptor    111001605 Domain-containing proteins not elsewhere classified [BR:prap04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    111001605 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Serglycin Motif Other DBs NCBI-GeneID:  111001605 NCBI-ProteinID:  XP_045485471 LinkDB All DBs Position 9:complement(8182383..8278940) Genome browser AA seq 5117 aa AA seqDB search MAEAEGGASEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDL SQCVFVIEQALSVRALQELVTAAGSETGKETLGKGTGSGHRTLLYGNAILLRHLNSDMYL ACLSTSSSQDKLAFDVGLQEHSQGEACWWTLHPASKQRSEGEKVRVGDDLILVSVATERY LHTTKENEVSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPST WNKDGGLNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWYHPMRIRHITTGRYLGVND QNELYLVSREEATTASCAFCLRQEKDDQKVVLEDKDLEVIGAPIIKYGDSTVIVQHSETG LWLSYKSYETKKKGLGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTK FINGLETLQENRRHSMFFASVNLGEMVMCLEDLINYFAQPEEDMEHEEKQNRFRALRNRQ DLFQEEGILNLILEAIDKINVITSQGFLAGFLAGYESGQSWDMISVYLYQLLAAIIKGNH TNCAQFANSNRLNWLFSRLGSQASGEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLL EKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTALVDHVSSVRPNIFV GRVEGSAVYQKWYFEVTMDHIEKTTHMMPHLRIGWANTSGYVPYPGGGEKWGGNGVGDDL YSFGFDGAYLWSGGRKIQVNKTHAEEPFIRKGDVIGCALDLTVPIINFMFNGVRVTGSFT NFNLEGMFFPVMSCSSKLSCRFLMGGEHGRLRYAAPEGYSPLVESLLPQQILNLEPCFYF GNLSKRALAGPPLVQDDTAFVPTPVDTASITLSSYIEQIRDKLAENIHEMWAMNKIEAGW MYGDQRDDLHKVHPCLVPFERLPAAEKRYDIQLAVQTLKTILALGYYISLDKPPARIRNV RLPNEPFMQSNGYKPAPLDLSAVTLTPKMDELVDQLAENTHNLWARERIQQGWTYGLNED PDMNRSPHLVPYPKVDDAIKKANRDTASETVRTLLVYGYNLDPPTGEQHEALLAEASRQK QAEFRTYRAEKNYAVSSGKWYFEFEILTAGPMRVGWAHADMPPGMMLGQDENSWAFDGYN EEKVYSGSLESFGKQWAVGDVVGVFLDLIDKTISFSLNGELLMDALGGETTFADVQGDNF VPACTLGVGQKARLSYGQDVNSLKYFTTCGLQEGYEPFCVNMNRDVTHWYTKDQPIFENT DEMIDTRIDVTRIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICHAEFIDESEKA RRWVEIKDRQQILMKEAVEAQMPAHIDQIMRSGFTMNDIKGLHYDENQEDVKIKRQPSRP PRKGSITRNVTIQNYNSQPGQNGMNRSTSEAEMSKYELGVQNLPEDTKKDKRGRSPFKFF RSKRGESGDRGKSRKSKTPDPYTDTEVSPDRARRPNPQIRISQANQRYNMQNRNDGANIY DSQGALSTNLTVPTPTQDRKQMTTATLDKSATETIGNEIFDADCLKLINEYFYGVRIFPG QDPTHVYIGWVTTQYHLHSKDFNQNKVTKSSVIITDDYDRVIESVNRQSCYMVRADELYN EVMAEATAKGASQGMFIGCSVDTSTGTVSFTCEGKDTSIKFKMEPETKLFPAIFVEATSK EILQIELGRSSTSLPLSAAVLPTSDKHVNPQFPPRLKVQCLKPHQWARVPNQFLQVHALK LSDIRGWSMLCEDAVSMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNY RAAHALCQHVDQKQLLYAIRSQYMSGPLRQGFYDLLIALHLESHATTMEACKNEFVIPLG PELKALYEDREMCHSLRSLQTESVRPQMNMTNIAENISDISNLYSPYFPLEVVREFVMQA LAEAVETNQVHNRDPTGGSNENLFLPLIKLVDRLLLVGMMRDEDVEKLLIMINPETWDPT FDKEGKDEHRKGLLHMKMAEGAKLQMCYLLQHLNDIQLRHRVESIIAFAHDFVGELQTDQ LRRYTEIKQSDLPSAVAAKKTREFRCPPREQMNAILSFKHLEDEDPENCPCGEELIARMN DFHDALMSHVSLSALQEPDGDQSNEPEVKPGAFGKLYNIINTVKELEDDAKALEEEKKKT PEEKFRKVLIQTIVNWAEESQIETPKLVREMFSLLVRQYDAVGELIRALEKTYVINAKTK LDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRVLRVHENVMA VMMNTLGRRAQAQSDAPATSPPTPEDKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDH FDFLLENSNILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSN SELIEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRG EGEGLLKAIVDANKMSERIADRRKLRDLEQEGDISFSHPLPESEDDEDYIDTGAAILNFY CTLVDLLGRCAPDAGVIALGKNESLRARAILRSLVPLEDLQGVLSLRFTLNNPAAGEERP KSDMPSGLIPGHKQSVGLFLERVYGIETQELFYRLLEEAFLPDLRAATMLDRNDGCESDM ALSMNRYIGNSILPLLIKHANFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDF LVALTSAMQPSMLLKLLRKLTVDVSRLSEYTTVALRLLTLHYERCAKYYGSTGGQGSYGS SSDEEKRLTMMLFSNIFDSLSKMDYEPELFGKALPCLIAIGCALPPDYSLSKNYDDEFYG KDSQASGADNPQYDPQPINTSSVALNNDLNTIVQKFSEHYHDAWASRKIENGWVYGENWS DSQKTHPRLKPYNMLNDYEKERYKEPVRESLKALLAIGWSVEHSEVDIPSNNRSSMRRQS KSGIDSATPFNYNPHPVDMTNLTLSREMQNMAERLADNAHDIWAKKKKEELVTNGGGIHP QLVPYDLLTDKEKKKDRERSQEFLKYLQYQGYKLHRPSKASQIDTEQTTTGVAIELRFAY SLLEKLIQYIDRATINMKLLKPSTTFSRRSSFKTSTRDIKFFSKVVLPLMEKYFSTHRNY FIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFGPDVRITVRCLQVLVKGIDA KSLVKNCPEFIRTSMLTFFNNLADDLGHTIYNLQEGKYAHLRGTHLKTSTSLGYINGVML PILTAMFDHLANCEYGADLLLDEIQVASYKMLGSLYTLGTDVTLTHDRKYLKTEIERHKP ALGSCLGAFSSTFPVAFLEPHLNKHNQFSLLNRIADHSLEAQDIMAKMEQSMPTLETILN EVDHFVESDKTYSEAPHIIDVVLPLLCSYLPFWWAQGPDNVTPTGGNHVTMVTAEHMNQL LKNVLKLIKKNIGNENAPWMTRIATYTQQIIINSSEELLRESFLPLAERVRKRTDNMFHK EESLRGFIKSSTDDTSQVESQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLRNNVPEAE ELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMVLIMPTATRRVTTVVDGTQQGGGKK KKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLKKMSEQDVA EFAKTQLTLPDKIDPADEMSWQHYLYSKLGSKSKTAITVETSENKAKIIDDTVERIVAMS KVLFGLHMIDHPQQMSKNVYRSVVSIQRKRAVIACFRQTSLHSLPRHRACNIFARTYYEL WLEEENIGQEVMIEDLTQTFEDAELKKSDIVEEEGKPDPLTQLVTTFCRGAMTERSGALQ EDPLYMSYAHIIAKSCGEEEEEGGEEEEGGGEPEGEDEGKSSIHEQEMEKQKLLFHQARL ANRGVAEMVLLHISASKGVPSDMVMKTLQLGISILRGGNIDIQMGMLNHLKDKKDVGFFT SIAGLMNSCSVLDLDAFERNTKAEGLGVGLEGAAGEKNMHDAEFTCALFRFIQLTCEGHN LEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKAIG VASQVFNTLTEVIQGPCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKEL LNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLKDLTSSAS FKEIDANNDGWVLPKDFKEKMEQQKSYSPEEIEFLLACCETNHDGKLDYIGFCDRFHEPA KEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEIMGGSKRIERVYFE IKESNIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMAASE ESASGPKNREAAYTYLGDDDDERAGKDPFRRGYQSVKDAIAATFSFLSPSNIKAKIADMQ QMPPAELLVGFLKLFFYLFYYIGYGFVVVIRYIFGVLLGLMRGPHVEEPPPQEPTEEEKI GQFKHRLITQSPSRHLPALPAADDTGQMQVSAFGLDITKEDNGQLQVKPHESPTTSTPSS GEEAEVSPDESIEHTEEQQPPSLIDLLGGEQAKKQAQERVEAQAAQQAAMSAIEAESKKA VQVPAPSALSQVDLSQYTKRAVSFLARNFYNLKYVALVLAFCINFVLLFYKVSIPDSDKE GSGIGDIISGSGSGQGSGSGEGSGETEDDDSLEVVRIDEDFFYMEHVIKMAAALHSIVSL AILIGYYHLKVPLAIFKREKDIARRLEFDGLYIAEQPEDDDLKSHWDKLVISAKSFPVNY WDKFIKKKVRAKYSETYDFDSISNMLGMEKTSFSAQEDEGNKGLWNYIVNIDWRYQVWKA GVTITDNSFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLT VMLLTIIVYIYTVIAFNFFRKFYVQEEDDEINRNCHDMLSCFVFNLYKGVRAGGGIGDEL EPPDGDDSEVYRIIFDISFFFFVIIILLAILQGLIIDAFGELRDQLESVKEDMESNCFIC GINKDYFDKVPHGFDTHVQREHNLANYMFFLMHLINKPDTEYTGQETFVWNMYTQRCWDF FPVGDCFRKQYEDVMGE NT seq 15354 nt NT seq  +upstreamnt  +downstreamnt atggcggaagcggaaggaggagcaagcgagcaggatgatgtttcatttctccgaacggag gacatggtctgtctctcgtgcacggctacgggagagagggtgtgcctggctgcagagggc ttcggaaaccgacactgcttcttggagaacatcgctgataaaaatatcccaccagatcta tcacagtgcgtctttgttattgaacaggcgttgtcagtgagagctctccaggaattagtc acggcggctggctcagaaaccggcaaagaaaccttaggcaaaggcacaggttccggtcac agaacattgctttacggcaatgctatattgctacgtcatctcaatagtgacatgtacctg gcgtgtctttccacgtcatcatcacaagacaagttggcgtttgatgtcggtttacaagag cattctcaaggtgaagcatgctggtggacacttcatcctgccagcaaacaaaggtctgag ggtgagaaggtgcgagttggtgatgatctgatcttagtgtcagtcgctactgagagatat ttgcatacaaccaaagagaacgaagtctcaatagtaaacgcctctttccacgtcacacac tggtcagtgcagccttatggtactggaatatcccgtatgaagtacgtgggttatgtcttt ggaggggacgtgctgaggttcttccatggaggtgatgaatgcctcacgatacccagtaca tggaacaaagatggggggctaaatatcgtggtatatgaaggtggttcagttatgtcccaa gcccgctcgttatggcggctggaactggcgcgtactaaatgggctggtgggtttataaat tggtaccaccccatgaggataagacacattaccacaggccgctatttgggggtaaacgat cagaacgagctgtatttagttagcagagaggaagctacaacagcatcgtgtgctttctgc ctccgacaagagaaggatgaccagaaagtggttttggaagacaaagacttagaggtgatt ggggctcccatcatcaagtatggagactccactgtcattgtacagcattctgaaaccgga ttgtggttatcttataagtcgtacgaaacgaagaaaaagggacttggtaaagtagaagag aaacaagcgatactccacgaggaaggcaagatggatgatggtctggatttctctcggtcc caagaagaggaatctagaaccgcaagagtaattagaaagtgttcttcactttttacgaag ttcattaatggccttgagacgttacaagagaacagacgtcactctatgttcttcgcgtct gtgaatcttggagaaatggtaatgtgtcttgaggatttgattaattacttcgcacaacct gaagaggatatggaacacgaagaaaaacaaaatagattccgtgcccttcgaaaccgccaa gatctattccaagaggaaggaatattgaatctcattttagaagccatagacaagataaat gtgattacgtcacagggcttccttgccggttttttggcgggatacgaatccggacagagt tgggatatgatatctgtgtatttatatcaacttttagctgcgataatcaaagggaaccac acaaactgtgcccaattcgccaactcgaaccgcctgaactggttgttctctcgtctggga tcgcaggcgtctggagagggaactgggatgctggatgtactgcattgtgtgcttatcgac tcgcctgaagcgttgaatatgatgcgagatgagcacatcaaagtaataatctcgcttcta gagaaacatggccgtgatccgaaagtattggacgtgctgtgttcgctttgtgtgggtaat ggtgtcgctgtcaggtcgtcgcagaataacatctgtgattatttactaccagggaagaac ttgctactgcagactgctttagtagaccatgtgtcaagtgtgcgaccaaatatttttgtg ggtcgtgtagaaggttcagccgtataccaaaaatggtatttcgaagtcaccatggaccat atcgagaagaccacacacatgatgccccatttgaggattggatgggcaaatacatcgggt tacgttccgtaccccggcggtggtgaaaagtggggtggtaatggggtcggcgacgatctt tattcctttgggtttgatggagcatacctttggtctggtggacggaagattcaagtcaac aagactcatgctgaggaaccctttatcaggaaaggtgacgtcattggctgtgctttagac ctcacagtccctatcatcaacttcatgttcaacggagtgagagtcaccggttccttcacg aatttcaacctggaaggaatgttcttccctgtcatgagttgttctagcaagctgagttgc cgttttctcatgggaggcgaacacggtcggctaagatacgccgctccagaaggatattcc ccattggtagaatctctgttaccgcagcagatattgaacctggagccatgcttctacttt ggcaacttgtctaaacgcgctctggcaggtccgcccttggtccaggatgacactgctttc gtgcctacacctgttgatactgcctctattacactgtcgtcatatatcgaacaaattcgg gacaaacttgctgaaaatatacacgaaatgtgggcaatgaataagattgaagcaggttgg atgtacggggaccaaagagatgatttgcataaagtacatccttgcctggtccccttcgag cgtctaccggctgctgagaaacgatacgatatccaattagcagttcaaactcttaagact atattagctctgggttactacataagtttggataaaccaccggctcgtattcgtaacgtc agattgcccaacgaaccatttatgcagtcgaacggctacaaaccagctccattggattta agtgcggtgacccttactcctaaaatggatgaattagtagaccaattagcagagaatact cacaatttatgggcgagagagcggatacaacaaggatggacttatggtctgaatgaggat cccgatatgaatcgttcaccccatttagtgccgtatccaaaggttgacgacgcaattaaa aaagctaacagagacaccgcgtctgagaccgtaagaactctactagtctatggatacaac ttggatccacccactggagaacaacatgaagcattactggctgaagcctcaagacaaaag caagcagaatttagaacatacagagccgagaagaattatgctgttagttcaggcaaatgg tactttgaattcgaaatacttaccgctggacctatgagggttggttgggcccacgctgat atgcctccaggtatgatgttggggcaagacgaaaattcctgggcattcgacggatataat gaggaaaaagtgtattccggtagcttggagtcgtttgggaagcaatgggcggtcggtgat gttgtaggcgtcttcctagatctcatagacaagacgataagtttctcgctaaatggtgaa ttgttgatggacgcacttggtggtgaaactacatttgcggatgtccaaggggataacttc gtgccagcctgtacccttggagtcggtcaaaaggctaggctatcatatggtcaagacgta aattctctaaagtacttcacaacctgcggtctccaagagggttacgaacctttctgtgtc aacatgaaccgtgacgtaacacattggtatacaaaagatcagccgatatttgagaacaca gatgaaatgatcgatacaaggatcgatgttaccaggattccagctggctccgacacgccg ccatgcttaaaaatatcgcacaacacgtttgagacgatggaaaaggcgaattgggagttc ctgaggctgtcgctacctgttatatgccatgctgagtttattgatgaatcggaaaaagct cgccgctgggtggagatcaaggatcgacagcagattctgatgaaggaagcggttgaagcc caaatgccggcgcatatcgatcaaataatgagaagtggcttcaccatgaacgatattaaa ggtctccactacgatgagaatcaagaagacgtaaaaatcaagaggcagccctcacggcca ccccgcaaagggtcaatcacacgcaacgtcacaatacagaattacaattcacaaccaggt caaaatggaatgaaccggtcgacaagtgaagcggaaatgtcaaaatatgaactcggcgta cagaatctgcctgaagataccaagaaagataagagagggaggtcaccattcaaattcttt agaagtaaaagaggtgagagtggcgatagaggtaaatcgaggaagtcgaaaacaccggat ccctacacagatacggaagtgtccccagatagggctcggcgacccaatccacaaatcaga atatcacaggccaatcagaggtataacatgcaaaataggaatgatggggccaatatctac gatagtcaaggcgcgttaagcacaaacttgacagtgccaacaccaacacaagatcgtaag caaatgacaaccgccacactcgacaagtctgcgacagaaacgattggcaatgaaatattt gatgctgactgtttgaagcttatcaatgaatacttttacggcgtcagaatattccccggt caggatcccactcatgtgtacataggatgggtgaccactcaataccatttgcactccaag gactttaatcaaaataaggtcaccaagtcttcagtcatcatcacagacgattatgatagg gtgattgagagtgtaaaccgccagtcatgttatatggtgcgagctgatgaattgtacaat gaagtgatggcggaagcaacagccaaaggtgcttcccagggaatgttcattggttgttct gttgatacttctactggtactgtatccttcacgtgtgagggaaaggataccagcattaag tttaagatggaaccagaaacaaaactcttcccggccatattcgtggaggcaacatcaaaa gaaatcttgcaaatagagctgggtcggtcttccaccagtcttccgcttagtgctgcagtg ctgccaactagtgacaaacacgtgaacccacaattcccaccgaggcttaaagtacagtgt ttgaaaccgcatcagtgggctagagtgccaaaccaattccttcaagttcacgctctgaag ttgtcagacattcgtggttggtccatgctctgtgaagacgctgtatccatgctggcttta catattccagaggaggatcgatgcatagacatcttagagttgatagagatggataaactt ctaagcttccacgcccatactctcacattatacgccgctctctgttaccaaagcaattac agggctgcacatgctttgtgtcaacacgtcgatcagaaacaactgctatacgcgatccga tctcagtacatgtcgggacctctacgtcaaggcttctacgatttgctcatcgccttgcat ttggagtctcatgccactactatggaagcgtgtaagaacgaatttgtgatacctttggga ccagaactgaaagcgttgtacgaggatcgggagatgtgtcacagccttcgatctttgcag actgagagtgttcgaccgcagatgaatatgactaatattgcagaaaacatatcagacata agcaacctctactccccctatttccccctcgaagtggtacgggaattcgtcatgcaggct ttggctgaagccgtggagaccaaccaagtacacaacagagatcctactggtggaagcaat gagaatcttttcttgcccttaataaagttggtggatcgcttactgttagtgggtatgatg agagatgaagatgttgagaaacttctcataatgatcaacccggagacttgggatccgacg tttgataaagagggcaaagatgagcacagaaaaggccttctacacatgaaaatggcggag ggtgcgaaactccaaatgtgctacttacttcaacatctcaacgacattcagttaagacac agagtcgagtcaataattgcgtttgcgcatgattttgttggagaacttcaaactgatcaa ttgagacgctacacagaaatcaaacagtcagatcttccaagtgcggttgctgctaagaag acaagagaatttcgttgtccaccgagggaacagatgaatgctatactaagtttcaagcac ttagaagatgaagatccggaaaactgcccatgcggtgaagagctcatcgcgagaatgaac gacttccacgacgctctcatgtcacacgtatctttgagtgcgttgcaggaacctgatggt gatcaatctaacgagccagaagtgaaaccaggtgcatttggtaaactttacaatatcatc aacaccgtgaaggagttagaagatgatgccaaggccctcgaagaagaaaagaagaagact ccagaagagaagttccgtaaagttttgattcagacaattgtcaactgggctgaggagtct caaatcgaaacgcctaaactggttcgggaaatgttcagtcttctcgtccgtcaatacgat gcggtgggagaacttatccgtgcgcttgagaaaacatacgtaatcaatgcgaaaaccaaa ctagatgtagcagaaatgtgggttggactgagtcagatcagagccttattgcccgtacaa atgagtcaagaggaagaagaacttatgagaaagagattgtggaaactcgtcaacaaccac acgttcttccaacatccggatttaattagagtgttacgtgtacacgagaacgtgatggca gtaatgatgaacacgctaggccgacgtgcgcaggcgcaatctgacgcccctgcaacttca ccgccaactcctgaggataaggaaaaggacacttcccacgaaatggtggtggcgtgttgt cgtttcctctgctacttctgtcgcacgggcagacagaaccagaaagccatgttcgaccat ttcgacttccttctcgagaactccaacattctgctcgctaggccttctttaagaggatct actccgctagatgtcgcatactcgagtcttatggagaatactgagctagcccttgctttg agagaacactacctggagaagatagcggtgtacttgtctcgttgtggtcttcaaagtaac tctgaactaatagaaaaaggttacccagacttaggttgggatccagttgagggagaacga tatctggatttcctaagattctgtgtttgggtcaacggtgaaagcgtagaagaaaatgca aaccttgttatccgtcttctcatcagaagaccggaatgtctgggtccagcgttgaggggt gaaggcgaaggtctgttaaaggctatagtagacgctaataagatgagtgaaagaatcgct gatagaaggaaactgagggatttagagcaggaaggtgatatcagtttcagccacccattg cccgagtcagaggacgatgaagattacatagacacaggcgccgccattttgaacttctac tgtactcttgtggacttactgggacgctgtgcacccgatgcaggtgttattgcactgggt aaaaacgaatctctacgtgcccgagccatcttaagatccctggtcccattggaggaccta caaggcgtactcagtttgagattcactctcaacaacccggctgctggcgaagagagacct aaatctgacatgccatccggtttaataccaggccataagcagagcgtaggacttttcttg gaacgagtgtatggaattgaaacgcaggagttattctatcgacttctggaagaagccttc cttcctgaccttagagctgctactatgttagacaggaacgacggttgcgagtcagacatg gccttatcaatgaacagatacatcggtaactcgatactcccgttgcttatcaaacatgct aacttctacaacgaggctgaaaactacgctagtttgcttgatgctacgcttcatactgtg tatagattatcaaagaaccgtatgctgacaaagggtcaacgcgaggccgtttcagacttc ttagttgctctgacatccgccatgcagccttcgatgttactcaagcttttgagaaaactt acggtcgacgtctcccgattgtctgaatatactactgtggctttaaggcttctaacgtta cactacgagcgatgtgcaaagtactatggcagtactggaggtcaaggctcctacggatcg tcgtctgatgaagaaaagagactcacaatgatgctcttctcgaacatcttcgactctctc agcaagatggactatgagccagaattgtttggaaaagctctgccttgcttgattgctatt ggttgtgctcttccgcccgactattctctctcaaagaactatgatgacgagttctatggc aaggattctcaggcttcaggcgcagacaatccgcagtacgaccctcagcccatcaatacc tcatcggtggctctcaataacgaccttaacacaatcgttcagaagttctccgaacattat cacgatgcttgggcgtcaagaaaaatcgaaaatggttgggtctacggcgaaaattggtct gatagccaaaagacgcacccacgcttgaaaccctacaacatgctcaatgactatgagaaa gaacgttacaaggagccggttcgtgaatctctcaaggcccttcttgctattggctggtct gtagaacattcagaagtggatatacctagtaacaataggagttctatgagacgccagtct aagagtggcattgactcagcaacgccgttcaactacaacccacatccagtggatatgacc aatttgactctgtcaagggagatgcagaacatggctgagaggttagctgataacgcgcac gatatctgggcaaagaagaagaaagaagaactcgttaccaatggaggtggtatacatccg caactagttccttacgatctcttaaccgacaaggagaagaaaaaggaccgtgaaaggtct caagaattcctcaaataccttcaataccagggatacaaactacacaggcccagcaaggct tcccaaattgacacagaacagaccactacgggtgtcgccatagagctcagattcgcatat tcattgttggagaaactgatccagtacatcgaccgggcgacaattaatatgaagcttctg aaaccgtctactaccttcagtagacgatccagttttaagacaagcacgagggacattaag ttcttctctaaggttgtactaccattgatggagaaatacttctcaacacatcgtaactac ttcatagcagttgccacagcgactaacaatgttggtgcagcgagtttgaaggaaaaggaa atggtggctgcattgttctgtaaattggctagtttattacgatctaggttagcagcattc ggcccggacgtacgtataaccgtccgttgtctccaagtccttgtgaagggcattgatgct aaatccttggtgaagaactgtccggaattcatcaggacctccatgttgacattcttcaat aatctcgctgacgatttggggcatactatatacaatttacaagagggtaaatatgcacat ctccgtggcacacacctcaagacatcgacatctttgggctacatcaatggagtgatgcta ccaatactgacagcgatgttcgatcatctagctaactgcgaatatggagctgatctattg cttgacgagattcaagtagcgtcttataaaatgttaggctcgctatacacgttgggaacg gatgtaacactaacacacgacagaaaataccttaagacggaaatcgagagacataaacct gcactgggttcatgcctcggcgcatttagttccacattccctgtggcattcctggagccg catctcaacaagcacaaccaattctcgttactcaaccgtattgctgatcattcattggaa gctcaagatataatggcaaaaatggaacaatcaatgccaaccctagaaacgattctaaac gaagtcgatcacttcgtggaatcagacaagacgtatagtgaagcacctcatatcattgat gtggtactgcctttgctgtgctcttatttgcctttctggtgggctcagggaccggataat gttactcctacgggaggcaaccacgtcaccatggtaacggcggagcacatgaaccagctc ctaaagaatgtcctaaagcttattaagaagaatattgggaatgaaaacgcaccctggatg acccgtattgcaacgtatacgcaacagattataataaactcctctgaggaattattgaga gagtcgttccttccattggccgaacgtgttcggaagaggacggataatatgttccataag gaggagagtttgcgaggttttattaaatcatcaacagacgacacatcccaagtagagtcg caaatacaagaagactggcagctattagtaagggacatctactccttctatccccttctc atcaaatacgtggatttgcagaggaatcactggctcagaaataatgtaccagaggcagaa gaactctacaaccatgttgcagaaatattcaacatttggtctaagagccagtacttcctc aaggaggaacaaaacttcatatcagctaacgaaatcgacaacatggtgttgataatgcct actgcgactagaagagtgaccactgttgtggatggaacgcaacaaggtggtggaaagaaa aagaaaaagcatcgcgataagaagagagacaaagacaaggaagtccaagcgtctttaatg gtggcctgtctgaagagacttcttccggttggtctgaacctctttgcgggtagagaacaa gagttggtgcagcactgcaaagacaggtttttgaagaaaatgtcagaacaagatgtggca gaatttgcgaagacgcagctaacattgccggataaaattgaccctgcagatgaaatgtcc tggcaacattatttgtacagcaaactcgggtccaagagtaagacagctatcaccgtagaa acttcagagaataaagccaagataatagatgacactgtggagagaattgtggctatgagc aaagtgttgtttggcttgcatatgatcgaccatccccaacaaatgagtaagaacgtttat cgttctgttgtgtccattcaacgtaaacgcgcagtcatcgcctgtttccggcaaacttca ctccattccttgccaaggcacagggcatgtaatatcttcgctagaacttattacgaactc tggttagaagaagagaatatcggacaagaagtcatgatcgaagatttaacgcaaacgttt gaagatgctgagttaaagaagagtgatattgtggaagaagaagggaaaccggatcctctc actcaactcgtcacaactttctgtcgcggggctatgactgaacgctcgggggctttacag gaggatcctctttatatgtcttacgcgcatattatcgcaaagtcatgtggagaggaagaa gaagaagggggagaagaggaggagggtggaggggaaccagaaggagaagacgaaggaaag tccagtattcatgaacaagagatggaaaagcagaagttgttattccaccaagcgcgttta gccaaccgaggagtagccgaaatggtcctactacacatctccgcttcaaagggcgttccc agtgacatggtgatgaagaccttgcaattggggatatcaattttgagagggggcaacatt gacatacagatgggtatgctaaatcacctcaaagataagaaggacgtgggtttcttcaca tcaatagctggtctcatgaattcctgttctgtgcttgacttggatgccttcgaacggaac actaaagctgaagggctgggtgtaggcttagagggcgcggcgggtgagaaaaatatgcac gatgctgaatttacatgcgccctctttaggttcatacaacttacctgcgaaggacacaac ttggagtggcagaactaccttcgaactcaggctggtaatactactacggtgaacgtggtt atatgcacagtagattatctactaaggcttcaggagtctatcatggacttctactggcat tactctagcaaggaacttatagacccagcgggaaaagcgaatttcttcaaagctattggc gtggcttcacaagtctttaacacactcactgaagttattcaagggccttgtacgcaaaat cagcaggcgttagctcattccaggttatgggatgcagtaggcggttttcttttcctcttc tctcatatgcaagataaactatccaagcattcatcccaagtagatctgctgaaggaactg ctaaatcttcagaaagacatgatcaccatgatgctgtctatgctggagggaaacgttgtt aatggaacaattggtaaacagatggtggacactctagtagagtccgcatctaacgtggaa ctaattctgaaatactttgatatgttcctgaagctgaaagatctgacatcaagcgctagt ttcaaagagattgacgctaataatgatggctgggttctgccaaaggactttaaggagaag atggaacagcagaagagttatagtccggaagagatagagttccttctggcttgttgcgag acaaaccacgacggtaaacttgactacatcggcttctgcgatcgattccacgagcctgcc aaagaaattggattcaacttggctgtacttcttaccaacttgtcagagcacatgccaaat gaacccaggcttgctcgtttcctggaaaccgccggttcagttttgaattatttcgaacct ttccttggaagaattgagataatgggtggttctaaacgcatagagcgggtttacttcgaa atcaaggaatccaacatcgaacagtgggagaaaccacagattaaggaatcgaaacgcgcg ttcttctacagcatagtaacagaaggcggtgacaaggagaagttggaggcgttcgtcaat ttctgtgaagatgccatctttgagatgacccatgcttcgggattgatggccgcttcagag gaatccgcaagtggaccaaagaatcgcgaggctgcgtatacatacttgggagatgatgat gatgaacgagctggcaaggacccattccgccgtggctaccaatcggttaaggatgcgata gctgcaacattttcgttcttatcgccctccaacataaaggctaaaatcgcggacatgcaa caaatgccacccgcggaactcttggttggcttcctgaaactcttcttctatctcttctac tatattggatatggatttgttgttgttataaggtatatattcggcgtattactcggcttg atgcgtggacctcatgtagaagaacctccccctcaagagcctactgaggaggagaaaatc ggtcagtttaaacacagattgatcacacaaagtccgtctcgccatctacccgcattgcca gcggcagatgatactggacaaatgcaagtttctgctttcggtctagatattactaaagag gataatggccagttacaagttaagccccacgagtcaccgaccacttcgacgccatcttcc ggtgaggaggcagaggtgtccccagacgagagtattgaacatactgaagaacaacaaccg ccgtcacttatcgatttgctcggtggggaacaagcaaagaagcaggcccaagaacgagtc gaagctcaggcagcgcaacaagccgctatgtccgccatcgaagctgaaagcaaaaaggca gtacaagttcccgctccgtcagccctgtcccaagtagacctctcccagtatacgaagcgt gccgtttccttcctcgctagaaacttctacaatctgaagtacgtcgctctggtgctcgcc ttctgcatcaacttcgtgttgctcttctataaggtgtcgattccggatagtgataaagaa ggttccggtatcggagacatcatcagcggatctggatcaggccagggttcgggaagtgga gagggaagcggtgaaactgaagacgatgatagtctggaagtggttcgaatagacgaagac ttcttttatatggagcacgttatcaagatggccgctgctcttcactctattgtatcgctt gctattctcattggatattatcatctgaaggtacctctggccatattcaaacgtgagaag gacatcgctcgtcgcctggagtttgacggcctctacatcgctgaacaaccggaagatgac gatctcaagagccattgggataaacttgttatctctgccaaatcgttcccagtgaactat tgggacaagtttataaagaagaaagttcgggctaagtattctgagacctacgactttgac tccatatccaacatgttggggatggaaaagacttctttctcggcccaagaagatgaaggc aataaaggactatggaactacatcgttaacatcgactggcgctaccaagtgtggaaggcg ggcgtgactatcacagacaactccttcctctactccctctggtacttcagtttctccgtg atgggcaatttcaacaacttcttcttcgctgcccatttgctggatgttgccgtcggtttc aagactctaagaaccattcttcagtccgtcacgcataatggaaaacagttggtgttaact gtgatgctgttaacaatcatagtatacatctacacggtgatagcgttcaatttcttccgc aaattctacgttcaagaagaggatgacgagatcaacaggaattgccatgacatgctttct tgtttcgtgttcaacctatacaaaggcgtacgcgcaggagggggtatcggagatgagctc gaacctcctgatggagacgattcggaggtgtaccgcatcatcttcgacatatctttcttc ttcttcgtcatcatcatcctactggctatccttcagggtttgatcattgatgcgttcggt gagctccgtgaccaactggagtcagtcaaagaagacatggagtccaactgcttcatttgt ggcattaataaggactactttgataaggtgccgcacggtttcgacacacacgtgcaacga gagcataatctagcaaattacatgttcttcttgatgcatctaatcaacaaacccgacact gaatatacaggtcaagagacattcgtatggaacatgtatacgcaaagatgctgggacttc ttcccagtcggagattgcttccggaaacagtatgaagacgtcatgggagaatag

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