Poecilia reticulata (guppy): 103457636 Help Entry 103457636         CDS       T05149                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism pret  Poecilia reticulata (guppy) Pathway pret04020   Calcium signaling pathway pret04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pret00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103457636 (ryr3)    04020 Calcium signaling pathway     103457636 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pret04040]     103457636 (ryr3) Ion channels [BR:pret04040]  Voltage-gated cation channels   Ryanodine receptor    103457636 (ryr3) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  103457636 NCBI-ProteinID:  XP_081458481 LinkDB All DBs Position 21:6141569..6266692 Genome browser AA seq 4943 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSVATIQKEHRKFCLAAEGLGNRLCYLEPTSEAKYVPP DMCICNFVLEQSLSVRALQEMLANTGASSEGKADHEKWAGQGGGHRTLLYGHAILLRHSF SDMYLTCLKTSRSLTDKLSFDVGLQEDSVGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSNCNGNIQVDASFMQTLWNVQPTCSSGNMAVGYLIGGHVMRLCHGHDESLT NPGADKSEEEQRIVNYEAGKGASRARSLWRLEPLRISWSGSHIRWGQSFRLRHLSTGHYL ALTEDRGLVLEDREKCHTKATAFCFKPSKEKGDSGMKRDIDGMGVPEIKYGDSVCFVMHV ATGLWLSYLAPDAKSSRLGPLKRRACLHSEGHMDDGLILQRCQHEESRAARIIRNTTFLF KNFIKALDSAAAGETNAVAGYVEEVLQTLNDLIEYFKQPDVDLEHEEKQARLRSLIKRQD LFKEEGMLALLSKCIDRMNLYDSAAHFGEMAGEEAGAAWKDILNLLYELLAALIRGNRTN CTQFSRNLDWLVSKLERMESSSGILEVLHCILVESPEALNIIQKGHIKSIISLLYKHGRN HKILDVLCSLCVCNGVAVRTNQNLICDNLLPKRDLLLQTRLVNDVQSMRPNIFLGIAEGS AQYKKWYYELVIDQVDHFVTGEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDRF FFPVVSFSAGVKARFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKEYKRDHDGV RDLLGTTQFLSQASFIPTPVDTSQIVLPPHLENIRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFSKLPETEKNYNVQMSSETLKTLLALGCHVAQVNVHAEEDLKKIKLP KDYMMSNGYKPAPLELSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDVKSR RNPRLVPYALLDERTKKSNRDSLREAIRTMVGYGYDIDPPDQEVVHALDNQSIETIRFFR VEQTYAVKTGKWYFEFEALTGGDMRVGWARPGCRPDVELGTDDQAYVFDGYRGRRMHAGS RYFGQPWKKGDVVGCMINMEDKSMIFTLNGELLITSKGSELGFADFETEDGFIPVCSLGM SQIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREITMWFSKRLPTFFNVPQDHMHIE VTRIDGTVDSPPCLKVTHKTFGTQNSNSDMVYCRLSMPVEFYSADRLLDESLKLSQPPKE DGSTDYGSITTYYHSVRVFAGQDPASVWVGWVTPDYHYYSKNFSLSKTQTVTITLGDERG RVHESIQRSNCYMVCAADALGPSSSSRSNTDLEIGCLVDLATGLVSFTANGKELPTVYQV EPNTKLFPAVFCCPTSSNLFQFEFVKIQDAMPLSSAMFRSEQRNPVPQCPPRLDVQTIVA VLWSRMPNTFLNVEAARVSERHGWVVQCLESLQMMAVHIPEENRCLDIMELSEHEDLRTF HSHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYDVLISIHLET AKEARLMMNNEFIIPVTDETRSIKLFPDESKHHSLPGVGLSTSLKPRVNFSPVGIISTKR HQLLYSPQIPLGVLKEKAISMLTEAVQGGGSHIRDPVGGSLEYQFVPILKLIGTLLIMGV LTSDEVRLILLLIEPNVFGEAKEGEEGSGGEVVVAGEKEEVSKNEEKAVEAGEEETKESK PAAKGLLEKSLPESVKHQMCELLHYFCDCELQHRIEAIVSFSDRFVSKLQYNQKFRYNEL MLAFNMSAAVTAKKTKEFRSPPHEQINILLNFSAGEDCPCPEEIQDELTSFHEELRLHCG IPVEEEEEEQDTSIKGRLLALLYKIKGPPQKTEEEPAETEQAAPTNLKELISQTITSWAQ ESHIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLS VRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPK MVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNN GLALALEEPDLEKVVTYLAGCGLQSCAILVAKGYPDLGWNPIEGERYLSFLRFVVFCNGE SVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPKSPAGATAG SGEEEGEVIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLV GIISIPLKMPVINKDGSVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFLLQMLEVGFL PDLKASASLDTEVLSTTETALAMNRYIGSALLPLLTRCAALFGNTEHYAHLVDSTLETIY RLSKGRSLTKAQRDAIEECLLAICKHLRPSMMQQLLRRLVFDVPLLTEYCKMPLRLLTNH YEQNWKYYCLPSGMGGFGMASEEELLLTKKLFWGIFDSLSQKKYDSELFKMAKSCLCAIA GALPPDFVDTSLGAMVEKQESVDAQGNFEPKPINTANISLPEKLDYIANKYAEHSHDKWA SEKMSAGWKHGDSLDEQAKAHPLLKPYKSLSEKERETYRWPVKESLKSMLAMNWNIERTK EGEAMFQQRESEKQRKLSETQSNGFSPAPMDLHNVTLSRELQSMVEVVAENYHNIWAKKK KSELLSKGGGLAHPLLVPYDTLTAKEKYRDKEKAQELFKFLQISGYAITRGLKDMEQDSS SMEKRFAYKFLKRLLKNIDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPMIDQT FKNHCLYFLSTPSKNLSSCGCASNKEKEMVTSLFCKMAALVRHRISLFGSDSAIMVSCLH ILSHSLDTRTVMKSGAELVKVGFKAFFENAAEDLEKLVEMLKLGKFMQSRAQMKSVTQSI NYVTVALLPILTALFEHITTHEFDVDLLVDDVQLSCYRILMCFYSLGTGKNVFVERHLPA IGESLATLVGAMPVAFLEPHLNAHNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKL LKDVNDVSESGARYSDMPQVIEVVLPMLCNYLSYWWEKGPENSPPDSDCCTMVTSEHLSI ILGNILKILNNNLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTMEKLKKKTVKVVS EEELLKADGKGDNQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDADSTEL FRMVAEIFILWCKSNNFKREEQNFVIQNEINNLGFLTGEGKSKMSKSGGDQERKHKRRRG EYYSIQTSLIVAALKKLLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKEHLRQNLHLQ EKSDDPAVHWQLNLYKDVVVKSEEPSDSEHTVERIQSISAAVFNLEQVEQPLRNKKCVVQ KLLSKQRKRAVVACFRMAPLYNLPRHRAINFFIPAYERLWIEAEEYSFEEKLVQDLAVST GLALPLPLPCVGTPLPVLFAECFLRLAPVEPWERVGAGTPPKAPGGPRSRHAKSFRQRSV RSQRLHDELRRRRARKAGGGVLTAAKTPMKIVEEEEEEEAEIKPDPLHQLILHFSHNALT ERSYLEVDPLYIAYADMMAKSCAEDEEEEEEEGREKTFEEKEMEKQKILYQQARLHARGA AEMVLQMISASKGRLGPMVTCTLKLGISILNGGNVQVQQKMLGYLTDKRDAGFFKSLSGL MQSCSVLDLNAFERQNKAEGLGMVTQEGSINTQRGSKVLQNDEFTKDLFRFLQLLCEGHN GDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDETGKHNFSKALS VAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDASQIELLKEL MDLQKDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDN FKEYDPECKGIISKKEFQKSMESQKQYNQSEIEFLLSCAEADENDMFNYKEFVERFHEPA KDIGFNVAVLLTNLSEHMPHDARLATFLDLAESVLSYFEPYLGRIEILGSAKRIERVYFE ISESSREQWEKPQVKESKRQFIFDVVNEGGESEKMEMFVNFCEDTIFEMQLASQISEPDA VEQPEEEEEEEVHSILEELSGGDDAALESASAFTTACRSVKKNLSEIRQIFTIKTARKQF KKIKKLSIKELITGFFSFLWMIFIGFFKGIFSLVFGFFHVIWSSMFGGGLVEGAKNIKVT DILGNMPDPTQFGIHGDVGEGDKVEAMESSGSLDKAMAPAGDATEVDVMLEMLAPKKEGG KHVEPGLGDVSELSGESSAADSKKKAAAKTAAPSESETEKADTETREKEDKPKEEEAKEP AVEEKPKPKSSQPKEASPAFMSTVFAILDVYLNKILNYLARNFYNLRFLALFVCFAINFI LLFYKVTGEAEEEEEGDEENSWGDDDGENTLFDMDEFVLQESTGYMLPTLRFLAIFHTVI SLLCLFGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTPSFPN NYWDKFIKRKVINKYGDMYGAERIAELLGLDKSALDFDPTVETVEKEASLLSWLSSIDTK YHIWKLGVVLTDNYFLYLIWYTTMSIFGHFNNFFFAAHLLDIAMGFKTLRTILSSVTHNG KQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAG GGIGDELEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDM ETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMY QERCWDFFPAGDCFRKQYEDQLG NT seq 14832 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaggatgagatccagttcttgagaactgacgatgaggtg gtgctccagagcgtggccaccatccagaaggagcatcgcaagttctgcctggccgcggag ggactcggaaaccgcctgtgttacttggaacccacctctgaagccaagtatgttcctcca gacatgtgcatttgtaactttgtgctggagcagtcgctgtcggtccgcgccctgcaggag atgctggctaacaccggagcgagcagcgaagggaaagccgaccatgaaaaatgggcgggt cagggaggcggacaccggaccctgctctacggtcacgccatcctcttacgtcactccttc agtgacatgtacttgacctgtttgaagacatcaaggtctctgacagacaagctgtcattt gatgtcggactgcaagaagattcagtaggagaagcctgctggtggacgattcatccggcg tccaagcagagatcggaaggagagaaagtccgcataggagatgatctgattctcgtcagc gtgtccactgagagatatctgcatctctcgaactgtaacggcaacattcaggtagacgcc tccttcatgcagaccctctggaacgtccagcctacgtgttcgtcaggcaacatggctgta gggtatttgattggcgggcatgtgatgcgtctctgtcatggtcacgacgagagcttgacg aaccctggagcagataagagtgaagaggagcaaagaatagtgaactacgaggcggggaag ggagcgtcaagagcccgctccctgtggagactggagcctctcaggatcagctggagcggc agccatattcgatggggccagtctttccgcctgcgtcatctctccactggtcactatctg gccttgactgaagaccgtggtttggttctggaggacagagagaagtgccacaccaaagcc actgctttttgctttaagccatccaaggaaaaaggcgattctggcatgaagagggatatt gacgggatgggagtccccgagataaagtatggtgactccgtctgttttgtcatgcacgtg gccaccggactgtggctgtcctacctggcgcctgatgccaaatcgtctcgtcttggtccc ctgaaaagaagggcctgccttcactctgagggccacatggatgatggtctcatcctacag cgctgccagcatgaggagtctcgggctgctcgcatcatccgaaacaccacattcctcttc aaaaacttcataaaggcactggacagcgctgcagccggagagacgaatgcggtggccgga tatgttgaagaggtgctgcagacgctgaacgatctgattgaatatttcaagcagcccgac gtagatctggagcacgaggaaaaacaggcgaggcttcgctcgctcatcaaacgacaagac ctcttcaaggaggagggtatgctggccctgctctccaaatgcattgaccggatgaacctg tatgatagtgcggcccacttcggagagatggccggggaggaagctggtgcagcatggaag gacatcctcaacctcctctatgaactcctggctgcactgattcgtggaaaccggaccaac tgcacccagttctcccgaaacctggactggctggtcagcaaactggaaagaatggagtca tcatcaggaatcctagaagtcctccactgtatcttggtggaaagtccagaagccctgaac atcattcagaaaggtcacattaaatctatcatctctcttctctacaagcatggacgcaac cacaagattctggatgtgctgtgctctctgtgtgtgtgcaatggggtggcagtgagaacc aatcagaatctgatctgtgacaacctgctgccaaaaagggacctgctgctccagacacga ctggtcaacgatgttcaaagcatgaggcccaacatcttcctgggcatcgctgaaggttcg gctcagtataagaagtggtactacgagttggtcatcgaccaggtggaccactttgtgacc ggagagccgacccacctgagagtgggctgggccaacaccaaaggctacgctccgtatccc ggcggaggagagggctggggtggaaacggcgttggggatgacctttactcctacagcttt gatggacttcatctgtggtcaggtcggatccccagagccgtggcctccattaaccagcac ctgctgaactcggacgacgtggtcagttgctgcttggatttgggcgctcccagcatgtcc ttcaggatcaacgggcagccggtgcaggggatgtttgaggactttaacaccgacagattc ttcttccccgtcgtcagcttctctgctggagtgaaagcccgtttcctgctgggtgggcgc cacggagactttaagttcctgccgccagccggttactctccgtgctacgaagcactcctg cccaaggagaagatgcatgtggagcctgtgaaggagtacaagcgggaccatgacggcgtc cgtgacctgctgggaaccacccagttcctgtcccaggcctcctttattcccactccggtt gacaccagccagattgtcctgccgcctcatctggagaacatccgcgacaagttggcagaa aacatccacgaactttggggaatgaataagatcgaactgggctggacgtatggcaaggtt cgtgacgacaacaagaggcagcacccttgtcttgtggatttcagcaagctgcctgaaact gaaaagaactacaacgtgcagatgtcaagcgaaacacttaagacgctgttggcactcggc tgccatgttgcccaggttaatgttcacgctgaagaggacctgaagaaaatcaaattacca aaagactacatgatgtctaatggatacaagcctgcgccgctggaactctctgacgtgaaa ctgactccaggtcaagaggttctggttgataaactggccgaaaacgcacacaacgtttgg gccaaagacagaatcaaacaaggatggacctatggcatccagcaggatgtgaagagcaga cgtaaccctcgcttggtgccatatgctttattggatgaacgcacaaagaaatctaacaga gacagtctgagagaggccattcggacgatggttggatacggatatgacatcgaccctcca gaccaggaggttgtgcatgcattagataatcagagcatcgagacaatccgctttttccgc gtggagcaaacgtacgccgtgaagaccgggaagtggtactttgagtttgaggccctgacc ggaggcgacatgagggtcggctgggccaggccgggctgcaggcccgacgtggagctggga acggatgaccaggcctacgtctttgatggatataggggtcgacggatgcatgctggtagc cgttactttgggcagccttggaagaagggcgacgtggttggttgcatgatcaacatggag gacaaatccatgattttcactctgaacggagagctcctgatcaccagcaagggctctgag ctcggcttcgctgactttgaaacagaggatggttttattccggtgtgcagcctcgggatg tctcagatcggccgcatgaacctcggaaaggacgccagcacgtttaagtactacaccatg tgtggcctccaggagggcttcgagccctttgctgtcaacatgaacagggagataaccatg tggttcagcaagcgtttgcccacctttttcaacgtaccccaggaccacatgcacatcgag gttaccaggattgacgggacagtggacagccccccgtgtctcaaggtcacacataagacg tttggcacccagaacagcaacagcgacatggtttactgcaggctgagcatgccggtggag ttctactctgcagacaggctgctggacgagtcgctgaagctcagccaacctcccaaagaa gatggaagtactgactatggaagcatcacaacttactaccactcggtgagagtgtttgcc ggacaggacccggccagcgtgtgggtgggctgggtcacaccagactatcactactacagc aagaacttcagtctcagcaagacgcaaaccgtcaccatcaccctgggagacgagcggggc cgggtccacgagagtatccagaggagcaactgctacatggtgtgtgcagcagatgcactc ggcccgtcttcctccagccgctcaaacaccgacctggaaatcggctgtctggtcgacttg gccaccggcctcgtctccttcaccgccaacggcaaagaactgcctacagtgtatcaggtg gagccgaacaccaagctgttcccggctgtgttttgctgccccaccagttccaacctcttc cagtttgaatttgtcaaaatacaggatgccatgccgctgtcgtcagccatgttcagaagc gagcagcggaacccggttcctcagtgtccaccgcgtctggatgtgcaaaccatcgtggcc gtgctttggagccggatgccaaacaccttcctaaacgtggaggcggctcgggtcagtgag cggcacggctgggtggtgcagtgtctggagtctctgcagatgatggccgtgcacatacct gaggagaacaggtgtttggacatcatggagctgtcggagcatgaagacctgaggacgttt cactcccacactctgaagttgtactgcgccctctgcgctctgggaaacacgcgtgtggct cacgctctctgcagccacttagaccaatcacagcttctctacaccatcgacaaccagtac ctgtcgggcatgctcagagaaggcttctacgacgtcctcatcagcattcatctagagacg gcgaaagaggcacggctaatgatgaacaacgaattcatcatccctgtgacggacgagacc cggtccatcaagctgttcccggatgaatccaagcaccattctcttcccggagtcggcctg agcacttccctcaaaccccgggttaacttctccccggtcggcatcatcagcaccaaacgc caccagctcctctacagcccccagatccccctgggcgtcctgaaggagaaagccatcagc atgctgacggaggccgtgcagggaggaggctcccacatccgagacccggtaggcgggagc ctagagtaccagttcgtccccatcctgaagctcatcggaacgctgctcatcatgggggtg ctgaccagcgacgaggtgaggctgattctcctcctcattgagcccaacgtgtttggggag gccaaggagggagaagaggggagcgggggcgaggtggtggtggcgggggagaaagaggag gtgagcaagaacgaggagaaggctgtggaggcgggagaggaggagaccaaggagagcaaa ccggccgccaaaggtctgctggagaagtccctgccggagtctgttaaacaccagatgtgc gagctgctgcactacttctgcgactgcgagctgcagcaccgtatcgaggccatcgtctcc ttctccgaccgcttcgtctccaaactgcagtacaaccagaagtttcgctacaacgagctg atgctggctttcaacatgtccgccgccgtcacggccaagaagaccaaggagtttcgctcg ccgccacatgagcagatcaatattctgctgaacttcagtgcaggggaggactgcccttgt cccgaggagatccaggatgaactcacgtctttccatgaagaattacggctgcactgtgga atccccgtggaggaggaggaggaagagcaggacacatcgattaaaggtcggctcctggct ctgctctacaagatcaagggcccgcctcagaagacagaggaggagcccgcagagacagaa caggccgccccgaccaacctgaaggagctgatttctcagacgatcaccagctgggcccag gagtcccacatccaggacccggagctggtccgagtcatgttcagtctgctgaggaggcag tatgatggcatcggcgaactgctgcgggccatgaagaaatcgtacaccatcagcgccgcc tcggtgcaggacgccatcaacctgctggcctctctgggtcaaatcaggtcgctgctttca gtgcgcatgggcaaggaggaagagaagctcatgattgatgggctcggggacatcatgaac aacaaggttttctaccagcatcccaatctgatgagagttttgggaatgcatgagacggtc atggaggtcatggtcaacgtcctgggtggagacaagtcccaggagattgcctttcccaag atggtggccagctgctgtcgatttctgtgctatttctgccgcatcagccggcagaaccag aaggccatgtttgaccacctgagctacctgctggagaacagcagcgtaggactggcgtct gaagcgatgcgaggctccactcctctggatgtcgcagcatcttcagtgatggacaacaac ggtctggctttggctctggaggaacctgacctagaaaaggtggtgacgtacctggcagga tgcggcctgcagagctgtgccatactggttgccaagggttacccggacctgggctggaac cccatagagggagagcgttacctctcattcctgagatttgtcgtcttctgcaatggtgag agcgtggaggaaaatgctaacgtggtggtgaagctgctgatccgacgtcccgagtgcttc ggccccgctctgagaggcgaggggggacaaggtctgctggctgcgatgaaggaggccatc aagatctctgaggatcccgcgttggacctgcccaagagcccggctggagccaccgcgggg tctggtgaagaggaaggagaagttatccacatgggcaacgccatcatgtccttctactcc gccctcatcgacctgctgggacgctgcgctccagagatgcatcttatcaatgcaggaaaa ggtgaagcgttgcgtatcagagccatcctgcgctctctggttcccacgtcagacctggtg ggcatcatcagcatccccctcaagatgcctgtgattaacaaagacggatccgtgacagaa cccgacatgtcggcctgcttctgcccggaccacaaggcccccatggtgcttttcctggac agagtttacggcattgaggaccagagtttcctgctgcagatgctggaagtcgggttcctg ccggacctcaaagcctcggcgtctctggacacggaagtactgagcaccacggaaacggcg ctggccatgaatcgctacatcggttcggctctgcttcctctgctgacccgctgcgccgct ctgttcggcaacacggagcactacgcacatctggtcgactccacgctggagaccatctat cgactgtccaaaggtcgctcgctcactaaagcccagcgggacgccattgaggagtgtctg ctggccatctgcaagcatcttcgaccatccatgatgcagcagctgctcaggcgcctcgtc ttcgacgttcctctgctcactgaatactgcaagatgcctctccggctgctgaccaaccac tatgagcagaactggaagtactactgcctgccgtctgggatgggcggcttcggcatggcc tctgaggaagagctgctgctcacaaagaaactcttctggggaatttttgactctctttct cagaagaaatacgattctgagctgtttaaaatggccaagtcgtgcctgtgtgccatcgct ggagctttgcctccagacttcgtggacaccagcttaggggcgatggtggagaagcaggag tcagtggatgcacagggaaactttgagcccaaacccatcaacactgccaacatctccctt cctgaaaaacttgactacattgctaataagtatgcagagcattcccacgacaagtgggct tcagagaagatgtcggctggctggaaacacggagacagtttggacgagcaggccaaagcc catccgctgctgaagccgtataaatctttaagtgagaaggagagggagacgtaccgctgg cctgtgaaagagtctctgaagagcatgctggcgatgaactggaacatcgagaggaccaag gagggagaagccatgttccagcagcgagagagtgaaaaacagaggaagctttcagaaact cagtctaacggattcagtcctgctccgatggacctgcacaatgtcactttgtcccgagag ttacagagtatggtggaagtggttgcagaaaattaccacaacatctgggctaagaagaag aagtcagaacttctgagtaaaggaggagggttggctcacccgctgcttgtgccctatgat accctgactgctaaagagaagtacagagacaaagaaaaggcccaagagctcttcaagttc ctgcagataagtggctatgctatcacaagaggtctgaaggacatggagcaggactcgtca tccatggaaaaacgttttgcctacaagttcctaaagaggttgctgaagaatatcgactct gctcaggagtttatcgcccatcttgaggcgatggccaccagtgggaaaactgacaagtcc ccccatgaccaggagatcaagttctttgcaaaggttttacttccaatgattgatcagaca tttaagaaccactgcctttacttcctgtccacacccagcaagaacctgagcagctgcggc tgcgcctccaacaaggagaaggagatggtcaccagcctgttctgtaagatggcagctctt gttagacacaggatttctctctttggaagtgactctgcgatcatggtgagctgtcttcac atcctgtcccactcactcgacacgagaacagtgatgaaatccggcgcagagctggtcaaa gtcggcttcaaggccttctttgagaacgcggcggaggacttggagaagctggtggagatg ctgaagctggggaagttcatgcagtcgcgcgcgcagatgaagagcgtcactcagagcatc aactatgtgaccgtggccctgctgcccatcctcactgccctgtttgaacacatcacgacg cacgagtttgacgtggacctgctcgtggatgatgtgcagctgtcctgctaccgaatcctg atgtgcttctacagcctgggaaccggaaagaatgtctttgtggagaggcatctgccagcg attggggagagtctggcgaccttggtgggagcgatgccggtggcgttcctggagcctcat ctcaacgcccacaacccactttcagttttcaacaccaagacgccccgagagcgagccatc ctgagcatgcccgacacggtggaggagatgtgtccagagatgcctcgcctcgacaagctg ctcaaggacgtcaacgacgtgtcggagtccggcgctcgctacagtgacatgccacaggtc attgaggtcgtcctccccatgctgtgcaactacttatcctactggtgggagaaaggcccg gagaactcgccgccggactccgactgctgcaccatggtgacgtctgaacacctgagcatc attctgggaaacatcctgaagatcctcaacaacaacctcggcattgatgacgctccctgg atgaagaggattgcagtttactcgcagccaatcatctgcaaagccggagctgatttgttg agaacccacttcctgcccacaatggagaaactgaagaagaagacggtgaaggttgtgtct gaggaggagctgctgaaggccgacggtaaaggagacaaccaggaagcagagctgctcatc ctggacgagttcgcggtgctctgcagggacctctacgctttctaccccatgctcatccgt tacgtggacaacaacaggtccaggtggctgaaggagccggatgcagactccactgagctc ttcaggatggtggctgagattttcatcctctggtgcaaatccaacaacttcaagcgtgag gagcaaaactttgtgattcagaacgagatcaacaatctgggcttcctgaccggggagggc aagtccaagatgtccaagtctggtggagaccaggagcggaaacataaacggcgccgcggt gaatattactccatccagacgtctctgatcgtagctgcgctcaagaagctgctgcccatc ggcttgaacatgtgcacaccgggagaccaggagctcatctctttggcaaagattcgctac agcctgaaagacacggacgacgaggtgaaggagcatttgcgccagaacctccacctgcag gaaaagtctgatgatccagcagttcactggcagctgaacctttataaagacgtagtggtg aaatcggaggagccgtcggattcggagcacacggtggagagaatccagagcatctctgca gccgtcttcaatttggagcaggtggagcagcctctgaggaacaagaagtgcgtcgtccag aagctgctgtccaagcagcgcaagcgagccgtcgtcgcttgtttccgcatggctccactc tacaacttacccaggcatcgtgctatcaacttcttcatcccggcctatgagagactttgg atagaggcagaggagtactcctttgaggaaaagctagttcaggacctggcagtaagtacg gggctcgccctgcccctgcccctgccctgcgttggcacccctctgccggtcctgtttgca gaatgcttccttagattggcgcctgttgagccttgggagcgagtcggggcggggacgccg cccaaagcgcccggcggcccgcgcagcaggcatgctaagtccttcagacagagatccgtc aggagtcagaggctgcatgatgagctcaggaggcgcagggccagaaaagcaggcggtggc gttctgacggcggcgaaaaccccgatgaagatcgtggaggaagaggaggaggaggaggct gagatcaagccggatccgctccaccagctcatcctccacttcagccacaacgctctgacg gagagaagctacctggaagttgatcctttatatattgcatatgcagacatgatggcaaag agctgtgcagaggatgaggaggaagaggaagaagaagggcgggaaaagacattcgaggaa aaggagatggagaagcagaagatcctgtaccagcaggcgaggctgcacgcgcgtggggct gcagagatggtgctgcagatgatcagcgccagcaaaggtcgtctgggccccatggtgacc tgcaccctcaaactgggcatctccatcctaaatggaggcaacgtgcaagttcaacagaaa atgctcggctacttgacggacaaaagagatgcaggctttttcaagagtctgtcaggactc atgcagtcttgcagtgtcctggacctgaatgcattcgagaggcaaaacaaggcagaagga cttggcatggtgacgcaagaaggttcaatcaacactcagcggggctccaaggtgcttcag aacgacgaattcaccaaagatctgttccgctttttgcaacttctctgtgagggacacaac ggagatttccagaacttcctgagaacccaaactggaaacacgaccacagtgaacatcatc atcagcacggtggactacctgctccgcctccaggaatccatcagtgatttttactggtat tattctgggaaagacgtaattgatgaaactgggaagcacaacttctccaaagctttatct gtcgccaagcagatatttaactcgctcactgagtacattcaggggccttgcattggaaac cagcagagtttagctcacagcagactgtgggacgcagtcgtcggcttcctgcatgtgttt gcaaacatgcaaatgaagctttcacaggatgccagtcagattgagttgttgaaggaactg atggatttacagaaggacatggttgtcatgctgctgtctctccttgagggaaacgtggtg aacgggacaatcgggaagcagatggtcgacaccctggtggagtcttccagtaacgtggag atgatcctgaaattcttcgacatgttcctcaaactgaaagacctcaccacgtccgacaac tttaaggagtacgacccggaatgcaaagggatcatttccaagaaggagttccagaagtcg atggagagccagaagcagtacaaccagtcagaaatcgagttcctgctgtcgtgcgcggag gccgacgagaacgacatgttcaactacaaggagtttgtggagcgattccacgagccggcc aaggacatcgggttcaacgtggccgtgctgctgaccaacctgtccgaacacatgccgcac gacgcccggctcgccaccttcctggacctggccgaaagcgtcctcagctacttcgagccg tacctggggcgcatcgagatcctgggcagcgccaagcgaatcgaacgcgtttacttcgag atcagcgagtcgagccgcgagcagtgggaaaagccgcaggtgaaggagtccaagcggcag ttcatcttcgacgtggtgaacgagggaggagagagcgagaagatggagatgtttgtgaac ttctgcgaggacaccatctttgagatgcagctggcctcgcagatctccgagccggacgcc gtggagcagccggaggaggaggaggaggaagaggtgcacagcatcctggaggagctctcc gggggagacgacgccgccctggagtccgcctcggcgttcaccaccgcctgccgttcggtc aagaagaacctctcagaaatccggcagatcttcaccattaaaacggcgcgcaagcagttc aagaaaatcaagaagctgagcatcaaggagctgatcaccggcttcttctccttcttgtgg atgatcttcatcggcttctttaagggcattttcagcctcgtgttcggtttcttccacgtc atttggtcgtccatgttcggcggagggcttgttgaaggagccaagaacataaaggtgacg gacatcctgggcaacatgccggacccgacgcagttcggcatccacggcgacgtgggggaa ggagacaaagtggaagccatggagtcgtcgggcagcttggacaaagccatggctcctgca ggagacgccacagaggtggacgtgatgctggagatgctggcgcctaagaaggagggaggg aaacacgtggagcccggcctgggggacgtgtcggagctgagcggggagtcgtccgctgca gacagcaaaaagaaagccgctgccaagacggctgctccctccgagagcgagacggaaaaa gcagacactgagacccgggagaaggaggacaaaccaaaggaggaggaggcgaaggaacca gccgtggaggagaaacccaaacccaagtccagtcaacccaaagaggcgtctccggccttc atgtcaaccgtcttcgccattcttgacgtctacctgaataagatactgaactacctggct cgtaacttctacaacctccgtttcctggctctgttcgtttgcttcgccatcaacttcatc ctgctcttttacaaggtcactggtgaagctgaggaagaggaggaaggcgacgaggagaac agttggggtgacgatgacggcgagaacacgctgttcgacatggacgagtttgtgctgcag gagagcaccgggtacatgctgccgacgctgcgcttcctggccatcttccacaccgtcatc tcgctgctctgcctgttcggctactactgcctgaaggttcctctggtggtgttcaagagg gagaaggagatcgccaggaagctggagttcgacggtttgtacatcactgagcagccgtcc gacgacgacatcaagggccagtgggatcgactcgtcatcaacacgccatctttccccaac aactactgggacaagtttatcaagcgcaaggtgatcaacaaatatggcgacatgtatggg gccgagcgcatcgctgagcttctgggtctggataagagcgctctggactttgaccccacc gtggagacggtggagaaggaggcgtccctgctgtcctggctgagctctattgacacaaag taccacatctggaaactgggagtggttttgactgacaactacttcctgtatctcatctgg tacaccaccatgtccatctttggacacttcaacaacttcttcttcgctgcacatctgctg gacatcgccatgggcttcaagacgctgcgcaccatcctgtcctccgtcactcacaacggc aagcagcttgtgctgaccgtcggtctgctggccgtggtcgtctacctctacactgtggtg gccttcaacttcttcagaaagttctacaacaagagcgaggacgaagacgagcccgacatg aagtgtgacgacatgatgacgtgctacttgttccacatgtatgtgggcgtgagagccggc ggaggaatcggagacgagctggaggacccggccggagatccctacgaactctaccgtatc ctgttcgacatcaccttcttcttcttcgtcatcgtcatcctgctggccatcattcagggt ttgatcatcgacgcctttggggagctgagagaccagcaggagcaggtcaaggaggacatg gagaccaaatgcttcatctgcggcatcgggaacgactactttgatcggacgcctcacggg tttgaaactcacaccctgcaagagcacaacctggccaactacctgttcttcctgatgtac ctaatcaacaaggatgagactgaacacacgggtcaggagtcgtacgtgtggaagatgtac caggagagatgctgggacttcttccctgcaggagactgcttccgtaagcaatacgaggac cagctgggttag

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