Poecilia reticulata (guppy): 103476718 Help Entry 103476718         CDS       T05149                                  Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism pret  Poecilia reticulata (guppy) Pathway pret04020   Calcium signaling pathway pret04260   Cardiac muscle contraction pret04261   Adrenergic signaling in cardiomyocytes pret04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pret00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103476718    04020 Calcium signaling pathway     103476718  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     103476718    04261 Adrenergic signaling in cardiomyocytes     103476718  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pret04040]     103476718    04990 Domain-containing proteins not elsewhere classified [BR:pret04990]     103476718 Ion channels [BR:pret04040]  Voltage-gated cation channels   Ryanodine receptor    103476718 Domain-containing proteins not elsewhere classified [BR:pret04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    103476718 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 Motif Other DBs NCBI-GeneID:  103476718 NCBI-ProteinID:  XP_017164629 LinkDB All DBs Position LG15:11448306..11521219 Genome browser AA seq 4952 aa AA seqDB search MTATGEGEDEGQFLRMGDEVVLQSTFTSHNEHLKLCLAAEGFGSRLCRLELTSNCKKVPP DLSVCGFILAQCLSVRALQEMLAHSEQLAAEAKAGVAHRTLLYGQAVMFTHSFSGMYLSC LSSSQTSPDKLAFDVGLQEDKAGEACWWTVHPASRQRSEGEKVRVGDDLILVSVSSERYL HLSFAPVSDNKSLSDSLIVSASFQQTLWSVAPICSGGAIAQGYLKGGETLRLLHSHSDAC LTIPCSEQGEELQRVMHYEIGSVSGHGRSLWRLEILRVAWSGRHTCWGEPFRLCHVTTGR YLGLTEENGLHLVDRDKADINTTSFCFRSSKEKLDAGKNTNSDCMGIPEIKYGDSMCYLQ HLYSGLWLTYQATDAKCRMGGNMRKAILHSEGHMDDGLTLSRSQREESHTAGLIRNTVSL FTRFIRKLDCFSHEGSLSSLCLPTKTVTCSLQDLIKYFQSPLDGQSHEDKQKKMAALRKR QNMFKEEGVIDLVLDCIDHLHHYSSDSYITDSAQWEAVVYLFYELLAALIRGNRVNCAHF SSSVDWLISRLDHLEASSGVLEVLHCVLLESPEAINVIKDGHIQSIISFLEKHGHNNKVL EVLCSLCVSHGVAVRSNQNLICDSLLPDRDLLLQTRLTNQVTSMGANIFLAIGEASAQHR RWYYELVVDHADPFLTAEPTHLRVGWAFTKGYLPRPTGGEGWGGNGVGDDLYSFGFDGLH LWSGCVGRKVSSPFSHLLKDNDVVSCCLDLTVPCISFRVNGLPVQGMLENFNANGLLYPV VSFSAGVRVRFLFGGGHGEFRFLPPPGYASCSEALLPKVKLRVEPCQKYILDCEEGKKEL IGPSVPVTPVTFTPIPVDINKVVLPPQLEDIREKMAENFHKLWVKDRIDLGWTNGPVKDE GKQHDPCLVEFAKLPEQERNQNLQMAEDILKTVLALGFHIGLADDHAEEHVKYTRLHTKY ELPCGYRPAPIDLRQITLSSADKDVVTLLAENHHNIWARERIKQGWTYGPEQDIKGKRSP HLVPYSLVDEGMRKAGMASMREAVRLLLAFGYSLESLSQEQTPLSKPCLFSVEKSRVFRP DKSYAVTMGKWYFEFEVLTAGNMRVGWARPGCTPDKELGSDDQAYVFDGFEAQWCHQGGE PLGRRWLRGDVVGCLVDMFEGTMMVTLNGELLFNDRGSELAAKDLDVGDGLLPVVSVGVN QVGRMNLGRQVESLQYFNVCGQQEGYKPFAFNMTRDPSLWMSWNLPQFTSVLPDDHSLQV TRLRGSMDSLSSLRVSQRVLVQHGGGSEMGFYRLSMPIQCAATLRSPAEGGLQVPSSSLT PSSVRKELEDKDSDFEVLMKSARSFAGSRDELDHKDHSHDKTSKLKQRFMMKRTKPGLVS SNSSARLLEDVIVEKDNYDHLIQSSRYYYAVRILPGQEPFSVWIGWVTSDFHQHGSTFDT DSVGTVTVTLGDDSGKVQESVKRSNCFVVCAGEATGLSQSRRSAGLEIGCLIDTATGLLT FTSNGIEMSTFFQLEAGTKLFPAVFVKPTTSNMFQFELESIKNAMPLSSAFLRSQRRNPS PKCPPRFQVQYLKPVTWTRVPDSGLKVLVDWPDEHHGWRVQCFDPHQVMTLQIPDENRCV DILELSELDDLLAFHQNVLLLYCSLCALGNTRVCHALCSHVDQSQILYAIQNPHLAGPLR LAYYQLFIQVYLSSHTTACLTMNHEYIIPMTDQTGEASFYLCPVIGVSDGGNGQTPGGTC RSTCLKPQMRFSSPCFVRGDGTEAEGAVEIACPDSPEIPLDKLRNLTADMLTAGVVAVGQ AVRDPAGGSVELLLVPLLRLLYNLLVMGVFEDEDLVRVLRLIEPNVFSKNVKTVEEAKDG KQRGESINIKEDDAIKQGLLQMELPEPVQLELCHLLSYLCDCQVRHKVEAVTAFSGNFVR QLQENQRFRYTQVMQALNMSAALTARKTKEFRLPPQEQINLLLSFREDEQQENCPCPVEL QQLLRDFHHLLNTHCGTEMVPDSEEEDDTKMSLKDRLFSRAAKAVGHKKKPTDELEKYKS HSLKSLRRLISEMMVCWAQEREIEDPELVRAIFTLLYRQYQGLEGQMEGSLSKAYVISQS SVEDTMALLSSLGQIRSLLSVRMGNEEEKLMIRRLGDIINNKVFYQHPNLMRSLGMHETV MEVMVNVLGEGESKEIAFPKMVASCCRFLCYFCRISRHNQGALFDRLSYLLENSRVGLAS PSMRGSTPLDVAAASVMDNNELALSLKEADLEKVVQYLAGCGLQSCSLLLAKGYTDIGWN PVEGERYVDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALRGDGGDGLLAAMKEAI SISQDPSMDGPFPTQHNKTMDAVHSNEDDLIHMGHAIMTFYSALIDLLGRCAPEMHLIQG GKGEAIRIRAILRSLIPVQDLEGVISICFQLPSVSEDGVLVEPDLTTAFCPDHKAAMVLF LDRVYGVESQSFLLHLLEVGFLPDLHAAVSLDTTDLGSTDMALALNRYLCTAVLPLLTKC SALFHDLEDHALLVDSLIQAIYRLSRALSLTRAQRDTTEDCLLALCSKLQPSTMQPLLQR LVFDVLHLSDHSKLPLKMLTSHYEQMWKYYSYSGNQDKQKLASERELQLSRKLFWGVFKA LTKKSFIPQLLSLCVQCLVAVAKALPPDYVEPGCLSQVDRITSVDTDGYFEPHPVDTSNV SVPERLDFVVNKYAEHTHEKWSLEKFASGWVHGDQLCENAKVHPLLKPYRALAEKEKDSY RWAIKETIKSMLAFGWTIERTKEGDAFGILACARRISQAGQLSFEGASTFSPKPLDMSSI ILSWEQCAMAEQLAENYHNAWAKTKKLELESRGGGHSMLVPYDALTAKEKTKFREKAQEI LKFLLLHGYTVWRDRKSMEIDFPATANCFGHIFLQRMLYYTEETQENMLKLEVIQARGQV PKGERAQDQQPIIFFQKVVLPLLEQYVKSHRLYFLSSSLKSSENRSHASKREKEMVLCVF CKLAALVRHRISLIGDEASAATSCLRILAQALDARILTAAASESIQTSLHSFFEAAAADL EMTVGKISETLPHSRGQLSKGVVNTLNYTTSILMPTLTSLFHHLANQNYGVDVLVGGIQV SCYKILNSLYSLGTSKSFYMEGQRSAAGACVAALTGAFPVCFLEPTLDHNNPHSIYNVMS PTEIKDQGLPDRMEDACRPLPSLGEALEKVEELAGAGSAAHQMQYIHVAEVTLPMLCSYI LHWCPWGPKGPPEGPVLTSVVPQHASDLIGHILRIIHNHVGASQGDWMKQLAVFSQPIVC KADGELLRSHFLPLMEKLRKRAECVQSEEEVIKAEDCCSSEAELQIQEKYRVLVQDLYAF YPLLIQFVDFNRARWLKETIPEAEQLFSMVAEIFVFWAKSHHFKWEEQSYVVQNRINNLA FLLSSDNMLEFDHKNKGMKRKGDRYSAHTSLIVAAIKKMVPVGLRVCFPCDQNLIMLVKN CYSQNNLEDEIREHILRYLKHSFGQASNSVSRGILSADLPAQLEAPADTQRTVDRVLEIA RVLYYLDQVEHPQRSKKPAWNKILSKQRKRAVVACLRMTPLYNLPLHRAVNLFLQGYNRS WISTEGNDLVEMLVEDLAKGRVTKPWEGEKGEAKEVEEGTKAIDPLLQLIMLFSRSALTE SSNLDNDNLYKDYAAIMAKSCRRESQDDAEQEVESFEEKEMEKQKLLYQQARLHCRGAPE MVLQAISTSNGTMGFMIGPTLKLGIALLNGGNATVQQKMLDYLREKRNVGFFQSMAGLMR SCSVLDLNAFERQNKAEGLGMATDESSGEKVMQDKDLTCDLFRFLQLLCEGHNSDFQNYL RTQTGNNTTVNIVISTVDYLLRVQESISDFYWYYSGKVVIDPLGQHNFSKAIEVAKQVFN TLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSRQIKLLKELMDLLKDM VVFLLSMLEGNVINGTIGKQMVDMLVESSGNVEMVLKFFDMFLKLKDLTSSEGFREYDSD CKGSICRKDFQKAMENCKCFSQAEIHFLLSCIETNDGDILEYETFVDRFHEPAKDIGFSI AVLLTNLSEHMPKESRLKTFTELAECILTYFQPSLGRIEILGSGKRFERVYFEISEYSRT QWEKPQVKESKRQFIFDVVNKGGDKEKMEMFVNFCEDTIFEMQLAAQISGSNSGEKWYEK TEVETRELEEYSPSDYKRWTSIYYWWLMLTCALSVKNLKTLMKMTPKDFLLAAVRFIRFV CVLQIRCISAIICRIMYLLYVTFVNSGLIEAAKRMKVSDLLGGILEPTLDEVMEVSSNVD QLRKYSASFSSQKELREIGQMASLTFPKEVDILSDIFGLKLKKEGDQYRLVTQDLSDSLT DLFSSTSRTIIDTDVSEEHHTLQFTDHLDKEKTQDEKTENLQEKEWKKTEKECRNAKEET KHGAKRGSNGSKEPQRQPSALWETIRSHSKSLMNYFARNFYNMRLLALFVAFAINFILLF YKVAFFPASKEEQATISAYGKEQLSATTNASNGRVYFVLEESSGYMELCLHFLSIAHTII SFCCIIGYYCLKVPLVIFKREKEVARKLEFDGLYVTRQPPEEDVKGQWDHLVINTLSFPS NYWDKFVKRKVMDKYGDFYGRKKISELLGLDQAALDFSTERKEQKRLRRDSAWSVLTAVC SRFNSLDAKYQVWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRT ILSSVTHNGKQLVLTVGLLAVVVYLYTVIAFNFFRKFYNHSRGKETEDMKCNDMLTCYMF HMYVGVRAGGGIGDEIEDPAGDEFEVERIVFDITFFFFVVVILLAIIQGLIIDAFGELRD QQEQVKEDMETKCFICGIGSEYFDKIPHGFETHTLQEHNLANYLFFLMYLINKDETEHTG QESYVWKMYQERCWEFFPVGDCFRKQHEDQLG NT seq 14859 nt NT seq  +upstreamnt  +downstreamnt atgaccgccacaggagagggtgaagatgagggacagtttttacgaatgggagacgaggtg gttttgcagagcacctttacctcccataacgaacatttgaagctctgtcttgctgctgaa ggatttggcagcaggctttgcaggcttgagctcacttcaaactgcaagaaggttcctcca gacttgtctgtgtgtggcttcatcctggctcagtgtctctctgttcgagccctgcaggag atgctggcccacagcgaacaactggcagcagaggcaaaagctggagttgctcatcgcact ctgctgtacggccaggcagtgatgttcacacactccttcagcggcatgtatcttagttgc ttgtcttcatctcagacttcacctgacaagttggcgtttgacgtgggtctgcaagaggat aaagcaggagaggcatgttggtggactgtccatccggcttccaggcagaggtcagagggc gagaaggtgcgtgtcggagatgacctcatactggtcagtgtctcctctgagagatatctg catctgtcctttgcccctgtatctgacaacaaaagcctgagcgacagtctgattgtcagt gcctccttccagcagactctttggagtgttgctcccatctgctctggaggtgccattgct caaggctatctaaaggggggagaaacgttgcgtctgctccacagccatagtgatgcttgt ctgactattccttgttcagagcagggagaggagcttcaaagagtgatgcattatgagatt ggatctgtgtctggtcatggacggtccctctggaggctggaaattctgcgtgtcgcgtgg agtgggaggcacacatgttggggcgagccttttcgcctgtgccacgtaacaacggggagg tacctgggtctgactgaggaaaacggattgcacctagtcgatcgggacaaggccgacatc aacacgacctccttctgcttccgatcatcaaaggagaaactcgatgctggcaaaaacaca aatagtgattgcatgggaatcccagaaatcaaatatggagactcgatgtgttaccttcag catctgtactcaggactgtggctaacctatcaagccacagatgccaaatgccgcatgggt ggaaatatgcgcaaggccattttgcacagcgagggtcacatggatgatggactgacgtta tctcgctctcagagagaagaatctcacaccgccggactcatccgaaacactgtctctttg tttactcgctttataaggaaactcgactgttttagtcacgaaggaagcctctcctcactc tgtctgccaacgaagacggtaacctgcagcctccaggatctcatcaagtacttccagtct ccacttgatggacaaagccatgaagataaacagaaaaagatggctgcccttaggaaacgc cagaatatgtttaaagaagagggtgtaatagatctggtcttagattgcattgatcatctg caccactacagtagtgattcttatataaccgattctgctcagtgggaggccgtcgtctac ttgttctatgagttacttgctgctttgatccgtgggaaccgtgtaaactgtgctcatttc tcaagctctgtggattggctcataagcagactggaccatctagaagcatcttctggagtc ttggaggttctgcactgtgttcttctagagagtcctgaggcaattaatgtcataaaagat ggacacattcaatctattatctcttttctggaaaagcatggacacaacaacaaggtgctg gaggttctgtgctcgctgtgtgtgtcccatggtgtggcggtgcgctccaatcagaacctc atctgcgacagcttgctgccagacagagatttgctacttcagacgcgactgactaatcag gtcaccagcatgggagcaaacatcttcctggccataggagaggcctcggctcagcatcgg aggtggtactatgagttggtcgttgatcatgctgacccgtttctcacagctgaaccgaca cacctgcgtgttggctgggccttcaccaaaggctacctgcccaggcccacaggaggagag ggatgggggggcaatggagttggtgatgacctctattcgtttggcttcgatgggctacac ctgtggtcaggttgtgtgggccgtaaagtcagttcccccttctctcatctgctgaaagat aatgatgtggttagctgctgtctcgacctcacggttccatgcatctccttccgggtcaac ggtctgccagtgcagggcatgctggagaacttcaatgctaatggacttctgtatcctgtg gtcagcttctcagctggagtcagggttcgttttctgtttggtgggggacatggagagttt cgcttcctgcccccaccaggctatgcttcatgctctgaggctttgctccccaaagtcaaa ctgagggtggagccgtgtcagaaatacatcttggactgtgaagagggaaaaaaagagctc attggcccctcggtgccagtcactccagttaccttcacccccattccagtagacatcaac aaggttgtgttaccgccacaacttgaagacatccgagaaaaaatggcagaaaattttcac aaactctgggtaaaggacagaattgacctcggatggacaaatggaccagtgaaagacgaa ggtaaacaacatgacccttgtctcgtggagttcgccaagcttcctgagcaggagagaaac cagaaccttcaaatggctgaggacatacttaagacggtgcttgcccttggtttccacatt ggtttggcagatgaccacgctgaagaacacgtcaaatacacgagactacacacaaagtat gagttgccctgtggctacaggcctgcaccgatagatttaagacaaatcactctgagttca gctgacaaggatgtggttaccctcttggccgaaaaccatcataatatctgggccagagag cgtatcaaacaggggtggacctatggaccggagcaggatataaagggtaaacggagtcct catctcgtgccttacagccttgttgatgaagggatgaggaaagcgggcatggcgagcatg agagaggccgtccgtctcctgctggcatttggctacagcctggagtccctaagccaggaa cagactcctttatcaaagccatgcctcttttctgtggagaagagcagagtgttcagacca gataaatcctacgcggtcaccatggggaagtggtattttgaatttgaagtactgacagcc gggaatatgagagtgggctgggcccgaccgggctgtactccagataaagagctcggctca gatgaccaggcttatgtctttgatgggtttgaggctcagtggtgccatcagggtggcgag cccctgggacggcgctggctcagaggcgatgtggtgggttgcctggtggacatgttcgaa ggcaccatgatggtcacgctcaatggagagctgctgtttaatgacagaggatcagagctg gctgccaaggatttggatgtcggagatggcttattgcctgtggtcagtgttggggttaac caggtggggaggatgaatctgggccgccaggtggagtctctgcagtactttaacgtgtgt gggcagcaagaaggttacaaaccctttgcctttaatatgaccagagacccgtctctgtgg atgagttggaacctgccccagtttacttcagttctgcctgatgatcacagcttacaggtt actcgacttaggggctcaatggattccttatccagcctgagggtctctcagcgggtgttg gtgcaacacggtggaggaagtgagatgggcttttaccggctcagcatgcccatccaatgt gctgccacactcagaagccctgcagaggggggccttcaagtcccctccagctctctaact ccaagttcagtgaggaaggagctggaggacaaggactctgactttgaagttcttatgaag tcagcacgcagcttcgccggctcgagagatgagctggaccacaaagatcacagtcatgac aaaacatctaaactgaaacagcggttcatgatgaaaaggactaaaccaggcttagtcagc agcaactcctctgcacggcttctagaagacgttattgttgaaaaggataactacgatcac cttatccagagctccagatattattatgcagtgaggattcttcctggccaggagccgttc agtgtgtggataggctgggtgacctctgactttcatcagcacggctcaacatttgacacg gacagcgttggcacagtaactgtcacccttggcgacgacagtggcaaagttcaagaaagt gtgaagcgaagcaactgtttcgtggtttgtgctggagaagctacgggcttgtctcagagc cgtcggagtgcggggttggaaattggctgcttgattgacacagcgaccggactgctcact ttcacttctaatggcattgagatgtcgactttcttccaactggaggctggtaccaagctg tttccggctgtttttgtcaagcccaccaccagcaacatgttccaattcgaactggaaagc atcaagaatgccatgcctttgtcatcagctttccttcgcagtcagagaaggaatccgagt cctaagtgccctccaaggtttcaggttcagtatctgaaaccagtgacctggacaagagta ccagacagtggattaaaggtgcttgttgattggcctgatgaacaccatggctggagagtc cagtgctttgacccccatcaagtgatgacccttcagattcctgatgaaaacagatgtgtt gacattttggagctgtccgagctcgacgacctcctcgcttttcatcaaaatgtcctcctg ctctactgctcgctctgtgccctgggcaacaccagagtttgccacgctctctgcagtcac gttgaccagtcgcagatcctttatgctattcagaatcctcacctcgcggggccactccgc ttggcatattatcagctgtttattcaggtttatctaagcagtcacaccacagcatgcctc acgatgaaccatgaatacatcatcccaatgacggaccagaccggagaagcctcattttat ctctgccctgtcattggcgtttcagacggagggaatggtcaaacaccagggggcacttgt agaagcacatgccttaaaccacagatgcgtttttcatctccttgttttgtcaggggtgat gggacggaagcagaaggtgcggttgaaatagcctgcccagacagcccggaaatccctctg gacaagctgaggaatttgacagcggacatgctgactgccggggttgtggctgtcggccaa gcagtgagggatcctgcgggaggcagtgttgaactgttgctcgtaccccttttaagattg ctgtacaaccttttggtcatgggggtgtttgaggatgaagaccttgtgagggtgctcagg ctaattgaaccaaatgtcttctccaaaaatgtcaaaaccgttgaggaagccaaggatgga aagcaaagaggagaaagcatcaacataaaagaagatgatgccattaaacaaggacttctt caaatggagcttccagagcctgtccaactagagctctgtcatctgctgtcctacctgtgt gactgccaggtgcgacacaaggtcgaagcagtgactgcattctctggaaactttgtgcgt cagctgcaggagaaccagcgatttcgctacactcaggtcatgcaggcactcaacatgtct gcagcactgaccgcacgcaaaaccaaggagttccgacttcctccgcaagagcagatcaat ttgctgctgagcttcagagaagatgagcaacaggagaactgtccgtgtccggtcgaactc cagcagctcctgcgcgactttcatcacctcctcaacacacactgtggcactgaaatggtc ccagactctgaggaggaagatgataccaagatgtctttgaaagatcgactattcagtcga gcagcaaaagcagttggacataaaaagaaacccactgatgaactggagaaatataaatca cacagtctcaagtccctcagaaggctgatttctgagatgatggtgtgctgggctcaggag agagagatagaagaccctgaactggtcagggctatcttcaccttgctataccgccagtat cagggcctcgagggccaaatggaagggtcactctcaaaggcatacgttatcagccagtcg tccgtggaggacaccatggcactcctgtcctctctgggtcaaattcgttctctcctgagt gtccgcatggggaacgaagaagagaagctgatgattagaagactaggagatattataaat aataaagttttctaccaacatcccaatttaatgagatctttgggcatgcatgagacagtg atggaggtgatggttaatgttctgggagaaggggagtctaaggagattgccttccccaag atggtagccagttgctgtcgattcctctgttacttttgtcggatcagtcgtcacaatcag ggggcgctgttcgaccgcctctcatacttactggaaaatagcagagttggactagcttca ccgtccatgcgtggctccactcctcttgatgtggcagcagcctctgttatggataataac gagctggctttatcgttgaaggaagctgacctagagaaggttgttcagtaccttgctggg tgtggtctccagagctgttcactgctactggcaaaaggctacactgatattggatggaac cctgtggagggagaacgctatgtggattttttacggtttgctgtgttctgcaatggcgag agtgtagaggagaatgcatatgtggttttgaggttgctgatccgtcggcctgagtgcttt ggccctgcgctcagaggagacgggggagacgggctgctagccgccatgaaggaagccatc agcatctctcaggacccatctatggacggacctttccccactcagcacaacaaaacaatg gatgcagtccacagcaacgaggatgaccttattcacatggggcacgccatcatgaccttc tactcggcacttattgacttactgggacgctgtgctccagagatgcatttaattcagggt ggcaaaggagaagccattcgcatcagggccatcctgagatctctcatcccagttcaggat cttgaaggagtcatcagcatctgctttcaactcccatccgtgtcagaagatggtgtgttg gtggagcctgacctgaccacagctttctgtcctgaccacaaggcagccatggttttattc ctggatcgtgtttatggtgtggagagtcaaagttttcttctgcaccttctggaagttggc tttctgcccgaccttcacgcagctgtttctcttgacactactgacctgggatctactgac atggctcttgccctcaatagatacttgtgcacagctgtccttcccctgctcaccaaatgt tcagccctctttcacgatttagaggatcatgccttgctggtagattctctcatccaggca atctaccggctctcaagggctctaagcttgaccagggctcagagagacaccacagaggat tgtttgctggctttgtgcagtaaactccagccatctacgatgcagcctctccttcaaagg cttgtgtttgatgttctccatctctcagatcacagcaaattgcccctgaaaatgttgacc agtcattatgagcagatgtggaagtattactcctactctggaaatcaggataaacaaaag ttagcctctgaaagggagctccagctgtctagaaagttattctggggtgtgtttaaggcc ttgacgaaaaagtccttcattcctcagctgcttagtttgtgtgtgcagtgtcttgttgca gttgccaaagccttgcctcctgactatgtggagcctggctgtttgtctcaagtggacaga ataacctcggtggacacggacggatattttgagccgcatcctgtagatacatcaaatgtc tctgtgcctgaacgactggactttgtagttaacaagtacgcagagcacactcatgagaag tggtctctagaaaagtttgccagtggctgggtgcatggtgatcagctgtgtgaaaacgcc aaggtccaccctctcctgaagccatacagggctctggctgagaaggagaaggattcatat cgctgggccatcaaagagacaataaagagcatgttggcctttggatggactatagaacgt accaaagaaggagatgcatttggcattctcgcctgtgctcgtaggatctctcaggccggt cagctctcatttgaaggagcatccacctttagccctaaacctttggacatgagcagcatc atcttatcctgggaacagtgtgcaatggccgaacagttggctgaaaactatcataatgcc tgggccaagactaagaagttagaactggagagcagagggggaggccattcgatgctggtt ccatacgacgctctgactgccaaggagaagaccaagttcagagaaaaagctcaggagata ctgaagttccttttgctccatggctacactgtgtggagggatcgaaaatccatggaaatt gacttccctgctactgcaaactgctttggacacatttttctccaacgcatgctgtattac accgaggagactcaggagaacatgctaaagctcgaggtgattcaagccagaggacaggtg cctaaaggagaaagagctcaagatcagcagccaattattttttttcagaaggtcgttctt ccactattggagcagtatgtaaaaagccatcgtctgtattttttgtcctcttctctgaag tcaagtgaaaacagaagtcatgcctccaaaagggaaaaggagatggttctgtgtgtcttc tgtaagcttgctgctttggttagacacagaatctcactaattggagacgaagcctctgct gctacaagctgcctccgcattctggctcaggcgcttgatgcaagaatattgacagcagca gcttcagagtccatacagacgtctttgcattcatttttcgaagcagccgcagcagatttg gagatgactgtggggaaaatatcggagaccttgcctcacagcagaggtcagctgtctaaa ggagttgtcaacactcttaactacacaacgtccatcctaatgccaacacttacctccctc ttccatcatcttgccaatcaaaactatggagtggatgttctggtcggtggtatccaggtg tcatgttacaagattttaaacagcctctactctctggggaccagtaaaagcttctacatg gaggggcagcggtcagcagcaggcgcatgtgtagcagctctgaccggagcttttcctgta tgcttcctggagccaactctagaccacaacaatccacattctatctacaatgtcatgagt cccactgagattaaagaccagggactgccggaccggatggaggacgcgtgtcgccctctt ccttcactgggagaggcgctggagaaagtggaggagctggctggtgctggttctgcagct catcagatgcagtacatccatgtggcagaggtcactttgcccatgttgtgcagctatatt ttacactggtgtccctggggccctaaaggccccccagagggcccagtcctcacctctgtt gttcctcagcatgcgagcgacctgattggccacatccttcgtatcatccacaaccatgtg ggcgctagccagggtgactggatgaagcagcttgcagttttttcgcagccgatcgtatgc aaagctgacggcgagctgctgagaagtcactttctccccctgatggagaagctgaggaag cgggccgagtgtgtccagtcagaagaggaagtgattaaagcggaagactgctgtagttct gaagcagagctgcagatacaggagaagtacagagttctggtccaggatctctatgccttt tatcctcttctcatccagtttgtcgattttaatcgagccagatggctgaaagagacaatc cccgaggctgagcagctgttcagcatggtggcagagatctttgtattctgggccaaatct catcatttcaaatgggaagagcagagttacgtggtccagaatcggatcaacaatttggct tttttgctctccagtgacaacatgctggagtttgaccataaaaacaaagggatgaagagg aagggggatcgttactctgcacacacttctctcatagtggctgccataaagaagatggtg cctgtgggactcagagtttgttttccatgtgaccagaaccttattatgttggtgaaaaac tgctattctcagaataaccttgaagatgagattcgggagcatattttgagatacctcaag cattcttttggtcaggcatcaaacagcgtcagccgtgggattctgtctgctgatctccca gcacagcttgaggccccagctgacacacaaaggactgtggacagggttctagaaatagct cgggtgctttattacctggatcaggtagagcacccacagagaagcaaaaaacctgcttgg aacaaaattttatccaaacagaggaaacgtgcggtggtggcttgcctgaggatgactccc ctctacaatctgccactgcaccgagctgtcaaccttttcctgcaaggctacaacagatct tggatatcaacagagggaaatgacttggtagaaatgcttgtggaggatttagctaagggg cgagtgacgaaaccgtgggaaggtgagaaaggggaagcaaaggaggtggaagaaggcacc aaggcaattgatcctctccttcagctcattatgctcttcagtcgaagtgcactgacggaa agcagcaaccttgataatgacaacctctacaaagattatgctgctattatggccaagagc tgccgcagagagagccaagatgatgcagagcaggaagtagaaagctttgaagagaaagag atggaaaagcaaaagctgttgtaccaacaggccaggctgcattgtcgtggagcccctgaa atggtcctgcaggctattagtaccagcaatggcaccatgggattcatgattggtcctact ctgaaactaggtattgctcttcttaatggagggaatgcaacggttcagcagaaaatgttg gattatctaagagagaagcgcaatgttggcttttttcagagcatggctggactcatgcgg tcatgtagtgttctggatttgaatgcatttgagaggcagaacaaagcagagggattaggc atggccacggatgagagctcaggagagaaggtgatgcaagacaaggacctgacttgtgac ctattccgtttccttcagctgctttgtgaaggacacaattcagatttccagaactattta agaactcaaactgggaacaacaccaccgtcaacattgttatatcaacggttgactattta ctaagggtacaggaatcgatcagtgatttctactggtactactcggggaaagtcgttatt gatcctctgggtcaacacaacttctccaaggccattgaagttgccaaacaggtcttcaac acactcaccgagtatatacagggtccgtgtattgggaaccagcagagtctggctcacagt cgtctgtgggatgctgtcgtgggattcctccatgtctttgctcacatgcagatgaagctc tctcaggattcaaggcagataaaactcctaaaggaactgatggacttattgaaggacatg gttgtgttcctcctttccatgttagaaggcaatgttatcaatggaacaattgggaagcag atggtggatatgttggtggaatcatcaggcaatgtggaaatggtccttaagtttttcgac atgttcctcaaactaaaagacctgacttcatctgagggcttcagagagtacgactctgac tgtaagggcagcatatgcaggaaggacttccagaaagccatggaaaactgcaaatgcttc tcacaagccgagatccacttcctgctctcttgcattgaaacgaacgacggcgatatcttg gaatacgaaacgtttgtggatcgcttccacgagccggcgaaagacatcggcttcagcatc gctgttctcctcaccaatttgtcggagcacatgcccaaagagtccaggctgaagacattc acggagcttgcagaatgcatcctgacctactttcagcccagtcttggacgcattgagatt cttggcagcgggaagcgctttgaacgggtctactttgagatcagcgaatacagtcgcaca cagtgggagaagccacaggtgaaggaatccaagaggcagttcatctttgatgtggtcaat aagggaggagacaaagagaaaatggagatgttcgtcaacttctgtgaggacaccatattt gagatgcaacttgcagcccagatatccggatccaactctggagagaagtggtacgagaaa acagaggtggagacgagagagcttgaagaatattcaccctcagattacaagaggtggact tctatctactattggtggctgatgttgacttgtgccctttctgtgaaaaacctgaaaaca ctgatgaagatgacgccaaaggatttcctcttagcagcagttcgattcatcagattcgtt tgcgtgcttcagatccgctgcatttctgctatcatctgccgcatcatgtatttgctgtac gtcacatttgtcaacagtggtctcatagaggcggcaaaaagaatgaaggtgtcagacttg ctcgggggtatccttgagccaactcttgatgaggtcatggaggtgtcgagtaatgtggat caactgagaaagtactctgctagtttctcttctcagaaagaattgagggagatcgggcag atggcttcattgacctttcccaaggaggtggacatattgtcagacatatttggtctcaag ctgaagaaggagggagatcagtacagacttgtaacgcaagatctctctgacagtctgact gatctgttcagttcaacttccagaacaataatcgacacagatgtttctgaggagcaccac actttgcagtttacagaccacttggacaaagagaaaacacaagatgagaaaacggagaac ttacaggaaaaagaatggaagaaaactgaaaaggaatgtaggaatgcaaaagaagagaca aaacacggagccaagagaggcagtaatgggtcaaaggaaccacagagacaaccttctgct ctctgggaaacgatacgctcacatagcaagagtctaatgaactactttgcaagaaatttt tataacatgcgtctgctggcattgtttgttgcttttgcaatcaacttcatcctcctgttc tataaggtagcattttttcctgcatccaaagaagaacaggcgactatatcggcatatgga aaagaacagctctctgccacgacaaacgccagcaatggcagagtttattttgtgcttgaa gaaagcagtggctacatggagctgtgcctccattttctttccatcgcacacacaatcatc tcattctgctgcattattggctactactgcctcaaggtgccgttggtgatcttcaaacgt gagaaggaggtggccagaaaactggagtttgacggactgtacgtgactcggcagcctcct gaggaagacgttaaagggcaatgggaccacctggtcatcaacacactatcatttccaagt aattactgggataaatttgtgaaaaggaaggtgatggataagtatggagacttttatggc cgtaagaagatcagtgaactgttaggcctggaccaagctgctttagacttcagcaccgag aggaaagaacagaagagactcagaagagacagtgcctggagtgtccttactgctgtttgt tccagattcaactcccttgacgcaaagtaccaggtctggaagctaggagtggtgttcact gacaactccttcttgtacttggcgtggtacatgaccatgtcagttttgggtcattataac aacttcttctttgctgcccaccttttggacatcgctatgggctttaagacactccgtacc atcctttcctccgtcacacacaatggaaaacagctggtgctgactgtgggtctgttggca gttgtggtgtatctctacaccgtcatagccttcaacttcttcagaaagttttacaaccac agccgtggcaaggaaactgaagatatgaagtgcaatgatatgcttacttgttacatgttc cacatgtacgtgggagtgcgagcaggtggcgggattggcgacgagatcgaggatcctgct ggagacgagttcgaagttgaacggatcgtctttgatattacgtttttctttttcgtcgtc gtcatcctgctcgccattatccagggcttaataattgatgcctttggtgagcttcgagac cagcaggagcaggtgaaggaggacatggagaccaaatgtttcatatgtggaataggaagc gagtactttgacaagattcctcacggcttcgagactcacactctgcaggagcacaacttg gccaactatctatttttcctgatgtatctcattaacaaggatgaaactgaacacacggga caggaatcctatgtgtggaaaatgtaccaggagcgttgctgggaattctttcctgtggga gactgtttccgtaagcagcatgaggatcaactcggctga

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