Phodopus roborovskii (desert hamster): 127213181 Help Entry 127213181         CDS       T08852                                  Symbol Ubr4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism prob  Phodopus roborovskii (desert hamster) Pathway prob05165   Human papillomavirus infection prob05203   Viral carcinogenesis Brite KEGG Orthology (KO) [BR:prob00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     127213181 (Ubr4)   09172 Infectious disease: viral    05165 Human papillomavirus infection     127213181 (Ubr4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:prob04121]     127213181 (Ubr4) Enzymes [BR:prob01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      127213181 (Ubr4) Ubiquitin system [BR:prob04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     127213181 (Ubr4) SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4_TPR UBR4_Ub UBR4 zf-UBR_1 zf-UBR Motif Other DBs NCBI-GeneID:  127213181 NCBI-ProteinID:  XP_051029428 LinkDB All DBs Position Unknown AA seq 5220 aa AA seqDB search MATSGGDEAAAAAPAPGAPATGQDTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESE SEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDE ACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVTTLSDVEDQKELASPV SPELRQKEVQMNFLNQLTSVFNPRTVPSPPISPQALVEGENDEQPSTDQASAVKTKNVFI AQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVVANSFFIMPATVADATAVRNGFH SLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHFQNFQLLGAWCLLNSLFL ILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHA IKLLTSLFQDLQVEALHKGWETDGPPAVLSIMAQSTSTQRIQRLIDSVPLTNLLLTLLST SYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETIS PSKEKAAPPPPPLPPPLESSPRVKSPSKQASGEKGNILASRKDPELFLGLASNILNFITS SMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEDFAAALYHFNHSLVTS DLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQGLSVLSRLLLIWQHKAGAQGDPDVPECL KVWDRFLSTMKQNALQGAVPSETEDLNVEHLQLLLLIFHNFSEKGRRAIFTMLVQSIQEL SVNMEVQMRSVPLTLARLLLIFDYLLHQYSKAPMYLFEQVQHNLLSPPFGWASGSQDSSS RRANTPLYHGFKEVEENWSKHFPSDAAPQPRFYCVLSPEASEEDLYRLDSVACEVLFSKI VKYDELYTSLTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYM NQLAMNLPEMSECDILHTLRWSSRLRISSYVNWIKDHLVKQGMNPEHAGSLVDLTSSKCS SVKYDVEIVEEYFARQISSFCSIDCTTVLQLHEIPSLQSIYTLDAAISKVQVSLDEYFSK MAAETDPHKSSDITKNLLPATLQLIDTYASFTRAYLLQNLNEEGSTEKPSQEKLHGFAAV LAIGSGRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDIIPSESY ISAVQAAQLGTLCGQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPAQVIRTLLPLLLES STESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECL QYLEKQLESNQARKAMEEFFSDGGELVQIMMATANEDLSAKFCNRVLKFFTKLFQLTEKS PNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLEVIQENRQLLQLLTTYIVR ENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAV DWLGRCKKYLSQKNVVEKLNANVMHGKHVTVLECTCHIMSYLADVTNALSQSNGQGPSHL SVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHT CKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMK ESAFQSEPRVSESLVRHASTSPADKAKVTISDGKVTDEEKPKKSSLCRTVEGCREELQNQ ANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHSVDKVVEMTDQLMVPT LGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKIT VLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSS SGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLSIDALSPTFYFLLP SSKIRDVTFLFNEEGKNIIVIMSSAGYMYTQLMEEASSAQQGPFYVTNVLEINHEDLKDS NSQVAGGGVSVYYSHVLQMLFFSYSQGKSFAATVSRSTLEVLQLFPINIKSSNGGSKTSP ALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTAC NEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITARTS SQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISN NSSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLN LFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGES DSTTPATSSGTVLESSETESLTKLDRLVVSSLEALESCFAVGPIIEKERNKHAAQELATL LLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQ RLVITARSIAIMRPNNLVHFTESKLPQMETDCFFPRCACWNLGIVGILIGAPVETPSAEG ADEGKEPQKQVEGDSCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDI IHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSN TPMGDKDDDDDDDADEKMQSSGIPDGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVN NGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGL SGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVD SVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGEAEGD VHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDN LLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISS ATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQ YVKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTSSRIPPPVFDHSWFYFLSEYLMIQQT PFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSA LQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLL SCALCGSKVLAALAASTGSSSVASSSAPAAASSGQATTQSKSSTKKSKKEEKEKEKEGES SGSQEDQLCTALVNQLNRFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSNKAQ QELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTAQTEKKLKEYSQKAVEILRTQNHI LTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVV KLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPG QTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQ CHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLL DKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQEDSGTSGGISSTSASVNRYILQLAQEY CGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLG CGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAIRE EVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKED SCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALT TVKPYCNEIHAQAQLWLKRDPKASYEAWKKCLPIRGIDGNGKSPSKSELHRLYLTEKYVW RWKQFLSRRGKRTTPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATVPSRKQQVL DLLTSYLDELSVAGECAAEYLALYQKLIASCHWKVYLAARGVLPYVGNLITKEIARLLAL EEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVLQRTKL IDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEE NEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDD SGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTT DEEEDEEEVYKMASVMAQCGGLECMLNRLAGIKDFKQGRHLLTVLLKLFSYCVKVKVNRQ QLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKG NLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCS FDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAK NLDADIWKKFLSRPALPFILRLLRGLAMQHPATQVLIGTDSITNLHKLEQVSSDEGIGTL AENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTAL LKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHF NIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYL QECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNT TRATSREEKNLQGFLEQPKEKWVESAFDVDGPHYFTILALHVLPPEQWKATRVEILRRLL VASHARAVAPGGASRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSL AEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDAAGLLSEITDPEGFLKDLLNSIP NT seq 15663 nt NT seq  +upstreamnt  +downstreamnt atggcgacgagcggcggcgacgaggcggcggcagcggctccagcgcccggagccccggcg accgggcaggacacgaccccgggctgggaggtggcggtgcggcccctactgtccgcgtcc tactccgcctttgagatgaaggagttgccgcagctggtggcctcagtcatcgagagtgag tcagaaatcctgcaccatgagaagcagtacgagccattctactcatcttttgttgcactg tccacacactacatcaccacggtctgtagcctcattccccggaaccagcttcagtcagtg gcggcagcctgtaaagtcctcattgagttttctctccttcgtctggagaacccggatgag gcatgtgctgtgtcccagaaacacttgattctgctgatcaaaggcctgtgcactggctgt agccgactagacagaacggaaattatcacctttacggcaatgatgaagtccgccaagctt ccacagacagtgacgacactttcggatgtggaagaccagaaagagctggcttcaccagta agccctgagctaaggcagaaggaggtacagatgaactttctgaaccagctgacctcagtt tttaaccctagaactgtaccatctcctcctattagtccacaggctctggtggaaggagaa aatgatgagcagccatctacagatcaggcttctgctgtcaagaccaagaatgtgttcatc gcacagaatgtggctagccttcaagagcttggtggttcagagaagctacttcgagtgtgc ctaaacctcccgtatttcctgcgctatatcaatcggttccaggatgcggtggtagccaat tccttcttcatcatgcctgcaacagtagctgatgccactgctgttcgtaatggttttcac tcactggtgattgatgtaaccatggccttggataccctttctctacctgtgttggaaccc ctcaatccttctcgtctgcaagatgtgacagtcctcagcctcagctgtctatatgcaggt gtgagtgtagctacctgcatggccattcttcatgtgggtagcgcccagcaagtgaggaca ggatccacgagctccaaagaagatgactatgaaagtgatgcggccacaattgttcagaaa tgtcttgagatctacgacatgatcggacaggcgattagcagctcccgccgtgctggtggt gagcacttccagaacttccagctgttgggcgcctggtgtctgctgaatagcctcttcctt atactgaatctcagtcctacagccctggctgacaaggggaaagagaaggacccgttggct gccctacgagtcagagacatcctttctcgtacgaaagagggagtaggctctcctaagctg ggacctggcaaaggacatcagggatttggggtgctctcggtgatcctggcaaaccatgcc atcaagctgctgacatctctttttcaagacctgcaggtggaggcgctccacaagggctgg gagacagatggtccccctgcagtcctgagcattatggcccagagcacctccacacaaagg atccaacggctgattgactctgtcccactgacaaacctgcttttgactttgctttcaaca tcatacagaaaggcatgtgtcctgcagcggcagaggaagggctccatgagcagtgatgcc agcgcctccaccgactccaacacgtactacgaggatgacttcagtagcacagaggaggac agcagccaagatgatgacagtgagcctattttggggcagtggttcgaggagaccatctct cccagtaaagagaaagctgcacctccacctcctccactgccccctcccctggagagctct cctcgggttaaaagccccagtaaacaggcttctggtgagaagggcaacatcttggccagt cgcaaagatcctgagttgttcttaggtctggcttccaacatcttgaactttatcacatcg tccatgctgaactctcggaacaatttcatccggaactatctgagcgtgtctctttcagag caccatatggccaccctggccagcatcattaaggaggtggacaaagatggactcaagggg tcatcagatgaggacttcgctgctgctctctatcatttcaaccactccctggtaacttct gacctccagtccccgaacctgcagaatacactgctacagcagctgggagttgctcctttc tctgagggcccttggcccctgtacattcacccccaaggcctctctgtgctttcccgcctc ctgcttatctggcaacataaagctggagcacaaggtgatcctgacgtcccagaatgtctg aaagtgtgggacaggtttttgtctacaatgaagcagaatgcactgcaaggggcggtgccc agtgagacagaggacctaaatgttgagcacctgcagctgctgctcctcatcttccacaac ttctctgagaaaggccgccgggccatcttcactatgctggtgcagagcatccaggagctg agtgttaacatggaggtgcagatgcgctctgtgccactaactctggcacgcctccttttg atcttcgactacctgcttcatcagtactccaaagcccccatgtatctgtttgagcaggtg caacacaacctgctgagccccccttttgggtgggcaagtggatcccaagacagcagcagc cgtcgggccaacactcctttgtatcatggattcaaggaagtagaagaaaactggtccaaa cactttccatcagatgcagccccacaacccaggttctactgcgtcctgtccccagaggcc tctgaggaggatttgtaccggctcgattctgtggcatgtgaagttctcttctccaagatt gtcaagtacgatgagctttatacctcgctgacagccctgcttgcagctggttctcagctt gatacagtcaggaggaaggaaaataagaacgtgacagccctggaggcctgtgccctgcag tattacttcttgatactctggaggatcttgggaattttgccaccttcaaagacttacatg aaccagctggccatgaacttacctgagatgagtgaatgtgacatcttacacactctgcga tggtcgtcccgcctccggatcagctcctatgtcaactggataaaggatcaccttgtcaaa cagggcatgaaccctgagcatgctggctctctcgtagacctgacctccagcaagtgtagc tcagtgaagtatgatgttgagattgtagaggagtattttgcccgacagatctcgtcattc tgctccatcgactgcaccactgtcctacagctccatgagatccctagtctgcagtctatc tacaccttggatgcagctatctcaaaggtccaggtctctctggatgagtacttctctaag atggctgcagagactgatcctcacaagtcatctgacatcaccaagaacctccttccagct acgctgcaactcatcgacacctatgcctcgttcaccagagcctatttgcttcagaacctt aatgaagagggatccactgagaagccctcccaggagaagctgcatggctttgcggctgtt ttggcaattggctctggcaggtgcaaggcaaacacgctgggtccaacgctggtgcagaat ttaccatcatcagtgcagactgtctgtgagtcctggaataatatcaacaccaatgagttt cccaacattggatcctggcgcaatgcttttgctaatgacatcatcccatctgagagttac atcagtgctgtgcaggctgctcagctggggactctttgtggccagagtctgcccctggcg gcttccctgaagcataccctgctctcgctggtcaggttgactggggatctgattgtgtgg tcagatgagatgaatccagcacaggtcatccggaccctgctaccccttctcttggagtcg agcacagagagtgttgctgagatcagcagtaactccctggagcgcatcctgggacctgcg gagtctgatgagttcctggcgcgtgtgtatgagaagctgatcaccgggtgttacaacatt ctggccaatcatgctgatcccaacagtgggctggatgagtccatcctggaggaatgtttg cagtatctggaaaagcagctggagagcaaccaggccaggaaagccatggaagaattcttc tctgatggtggggaacttgtgcagatcatgatggccacagccaatgaggacctctctgct aaattctgtaaccgagtcttgaaattcttcaccaaactcttccagctgactgagaagagc cctaacccaagcctccttcatctctgtggctctcttgcccagctggcctgtgtggagcct gtgcgcctacaggcctggctcacccgcatgacaacatcaccccctaaggattctgaccag ctggaggtcattcaggagaaccggcagctgctgcagttgctgaccacatacattgttcgg gaaaacagccaagttggagaaggtgtatgtgctgtgcttctgggcaccctgactcccatg gcaacagagatgctggcaaatggcgatgggactggctttccggaactcatggttgtgatg gccactctggccagtgctggacaaggcgctggccaccttcagcttcacaatgctgctgtg gactggctgggcagatgcaagaaatacctgtcacagaagaatgtggttgagaaactgaat gccaatgtaatgcatggaaagcatgtgacagtcttggaatgcacttgtcatattatgtcg tacttggctgatgtcacaaatgccctgagccagagtaatggccaaggaccaagtcacctc tctgtggatggggaagaacgtgccattgaggtcgattcagactgggtagaagagttggcc gtggaggaggaagattcccaggctgaggactctgatgaagattctctctgcaataaactt tgtaccttcaccatcacacagaaggaatttatgaaccagcactggtatcactgtcatacc tgtaagatggtggatggggtgggtgtgtgcacagtatgtgcgaaggtatgccacaaggat catgagatttcctacgccaagtatggttcttttttctgtgactgtggagccaaggaagat ggcagttgcttggcattggtgaagcgaactcctagcagtggcatgagctctaccatgaag gagtcggcatttcagagtgaacctagggtctcagagagcttggtgcgccatgctagcacc tcgccagctgataaagccaaggtcaccatcagtgatggaaaggttactgatgaagagaag cccaagaagagcagtctgtgccgcacagttgagggttgccgtgaggagctgcagaatcag gccaatttctccttcgctcctctcgtgttagacatgctcaatttcctcatggatgccatt cagaccaactttcagcaggcttcagctgtggggagcagcagccgggcacagcaggccctc agtgaactgcattcagtggacaaggttgtggagatgacagaccagctgatggttccgacc ttaggctcacaggagggtgcctttgagaatgttcggatgaattacagtggagaccagggc cagactataaggcagctgatcagcgcccatgtgctcaggcgggtggctatgtgtgtgctt tcttccccccatgggcgtcgccagcatttggctgtcagccatgaaaaaggcaagatcaca gtgctacagctctccgcactcctgaaacaagcagattccagcaagaggaagttgactctg actcgcttggcctctgccccagttcccttcacagtgctgagtcttactggaaacccttgc aaggaggactacctggcagtgtgtgggctaaaggactgccacgtgctcaccttcagtagc tcgggctctgtttccgatcacttggtattacatccccagttggcaacagggaactttatc atcaaagctgtgtggttaccaggttcacagactgagctggccattgtcactgcagacttt gtcaagatttacgacttgtctattgatgccttgagtccaaccttctactttctgctgccg agctcaaagataagagatgttaccttccttttcaatgaagaaggcaagaacatcattgtc atcatgtcctctgctgggtacatgtacacccaactcatggaggaagccagcagtgcccag caggggcccttctatgtcactaatgtactggaaataaatcacgaggacctgaaggacagt aacagccaggtggccggcggcggtgtgtctgtgtactactcgcacgtgttgcagatgctt ttcttcagctatagccagggcaagtcctttgcagccactgtcagcagaagcactctggag gtgttgcagctcttccccatcaacatcaaaagctccaatggtggcagtaagacttctcct gccctttgccagtggtctgaggtgatgaaccaccctggcttggtctgttgtgtccaacaa actactggtgtacctctggtagtcatggtgaaaccagacaccttcctcatccaggagatt aagactcttcccgccaaagccaagatccaagacatggttgccattaggcacactgcatgc aatgagcagcaacggacgaccatgatcctgctgtgtgaggatggcagcctgcgcatttac atggccaatgtggagaatacctcttactggctccagccctctctgcagcccagcagcgtc atcagcatcatgaagcctgtgcgaaagcgcaaaacagctacaatcacagcccgcacatcc agccaggtgaccttccccatcgacttttttgaacacaaccagcagctgacggatgtggag tttggtggtaatgaccttctgcaagtctacaatgcacaacagataaagcacaggctgaac tccactggcatgtacgtggctaacaccaagcctggcggcttcaccattgagattagtaac aacagcagcactatggtgatgacaggcatgcggatccagattgggacccaggcaattgaa cgggccccatcatacatcgagatctttggcagaaccatgcagcttaatctgagccgttcc cgctggtttgacttccccttcaccagagaagaagccctgcaggctgacaagaagctgaac ctcttcattggtgcgtctgtggatccagcaggagtcactatgattgatgctgtaaaaatt tatggcaagactaaggagcagtttggctggcctgatgagcctccagaagaatttccttcc gcttctgtcagcaacatctgcccttccaacctgaatcagagcaacggcactggggagagt gactcgaccactccagctacgtccagtggcactgtcctggagagttctgaaactgagtcc ctaaccaagctggaccggctggtcgtgagttctttggaagccttggaaagctgctttgct gttggtccaatcattgagaaggagagaaacaagcacgcagcccaggagctggccactttg ctgctctccctgccagcacctgccagtgtccaacaacagtccaagagcctcctggccagc ctgcacaccagccgctcagcctaccacagccacaaggaccaggccttgctgagcaaggct gtgcagtgtctcaacacatccagcaaagaaggcaaggacttggaccctgaggtgttccag cggctagtgatcacagctcgctcgattgccatcatgcgtcctaacaacctagtgcacttt acggaatcaaagctgccccagatggaaacagactgttttttccccagatgtgcctgctgg aatctagggatagttggcatattgattggggccccagttgaaactccctccgcagaagga gcggatgaggggaaagaaccacagaagcaggtggaaggagacagctgtagtttcatcact cagcttgtgaaccacttctggaaactccatgcctctaagcccaagaatgccttcctggca cctgcctgcctgccaggcctcactcatattgaagctactgttaatgcactggtagacatt atccatggctattgtacctgcgagctggactgtatcaacacagcatccaagatctacatg cagatgctgttgtgtcctgaccctgctgtgagcttctcctgcaaacaagctctaattcga gtcctaaggcccaggaacaaacggagacatgtaacattgccttcctcccctcgaagcaac actccaatgggagacaaggatgatgatgatgacgatgatgctgatgagaaaatgcagtca tcgggcatccccgatggtggtcacatccgtcaggaaagccaggagcaaagtgaggtggac catggagattttgagatggtgtctgagtcgatggtcctggaaacagctgaaaatgtcaac aatggcaacccctcacccctggaggcccttttggcaggggccgagggctttcctcccatg ctggacatcccacctgatgcagatgacgagaccatggttgaactagccattgccttgagc ctgcagcaggaccagcaaggcagcagcagcagtgccctgggcctgcagagcctgggactg tccggccaggcacccagctcttcctctctggacgcaggaaccctctctgacaccacagca tcagctccagcctcagatgatgagggcagcactgcagcaactgatggctctaccctgcgg acctcgcccgccgaccatggcgggagtgtgggctcagagagtgggggaagtgcagtggac tctgtggctggcgagcacagtgtgtctggccggagcagtgcgtatggtgatgccacagct gaggggcacccagctggaccagggagtgtcagctcaagcacaggggccatcagcaccacc actgggcaccaggagggagacggctctgagggagaaggtgaaggggaagctgaaggagat gtacacactagcaacaggctacacatggttcgtctgatgctgttggagagattactgcag accctgccgcagttacgaaatgttggaggtgtccgagccatcccatacatgcaggtcatt ctgatgctcacaacagatctggatggagaagatgagaaagacaagggggccctggacaac ttgctctcccagctcattgctgagcttggcatggacaaaaaggatgtctccaagaagaat gagcgcagtgccttgaatgaagtccatttggtcgtaatgagactcctgagtgtcttcatg tcccgcaccaagtccggatccaagtcttccatctgtgagtcgtcttccctcatctctagt gccacagcagcagccctgctgagctcaggggctgtggactattgtctgcatgtgctcaag tctctgctggaatactggaagagccagcagaatgatgaggagcctgtggccaccagccag ttgctgaaaccacacacgacatcatccccaccagatatgagcccattctttctccgccag tatgttaagggtcatgctgctgacgtctttgaagcctatacccagctgctcacagaaatg gtcctgaggcttccctaccagatcaaaaagatcgcagacaccagctctcgcatccctcct cctgtctttgatcactcctggttctactttctctctgagtacctaatgatccagcagacc cctttcgtgcgccgacaagtccgaaaacttctactcttcatctgtggatcaaaggagaag taccgacagctccgagatctgcacaccttggactcccatgtgcgtgggatcaagaagctg ctggaagagcagggcatcttcctccgggccagtgtggttacagccagttctggctctgct ttgcagtatgacacgctcatcagcctgatggagcatctgaaggcctgtgcagagattgct gcccagcgaaccatcaactggcagaagttctgcattaaagatgactctgtcctatacttc ctcctgcaagtgagtttcctggtggacgagggagtgtcccctgtgctgctgcaactgctc tcctgtgccctgtgtggcagcaaagtcctcgcagccctggcggcctccacggggtcctcc agtgtggcttcctcctcagcccctgctgcggccagttctggacaagccacaactcagtcc aaatcttcgaccaaaaagagcaagaaagaagaaaaggaaaaagagaaagaaggtgagagc tcaggcagccaagaggaccaactgtgcacggctctggtgaaccagctgaatagatttgca gacaaagagactctgatccagtttctgcgctgtttcctgttggagtccaactcttcctca gtgcgctggcaggcccactgcctgacactgcacatctacagaaactccaacaaggctcag caggagctcttgctagatctcatgtggtctatctggccagaactcccagcgtacggtcgt aaggctgcccagtttgtggatctactgggctatttctccctgaaaactgcacagacagag aagaagttgaaggagtattcacagaaggctgtggagattctgaggactcaaaaccacatt ctcaccaaccatcccaactccaacatttataacaccttgtctggcttagtggagtttgat ggctattacctggagagtgacccctgcctagtgtgtaacaatcctgaggtgccgttttgt tatatcaagctgtcgtccattaaagtggacacgcggtacaccaccacccagcaagttgta aagctcattggcagtcacaccatcagcaaggtgacagtgaaaattggagacctgaagcgg accaagatggtgcggactatcaacctgtactacaacaaccgaactgtacaggccattgtg gagttgaaaaacaagccagcacgctggcacaaagccaagaaagttcagctgacacctgga cagacagaagtcaagattgacctgcctttgcccattgtggcctctaacctgatgatcgag tttgcagacttttatgagaactaccaggcctccacagagacccttcagtgtcctcgatgc agtgcctctgttcctgccaacccaggcgtctgtggcaattgtggcgagaatgtataccag tgtcacaagtgcaggtccatcaactatgatgaaaaggatcccttcctctgcaatgcctgt ggcttctgtaaatacgcccgctttgatttcatgctttatgccaagccttgctgcgcagtg gatcccattgaaaatgaagaagatcgaaagaaggccgtttccaacatcaacacacttctg gacaaagctgatcgtgtgtaccatcagctcatggggcatcggccacagctggagaacctg ctctgcaaagtgaatgaagcagctccagaaaagccacaggaagactctggaacgtctggg ggcatcagctccacttcagccagtgtgaatcgctacatcctgcagctggctcaggagtac tgtggagactgcaagaactcattcgatgagctctccaaaatcatccagaaagtttttgct tcacgcaaagagctgctagaatatgatctacagcaaagggaagcagccacaaagtcgtcc agaacatcagtgcagcccacgttcactgccagccagtaccgtgctttgtctgtcttaggc tgtggccacacttcctccaccaaatgctatggctgtgcctcagctgtcacggagcattgc atcacattactgagggctctggccaccaatccagctctgaggcacatcctcgtctcccag ggcctcatcagagagctctttgattacaacctccgaagaggggctgcagccattcgtgaa gaggtccgccagctcatgtgcctcctgaccagggacaacccagaggccacccagcaaatg aacgacctgatcattggcaaagtctccacagccctgaaaggccactgggccaatcctgac ctggcaagcagccttcagtatgagatgctgctgctgacagattccatctccaaggaggac agctgttgggaactccgcttacgctgtgcactcagccttttcctcatggccgtgaacatc aaaacaccagtggttgttgagaatattaccctcatgtgcctgcggatcttacagaaactg attaagccacctgcaccaaccagcaagaagaataaggatgtccctgttgaggccctcacc acggtgaagccatactgcaatgagatccatgcccaggcacagctgtggctcaagagagat cccaaggcatcttacgaagcctggaagaagtgtctgcctatccgagggatcgatggcaac gggaagtcccccagcaagtcagagctccaccgtctctacctgaccgagaagtacgtgtgg aggtggaaacagttcctgagccggcgggggaagaggaccacccctcttgacctcaagctg ggtcacaacaactggctgcggcaggtactctttactccagcaacacaggcagcacggcag gcagcatgtaccatcgtggaagcccttgctactgtccccagccgcaagcagcaagtcctt gacctcctcaccagttacctggatgaactgagtgtagctggggagtgtgctgcagagtac ctggctctctaccagaagctcatcgcctcatgtcactggaaagtctacctggctgctcgg ggagtcctgccctatgtgggcaacctcatcaccaaggaaattgcccgcttgctggccctg gaggaggctaccttgagcacagacctgcagcagggctatgccctcaagagtctcacaggc cttctctcctcctttgtagaggtggagtccatcaagaggcattttaaaagccgcctggtg ggcactgtgctgaatgggtacctatgcttgcggaagctagtgctgcagaggaccaagctt atcgacgagacccaagacatgctgttggagatgctggaggacatgaccacaggtacagag tctgaaaccaaggccttcatggctgtgtgcattgagacagccaagcgctacaatctggat gactaccggactcctgtgttcatctttgagaggctgtgcagcatcatctaccctgaagag aatgaagttaccgagttcttcgtgaccctggagaaggatccccagcaagaggactttcta cagggcaggatgcctggaaacccctatagcagcaatgagccaggcattgggcctcttatg agggacataaagaacaagatttgccaggactgtgacctggtggctcttctggaggatgac agtggaatggagctcttagtgaacaataaaattatcagtttggaccttcctgtggctgaa gtttacaagaaggtctggtgtaccacaaatgagggagagcccatgaggattgtttatcga atgcgggggttactgggtgatgccactgaggagttcatcgagtccctggactccaccaca gatgaagaagaagatgaggaagaagtatacaagatggctagtgtgatggcccagtgtggg ggtctggaatgcatgcttaacagactggcaggaatcaaagattttaagcaggggcgccac cttctaacagtgctgctgaagctgttcagttactgcgtgaaggtgaaagtcaaccggcag cagctggtcaagctggagatgaataccctaaatgtcatgctggggactttaaacttggct ctggtagctgaacaagagagcaaggacagcggtggagcagccgtggctgagcaggtgctg agcatcatggagatcattctagatgagtccaatgcagagcccctgagtgaggacaagggc aacctcctcctcacaggtgacaaagatcagctggtgatgctcctggaccagatcaacagc acctttgttcgatccaaccccagtgtactccagggcctgctgagaatcatcccatacctg tcctttggagaggtggagaagatgcagatcctggtggagcggttcaagccgtactgcagc ttcgataagtatgatgaagaccacagtggggatgacaaagtcttcctggattgtttctgc aaaattgctgctggtatcaagaacaacagcaatgggcatcagttgaaggatcttatcttg cagaagggaatcacccagaatgctctagactacatgaaaaagcatatccccagtgccaag aatttggatgctgacatctggaaaaagtttttgtctcgccctgctctgccatttattttg aggcttcttcggggattggccatgcagcaccctgccacccaggttctgattggaacagac tctatcacaaacctgcataaattagagcaggtatccagtgatgagggcattggtaccctg gctgagaacctgttggaggcccttcgagaacaccctgatgtgaacaagaagattgatgca gcccgcagggagacccgagcagagaagaagcgcatggccatggccatgaggcagaaggct ctgggcactctgggcatgacgacaaacgagaagggccaggtggtgaccaagactgcgctt ctgaagcagatggaggagctaatagaagagccaggcctcacctgctgcatctgcagggag gggtacaagttccagcccacaaaggtcttaggcatttataccttcaccaagcgggtagct ttggaggagatggagaacaagccccggaaacagcagggctacagtactgtgtcccatttc aacattgtgcactacgactgtcacttagctgctgtcagattggctagaggccgggaagaa tgggagagtgctgccctgcagaatgccaacacgaagtgcaatgggctccttccagtctgg ggcccccacgtccctgaatcagcttttgccacttgcttagcaaggcataacacttacctc caggagtgtacaggccagcgggaacccacgtaccagctcaacatccatgacatcaagctg ctcttcctgcgcttcgccatggagcagtcattcagtgcagacactggtgggggcggccgg gagagcaacatccacctcatcccgtacatcattcacaccgtgctttacgtcctgaacaca acccgagcaacatcccgggaggagaagaacctgcaaggcttcctggaacagcccaaggag aagtgggtagagagcgccttcgatgtagatggcccccactacttcaccatcctggccctg catgttttaccccctgagcagtggaaggccacacgtgtggagattctacgcaggctgctg gtggcctcgcatgcccgggcagtggctccaggaggagcctccaggctaacagataaggca gtgaaggactattctgcctaccgttcttccctgctcttctgggctcttgttgatctcatt tacaacatgtttaagaaggtgcccaccagtaacacggagggcggctggtcctgctctctg gccgagtacatccgccacaatgacatgcccatctacgaagctgctgacaaagccctgaaa accttccaggaggagttcatgccagtggagaccttctcagagttcctcgatgcagcaggt ctcctgtctgaaatcaccgatccagagggcttcctaaaggacctattgaactcaatcccc tga

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