Phodopus roborovskii (desert hamster): 127224978 Help Entry 127224978         CDS       T08852                                  Symbol Jak1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism prob  Phodopus roborovskii (desert hamster) Pathway prob01521   EGFR tyrosine kinase inhibitor resistance prob04151   PI3K-Akt signaling pathway prob04217   Necroptosis prob04380   Osteoclast differentiation prob04550   Signaling pathways regulating pluripotency of stem cells prob04620   Toll-like receptor signaling pathway prob04621   NOD-like receptor signaling pathway prob04630   JAK-STAT signaling pathway prob04658   Th1 and Th2 cell differentiation prob04659   Th17 cell differentiation prob05140   Leishmaniasis prob05145   Toxoplasmosis prob05152   Tuberculosis prob05160   Hepatitis C prob05161   Hepatitis B prob05162   Measles prob05163   Human cytomegalovirus infection prob05164   Influenza A prob05165   Human papillomavirus infection prob05166   Human T-cell leukemia virus 1 infection prob05167   Kaposi sarcoma-associated herpesvirus infection prob05168   Herpes simplex virus 1 infection prob05169   Epstein-Barr virus infection prob05171   Coronavirus disease - COVID-19 prob05200   Pathways in cancer prob05203   Viral carcinogenesis prob05212   Pancreatic cancer prob05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:prob00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     127224978 (Jak1)    04151 PI3K-Akt signaling pathway     127224978 (Jak1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     127224978 (Jak1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     127224978 (Jak1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     127224978 (Jak1)    04621 NOD-like receptor signaling pathway     127224978 (Jak1)    04658 Th1 and Th2 cell differentiation     127224978 (Jak1)    04659 Th17 cell differentiation     127224978 (Jak1)   09158 Development and regeneration    04380 Osteoclast differentiation     127224978 (Jak1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     127224978 (Jak1)    05203 Viral carcinogenesis     127224978 (Jak1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     127224978 (Jak1)   09162 Cancer: specific types    05212 Pancreatic cancer     127224978 (Jak1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     127224978 (Jak1)    05161 Hepatitis B     127224978 (Jak1)    05160 Hepatitis C     127224978 (Jak1)    05171 Coronavirus disease - COVID-19     127224978 (Jak1)    05164 Influenza A     127224978 (Jak1)    05162 Measles     127224978 (Jak1)    05168 Herpes simplex virus 1 infection     127224978 (Jak1)    05163 Human cytomegalovirus infection     127224978 (Jak1)    05167 Kaposi sarcoma-associated herpesvirus infection     127224978 (Jak1)    05169 Epstein-Barr virus infection     127224978 (Jak1)    05165 Human papillomavirus infection     127224978 (Jak1)   09171 Infectious disease: bacterial    05152 Tuberculosis     127224978 (Jak1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     127224978 (Jak1)    05140 Leishmaniasis     127224978 (Jak1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     127224978 (Jak1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:prob01001]     127224978 (Jak1) Enzymes [BR:prob01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      127224978 (Jak1) Protein kinases [BR:prob01001]  Non-receptor tyrosine kinases   JAK family [OT]    127224978 (Jak1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  127224978 NCBI-ProteinID:  XP_051044191 UniProt:  A0AAU9ZD39 LinkDB All DBs Position Unknown AA seq 1152 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVVPEPGVEVTFYLLDREPLRLGNGEYTAEEL CIKAAQECNISPLCHNLFALYNESTKLWYAPNHPITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRLRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIYETSMLLISSENELS RFHSNDSGNVLYEVMVTGNLGIQWRQKPSVVPVEKEKNKLKRKKLEYKHKKDEEKNKLRE EWNNFSYFPEITHIVIKESVVSINKQDNKNMELKLSSHEEALSFVSLIDGYFRLTADAHH FLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTC FEKSEVLGGQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDLMNHLKKQILRTDNISFVLKR CCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTL LDYKDDEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVE NIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL AREGIDSEIGPFIKLSDPGIPVSVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTT LWEICYNGEIPLKDKTLVEKERFYESRCRPVTPSCKELADLMTRCMNYDPSQRPFFRAIM RDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSG SLKEYLPKNKNKINLKQQLNYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDF GLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDF SPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTF QSLIEGFEALLK NT seq 3459 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggcgttctgtgctaaaatgagg agcttcaagaagactgaggtaaagcaggtggtccctgagccaggagtggaagtgaccttc tatctgttggatagggagccactccgcctgggcaatggagagtatactgcggaggagctg tgcatcaaggctgcccaggagtgcaatatttctcctctatgtcacaacctcttcgccctg tacaatgagagcaccaagctctggtatgctccgaaccaccccatcactgtggatgacaag acgtctctccgactccactatcgcatgaggttctactttaccaactggcatggaaccaat gacaatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggatatgagaag aaaaaggttccagaagcaaccccactccttgatgctagttcgctggagtatttgtttgca cagggacagtatgatttgatcaaatgcctggctcccattcgggaccccaagacagagcag gatggacatgacattgagaatgagtgcctggggatggctgttctggccatctcacactat gccatgatgaagaagatgcagttgccagaacttcccaaagacatcagctacaagcgatat attccagaaacattgaataaatccatcagacagaggaaccttcttaccaggctgagaatc aataatgtcttcaaggatttcctgaaggaatttaacaacaagaccatctgtgacagcagt gtgtccacacatgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggagctgaaatatatgagacgtctatgctactgatttcatccgaaaatgaattgagt cggttccattcgaatgacagtggcaatgttctctatgaagtcatggtgactggaaatctt ggaatccagtggcggcagaaaccaagtgttgttcctgttgaaaaggaaaaaaataaactg aagcggaagaaactggagtataaacacaagaaggatgaggagaaaaacaaactccgggaa gagtggaataatttttcctatttccccgaaattacccacattgtaataaaggagtctgtg gtcagcattaacaaacaggacaacaaaaacatggaactgaagctctcttctcacgaggag gccttgtcctttgtgtccctgatagatggctacttccggctcacagcagatgcccaccat ttcctttgcaccgatgtggctcccccactgattgtccacaatatacagaatggctgtcac ggtccaatctgcacagaatatgccatcaataagctgcggcaagaagggagtgaggagggg atgtacgtgctgaggtggagctgtactgactttgacaacatcctcatgactgtcacctgc tttgaaaagtctgaggtgttgggtggccagaagcagttcaagaactttcagattgaggtg cagaagggccgctacagcctgcatggctctgtcgaccacttccccagcctgagagacctc atgaaccacctcaagaagcagatcctgcgcacagacaacataagctttgtactgaagcgt tgctgtcaacctaagccccgagaaatctccaatctgttagtagccaccaagaaagcccag gagtggcagcctgtctaccccatgagccagctgagttttgatcggatccttaagaaagat attatacaaggtgagcacctcggcagaggcacaagaacacatatctactctgggaccctg ctggactacaaggatgatgaaggaattgctgaagagaagaagataaaagtgatcctcaaa gttctagaccccagccacagggacatttctctggccttctttgaggcagccagcatgatg agacaggtttcccacaaacacattgtgtacctctatggcgtctgtgtccgagatgtggaa aatatcatggtggaagagttcgtggagggggggccattggatctcttcatgcaccggaaa agcgatgtacttacaaccccctggaagttcaaagttgccaagcagctggccagtgccctg agttacctagaagataaagacctggtccatggaaatgtatgcactaaaaacctcctctta gcccgtgagggcattgacagtgaaattggcccattcatcaagcttagtgatcctggcatc ccggtctctgtgctgtccaggcaagagtgcatagagcggatcccctggattgctcctgag tgtgttgaagactccaaaaacctgagtgtggctgcagacaagtggagctttggaaccaca ctctgggaaatctgctacaatggcgagatccccctcaaagacaagaccctggtggagaag gaaagattctatgaaagccgctgcaggccagtgactccatcttgcaaggagcttgctgac cttatgactcgctgcatgaactatgatcccagtcagagacccttcttcagagccatcatg agggacattaacaagctggaagagcagaatccagacattgtttcagaaaagaagccagca acagaggtggaccccactcattttgaaaagcgtttcctgaagaggatccgtgacttggga gagggccactttgggaaggtcgagctctgcagatatgatcccgagggagacaacacaggg gaacaggtagctgtcaagtccctgaagcctgagagtggaggtaaccacatagctgatctg aagaaggagatagagatcttacggaacctctaccatgagaacattgtcaagtacaaaggg atctgcatggaagatggggggaatggtatcaagctcatcatggagtttctgccttcggga agcctaaaggagtatctgccaaagaataagaacaaaattaacctcaaacagcagctaaac tatgccatccagatttgtaaggggatggactatctgggttcgagacagtatgttcatcgg gacttagcagcaagaaatgtccttgtcgagagtgaacaccaagtgaagattggagacttt ggtttaaccaaagcaatcgaaaccgataaggagtactacacagtcaaggatgaccgcgac agcccagtgttttggtacgccccagaatgtttaatccagtgtaaattttacatagcctct gacgtgtggtcttttggagtgacactgcatgagctgctcacctactgtgactcggatttc agtcccatggctttgttcctgaaaatgataggcccaactcatggccagatgacagtaaca cggcttgtgaatactctgaaagaaggaaagcgcctgccatgtccgcccaactgtcctgat gaggtttatcagctcatgagaaaatgctgggaattccaaccatctaatcggacaacgttt cagagccttattgaaggatttgaagcacttttaaaataa

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