Entry |
|
Symbol |
Plcb3
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
|
KO |
|
Organism |
prob Phodopus roborovskii (desert hamster)
|
Pathway |
prob04070 | Phosphatidylinositol signaling system |
prob04261 | Adrenergic signaling in cardiomyocytes |
prob04613 | Neutrophil extracellular trap formation |
prob04621 | NOD-like receptor signaling pathway |
prob04723 | Retrograde endocannabinoid signaling |
prob04750 | Inflammatory mediator regulation of TRP channels |
prob04925 | Aldosterone synthesis and secretion |
prob04928 | Parathyroid hormone synthesis, secretion and action |
prob04933 | AGE-RAGE signaling pathway in diabetic complications |
prob04935 | Growth hormone synthesis, secretion and action |
prob04961 | Endocrine and other factor-regulated calcium reabsorption |
prob04973 | Carbohydrate digestion and absorption |
prob05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
prob_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:prob00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
127228774 (Plcb3)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
127228774 (Plcb3)
04310 Wnt signaling pathway
127228774 (Plcb3)
04371 Apelin signaling pathway
127228774 (Plcb3)
04020 Calcium signaling pathway
127228774 (Plcb3)
04070 Phosphatidylinositol signaling system
127228774 (Plcb3)
04072 Phospholipase D signaling pathway
127228774 (Plcb3)
04071 Sphingolipid signaling pathway
127228774 (Plcb3)
04022 cGMP-PKG signaling pathway
127228774 (Plcb3)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
127228774 (Plcb3)
04081 Hormone signaling
127228774 (Plcb3)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
127228774 (Plcb3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
127228774 (Plcb3)
04613 Neutrophil extracellular trap formation
127228774 (Plcb3)
04621 NOD-like receptor signaling pathway
127228774 (Plcb3)
04062 Chemokine signaling pathway
127228774 (Plcb3)
09152 Endocrine system
04911 Insulin secretion
127228774 (Plcb3)
04922 Glucagon signaling pathway
127228774 (Plcb3)
04929 GnRH secretion
127228774 (Plcb3)
04912 GnRH signaling pathway
127228774 (Plcb3)
04915 Estrogen signaling pathway
127228774 (Plcb3)
04921 Oxytocin signaling pathway
127228774 (Plcb3)
04926 Relaxin signaling pathway
127228774 (Plcb3)
04935 Growth hormone synthesis, secretion and action
127228774 (Plcb3)
04918 Thyroid hormone synthesis
127228774 (Plcb3)
04919 Thyroid hormone signaling pathway
127228774 (Plcb3)
04928 Parathyroid hormone synthesis, secretion and action
127228774 (Plcb3)
04916 Melanogenesis
127228774 (Plcb3)
04924 Renin secretion
127228774 (Plcb3)
04925 Aldosterone synthesis and secretion
127228774 (Plcb3)
04927 Cortisol synthesis and secretion
127228774 (Plcb3)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
127228774 (Plcb3)
04270 Vascular smooth muscle contraction
127228774 (Plcb3)
09154 Digestive system
04970 Salivary secretion
127228774 (Plcb3)
04971 Gastric acid secretion
127228774 (Plcb3)
04972 Pancreatic secretion
127228774 (Plcb3)
04973 Carbohydrate digestion and absorption
127228774 (Plcb3)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
127228774 (Plcb3)
09156 Nervous system
04724 Glutamatergic synapse
127228774 (Plcb3)
04725 Cholinergic synapse
127228774 (Plcb3)
04728 Dopaminergic synapse
127228774 (Plcb3)
04726 Serotonergic synapse
127228774 (Plcb3)
04720 Long-term potentiation
127228774 (Plcb3)
04730 Long-term depression
127228774 (Plcb3)
04723 Retrograde endocannabinoid signaling
127228774 (Plcb3)
09157 Sensory system
04742 Taste transduction
127228774 (Plcb3)
04750 Inflammatory mediator regulation of TRP channels
127228774 (Plcb3)
09159 Environmental adaptation
04713 Circadian entrainment
127228774 (Plcb3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
127228774 (Plcb3)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
127228774 (Plcb3)
09174 Infectious disease: parasitic
05146 Amoebiasis
127228774 (Plcb3)
05142 Chagas disease
127228774 (Plcb3)
05143 African trypanosomiasis
127228774 (Plcb3)
09164 Neurodegenerative disease
05010 Alzheimer disease
127228774 (Plcb3)
05016 Huntington disease
127228774 (Plcb3)
05017 Spinocerebellar ataxia
127228774 (Plcb3)
05022 Pathways of neurodegeneration - multiple diseases
127228774 (Plcb3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
127228774 (Plcb3)
05415 Diabetic cardiomyopathy
127228774 (Plcb3)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
127228774 (Plcb3)
04934 Cushing syndrome
127228774 (Plcb3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:prob04131]
127228774 (Plcb3)
Enzymes [BR:prob01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
127228774 (Plcb3)
Membrane trafficking [BR:prob04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
127228774 (Plcb3)
Endocytosis
Macropinocytosis
Phospholipase C
127228774 (Plcb3)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
Unknown
|
AA seq |
1233 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQVLLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLSAGVPLPSPQDLMGRILVKNKKRHRPSAGIPDS
SVRKRPLEQSNSALSESSATTEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGE
EGLNRGPNVLIPADREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDMPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGRFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTETYQETQSQQP
GSQLLPNPTPNPLDASPRWPQGPTTSPTSTSLSSPGQRDDLIASILSEVTPTPLEELRNH
KAMVKLRSRQERDLRELHKKHQRKAMALTRRLDGLAQARAESKCRSSSSALGRATNTEDI
KEEEEEARQHREFQNPQVQSLLELRQAQADAETERRLEHLRQAQQRLREVVLDAHTTQLK
RLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEE
AQKQRHERLMAGQQQVLQQLVEEEPKLLAQLTQECQEHRDRLPQEIRRCLLGETSEGLGD
GPLVACASNGHAPGSGGHLSSADSESQEENTQL |
NT seq |
3702 nt +upstreamnt +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcgacgcgggagtaagtttatcaaatgggacgaggaggcctccagtcggaacctg
gtgaccctgcgtgtggatcccaatggtttcttcttgtactggacaggacccaacatggag
gtggacacgctggacatcagctccatcagggacacacggacaggtcgttatgcccgcctg
cccaaggaccccaagattcgagaagtactgggctttgggggccctgatacccggctggag
gagaagctgatgacagtggtggctgggccagacccagtaaacaccacattcttgaacttc
atggccgttcaggatgacacagtcaaggtctggtcggaggagttgttcaaattggctatg
aacatactggctcagaacgcctcccggaacaccttcctgcggaaagcatacacaaagctg
aagctgcaggtgaaccaggatggaaggattccggtcaagaacattctgaagatgttctca
gcagacaagaagcgggtggagactgcactggagtcctgtggcctcaacttcaaccggagt
gagtccatccggcctgatgagttttccttggaaatctttgagcgattcttgaacaagttg
tgtctgcgaccagatattgacaagatcctgcttgagataggtgccaagggcaagccgtac
ctcactctggagcagctcatggactttattaaccagaagcaaagagacccaaggctcaat
gaagtgctgtatccgccgctgcgcccctcgcaggctcggttgctcatcgagaagtatgag
cctaaccaacagttcctggaacgagaccagatgtctatggagggctttagccgctaccta
ggaggagaggagaacggcatcctgccgctggaggccctggatctgagcatggacatgacg
cagccactgagtgcatatttcatcaattcttcacacaatacctatctcacagcgggccag
ctggctggaacatcgtccgtggagatgtaccgccaggtgctgctgtggggctgccgctgt
gtggagctggatgtatggaagggacggccaccagaggaagaacccttcattacccatggt
ttcaccatgaccactgaggtgccattacgtgatgtgcttgaggccatcgctgagacagct
ttcaagacctcaccctaccctgtcatcctctcctttgagaaccatgtggactcggcaaag
cagcaggccaagatggctgagtactgccgttctatttttggggatgcactgctcattgac
ccactggataagtatccgctatctgcgggcgtccccctgcctagtccacaggacctgatg
ggccgtatcctagtgaaaaataagaagcgacatcgtcccagtgcaggcatccccgatagc
tcagttcgcaagaggccactggagcagagcaactcagccctgagtgagagctcagccacc
acagagccctcttcaccacagcttgggtcccccagctcagacagctgccctggcctaagc
aatggggaggaggtgggacttgagaagaccagcctggagccccagaagtctctgggtgag
gaaggcctcaaccggggacctaatgttctcatacctgctgaccgagaggatgaggaagaa
gatgaagaagaagaggaaacaacagatccaaaaaaacccactactgatgagggcacagcc
agcagtgaggtcaatgccactgaggagatgtcgacacttgtcaactacgttgaacctgtc
aagttcaagtcttttgaggctgctcgaaaaaggaacaagtgcttcgagatgtcatccttt
gtggagactaaggccatggagcagctgacgaagagtcccatggagtttgtggaatacaac
aaacagcaacttagccgcatctatcccaagggtacccgtgtggattcttccaactatatg
cctcagctcttttggaacgtgggttgccagcttgttgccctcaacttccagaccttggac
atgccaatgcagctcaacgcaggcgtgtttgagtacaatgggcgcagtgggtacttgctg
aagcctgagttcatgcggcggccggacaagtcttttgaccccttcactgaggtcattgta
gatggcatagtggccaacgccttgcgggtcaaggtgatttcagggcagttcctgtcagac
aggaaggtgggtatctatgtcgaagtggacatgtttggtctcccagttgacacgaggcgc
aaatatcgtacaaggacatctcaggggaattcattcaaccctgtgtgggatgaagagccc
tttgacttcccgaaggttgtgctgcccacgctggcctcacttcgcattgcagcctttgag
gagggtggcagatttgttgggcaccgaatcctgccagtttctgccatccgctcaggatac
cactatgtctgcctgcgaaatgaggccaaccagccattgtgcctgcctgccctgcttatc
tacactgaagcttctgactatatcccagatgaccaccaggactatgcagaggccctgatt
aaccccatcaagcatgtcagcctaatggaccagcgggccaagcagctggctgctctcatt
ggggagagtgaggctcaggccagtacagagacatatcaggagacgcagtctcaacagcca
gggtcacagctcttgcccaatcccacacctaacccactggatgcctcacctcgatggccc
caaggtcctaccacctcccccactagcacgtccctcagtagcccagggcagcgagatgat
ttgattgccagcatactctctgaggtgacccctacccctctggaggagctccgaaaccat
aaggctatggtgaagctccggagccgacaggaacgagacttgagagagctgcataaaaag
caccagcgcaaggccatggccctcacccgccgtctggatggcttggcccaggcccgggct
gagagcaagtgccggtcctcctccagcgccctgggcagagccaccaatacagaggacatt
aaggaggaggaagaggaggccaggcagcatcgagagttccagaatccacaggtacagagc
ctgctggagttgagacaggcccaggcagatgcagaaaccgagcggaggctggagcacctg
agacaggctcagcagcggctcagggaggttgtcctggatgcacacacaacccagttgaag
agactgaaggagctgaatgaaagggagaagaaggagcttcaaaagatcctggacaggaag
cgcaacaatagtatctcagaggccaagacaagagagaaacataagaaggaggtggaacta
acagagattaatcggcggcatatcactgagtcagtcaactccatcagacggctggaagag
gcccagaagcagcgccatgagcgcctcatggcagggcagcagcaagtgcttcagcagcta
gtagaagaggagcccaagctgctggcccaactgacccaggagtgtcaggaacatcgtgac
aggttgccccaggagatccgccgatgtctgctgggcgagacatcagaggggctgggagat
ggccccctggtggcttgtgccagcaatggtcatgcacctgggagtggtgggcacctgtcc
agcgctgactcggagagccaggaagaaaacacccagctttaa |