Phodopus roborovskii (desert hamster): 127229776 Help Entry 127229776         CDS       T08852                                  Symbol Ryr2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism prob  Phodopus roborovskii (desert hamster) Pathway prob04020   Calcium signaling pathway prob04024   cAMP signaling pathway prob04260   Cardiac muscle contraction prob04261   Adrenergic signaling in cardiomyocytes prob04371   Apelin signaling pathway prob04713   Circadian entrainment prob04911   Insulin secretion prob04921   Oxytocin signaling pathway prob04972   Pancreatic secretion prob05020   Prion disease prob05022   Pathways of neurodegeneration - multiple diseases prob05410   Hypertrophic cardiomyopathy prob05412   Arrhythmogenic right ventricular cardiomyopathy prob05414   Dilated cardiomyopathy prob05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:prob00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127229776 (Ryr2)    04020 Calcium signaling pathway     127229776 (Ryr2)    04024 cAMP signaling pathway     127229776 (Ryr2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     127229776 (Ryr2)    04921 Oxytocin signaling pathway     127229776 (Ryr2)   09153 Circulatory system    04260 Cardiac muscle contraction     127229776 (Ryr2)    04261 Adrenergic signaling in cardiomyocytes     127229776 (Ryr2)   09154 Digestive system    04972 Pancreatic secretion     127229776 (Ryr2)   09159 Environmental adaptation    04713 Circadian entrainment     127229776 (Ryr2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     127229776 (Ryr2)    05022 Pathways of neurodegeneration - multiple diseases     127229776 (Ryr2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     127229776 (Ryr2)    05412 Arrhythmogenic right ventricular cardiomyopathy     127229776 (Ryr2)    05414 Dilated cardiomyopathy     127229776 (Ryr2)    05415 Diabetic cardiomyopathy     127229776 (Ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:prob04040]     127229776 (Ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:prob04990]     127229776 (Ryr2) Ion channels [BR:prob04040]  Voltage-gated cation channels   Ryanodine receptor    127229776 (Ryr2) Domain-containing proteins not elsewhere classified [BR:prob04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    127229776 (Ryr2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  127229776 NCBI-ProteinID:  XP_051050707 LinkDB All DBs Position Unknown AA seq 4974 aa AA seqDB search MADAGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTMEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFVFRSSKEKLDVGVRKEVDGMGTSEIKYGDSI CYIQHVDTGLWLTYQSVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKAPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTMSLTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKSGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG GLPGAGLYGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRIDKDKETPKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRGDYEYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGR IKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLV QCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSH VDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLF PNENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKAKTIQMLTEAV KEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEE EGGAPEKEISAEDSKLEGTGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVR HRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNF KDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYL KKKQAEKPVASDSRKSSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLV RALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHP NLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLS YLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQM LVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEG GNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDIEEEEDDTIHMGNAIMTFYAALIDLL GRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAG FCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRY LCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQ LRPSMMQHLLRRLVFDVPQLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELH LSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEG NFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKP YKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAH GYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTA KEKAKDREKAQDIFKFLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQY ILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNK EKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRA FLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGE DLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHN VYSIYNTRSSRERAALSLPASVEDVCPNIPSLEKLMAEIIELAESGIRYTQMPHMMEVVL PMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRL AVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEF TTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWSKSHNFKREEQNF VVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLN ICAPGDQELIALAKNRFSLKDTEEEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTE DTSDPERTVERVLDIANVLFHLEQKSKYTEYTGRRYFSLGSTVEHPQRSKKAVWHKLLSK QRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGTEPPE EDEAMKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKS FEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTV QQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDD EFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYS GKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAH MQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMI LKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETD ENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFL GRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFC EDTIFEMQLAAQISESDLNERSTNKEDNEKERPEEQAPRMGFFSLLTIQSALFALRYNVL TLVRMLSLKSLKKQMKRMKKMTVKDMVTAFFLSYWSVFVTLLHFVASVCRGFFRIVSSLL LGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEDGERKPLESALPSEDLTDLKELTEES DLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPIPVPEVQEKFQEQKAKEEKEEKEE SKSEPEKAEGEDGEKEEKAKDDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNY FARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPARSSSDTAKVTTSLDSNPHR TIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFD GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMD KAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGH YNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEH NLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14925 nt NT seq  +upstreamnt  +downstreamnt atggctgatgcgggcgaaggcgaggacgagatccagttcttgagaactgatgatgaggtg gttctgcagtgcactgcgaccgtccacaaagagcagcagaaactatgcttggcagccgaa ggatttggcaacagactttgttttttggagtctacatccaattccaagaatgtgcccccg gacctgtccatctgcacctttgtgctggagcagtccctgtcagtacgtgccctgcaggag atgctagccaacacgatggagaagtcagaagggcaggttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggaggccaccggacactcctctatggacatgccatattg ctacgccattcctacagtggtatgtatctgtgttgtctatccacctcccggtcttccact gacaaattagcctttgacgttggccttcaagaggataccacaggggaggcttgctggtgg accatacatcctgcctctaagcagagatcagaaggagaaaaggtgcgggttggagatgac ctcatcttggtcagtgtgtcctctgaaaggtacttgcacttatcatacggcaacagcagc tggcatgtggatgctgccttccagcagaccctctggagcgtggcccctatcagctctgga agtgaagctgcccaagggtatcttattggtggcgatgttctccggctgctacatggacac atggatgagtgtcttactgtcccttcgggagaacatggtgaagaacagcggagaacagtt cattacgaaggtggtgctgtatcagttcatgcacgctccctctggaggctagagactcta agagttgcgtggagtggaagtcatataagatggggccagccattccgactccggcatgtc acaacaggaaaatacttaagccttatggaagacaagaaccttctactcatggacaaagaa aaagctgatgtcaaatcaacagcatttgtcttccgttcttccaaggaaaaattggacgta ggagtgagaaaagaagttgatggcatgggaacatcggaaatcaagtacggagattccatt tgctatatacaacatgtggatacaggcctgtggctaacctaccaatcagtggatgtgaag tcagcacgaatgggatccatacagcgtaaggccattatgcaccatgaaggccacatggat gatggcttgaacttatcccgatctcagcatgaagagtcccgcacagcccgcgttatcagg agcacagtgtttctcttcaatagattcataaggggcctggatgctctcagcaagaaggca aaggcacccaccattgacttaccaattgagtctgtgagcctgagtttgcaggacctcatc ggctactttcatcccccggatgaacacttggaacatgaagacaagcagaacagactgcga gctctgaagaataggcagaatctcttccaggaagagggaatgatcaacttggttctggag tgcatagaccgcctacacgtttacagcagtgcagcccactttgcagatgttgcagggcga gaagcaggagagtcttggaaatccattctgaattctctatatgagttgctggcggctcta attagaggcaatcgtaaaaactgtgctcaattttctggctccctcgactggctgatcagc agactggaaagactggaggcgtcctctggcattctggaggtcctccactgtgtgttagta gaaagcccagaagctctgaatatcattaaagaagggcatatcaaatccatcatctcactt ttagacaagcatggaagaaaccacaaggtcctggatgtgttgtgctctctctgtgtttgc catggggttgctgtccgttctaaccagcatctcatctgtgacaatctcctgccaggacga gatctcttactgcagacccgtcttgtgaatcatgtcagcagcatgaggcctaatattttc ctgggtgtcagtgaagggtctgcacagtataagaagtggtactacgaactcatggtggac cataccgaaccttttgtgacagcagaagctactcacttgcgagtgggctgggcttccacc gaagggtattccccataccccggcgggggtgaagagtggggtggcaatggcgttggtgat gacctcttctcctatgggttcgatggccttcacctctggtcaggttgtatagctcggact gtgagctcacccaaccagcacctgttgagaactgacgacgtcatcagttgctgtttagat ctaagtgccccaagcatctctttccgaattaatggacaacctgttcaaggaatgtttgag aacttcaatatcgatggcctgttctttccagttgttagtttctctgcaggaataaaggtt cgctttttgcttggggggagacatggagaattcaagttccttcctccacctggctatgct gcttgctatgaagctgttcttccgaaagagaaattgaaagtagaacacagtcgagaatat aagcaagagaggacatacacacgagatttgctggggcccacaatgtccctgactcaagct gccttcacacccgttcccgtggacaccagccagatcgtgttgcctcctcacctggaaagg ataagagaaaaactggcagaaaatatccacgagctctgggttatgaataaaattgagctt ggatggcagtatggtccggttagagatgacaacaagagacagcacccatgtctggtggag ttctgcaaacttccggaacaggaacgcaactacaatttgcagatgtcgcttgaaactctc aagactttgctggcattgggatgtcacgtgggtatagcggatgaacatgctgaagagaag gtgaagaaaatgaagctgcctaagaattaccagctcaccagtggatacaagcctgcccca atggatctgagctttataaaactcaccccctctcaggaagcaatggtggacaagttggct gaaaatgctcacaatgtgtgggcccgagaccgaatccggcagggctggacttatggcatc cagcaggacgtgaagaacagaagaaaccctcgccttgttccctatacgcttctggatgac agaaccaagaagtcaaacaaagacagcctccgtgaggcagttcgcacgctgctgggctat ggctaccacctggaagctcccgatcaggatcatgctgccagagctgaggtgtgcagcggc accggggagaggttccgtatcttcagggcagagaagacctatgcggtgaagtccgggcgc tggtactttgaattcgaggcggtcactgctggagacatgcgggtgggctggagcaggcca ggatgccaaccggatctcgaattgggttctgatgaacgtgcctttgcttttgatggcttt aaggcccagcggtggcaccagggcaatgaacactatgggcgctcttggcaagcaggtgat gtcgtgggctgtatggttgatatgaacgaacataccatgatgtttactcttaatggcgag atcctgctggatgactcaggctccgaactggctttcaaggactttgatgttggtgatggc ttcatccctgtgtgtagccttggggtggcacaagtaggcaggatgaactttggaaaggac gtcagcactttgaaatattttaccatctgtggcttacaagaaggctatgagccatttgct gttaacacaaatagggacatcaccatgtggctgagcaagcggcttcctcagttccttcag gttccatcaaaccacgaacacattgaggtaacaagaatagatggcaccatagacagttct ccatgtctgaaggtcactcagaagtcatttggttctcagaacagcaacactgacatcatg ttttaccgcctgagcatgcccattgaatgtgccgaggtcttctcgaagacagtagcagga ggactccctggtgcaggcctctacgggcccaagaatgatctagaggattatgatgtggac tcggattttgaggttctaatgaaaactgctcatggtcatctggtgcctgaccgcattgac aaggacaaagaaaccccaaagccagagttcaataaccacaaagattatgctcaagaaaag ccctcacgcctaaagcaaagatttttacttagaagaacaaaaccagattacagcacaagc cattctgcaagactcactgaagatgtccttgctgatgaccggggtgactatgagtacctg atgcagacatccacgtactattactcagtaaggatctttcctggacaagaacctgctaat gtctgggtaggctggattacgtctgacttccaccaatatgacacaggctttgatttggac agagtgcgcactgtgactgtcactctaggagatgaaaaaggaaaagtccatgagagcatc aaacgcagcaactgctatatggtgtgtgcgggagagagcatgagccctgggcaaggacga aacaacagcaatggattggagattggctgtgttgtggatgctgccagtgggttgctcacg ttcattgccaatggcaaggagctaagtacttactaccaggtggagccaagcacaaagtta ttccctgcagttttcgcacaagctacaagtcccaatgttttccagtttgagttgggcaga ataaagaatgtaatgcctctctcagctggattgtttaaaagtgagcacaaaaaccccgtg ccccagtgtcctccacgtctgcatgtacagttcctgtcacatgtcctgtggagccggatg cccaaccagttcttgaaggtggatgtctctcgaatcagtgaacgccaaggatggctggtg cagtgtcttgatcctctgcagttcatgtctctccatatccccgaggagaacaggtctgtt gatatcttagagctgacagagcaggaggagttactgcagtttcactatcacaccctccgt ctctactctgcagtctgtgcccttgggaatcatcgggtggcccatgccctatgcagccac gtggacgaacctcagctgctctatgccattgaaaataagtacatgcctggcttgctgcgt gctggctactatgacctgctgattgacatccacctcagctcctatgccactgccaggctc atgatgaacaatgagttcattgtccctatgacagaggagacaaagagcatcaccctcttc cccaatgagaacaagaaacatggcctcccaggcattggccttagcacctccctcaggcct cggatgcagttttcctcccctagttttgtgagcattagcaatgaatgctatcagtacagt cccgagtttccactggacatcctcaaggccaagaccatccagatgctcacagaagcagtg aaggagggcagcctccatgcacgggaccctgtgggtgggaccacggagttcctctttgta cctctcatcaagctcttctacacgctgctcatcatgggtatctttcacaatgaggatttg aaacacatcctgcagttgatcgagcccagtgtgtttaaggaagctgccactccagaggag gaaggaggagctccagagaaggagatcagtgcagaagactctaagctagaaggaacaggt gaagaagaagccaaagggggcaaaaggcccaaggaaggcctgctccagatgaaactccct gagccagttaaactgcagatgtgtctcttgcttcagtacctctgtgactgccaggttcgg caccgaatagaagccattgtagccttttcagatgactttgtagctaagctccaagacaat caacggttcagatataatgaagttatgcaagccttaaacatgtctgccgcactcactgcc aggaaaacaaaggagttccggtcaccaccacaagagcagattaatatgcttctcaatttt aaggatgataaaagtgaatgtccctgccctgaagaaatccgagaccaacttctggatttc catgaggacctgatgactcactgtggaattgagctggatgaagatggatccctggatgga agtaatgacttaacaatcagaggacgtttgctgtccctggtggaaaaggtgacctacctg aagaagaaacaagctgaaaaaccagttgcaagtgactccagaaagtcctccagtctccag caattgatttctgaaactatggtgcgttgggctcaagagtctgtcatcgaggaccctgag ctggtgagggccatgtttgtgttgctgcatcgacagtatgatggcatcgggggtctagtc cgggcattgccaaagacctacactatcaatggcgtctctgtggaggataccatcaacctg cttgcatcacttggtcagatacgatctctgctgagtgtgaggatgggcaaagaagaagag aagctgatgattcgtggtctgggagatatcatgaataacaaagtgttttaccagcacccc aatctcatgagggcccttggaatgcacgaaacagtgatggaagtcatggtgaatgtcctt ggaggaggcgagtccaaggaaatcaccttccccaagatggtggccaactgctgtcgtttt ctgtgttacttctgccgtataagtaggcagaatcagaaagccatgtttgatcatctcagt tatttactggaaaacagtagtgttggtcttgcttcaccagccatgagaggttcaactccc ttggatgtggccgcagcttcagttatggacaacaatgaacttgcccttgctctacgggag ccggatctggagaaggtagttcgatatctggctggctgtggcctgcagagctgtcagatg ctggtatctaagggttacccagacattgggtggaatccagttgaaggagagcgatacctt gactttctcagatttgctgtcttctgtaatggggagagtgtagaagagaatgcaaatgtt gtggtgaggttgctcatccggaggccggagtgctttggtcctgccttgagaggagaaggt ggaaatggtctccttgcagctatggaagaagccataaaaatagccgaggatccttctaga gatggcccctccccaacaagtggatccagcaaaacccttgatatagaagaggaagaagat gacaccatccacatggggaatgccatcatgaccttctatgcagctttgattgacttgctc ggccgctgcgctcctgaaatgcatttgattcatgctggaaagggagaagccatccgaatc agatctattttgcgatccttgattccactgggagacttggtgggagtaatcagcattgca tttcaaatgccaacaatagccaaagatgggaaggtggtggagcctgacatgtccgcgggg ttttgcccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgag gtgcaagatttcctcctccatctccttgaggttggctttctgccagatctccgagctgct gcctctctagatacggctgcactcagtgctacagacatggccttggccctcaatcggtac ctttgtacagctgtcctgcctttgttaacgagatgtgctcccctgtttgctggaacagag caccatgcttccctcattgactctctgctgcatactgtatatagactgtctaagggatgc tccctcaccaaagctcagcgggactctattgaagtctgtctgctctctatatgtggccaa ctgcgaccttctatgatgcaacacctactcagaagactggtatttgatgttccacagctg aatgaacatgcaaagatgcctcttaagctcctgacaaatcattatgaaagatgctggaaa tattactgcctgcctggagggtggggcaattttggtgctgcctcagaagaagaacttcat ttatcaagaaagctattttggggcatttttgatgctttgtctcaaaagaaatatgaacaa gaacttttcaaactggccctgccttgcctgagtgcagttgcgggagctttacctccagac tacatggagtcaaactatgtcagtatgatggaaaaacagtcatccatggattctgaaggg aactttaacccacaacctgttgatacctcaaacattacaattcctgagaagttagaatac ttcattaacaaatatgcagaacattcccatgataaatggtccatggacaagttggcaaat ggatggatttatggggaaatatattcagactcttctaaggttcaaccactaatgaagcca tataaactattgtctgaaaaggaaaaagaaatttatcgctggcccatcaaggaatcttta aaaacgatgctggcttggggttggagaattgagagaacacgggagggagacagtatggct ctttataaccggactcgacgcatttctcaaacaagtcaggtgtctatagatgctgcgcat gggtatagccctcgtgctattgacatgagcaatgtaacactatctcgagacctgcatgct atggcggaaatgatggctgaaaactaccacaacatatgggccaagaaaaagaaaatggag ctggaatccaaaggaggaggaaaccaccccctgctcgtgccctatgacacactgacagcc aaagagaaagccaaggacagagagaaggcccaggatatcttcaagttcttacagatcagt ggttatgctgtatccagagggttcaaggacctggatctggacacaccttctattgagaag cggtttgcctatagtttcctgcagcagctgatccgctatgtggacgaggctcatcagtac atcctggagttcgatggcggcagcagaagcaaaggagaacacttcccgtacgagcaagaa atcaagttctttgccaaagttgttcttccattaattgatcagtatttcaaaaaccatcgt ctgtacttcttgtctgctgcaagcaggcctctctgcactggaggacatgcatccaacaaa gagaaggagatggtgacgagcctgttctgcaaacttggagttcttgtcaggcataggatt tcactgtttggcaatgatgctacctcaattgtgaactgtcttcatattcttggtcagact ttggatgcaaggacggtgatgaagacgggcctggatagtgtgaaaagtgctcttagggcc tttctggacaatgcagcagaggatctggaaaagacaatggaaaaccttaagcagggccag tttactcacacccggagccagcccaaaggggtgactcagatcatcaactacactactgtg gcactgttgcccatgctctcatccctctttgagcacatcggccaacatcagtttggagaa gatctgatattggaggatgtgcaggtgtcttgttatagaattttgaccagcttgtatgcc ttgggaaccagcaagagcatctatgtggaaaggcaaagatctgcacttggggaatgccta gctgcctttgctggtgcctttcctatagcctttttggaaacccacctggacaaacataat gtgtactccatctacaacaccagatcttcacgggagagagcagctctcagtttaccagca agtgtggaggatgtctgcccaaatataccatccctggagaagcttatggctgagattata gaactagcagagtcaggtatccgctacactcagatgccccacatgatggaggttgtactg cccatgctgtgtagctacatgtcacggtggtgggaacacggtcctgagaaccacccagag agagctgagatgtgctgcacagcactcaactctgagcacatgaacacactgctgggcaac attctcaaaatcatctacaacaacctggggattgacgaaggagcctggatgaaacgctta gcagtgttttctcagcctatcatcaataaggtgaaacctcagctcttgaaaactcatttc ttgcccttgatggagaaactaaagaaaaaggctgccatggtagtatctgaggaagaccac ttgaaagccgaggccagaggggacatgtctgaggctgagttgctcattttagatgaattc acaacattggccagggatctctatgccttctacccactcttgatccgatttgtggactat aacagggcaaaatggctgaaggagcccaacccagaagcggaagaactgtttcgaatggtg gctgaagtcttcatcttctggtccaaatcccataatttcaaaagagaagaacagaacttt gtggtacagaatgaaatcaacaacatgtcattcctcatcactgatacaaaatccaagatg tccaaggcagccgtttctgatcaagagaggaagaaaatgaagcgcaagggggacaggtat tctatgcagacatctctgatcgtggcagctctgaagcgactacttcccattggactgaac atctgtgctcctggagaccaagagctcattgctttagccaaaaaccggtttagcttgaaa gacaccgaggaggaagtacgagatataatccgcagtaatatacacttacaaggcaagttg gaagatcctgcaatcaggtggcaaatggctctctataaagacttgccaaacaggacagaa gacacctcagacccagagaggacagtggaacgtgtcctggatatagcaaatgtacttttt catcttgaacagaaatctaagtatactgagtatactggccggagatatttcagtctggga agtacagtggaacatcctcagagatcaaagaaggctgtgtggcacaaactactctctaag cagagaaaaagagctgttgttgcctgcttccggatggcacccttgtacaatctgccaagg catcgggctgtcaatctctttcttcagggatatgaaaagtcttggattgaaacggaggag cattactttgaggataaattgattgaagatttagcaaaaccaggcactgaacctccagaa gaagatgaagccatgaaaagagttgatcctctccatcaactcattcttctattcagccgc acggctttaacagagaaatgcaaactggaggaagattttctatatatggcatatgcagat attatggcaaagagttgtcatgatgaggaagatgatgatggtgaagaagaagtgaagagc tttgaagaaaaagaaatggagaagcagaaacttctctaccagcaagccagactgcatgac cgtggggcagcagagatggtgcttcagaccattagtgccagcaaaggtgaaaccggacca atggtggccgccacgttgaaattgggcattgctattttaaatggtgggaactccacagta cagcagaagatgctggattacctgaaggagaagaaagatgtaggctttttccagagcctg gcgggcctcatgcagtcctgcagtgtcctcgacctgaatgcctttgagaggcaaaacaaa gctgaaggacttgggatggtgactgaggaaggatcaggagagaaggtactacaggatgac gagttcacctgtgatctcttccgattcctgcagctgctttgtgagggacacaactcagat tttcaaaattacctgagaactcagactggcaacaatacaactgtcaatatcatcatctct actgtggactacctcctccgagtgcaggagtccattagtgatttctactggtactactct gggaaagacatcatagatgaacagggccagcgtaacttctccaaagccatccaagtggca aagcaggtgttcaacactctcacggaatacattcagggtccttgtactggaaaccagcag agcttggcacacagcaggctgtgggatgctgttgtgggtttccttcatgtatttgcccac atgcagatgaagctgtctcaggattcaagccaaatagagctcttgaaagaactaatggat ctccagaaggacatggtggtcatgctgctgtccatgctagaaggtaacgttgtgaacgga acaataggcaaacaaatggtagacatgcttgtggaatcgtccaacaatgtagagatgatc ctcaagttctttgacatgtttctgaagctaaaggacttaacatcctctgacacattcaag gagtatgaccctgatggcaaaggggtcatttccaagagagacttccacaaagccatggag agccacaagcactatacacagtcagagactgagttcctgctgtcctgtgcagagacagat gaaaatgaaacactagactatgaagagttcgtcaaaaggtttcatgagcctgcaaaggac attggcttcaatgttgctgtcctgttgaccaatctctcagagcacatgcccaatgacaca aggctgcagaccttcctggagttagcagagagtgtcctgaactatttccagcctttcctg ggtcgcattgagatcatgggcagtgccaagcgcattgagagggtctactttgagatcagc gagtccagcagaacccagtgggagaagccacaggttaaggagtccaaaaggcagttcata ttcgatgtggtcaatgagggtggggagaaggagaagatggaactgtttgtgaacttctgt gaggacaccatctttgagatgcagctggcagctcagatctcagagtctgacctaaacgag aggtcaacaaataaagaagataatgagaaggagaggcctgaagagcaggccccacggatg ggcttcttctccctcctcaccatccagtcagccctgtttgctctcaggtacaatgtgcta accctcgttaggatgctcagcttaaagagcctaaagaagcagatgaagagaatgaagaag atgacagtgaaggacatggtcacagctttcttcttgtcttactggagtgtgttcgtgacc ctcttgcactttgtggccagtgtctgtaggggcttttttcgcattgtctccagcctgctg cttgggggcagtctggtagaaggtgctaagaaaatcaaagtggcagagcttctagccaac atgccagaccccactcaggatgaggtgcgaggagatgaagaagatggagagcggaagcct ttagagtcagctctgccctctgaagatctgacagacttaaaggaactgacggaggagagt gaccttctttcggacatatttggcttggatctgaagagggaaggagggcagtataaacta attcctcacaatccaaatgccggcctcagtgatcttatgaccaaccccatccctgtgcct gaggtacaagaaaagtttcaggagcagaaggcaaaagaagagaaggaagaaaaggaagaa agcaagtctgaacccgagaaggctgagggggaagatggagaaaaagaagaaaaagccaaa gatgataagggcaaacagaagttgagacagcttcatacacatcgatatggggaacctgag gtgccagagtcagcattctggaagaaaatcatagcctatcaacaaaagctgctgaactat tttgctcgcaacttttacaacatgagaatgctggccttgtttgtcgcttttgccatcaat ttcatcctgctcttctacaaggtctccacttcttctgtggtagaaggaaaggagctgcct gccagaagctccagcgacactgccaaagtgaccaccagcctggacagcaaccctcacaga actattgcagtgcactatgtcctagaggagagcagtggctacatggaacccaccttgcgc atcttagccattttgcacacagtcatctctttcttctgcatcattggatactactgcttg aaagtccctttggttatttttaagcgagagaaggaagtggcacgcaaattggagtttgat gggctttacatcacagagcagccatcggaagacgatattaaaggccagtgggacagactc gtgatcaacacacagtcctttcccaataactactgggataaatttgttaaaagaaaggta atggataagtatggagagttttatgggcgagacagaatcagtgagttactgggcatggat aaggctgcactggatttcagcgatgcaagagagaagaagaagcccaagaaagacagttcc ttgtctgctgtattgaactctattgatgtgaagtaccagatgtggaaactaggagttgtg ttcacagacaactctttcctgtacctagcctggtatatgaccatgtctgttcttggacac tataacaacttcttttttgctgctcacctccttgacatcgccatgggattcaagaccttg agaaccatactgtcctcagttacccacaatggcaaacagctcgtgttaactgttggctta ttagctgttgttgtgtacctgtacactgtcgtggcattcaatttcttccggaaattctat aataaaagtgaagatggtgatacaccagacatgaaatgtgatgacatgctcacgtgttac atgttccacatgtatgtgggtgtccgtgctggagggggcattggtgatgaaattgaagac ccagcaggagatgagtatgagatctatcgcatcatctttgacatcacgttcttcttcttt gtgattgtcatccttttggccatcatacaaggtttgatcatcgatgcttttggagaactc agagaccaacaggaacaagtcaaagaggacatggagaccaagtgcttcatctgtgggata ggcaatgactactttgacacagtgccacatggctttgaaacacatactctacaggagcac aaccttgccaactacctgttttttctgatgtatctcataaacaaggatgaaacagaacac acaggacaggaatcttatgtctggaagatgtatcaagagaggtgttgggagttttttcca gcaggagattgtttccggaaacagtatgaagaccagttaaattag

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