KEGG   Phodopus roborovskii (desert hamster): 127233576
Entry
127233576         CDS       T08852                                 
Symbol
Chuk
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
prob  Phodopus roborovskii (desert hamster)
Pathway
prob01523  Antifolate resistance
prob04010  MAPK signaling pathway
prob04014  Ras signaling pathway
prob04062  Chemokine signaling pathway
prob04064  NF-kappa B signaling pathway
prob04068  FoxO signaling pathway
prob04150  mTOR signaling pathway
prob04151  PI3K-Akt signaling pathway
prob04210  Apoptosis
prob04380  Osteoclast differentiation
prob04620  Toll-like receptor signaling pathway
prob04621  NOD-like receptor signaling pathway
prob04622  RIG-I-like receptor signaling pathway
prob04623  Cytosolic DNA-sensing pathway
prob04625  C-type lectin receptor signaling pathway
prob04657  IL-17 signaling pathway
prob04658  Th1 and Th2 cell differentiation
prob04659  Th17 cell differentiation
prob04660  T cell receptor signaling pathway
prob04662  B cell receptor signaling pathway
prob04668  TNF signaling pathway
prob04920  Adipocytokine signaling pathway
prob04936  Alcoholic liver disease
prob05010  Alzheimer disease
prob05132  Salmonella infection
prob05135  Yersinia infection
prob05142  Chagas disease
prob05145  Toxoplasmosis
prob05160  Hepatitis C
prob05161  Hepatitis B
prob05162  Measles
prob05163  Human cytomegalovirus infection
prob05164  Influenza A
prob05165  Human papillomavirus infection
prob05166  Human T-cell leukemia virus 1 infection
prob05167  Kaposi sarcoma-associated herpesvirus infection
prob05168  Herpes simplex virus 1 infection
prob05169  Epstein-Barr virus infection
prob05170  Human immunodeficiency virus 1 infection
prob05171  Coronavirus disease - COVID-19
prob05200  Pathways in cancer
prob05208  Chemical carcinogenesis - reactive oxygen species
prob05212  Pancreatic cancer
prob05215  Prostate cancer
prob05220  Chronic myeloid leukemia
prob05221  Acute myeloid leukemia
prob05222  Small cell lung cancer
prob05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
prob05417  Lipid and atherosclerosis
prob05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:prob00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    127233576 (Chuk)
   04014 Ras signaling pathway
    127233576 (Chuk)
   04064 NF-kappa B signaling pathway
    127233576 (Chuk)
   04668 TNF signaling pathway
    127233576 (Chuk)
   04068 FoxO signaling pathway
    127233576 (Chuk)
   04151 PI3K-Akt signaling pathway
    127233576 (Chuk)
   04150 mTOR signaling pathway
    127233576 (Chuk)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    127233576 (Chuk)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    127233576 (Chuk)
   04621 NOD-like receptor signaling pathway
    127233576 (Chuk)
   04622 RIG-I-like receptor signaling pathway
    127233576 (Chuk)
   04623 Cytosolic DNA-sensing pathway
    127233576 (Chuk)
   04625 C-type lectin receptor signaling pathway
    127233576 (Chuk)
   04660 T cell receptor signaling pathway
    127233576 (Chuk)
   04658 Th1 and Th2 cell differentiation
    127233576 (Chuk)
   04659 Th17 cell differentiation
    127233576 (Chuk)
   04657 IL-17 signaling pathway
    127233576 (Chuk)
   04662 B cell receptor signaling pathway
    127233576 (Chuk)
   04062 Chemokine signaling pathway
    127233576 (Chuk)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    127233576 (Chuk)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    127233576 (Chuk)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127233576 (Chuk)
   05208 Chemical carcinogenesis - reactive oxygen species
    127233576 (Chuk)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127233576 (Chuk)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    127233576 (Chuk)
   05221 Acute myeloid leukemia
    127233576 (Chuk)
   05220 Chronic myeloid leukemia
    127233576 (Chuk)
   05215 Prostate cancer
    127233576 (Chuk)
   05222 Small cell lung cancer
    127233576 (Chuk)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    127233576 (Chuk)
   05170 Human immunodeficiency virus 1 infection
    127233576 (Chuk)
   05161 Hepatitis B
    127233576 (Chuk)
   05160 Hepatitis C
    127233576 (Chuk)
   05171 Coronavirus disease - COVID-19
    127233576 (Chuk)
   05164 Influenza A
    127233576 (Chuk)
   05162 Measles
    127233576 (Chuk)
   05168 Herpes simplex virus 1 infection
    127233576 (Chuk)
   05163 Human cytomegalovirus infection
    127233576 (Chuk)
   05167 Kaposi sarcoma-associated herpesvirus infection
    127233576 (Chuk)
   05169 Epstein-Barr virus infection
    127233576 (Chuk)
   05165 Human papillomavirus infection
    127233576 (Chuk)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    127233576 (Chuk)
   05135 Yersinia infection
    127233576 (Chuk)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    127233576 (Chuk)
   05142 Chagas disease
    127233576 (Chuk)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127233576 (Chuk)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    127233576 (Chuk)
   05418 Fluid shear stress and atherosclerosis
    127233576 (Chuk)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    127233576 (Chuk)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    127233576 (Chuk)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:prob01001]
    127233576 (Chuk)
Enzymes [BR:prob01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     127233576 (Chuk)
Protein kinases [BR:prob01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   127233576 (Chuk)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 127233576
NCBI-ProteinID: XP_051056073
UniProt: A0AAU9ZWX6
LinkDB
Position
Unknown
AA seq 745 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHREHDIKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLCDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLNWDPQQRGGPIDVTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPCDESFHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPTDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTIMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGTVTPPASAWLPPMLADREHPLTRVVTPQDGETLPQMIEENLNCLGHL
STIIREANEEQSHSMMSLDWSWLTE
NT seq 2238 nt   +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcggcccctgggagatgcgggagcgg
cttggcaccggcggcttcggcaacgtctgtctgtaccagcaccgggaacatgatatcaaa
atagcaattaagtcttgtcgcctagagttaagtaccaaaaaccgagagcgttggtgccat
gaaatccagatcatgaagaagttgaaccatgcaaatgtggtaaaggcctgtgatgttcct
gaggaactgaattttttaattaatgacgtgcctcttctagcaatggagtactgttctgga
ggagatctccggaagctactcaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttactgtgtgacataggatctggaattcgatatttgcatgaaaacaaaatc
atacatcgagatctaaaacctgaaaatatagttcttcaagatgttggtgggaagataatg
cataaaataattgatttgggttatgccaaagatgttgatcaaggaagtctatgtacatct
tttgtgggaacattacagtatttggctccagagctctttgaaaataaaccatacacagct
actgtggattattggagctttgggaccatggtgtttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgagaaaattaagaagaaagatccaaag
tgtatatttgcatgtgaagagatgaccggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttaatagtagagcccatggaaagctggctacaattgatgctg
aattgggacccacagcagagagggggacctattgatgttactttgaagcagccaagatgt
tttgtattaatggatcacattctcaacttaaagatagtacacatcctaaatatgacttct
gcaaaaatcatttcttttctgttaccatgtgatgaaagttttcattcactacagtctcgt
attgagcgtgaaacaggaataaatactggttctcaagaacttttgtcagagacaggaatt
tctctggatcctcggaaaccagcctctcaatgtgttctagatggagttagaggctgtgat
agctacatggtttatttgtttgataaaagtaagactgtatatgaaggaccatttgcatcc
agaagtttatctgattgtgtaaattatattgttcaagacagcaagatacagcttccaatt
atacagctgcgtaaagtatgggctgaagcagtgcactatgtatctggattaaaagaagac
tacagcaggctctttcagggacaaagagcagcaatgttaagtcttcttagatataatgct
aacttgacaaaaatgaagaatactttgatctcagcatcacagcaactcaaagctaaattg
gagttttttcacaaaagcattcagcttgacttggagagatatagtgagcagatgacttat
gggatatcttcagaaaaaatgctgaaagcatggaaagaaatggaggaaaaggccattcac
tatgctgaggttggtgtcattggataccttgaggatcaaattatgtctttgcacactgaa
atcatggagcttcagaagagcccctatggaagacgccaaggagacttgatggaatctctg
gaacagcgtgccattgatctctataagcagttaaagcacagacctacagatcactcatac
agtgatagcacggagatggtgaagatcattgtgcacactgtgcagagtcaggaccgcgtt
ctcaaggagctgtttggtcacttgagcaagttgttgggctgtaagcagaagattattgat
ctactccctaaggtggaagtggctctcagtaacatcaaagaagctgacaataccatcatg
tttatgcagggaaagaggcagaaagaaatatggcacctccttaaaattgcctgtacacag
agttctgcccgctctcttgtaggatccagtctagaaggcacagtaacccctccagcatca
gcatggctgccccctatgttagcagaccgtgaacatcctctgacacgtgtggtaactcct
caagatggagagacgttaccacaaatgatagaagaaaatctgaactgtcttggccattta
agtactattattcgtgaagcaaatgaggaacaaagccatagtatgatgagtcttgattgg
agttggttaacagaatga

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