KEGG   Phodopus roborovskii (desert hamster): 127238024
Entry
127238024         CDS       T08852                                 
Symbol
Pik3cb
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
prob  Phodopus roborovskii (desert hamster)
Pathway
prob00562  Inositol phosphate metabolism
prob01100  Metabolic pathways
prob01521  EGFR tyrosine kinase inhibitor resistance
prob01522  Endocrine resistance
prob01524  Platinum drug resistance
prob04012  ErbB signaling pathway
prob04014  Ras signaling pathway
prob04015  Rap1 signaling pathway
prob04024  cAMP signaling pathway
prob04062  Chemokine signaling pathway
prob04066  HIF-1 signaling pathway
prob04068  FoxO signaling pathway
prob04070  Phosphatidylinositol signaling system
prob04071  Sphingolipid signaling pathway
prob04072  Phospholipase D signaling pathway
prob04081  Hormone signaling
prob04140  Autophagy - animal
prob04150  mTOR signaling pathway
prob04151  PI3K-Akt signaling pathway
prob04152  AMPK signaling pathway
prob04210  Apoptosis
prob04211  Longevity regulating pathway
prob04213  Longevity regulating pathway - multiple species
prob04218  Cellular senescence
prob04360  Axon guidance
prob04370  VEGF signaling pathway
prob04380  Osteoclast differentiation
prob04510  Focal adhesion
prob04550  Signaling pathways regulating pluripotency of stem cells
prob04611  Platelet activation
prob04613  Neutrophil extracellular trap formation
prob04620  Toll-like receptor signaling pathway
prob04625  C-type lectin receptor signaling pathway
prob04630  JAK-STAT signaling pathway
prob04650  Natural killer cell mediated cytotoxicity
prob04660  T cell receptor signaling pathway
prob04662  B cell receptor signaling pathway
prob04664  Fc epsilon RI signaling pathway
prob04666  Fc gamma R-mediated phagocytosis
prob04668  TNF signaling pathway
prob04670  Leukocyte transendothelial migration
prob04722  Neurotrophin signaling pathway
prob04725  Cholinergic synapse
prob04750  Inflammatory mediator regulation of TRP channels
prob04810  Regulation of actin cytoskeleton
prob04910  Insulin signaling pathway
prob04914  Progesterone-mediated oocyte maturation
prob04915  Estrogen signaling pathway
prob04917  Prolactin signaling pathway
prob04919  Thyroid hormone signaling pathway
prob04923  Regulation of lipolysis in adipocytes
prob04926  Relaxin signaling pathway
prob04929  GnRH secretion
prob04930  Type II diabetes mellitus
prob04931  Insulin resistance
prob04932  Non-alcoholic fatty liver disease
prob04933  AGE-RAGE signaling pathway in diabetic complications
prob04935  Growth hormone synthesis, secretion and action
prob04960  Aldosterone-regulated sodium reabsorption
prob04973  Carbohydrate digestion and absorption
prob05010  Alzheimer disease
prob05017  Spinocerebellar ataxia
prob05020  Prion disease
prob05100  Bacterial invasion of epithelial cells
prob05132  Salmonella infection
prob05135  Yersinia infection
prob05142  Chagas disease
prob05146  Amoebiasis
prob05160  Hepatitis C
prob05161  Hepatitis B
prob05162  Measles
prob05163  Human cytomegalovirus infection
prob05164  Influenza A
prob05165  Human papillomavirus infection
prob05166  Human T-cell leukemia virus 1 infection
prob05167  Kaposi sarcoma-associated herpesvirus infection
prob05168  Herpes simplex virus 1 infection
prob05169  Epstein-Barr virus infection
prob05170  Human immunodeficiency virus 1 infection
prob05171  Coronavirus disease - COVID-19
prob05200  Pathways in cancer
prob05203  Viral carcinogenesis
prob05205  Proteoglycans in cancer
prob05206  MicroRNAs in cancer
prob05207  Chemical carcinogenesis - receptor activation
prob05208  Chemical carcinogenesis - reactive oxygen species
prob05210  Colorectal cancer
prob05211  Renal cell carcinoma
prob05212  Pancreatic cancer
prob05213  Endometrial cancer
prob05214  Glioma
prob05215  Prostate cancer
prob05218  Melanoma
prob05220  Chronic myeloid leukemia
prob05221  Acute myeloid leukemia
prob05222  Small cell lung cancer
prob05223  Non-small cell lung cancer
prob05224  Breast cancer
prob05225  Hepatocellular carcinoma
prob05226  Gastric cancer
prob05230  Central carbon metabolism in cancer
prob05231  Choline metabolism in cancer
prob05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
prob05415  Diabetic cardiomyopathy
prob05417  Lipid and atherosclerosis
prob05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:prob00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    127238024 (Pik3cb)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    127238024 (Pik3cb)
   04014 Ras signaling pathway
    127238024 (Pik3cb)
   04015 Rap1 signaling pathway
    127238024 (Pik3cb)
   04370 VEGF signaling pathway
    127238024 (Pik3cb)
   04630 JAK-STAT signaling pathway
    127238024 (Pik3cb)
   04668 TNF signaling pathway
    127238024 (Pik3cb)
   04066 HIF-1 signaling pathway
    127238024 (Pik3cb)
   04068 FoxO signaling pathway
    127238024 (Pik3cb)
   04070 Phosphatidylinositol signaling system
    127238024 (Pik3cb)
   04072 Phospholipase D signaling pathway
    127238024 (Pik3cb)
   04071 Sphingolipid signaling pathway
    127238024 (Pik3cb)
   04024 cAMP signaling pathway
    127238024 (Pik3cb)
   04151 PI3K-Akt signaling pathway
    127238024 (Pik3cb)
   04152 AMPK signaling pathway
    127238024 (Pik3cb)
   04150 mTOR signaling pathway
    127238024 (Pik3cb)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    127238024 (Pik3cb)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    127238024 (Pik3cb)
  09143 Cell growth and death
   04210 Apoptosis
    127238024 (Pik3cb)
   04218 Cellular senescence
    127238024 (Pik3cb)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    127238024 (Pik3cb)
   04550 Signaling pathways regulating pluripotency of stem cells
    127238024 (Pik3cb)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    127238024 (Pik3cb)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    127238024 (Pik3cb)
   04613 Neutrophil extracellular trap formation
    127238024 (Pik3cb)
   04620 Toll-like receptor signaling pathway
    127238024 (Pik3cb)
   04625 C-type lectin receptor signaling pathway
    127238024 (Pik3cb)
   04650 Natural killer cell mediated cytotoxicity
    127238024 (Pik3cb)
   04660 T cell receptor signaling pathway
    127238024 (Pik3cb)
   04662 B cell receptor signaling pathway
    127238024 (Pik3cb)
   04664 Fc epsilon RI signaling pathway
    127238024 (Pik3cb)
   04666 Fc gamma R-mediated phagocytosis
    127238024 (Pik3cb)
   04670 Leukocyte transendothelial migration
    127238024 (Pik3cb)
   04062 Chemokine signaling pathway
    127238024 (Pik3cb)
  09152 Endocrine system
   04910 Insulin signaling pathway
    127238024 (Pik3cb)
   04923 Regulation of lipolysis in adipocytes
    127238024 (Pik3cb)
   04929 GnRH secretion
    127238024 (Pik3cb)
   04915 Estrogen signaling pathway
    127238024 (Pik3cb)
   04914 Progesterone-mediated oocyte maturation
    127238024 (Pik3cb)
   04917 Prolactin signaling pathway
    127238024 (Pik3cb)
   04926 Relaxin signaling pathway
    127238024 (Pik3cb)
   04935 Growth hormone synthesis, secretion and action
    127238024 (Pik3cb)
   04919 Thyroid hormone signaling pathway
    127238024 (Pik3cb)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    127238024 (Pik3cb)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    127238024 (Pik3cb)
  09156 Nervous system
   04725 Cholinergic synapse
    127238024 (Pik3cb)
   04722 Neurotrophin signaling pathway
    127238024 (Pik3cb)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    127238024 (Pik3cb)
  09158 Development and regeneration
   04360 Axon guidance
    127238024 (Pik3cb)
   04380 Osteoclast differentiation
    127238024 (Pik3cb)
  09149 Aging
   04211 Longevity regulating pathway
    127238024 (Pik3cb)
   04213 Longevity regulating pathway - multiple species
    127238024 (Pik3cb)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127238024 (Pik3cb)
   05206 MicroRNAs in cancer
    127238024 (Pik3cb)
   05205 Proteoglycans in cancer
    127238024 (Pik3cb)
   05207 Chemical carcinogenesis - receptor activation
    127238024 (Pik3cb)
   05208 Chemical carcinogenesis - reactive oxygen species
    127238024 (Pik3cb)
   05203 Viral carcinogenesis
    127238024 (Pik3cb)
   05230 Central carbon metabolism in cancer
    127238024 (Pik3cb)
   05231 Choline metabolism in cancer
    127238024 (Pik3cb)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127238024 (Pik3cb)
  09162 Cancer: specific types
   05210 Colorectal cancer
    127238024 (Pik3cb)
   05212 Pancreatic cancer
    127238024 (Pik3cb)
   05225 Hepatocellular carcinoma
    127238024 (Pik3cb)
   05226 Gastric cancer
    127238024 (Pik3cb)
   05214 Glioma
    127238024 (Pik3cb)
   05221 Acute myeloid leukemia
    127238024 (Pik3cb)
   05220 Chronic myeloid leukemia
    127238024 (Pik3cb)
   05218 Melanoma
    127238024 (Pik3cb)
   05211 Renal cell carcinoma
    127238024 (Pik3cb)
   05215 Prostate cancer
    127238024 (Pik3cb)
   05213 Endometrial cancer
    127238024 (Pik3cb)
   05224 Breast cancer
    127238024 (Pik3cb)
   05222 Small cell lung cancer
    127238024 (Pik3cb)
   05223 Non-small cell lung cancer
    127238024 (Pik3cb)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    127238024 (Pik3cb)
   05170 Human immunodeficiency virus 1 infection
    127238024 (Pik3cb)
   05161 Hepatitis B
    127238024 (Pik3cb)
   05160 Hepatitis C
    127238024 (Pik3cb)
   05171 Coronavirus disease - COVID-19
    127238024 (Pik3cb)
   05164 Influenza A
    127238024 (Pik3cb)
   05162 Measles
    127238024 (Pik3cb)
   05168 Herpes simplex virus 1 infection
    127238024 (Pik3cb)
   05163 Human cytomegalovirus infection
    127238024 (Pik3cb)
   05167 Kaposi sarcoma-associated herpesvirus infection
    127238024 (Pik3cb)
   05169 Epstein-Barr virus infection
    127238024 (Pik3cb)
   05165 Human papillomavirus infection
    127238024 (Pik3cb)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    127238024 (Pik3cb)
   05135 Yersinia infection
    127238024 (Pik3cb)
   05100 Bacterial invasion of epithelial cells
    127238024 (Pik3cb)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    127238024 (Pik3cb)
   05142 Chagas disease
    127238024 (Pik3cb)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127238024 (Pik3cb)
   05017 Spinocerebellar ataxia
    127238024 (Pik3cb)
   05020 Prion disease
    127238024 (Pik3cb)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    127238024 (Pik3cb)
   05418 Fluid shear stress and atherosclerosis
    127238024 (Pik3cb)
   05415 Diabetic cardiomyopathy
    127238024 (Pik3cb)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    127238024 (Pik3cb)
   04932 Non-alcoholic fatty liver disease
    127238024 (Pik3cb)
   04931 Insulin resistance
    127238024 (Pik3cb)
   04933 AGE-RAGE signaling pathway in diabetic complications
    127238024 (Pik3cb)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127238024 (Pik3cb)
   01524 Platinum drug resistance
    127238024 (Pik3cb)
   01522 Endocrine resistance
    127238024 (Pik3cb)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:prob04131]
    127238024 (Pik3cb)
Enzymes [BR:prob01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     127238024 (Pik3cb)
Membrane trafficking [BR:prob04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    127238024 (Pik3cb)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 127238024
NCBI-ProteinID: XP_051062439
UniProt: A0AAU9YT50
LinkDB
Position
Unknown
AA seq 1070 aa
MCFSSMMPPAMADILDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEH
EPSVLENLEDKLYGGKLIVAVHFENSQDVFSFQVSPNLTPIKINELAIQKRLTIHGKEDE
VSPYDCVLQVSGRVEYVFGEHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRVISHVWDNNNPFQIVLVKGNKLNTEEAVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NTSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
MNPYAENATTLHIKFPENKKQPYYYPPFDKIIEKAAEIASGDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRHMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALDNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYSNRAFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNTGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRRDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagctctatgatgccccctgccatggcagacatccttgacatctgggcagtg
gattcacagatcgcttctgatggcgccatatctgtggatttccttctgcccactgggatt
tatatccagttggaagtacctcgggaagctaccatttcttatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggacattgactcctacatgttt
gcatgtgtgaatcaaactgctgtatatgaggaacttgaagatgaaactcgaagactttgt
gatgtcagaccttttcttccagttctaaaactagtgactagaagttgtgatccagcagaa
aaattggactcaaaaattggagtccttataggaaaaggtcttcatgaatttgatgccttg
aaggatcctgaagtgaatgaatttagaagaaaaatgcgcaaattcagtgaggacaagatt
cagtccctagtggggttgtcttggatcgactggctgaagcacacgtacccaccagagcat
gagccatctgtcctggagaacctggaagataaactgtatggagggaagctgatcgtggct
gtgcattttgaaaatagccaggatgtatttagttttcaagtgtctcctaatttgactcct
ataaaaataaatgaattggcaatccagaaacgcttgactattcacggaaaggaagatgaa
gttagcccctatgactgtgtgttacaagtcagcgggagagtggagtatgtattcggagaa
catccactaattcagttccagtatatccggaactgtgtaatgaataggaccctgccccat
ttcatccttgtggagtgttgcaagatcaagaagatgtatgagcaagaaatgattgccata
gaggctgccataaaccggaactcatccaaccttcctcttcctttaccaccaaagaaaact
cgagttatttctcatgtctgggacaacaacaaccctttccaaattgtcttggtgaaagga
aataagcttaacacagaagaagccgtgaaagttcatgtcagagccggtctttttcatgga
accgagctcctgtgtaaaaccgtcgtcagctcagagatatcaggaaaaaacgaccatatt
tggaatgaacaactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttacgccgttttggataaagtaaaaacgaagaaatcaacaaaaactatt
aatacctctaaatatcaaaccatcaggaaagctgggaaagtgcattatcctgtagcatgg
gtaaatacgatggtttttgacttcaaaggacagctgaggtctggagacataatcttacac
agctggtcttcgtttcctgatgagctggaagaaatgttgaatcccatgggcactgtgcag
atgaacccatatgctgaaaatgcgactaccttgcatattaagtttccagagaataaaaag
cagccttattattaccctccattcgataagatcattgagaaggcagctgagattgccagt
ggtgacagtgctaatgtgtcaagtcgtggtggaaagaaatttcttgctgtactgaaagaa
atcttggacagagaccccttgtctcagctgtgtgagaatgaaatggatcttatctggact
ctgaggcaagactgccgagaaaatttcccacagtccctgccaaaactactcctgtcaatc
aagtggaataaacttgaagatgtcgctcagcttcaggcactcctgcagatttggcccaaa
cttccgcccagggaagccctggagctcctggacttcaactacccagaccagtatgtgagg
gagtatgcagtaggctgcctgcgacacatgagtgacgaagaactctctcagtatctttta
cagttggtgcaagttctgaaatatgagcccttccttgattgtgctctttctagattcctg
ttagagagagcacttgataaccggaggattgggcagtttctgttttggcatcttaggtca
gaagtgcatattcccgccgtgtccgtacagtttggtgtcatcctagaagcgtactgtcga
ggaagtgtaggacacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa
acattaaatagcttaatcaaattgaatgctgtgaagctcaacagagctaaagggaaggag
gctatgcacacttgcttaaagcagaacgcttaccgggaggccctctctgacctgcagtca
cctctcaatccgtgtgtcatcctctcagaactctatgttgaaaagtgcaaatacatggac
tccaagatgaagcccttgtggctggtctacagcaacagagcttttggagaggactcagtt
ggagtgatctttaaaaatggtgatgatttgcggcaggacatgctgacactgcagatgcta
cgcctgatggacctgctctggaaagaggctggtttggaccttcggatgcttccctatggc
tgcttagcaacaggagatcgctctggcctcattgaggttgtgagcacctctgagacaatc
gctgacattcagctgaacagtagcaacgtggctgccacagcagcattcaacaaagacgca
ctcctgaactggcttaaggagtacaatacgggggatgatctggaccgagcaattgaggag
ttcaccctgtcctgtgctggctactgtgtagcttcttatgtccttggcattggtgacagg
cacagtgacaacatcatggtgaaaaaaactggccagctcttccacatagattttggacat
attcttggaaatttcaaatcgaaatttggcattaagagagaacgagtacctttcattctt
acttacgacttcattcatgtcattcaacaaggaaaaacaggaaatacagaaaaatttggc
aggtttcgccagtgttgtgaagatgcctatctgattttacggcggcatgggaacctcttc
atcaccctctttgcactgatgttgactgcagggcttcctgagctcacctcagtcaaagat
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagcactcaaacaa
tttaagcaaaagtttgacgaggcgctcagggaaagctggactactaaggtgaactggatg
gctcacacagttcgcagagactataggtcttag

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