Pseudomonas syringae pv. syringae B728a: Psyr_2608 Help Entry Psyr_2608         CDS       T00246                                  Name (GenBank) Amino acid adenylation   KO K16125   syringomycin synthetase protein SyrE Organism psb  Pseudomonas syringae pv. syringae B728a Pathway psb01054   Nonribosomal peptide structures Brite KEGG Orthology (KO) [BR:psb00001]  09100 Metabolism   09109 Metabolism of terpenoids and polyketides    01054 Nonribosomal peptide structures     Psyr_2608  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:psb01008]     Psyr_2608 Polyketide biosynthesis proteins [BR:psb01008]  Nonribosomal peptide synthetase (NRPS)   Nonlinear NRPS    Syringomycin synthetase     Psyr_2608 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Condensation AMP-binding PP-binding AMP-binding_C Thioesterase Motif Other DBs NCBI-ProteinID:  AAY37647 UniProt:  Q4ZT75 LinkDB All DBs Position complement(3062695..3091191) Genome browser AA seq 9498 aa AA seqDB search MDALFFFNVFNPPADWQSSSAMPRRPSTGDEPIDFANRCFEMNSLIDNLCTQGQELLPLA SVQQGIWLDQLAYPHLPYYNIGMTLEIKGDIDIALFEKAIQRVIDSHDALRLSFSHERGM GGQRVLSKAPFKLEVTDFPEVDGDTEQAIAHLRESFRHPFESMTGQLWESRLVRCGPQLH YWFNRLHHLVADGIGAVLIAHAVGDTYSGLLEGKETLAEGPSYLSFLEEDRAYMASCRYE RDRLFWEQSYAQLPPVLLQRRADFKAGLTNVPAPSDQVQAMLPRALYNALTQFASECNLS VAHVLVGVISTYFCRTVGVDEIVVGMPVHNRTNARQKATIGMFSSVSPIRVGFDPHETLI DLMNNIGTQLRRTYRHQRFPIAELNRSLRLAQNGRHQLFDVSLSFESFDGDVTFGSEDPA RVLMLDNGYEQTPMAIFVRDYHPSEDIHLDFNFNTAYFTFEEAQRVQQRIFAMLEAVLNQ HDTPLAHFPLMSTSEHQQLATFNETALAYPRDVLIHQLIEQQAAQRPDACAVRGDSGPLL TYAELNQQANQLAHRLIELGVEPDTRVAVSLRRGAEMVVALLGILKAGGAYVPIDPDLPS ARQAYMLEDSSPQAVLTTRDLSDNLPASDHPVLVLDGHDDRAQLASQPTGNPDAKALGLQ PNHLAYVLYTSGSTGTPKGVMNEHLGVVNRLLWARDAYQVNSQDRVLQKTPFGFDVSVWE FFLPLLTGAELVMARPGGHQDPDYLAQVMSDAGITLLHFVPSMLDVFLEHRSTRDFPQLR RVLCSGEALPRALQRRFEQHLKGVELHNLYGPTEAAIDVTAWECRPTDPGESVPIGRPIA NIQMHVLDTLGQLQPLGVAGELHIGGIGVARGYLNQPDLSAERFIADPFSSDPQARLYKT GDVGRWLANGALEYLGRNDFQVKIRGLRIEIGEIEAALAKHPAVHEAVVTAREDIPGDKR LVAYYTQSAEHTAVDLEILRSHLQQQLPEYMVPAIYVLLEAMPLTSNGKLDRKALPAPDG DALISRGYEAPQGEVETLLASIWADVLKVEQVGRHDHFFELGGHSLLAVKLIERMRQVGL SADVHVLFGQPTVAALAAAAGGGSEVVVPTNLIPEHCDRITPQMLALINLSQAQIDHVVK DMPGGVANVQDIYPLAPLQAGILYHHISAEQGDPYTLKALFALSDRARLDDFSGALQGVI NRHDILRTAVLWEDLDEPVQVVLRQAELHVTELFLDPADGPVDEQLHQRFDRRHYRLDVR TAPLMRIVFSHDPVNDRWLAMLLCHHLVSDATSLSVILQEIQAHLLGQGNALGEAVPYRN YVAQARLGVSEAQHEAFFRDMLGDIDEPTLPFGLQDVQDRGRNLEEASVTLAAELNLRLR AQARQAGVSVASLMHLAWARVLGNVSACEQVVFGTVLLGRMQAGDGADRALGMFINTLPL RVDIGATTVAEGLKATHERLTALLGHEHAPLVLAQRCSGVAAPTPLFSALLNYRHSVVSD VSAEAASAWGGIESFGTEDHTNYPLTLNVDDLGDAFTLTIQAVQQISATRIGEYMQVALR SLVDALEHTPQAALNSLSILPDDERELLLTGFNDTAHPYPRDVLIHQLIEQQAAQRPDAC AVRGDSGPLLTYAELNQQANQLAHRLIELGVEPDTRVAVSLRRGPEMVVALLGILKAGGA YVPIDPDLPSARQAYMLEDSSPQAVLTTRDLSDNLPASDLPVLVLDGHDDRAQLARQQSV NPDAKALGLQPNHLAYVLYTSGSTGTPKGVMNEHLGVVNRLLWARDAYQVNSQDRVLQKT PFGFDVSVWEFFLPLLTGAELVMARPGGHQDPDYLAQVMSDAGITLLHFVPSMLDVFLEH RSTRDFPQLRRVLCSGEALPRALQRRFEQQLKGVELHNLYGPTEAAIDVTAWECRPTDPG DSVPIGRPIANIQMHVLDALGQLQPLGVAGELHIGGIGVARGYLNQPDLSAERFIADPFS EDRQARLYKTGDVGRWLANGALEYLGRNDFQVKIRGLRIEIGEIEAALAKHPAVHEAVVT AREDIPGDKRLVAYYTQSAEHTAVDLEILRSHLQQQLPEYMVPAIYVLLEAMPLTSNGKL DRKALPAPDGDALISRGYEAPQGEIEEQIAIIWQDLLGVEQVGRHDHFFELGGHSLLAVS LIDRLRKQDLNLNVNTVFTAPSVREMALAISQEKQALFRAPANRIPAHCTQLTPDMLPLV ELSVAQIELIASAVPGGAANIQDIYPLAPLQEGILFHYLLNLERDAYLVRSTIEFDSRAR LDAFLEGLQTVIDRHDVLRSSVHWVGLPQAVQVVHRQAQLPIHTLTLRPDEDALSQLDRL SDPGRLRLDLRQAPLLLAYIARDPDSERWLLALIDHHMISDHVTLELILEEIRLLMRGQS ADLLPPQPYREFVAQTLASPSSAHEAYFTRRLADVDSPTAPFELLEVQGDGNDVEESELA LSSDLCARIRTQARERGMSPAVLFHVAWAQVLARCTGRDDVVFGTAVTGRLQGTLGAERA MGMFMNTLPVRVQLATQSVQELVMATHRDLSELLSHEQASLALAQRCSSVATGVPLFSSL LNYRHQNEDSQLQWPGLRLLDSAERTNYPLCLSVNDYGSDLGLLIHSVQPADPQRLCAMM QCALEQLTDALAHTPQKEVTQLDVLPAAERNLLLETFNQTRQDYPTDLCIQHLFEAQVRT QPDAIAVAFQAQRLSYAELNRQANRLAHHLIGLGIGPDDRVAICVERGVEMMVGLLGVLK AGAAYVPLDPAYPAERLAYMIEDSQPAALLTQRHLQEYLPTLTLPLVLLDDDQRKTFTER DDNPVVEALGVRNLAYVIYTSGSTGNPKGVMIEHRGLVNYSVDAARLFGLSQSDTVLQQN TLNFDLSVEEIFPALLAGATLTPSREIFGSEGTENHGIDPTVLHLTAAHWHTLVAEWHKQ PQVAEQRLQHVRLINVTGDALSAQKLKLWDEVRPAHTRLINTYGPTEATVSCTAAYVSHD AAAGSEGSGNATIGKPMANTRIYLLDAHQQPVPYGVAGEIYIGGDGVARGYLNLEEVNAE RFLADPFSESPDARMYKTGDLARYMADGRIEYLGRNDFQVKVRGFRIELGEIEARLGNCT GVKEAVVIAREDNPGDKRLVAYVVAQPQSQLTAADLRAELAPQLAEYMLPSAFVLLDELP LTPNRKLDRKALPAPDADALISRGYEAPQGETETQIVAIWQDLLGIEQVGRHDHFFELGG HSLLAVSLIERLRKQGLNLNVKTVFTAPTVREMALAISQDKHVLFQVPANRIPAHCTQLT PDMLPLVELSVAQIELITSAVAGGAANIQDIYPLAPLQDGILFHYLLNRERDAYLMRSMI EFDSRARLDAFLEGLQTVIDRHDILRSSVHWIGLPQAVQVVHRQAQLPVHTLTLTPEEDA LSQLDRLSDPGRLRLDLRQAPLLLAYIARDPNSERWLLALIDHHMISDHVTVELILEEIR LLMRGQSADLLPPQPYRDFVAQTLASPSSAHEAYFTRRLADVDSPTAPFELLEVQGDGND VEEAKLALNSDLCIRIRTQARERGMSPAVLFHVAWAQVMARCTGRDDVVFGTVVTGRLQG TAGAERAMGMFMNTLPVRVQLTTQGAQELVMATHRDLSELLSHEQASLALAQRCSSVATG VPLFSSLLNYRHQGEDSRLQWPGMRLLDGTERTNYPLCLSVNDYGSELDLIIHSMQPANP QRLCAMMQCALEQLTDALAHTPQMAVTQLDVLPAAERNLLLETFNQTRQDYPTDLCIQHL FEAQVRTQPDAIAVAVQGQRLSYADLNRQANRLAHHLISLGIVPDDRVAICVERGVEMMI GLLGVLKAGAAYVPLDPAYPAERLAYMITDSQPAALLTQRGLQERLPALSMPLVLLDDEQ YQGLAECDDNPVVPTLGVRNLAYVIYTSGSTGNPKGVMIEHRGLVNYSVDAARLFDLSQS DTVLQQNTLNFDLSVEEIFPALLAGATLAPSREIFGSEGTETHGIQPTVLHLTTAHWHTL VAEWHNQPQAAEQRLQHVRLINVTGDALSAQKLKLWDEVRPAHTRLINTYGPTEATVSCT AAYVSYDAAAGSEGSGNATIGKPMANTRIYLLDAHQQPVPYGVAGEIYIGGDGVARGYLN LEEVNAERFLADPFSESPDARMYKTGDLARYMADGRIEYLGRNDFQVKVRGFRIELGEIE ARLGNCKGVKEAVVIAREDNPGEKRLVAYVVAQPQTQITAAELRAELAPQLAEYMLPSAF VLLDELPLTPNRKLDRKALPAPADDAFASREHVEPQGATEIALAQIWQNLLDLERVGRHD QFFELGGHSLLAMRLISQVRHQLGVELGLAALFAHPELSALAVAIAQAGRSKLPDIVPVA RDQAWPLSFGQQRLWFLAQMEGASAAYHIPAGLSLHGNLNLKALQRALERIVARHEGLRT TFMQGDDGQPVQRISPADTGFNLQMHDLQGLADAEEKLQALASEESLQSFDLQQGPLIRG RLIRMAEDHHVLLLTLHHIVSDGWSVDVLTRELSALYAAFSQDQDDPLAPLELQYLDYAV WQRRWLSGDVLQQQSNFWQQTLADAPALLMLPTDRARPALQDYAGAALPVVFDKDLTRGL KALSQRRGSTLFMTVMAAWAGLLGRLAGQDDVVIGTPVANRTRSEVEGLVGLFVNTLAIR VDLSDKPTAETLLARVKQQTLDAQAHQDLPFEQVVEVINPLRSLSHSPIFQAMLSWENNE ASDLTLGDMTLKSIELAADTAQFDLTLDMAEVDEQLVGTLEYATALFDESTMRRYLGYFQ RVLEAMVADDQQVLEHVALLGADEREHLLAGLNATEAPFPQDRTIHQLFEERVQAQPDAI AVAFGAQRLSYAELNRQANRVAHHLISLGIKPDDRVAICVERGVEMLIGVLGVLKAGAAY VPLDPAYPAERLAYMIEDSTPSALLAQRDVQAHLPTLDLPLVLLDEDQRTTLSERGDNPV VETLGAHNLAYVIYTSGSTGVPKGVMVEHRGLFAVSAAWEQLYALHAPLNHLQMAGFSFD VFSADLIRSLAFGGTLVLCPRETLMDPPALYRLLSEESIGFADFVPAVLNALLGWVEETG HDLSFMRTVVCGSDIWTAHSARQLRKLCGDHVQIVQAYGVTEASIDSTCFEFEATSQVDG VLPIGRALANTRIYLLDELGQAVPPGVAGELYIGGAGIARGYLNLQQLTAERFMDNPFVA GERLYRSGDMARYRADGNIEFLGRNDSQAKLRGLRLELGEIEARLAEVAGVRESLVVIRE DSGGTPKLIAYFVEYATRDESGPALTPRALRQQLQLNLPEYMIPAAFVRMAALPLSANGK LDRRALPEPDADAFDQHDFEAADGPLETAIAAIWADVLGVAQVGRHDDFFALGGHSLLVM RVLAQVRQQLNLEVSPSVFFAAPVLRQFAERLGNTQDNARVAIKPVQRSGALPLSFAQQR LWFLAQLEGGSAAYHIPAGLRLRGNLDQASLQRALDRIVARHEALRTTFVQEQGQPAEQR ISAAETGFRLQLQVLAGQTDAEDKLLAIAAQEASEHFDLVNGPLVRGRLVRMADDDHVLL VTMHHIVSDGWSTGVLNRELGALYDAFRQGADDPLPALPVQYVDYALWQRDWLSGDVLQQ QRQYWQQALAGAPALLTLPTDRPRPAQQDYSGQTLELVLDTQLTRGLKTLSQRHGSSLFM TVMGAWAALLGRLSGQDDVVIGTPVANRMSAEVENLIGFFVNTLAIRVDLSGTPSVEALV RQVKQRTLAAQANQDLPFEQVVEVVQPQRSLSHSPIFQAMLSWQNNEDTALVLGDLTLQG VAVAGDTAKFDLALDIGEVDGQLIGTLEYATALFDESTMRRYRGYFLRLLEAMAADDQQV LEQVPLLDTAEREYLLKDINATERTYPVGQLMHRLFEAHAEAAPQAIAVRQGEQTLTYAE LDSRANALAQHLRKHGVGPGTRVAILLDRSVELLASMLATLKCGAAYLALDRLAPEERLR FMLEDSEAIMLLSRSDLTAPDMTPRLDLDTLELSALNQEPVVPATEVAGETPACIIYTSG STGVPKGVIVTHNGIVRLVQDNGYYDFSAEDRVAFSSNPAFDASTPEIWGALLNGGQSVI IEPQVLLEPVAFAALLKRHGVTAMISSTALFNLYAGLIPEALAGLRMIMCGGERADPASF RRVREHSAQVRLFNGYGPTEGTTCATSYEIFDVLPDTLSLPIGKPNANVRVYVLDARREP VPMGVVGEIYIGGTGVALGYLNRPELTAERFSEDPFSQQAGARLYRTGDLARWLPDGNLE YLARNDGQVKVRGFRVELGEIESVLHLCDGVRNSVVVAHEASPGDTRLVAYYTVHAGVDA PDPEDLRAQLSADLAEYMVPSVFVRLDALPLTLNGKVDQKALPVPDLNAMFERTYVAPEG ATEQALAEIFQELLGLERVGRHDGFFELGGHSLLAAQLVSRVRQQLNGDMALRQLFNHPT VAELAKVVDGLQTVDSDSIEPIERNAPLALSFSQQRLWFLDRLDPGASSAYHMPMSLLLR GELDHRALKAALDRLVARHESLRTTFELHGEQPVQVIAAADSGFALAEDDLRSQPYEQAS LNASRIADSEAAAPFDLRQGPLIRGRLLRLADDEHMLLITQHHIISDGWSVGVLINEFTA LYQAFTEQRSDPLPALSIQYADYAAWQRRTFTGERLAEQADFWREHLGGAPTLLSLPTDR PRPAVQSYRGGAVPVTIDAALHQRLERFCQAHNVTLFMGLLSAWSVLMARLGNERDVVIG VPSANRGRTETENLIGFFVNTLALRVDLTQNPSVAQLLEQVRQTTLAANEHQDIPFEQVI EALQPPRSMSHSPLCQVALSLDNTSIGGELKLPGLSLHPVLQAHETAQFDLMLTLASENG ALNGVIEYASDLFDRSTVERFAQHFHTLLEAMVEDVAQPVLGLPLLSPAQRLASPALLQP KAVFASGLMVHQRFEQFAAAHPQNIALVFGRHEVSYQALNRRANRLAHELLAQGVRPDDR VAILAERGTQMICAVLAVLKSGAAYVPLDPTYPTERLGYLLTDSAPVALLAQSACLDVLP AHSVPVLTLGADNDSADLADESLDRNPEPAALGLSREHLAYVIYTSGSTGLPKGVLVEHG NVARLFDATAGQFNFGHEDVWTLFHSFAFDFSVWEIWGALCYGGKLVIVPSEVARSPDDF YALVCEQQVTVLNQTPSAFRQFIQARERSPQEHALREVVFGGEALDFRSLQPWTARTPLS RTRLVNMYGITEITVHATYYPISQSEIDTAMPSLIGPALDDLCLRILDDYQQPVPVGVNG EIYIGGAGVARHYLNRTELNAERFIADPYALQSGARLYRTGDVAHYRSDGGVVYVGRNDS QIKIRGFRIELGEIEAQLLACPDVREAMVIVREDRPGDKRLVAYLIAEDGAAPESALLRS QLASVLAEHMLPSAFVTLETWPLTTNGKLDRAALPAPDQFATVSRDYEAPLGAIETTLAA AWQELLGVERVGRQDHFFELGGHSFLVISLIERLRQIGLLLDVSTVFSAPTLQAMAAVLA GGTAAERVAPANLIPVDCTALTPDMLPLVKLTRQELEHIVADVPGGVANVQDIYPLSSLQ EGILFHHLLQSEGDAYLMRTLATFDSRALLDKFLGALQVVINRHDIMRSSLRWQGLPQPV QVVHRQAQLPVIQLDTAPGEDALQMLRERTNTYHMRLDLQQAPLIAAYITYDTRQEKWLM ALLDHHLISDNVTLRLIMGEIQAVMDGRADALPPSQPYRNFIARAACVSQAEHEAYFRQL LGDVDTTTAPYGVLDVRGGDATILRSVQDLSDDLSARIHSTARAQGVPTSVLFHAAWGLV VAATSGCDDGIFGTVLSGRSQGTSGANHALGMFINTLPMRIRLQQNSVRDIVQDAYQQLS GLLTHEQAPLALAQRCSAVDASLPMFTVILNCRHGDLVNTAGENIEDMGEEQEGVHFLGS ETRTNYPIEIAVANEANGFSLTAQSIDGIDPHRIAAYLGQAVAELVNALEQDPARLASSL EVIPQAERQLLLNDFNDTASDFAPAVPIHALFEDQVRRNPDAVALVYEDRQLSYRQLNRR ANHVARQLLQLGVQPDERVAICAERSLDMIVGLLGVLKSGAAYVPIDPAHPADRMAFMLQ DSQPRALLTQGALSLPVGDTPLMLLDSAESLLAADDQAFDANPVVDGLTAENLAYVIYTS GSTGQSKGVMVEHRSVFNFWNVLTRTTHQHCPTPATVALNAGFFFDMSIKGISQLFSGHK LVIIPQLLRANGSELLDFLEAHQVHAFDSTPSQLDTLLSAGLLERSSYQPVSVLLGGEAI NASTWEKLRNCPTIRFYNMYGPTECTVDATIDLIRDLGEKPSIGRPIANVQVHVLDARGE PAPLGVAGEIHIGGSGVARGYLNRDELSAERFIVDPFSDVANARLYKTGDLGRWLADGTL EYMGRNDFQVKVRGFRIELGEIENVLLAVPGIREAIVIARNDSQGDSDSQRLVAYVCGES VAAEHLRSELLRHLPEYMVPSAFVQLDALPLTANGKLDRRALPAPGQDALASKAYEAPQG ETEEAIAEIWKALLHLDQVGRNDGFLELGGHSLLAVQLLSRLRRKLGTRITLRELFDAPT VLGLASLVNAAAPGEAQSIPRANRSGRLPLSFSQQRLWFLDHLDHAAGAAYHLPMALRLT GSLDTAALEATLDRLVARHETLRTRFELVDGEPVQKIAPADSRFPLLKQDLRDLSGDERT STLARLDQENATQLFDLTKGPMLRGHLLRVADAEHVLLITLHHIVSDGWSNSVLAQEVSA LYAAFSQGQKDPLPALPLQYVDYAAWQRQSLDGPALQAQIDFWRKHLEGAPSVLNLPLDR PRPAIQSYTGGMVEHVFSPALSADLRAFSQAQGSTPFMVLLAGWSMLMSHLSGQTDVVVG TPVANRQHPELEPMIGFFANTLALRVATDRETRLNDMLDRIKSLTLAAYNHQDLPFEQVV SALQPTRNMSHSPLFQVMLSLDNTPPSLLQLPDLEVELLDSEHHTTQFDLSLSLVDSSES LSGGLQYSSDLFDKTTAQAIMQLFARVLENMVSDARQSIGQVLDNTPALPRSAHTATIAA TVEDEQPEALPYEAPEGETEIALANLWKELLKLEKVSRHDDFFKLGGISLMAVQMASRLR KVLGKPIAVRDLFIEPTIAGFARTLDGQARPGQHSNLVPVRRTGSQRPLFLVHPLGGEVQ YVRDLAAAIDPQVPLYGLAASGLAAGETPLFEVPAMAARYLAAIRQVQPKGPYRIGGWSA GGLIAYEMARQLQSSGEKLEFLGIIDTSARLEQQAPEALSEGQFLMDWLPEQLDPEVFRQ LTELAGTDAIDEMLALCMAHRLLPEELPQDVDATLLRSHLAVAHATHIAIGNYVSPPAPL TVTLFTASAEERDDPLLGWTALLDSPVNVTELPGTHETLVRAPQVSALGQAISRALNKEP NQEPRREEVLRSITAPAE NT seq 28497 nt NT seq  +upstreamnt  +downstreamnt gtggatgctctattttttttcaatgtttttaatcctcccgccgactggcagtcgtccagc gccatgccgcgccgtccatcgaccggagacgagccaattgatttcgcaaacaggtgcttt gagatgaattcgttgatcgacaatctgtgcacgcaaggacaagagctccttccgctggct tcggttcagcaaggtatctggcttgatcagctcgcctatccgcacctgccttattacaac atcggcatgactctggagatcaagggcgacatcgatattgcactgttcgaaaaagccatc cagagggtcatcgacagccatgacgcgctgcgtctgagtttcagccacgaaagggggatg ggcggccagcgggttctgtccaaggcgccgttcaagcttgaggtgaccgattttcctgag gtcgacggcgacaccgagcaggccattgcgcatctgcgcgagtcgttccgccatcccttt gagtcaatgaccggacaactctgggaatcgcgtctggttcgttgcgggccgcaacttcat tactggttcaatcgcttgcaccacctggttgccgacggcatcggtgcagtgctgatcgcg cacgccgtaggcgatacctactcaggcttgctggaaggcaaggaaacgcttgccgagggg ccttcatacctctcgttccttgaagaagacagggcctacatggcgtcttgtcgctacgag cgtgatcgactgttctgggagcagtcctacgcacaactgccgccggttctgctgcaacgc agggcagatttcaaggcaggccttaccaacgtccctgcccccagtgaccaggttcaagcc atgttgcctcgcgcgctttacaacgcgctgacgcagtttgccagcgaatgcaacctgtcc gttgctcatgtactggtcggagtgatcagcacctatttctgccgcaccgtgggcgtcgat gagatcgttgtcggtatgccggtgcataaccgtaccaatgctcgtcagaaagccaccatc ggtatgttttcctcggtcagcccgattcgcgtgggcttcgatccgcatgaaacgctgatc gatctgatgaataacatcggcacgcaactacgtcgcacttatcgccaccagcgtttcccg attgccgaactcaaccgtagcctgcggctggcgcaaaacggacgccaccagttgttcgat gtttcactgtcattcgaaagcttcgatggtgacgtcacgttcggcagcgaggacccggcg cgggtgctgatgctggacaacggttacgagcagacgcccatggcgatcttcgtacgcgac taccatccttctgaagacatccacctggatttcaacttcaacaccgcttacttcaccttc gaggaagctcagcgcgtacaacagcgcattttcgccatgcttgaagctgtgctgaatcaa cacgacacgcctttggcgcacttcccgttgatgagcacaagcgagcatcagcaactggca actttcaacgaaaccgccctcgcctatccccgcgatgtcctgatccaccaactgatcgaa caacaggccgcccagcgtccggatgcctgcgccgtacgtggcgacagcgggccgttgctc acttacgccgaactcaaccagcaggccaaccagctcgcccatcgcctgatcgaactgggc gtggagccggatacgcgtgtcgcggtcagcctgcgtcgcggcgcggaaatggtcgtggcg ctgttgggtattctcaaggccggtggcgcctatgtaccgatcgaccctgacctgcccagc gctcgccaggcctatatgctcgaggacagctcgccgcaggcagtgctgaccactcgggac ctgagcgacaacctgccggcctcggatcatccggtgctggtgctcgatggccacgatgac cgcgcccagcttgcctcacagccgaccggcaacccggatgccaaggccctgggcctgcag ccgaatcacctggcttacgtgctctacacctccggttctaccggcacgcccaaaggcgtg atgaacgaacacctgggcgtggtcaaccgcttgctctgggcgcgcgacgcctatcaggtg aacagtcaggatcgcgtactgcaaaagaccccgttcggcttcgacgtgtcggtctgggag tttttcctgccactgctgaccggtgccgaactggtcatggcccgtcccggtggccatcag gatccggattacctggcgcaggtgatgagtgacgcgggcattaccctgctgcacttcgtg ccctcgatgctcgatgtgtttctggaacaccgctcaacccgcgacttcccgcaactgcgc cgcgtgctgtgcagtggcgaggccttgccgcgtgcgttgcagcgccgcttcgagcaacac ctgaagggcgttgaactgcacaacctgtatggcccgaccgaagcggccatcgacgttacc gcctgggaatgtcgtccgacggatccgggcgaaagcgtgcccatcggccgtccgattgcc aacattcagatgcacgtgctggataccttgggccagttgcaaccgctgggcgtagcgggc gagctgcacattggcggtatcggcgtggcgcggggttacctgaaccagccggacctgagt gccgagcgtttcatcgccgacccgttttccagcgacccgcaggcacgtctgtacaaaacc ggcgacgtcggtcgctggctggccaatggcgcactggaatacctgggccgtaatgacttt caggtgaagatccgcggcttgcgtatcgaaatcggcgaaatcgaggcggcgctggccaaa cacccggcggtccacgaagcggtggtcactgctcgcgaagacatacccggcgacaaacgt ctggtggcttactacacgcagtctgccgagcacactgctgtcgatcttgaaatcctgcgc agtcacctgcagcaacagttgccggagtacatggttccggccatttatgtgctgctcgag gccatgccactgacatcgaacggcaagctcgatcgcaaggcgctgccagccccggacggt gatgcgctgatcagccgtggttacgaagcgccgcaaggcgaagtggaaaccctgctggca tcgatctgggccgatgtgctcaaggttgaacaggtgggacgccatgaccatttcttcgaa ctgggtggccactcactgctggcggtgaaattgatcgaacgcatgcgccaggttggcctg agtgccgatgtgcatgtgctgttcggccaaccgaccgtggcggcactggcggcagctgcc ggtggaggctcggaagtcgtggtgccgaccaatcttattcccgagcattgcgaccgtatc accccgcagatgttggcgctgatcaacctctctcaggcgcagatcgaccacgtggtgaag gacatgccgggcggcgtggccaacgtgcaggacatctacccgctggcaccgttgcaggct gggattctttaccaccatatcagtgccgaacagggcgacccctacaccctgaaagcactg ttcgcgctatctgaccgggcgcgactggacgatttcagtggcgctttgcaaggcgtgatc aaccgccacgatatcctgcgcaccgcggtgctgtgggaagatctcgatgagccggtgcaa gtcgtgctgcgtcaagctgaactgcacgtcaccgagttgttcctcgaccctgcagacggc ccggttgacgagcaattacaccaacgcttcgaccgtcggcattaccgcctcgatgtgcgt actgcgccattgatgcgcattgtctttagccatgacccggtcaacgaccgctggctggcg atgctgctgtgccaccacctggtcagcgacgccacttccctgtccgtgatactgcaggaa attcaggcgcacctgctcggtcagggcaatgcgttgggtgaggcagtgccatatcgcaac tatgtcgctcaggcacgcctgggtgtcagcgaggcacagcacgaagcgttcttccgcgac atgctcggcgatatcgacgagccgacgctgccgttcggtttgcaggatgtgcaggaccgt ggccgcaacctcgaagaggccagcgtgaccctggcggccgaactgaacctgcgtttgcgg gctcaggctcgacaggcaggcgtcagcgtcgcgagcctgatgcatttggcctgggcacgg gtgctgggcaatgtctcggcctgcgaacaggtggtgttcggcacggtactgctgggccgt atgcaggccggtgatggcgccgaccgtgcgttgggcatgtttatcaacaccttgccgttg cgcgtcgatatcggcgcaacgacagtggccgagggattgaaggcgacccacgagcggctg acggctttgctggggcatgagcatgctccgctggtactcgcccagcgttgcagcggcgtg gccgcaccgacgccgctattcagtgcattgctcaactaccgacacagtgtcgtgagcgat gtttcggcagaagctgccagcgcctggggcgggatcgagtccttcggcaccgaagaccat accaactacccgttgaccctgaatgtcgatgatctgggcgatgcctttacgctcaccatt caggccgtccagcaaatcagtgccacgcgcatcggcgagtacatgcaggttgcactgcgc agcctggtggacgcactggaacacacgccgcaggcagcgctgaacagcctgtcgatactg ccggacgatgagcgcgagctgttgctgacgggcttcaacgacacagcccacccttatccg cgtgatgtactgatccaccaactgatcgaacaacaggccgcccagcgtccggatgcctgc gccgtacgtggcgacagcgggccgttgctcacttacgccgaactcaaccagcaggcgaac cagctcgcccatcgcctgatcgagctgggcgtggagcctgatacgcgggtcgcggtcagc ctgcgtcgcggcccggaaatggtcgtggcgctgttaggtattctcaaggccggtggcgcc tatgtaccgatcgaccctgacctgcccagcgcccgccaggcgtatatgctcgaggacagc tcgccgcaggcagtgctgactactcgggacctgagcgacaacctgccggcctcggatctt ccggtgctggtgctcgatggccacgatgaccgtgcgcaactggccaggcagcagagcgtc aacccggatgccaaggccctgggcctgcagccgaatcacctggcttacgtgctctacacc tccggttccaccggcacgcccaaaggcgtgatgaacgaacacctgggcgtggtcaaccgc ttgctctgggcgcgcgacgcctatcaggtgaacagtcaggatcgcgtgctgcaaaagacc ccgttcgggttcgacgtgtcggtgtgggagtttttcctgccactgctgaccggtgccgaa ctggtcatggcccgtcccggtggccatcaggatccggactatctggcgcaagtaatgagt gacgcgggcattaccctgctgcacttcgtgccctcgatgctcgatgtgtttctggaacat cgctcaacccgcgacttcccgcaactgcgccgcgtgctgtgcagtggcgaggccttgcct cgtgcgttgcagcgccgtttcgagcaacagctcaagggcgttgaactgcacaacctgtat ggcccgaccgaagcggccatcgacgttactgcctgggaatgccgtccgacggatccgggc gacagcgtgcccatcggccgcccgattgcgaacattcagatgcacgtactcgatgccttg ggccagctgcaaccattgggtgtggccggtgagctgcacattggcggtatcggcgtggcg cggggttacctgaatcagccggacctgagtgccgagcgtttcatcgccgacccgttttcc gaagaccggcaggcacgcctgtacaaaaccggcgacgtcggtcgctggctggccaatggc gcactggaatacctgggccgcaatgactttcaggtgaagatccgcggcttgcgtatcgaa atcggcgaaatcgaggcggcgctggccaaacacccggcggtccacgaagcggtggtcact gctcgcgaagacatacccggcgacaaacgtctggtggcttactacacgcagtctgccgag cacactgctgtcgatcttgaaatcctgcgcagtcacctgcagcaacagttgccggagtac atggttccggccatttatgtgctgctcgaggccatgccactgacatcgaacggcaagctc gatcgcaaggcgctgccagccccggacggtgacgcgctgatcagccgtggctacgaagcc ccacaaggcgaaatcgaggagcagatcgcgattatctggcaagacctgctgggcgtcgag caggtcgggcgtcatgaccacttcttcgaactcggcggccactcactgctggccgtctct ctgatcgaccgtctgcgcaagcaggacctgaatctcaacgtaaacaccgtattcactgcg cccagcgtgcgtgaaatggccttggccatcagccaggaaaaacaagccctgttccgggcg ccggccaaccgcattccggcccattgcacgcagttgacgccagacatgttgccgctggtg gaactgagcgtcgctcagattgaactgatcgcctccgcggttcccggcggagccgccaat atccaggacatctacccgctggcaccgctgcaagaaggcattctgttccattacctgctg aatcttgaacgcgacgcctacctggtgcgctcgacgatcgagttcgacagccgtgcgcgc cttgacgcctttcttgagggcctgcaaacggttatcgaccgccatgatgtcctgcgcagt tcagtgcattgggtcggcctgccgcaagcggtgcaagtggtgcaccgccaggcgcaattg ccgatccatactctcaccctgaggccggatgaagacgcactcagccaactggatcgtcta agtgatccaggtcgtctgcgccttgatctgcgacaggccccgctgctgctggcctacatt gctcgcgacccagactcggaacgctggctactggcgctgattgatcaccacatgatcagc gaccatgtcaccctggaactgatactcgaagaaattcgcctgttgatgcgaggccagagc gcagacctgctgccaccgcagccttatcgggagtttgtcgcacagaccctcgccagccct tcaagtgcccacgaagcttacttcacacgccgcctggctgatgttgattcacccaccgct ccgttcgaactgctggaagttcagggcgacggcaatgacgtcgaagagtccgaactggca ttgagcagtgacctctgcgcacgtatccggactcaggcccgggagcgcggcatgtccccg gcggtgctgttccatgtcgcctgggctcaggtgctggcacgttgtaccggtcgcgatgat gtggtgttcggcaccgcggtcaccggccgtctgcaaggtacgttaggcgccgagcgggcc atgggcatgttcatgaacaccctgccggttcgcgtgcaactggccacgcaaagcgtccag gaactggtcatggccacccaccgtgatctcagcgagttactgagccacgagcaggcatca ttggccctggcccaacgttgcagtagcgtggccacgggtgtgccgttgttctccagcctg ctcaactaccggcaccagaacgaggacagccagttgcaatggccgggcctgcgcctgctc gacagcgccgagcgcaccaactatccgctgtgcttgtcggtcaacgattacggcagtgac ctgggcctgttgatacacagtgtgcaacctgcggatccgcaacgcctgtgcgccatgatg cagtgtgcgttggagcaattgaccgacgcgctggcgcacacaccacagaaggaagttacg cagctggatgtgctgcccgccgccgagcgcaacctgctgctggagaccttcaaccagacc cgccaggactacccgacggacctgtgcattcaacacctgttcgaagcacaggtacgtacg caaccggatgccatcgccgtggctttccaggcgcagcgcctgagctatgccgaactgaac cgccaggccaaccgtctcgctcatcacctgatcggcctgggcatcggcccggatgatcgg gtggcgatctgcgtcgaacgcggcgtggaaatgatggtcggcctgctcggtgtactcaaa gccggtgccgcttatgtgccgctggacccggcttaccctgccgagcgcctggcctacatg atcgaagacagccagccagcggcgttactgacccagcgtcacttgcaggaatatctgccg accctgaccttgccactggtgttgctcgacgatgatcagcgcaaaacctttaccgagcgt gacgataaccctgtggtggaagccctcggcgtgcgcaacctggcgtatgtgatctacacc tcgggctccaccggtaatccgaagggcgtgatgatcgagcatcgcggcctggtcaactac agcgtcgatgctgcacgcctgttcggcctgtcccagagcgacaccgtgctgcaacagaac accctgaacttcgacctgtcggtggaagaaatcttcccggccttgctggcgggtgccacc ctgacgccgagccgcgagatcttcggcagcgaagggactgaaaaccacgggattgatccg actgtcctgcacttgaccgccgcacactggcatacgctggtggccgaatggcacaagcaa ccgcaggtcgctgagcaacgtctgcagcatgtgcgtctgatcaacgtcacaggtgacgca ttgtcggcgcagaagctcaagctctgggacgaggtgcgcccggcgcacactcgtctgatc aacacctatgggccgaccgaagcgacggtgtcctgcactgcggcctacgtcagccacgac gctgcggccggcagcgaaggcagcggcaatgcgaccatcggcaagccgatggccaacacg cgcatttacctgctcgacgctcatcagcagccagtgccgtatggcgtggccggtgaaatc tacattggcggcgacggcgtggcacgcggttacctgaaccttgaagaggtcaacgccgag cgcttcctcgctgatccgttcagcgaaagccctgatgccaggatgtacaaaaccggcgat ctggcgcgctacatggctgacggccggatcgagtacctgggccgtaacgatttccaggtc aaggtgcgcggtttccgcatcgaactgggcgaaatcgaagcccgcctgggcaattgcacc ggggtcaaggaagcggtggtgatcgctcgggaagataacccgggagacaagcgcctggtg gcctatgtggttgcccagccgcaaagccagcttacagccgctgacctgcgcgccgaactg gcaccgcaactggccgagtacatgctgccaagcgcgttcgtgctgcttgatgaactgccg ctgacgccgaaccgcaagctcgaccgcaaggccttgccggctccggatgctgatgcgctg atcagccgtggctatgaagccccacaaggcgaaaccgaaacgcagatcgtggctatctgg caagacctgctgggcattgagcaggtcgggcgtcacgaccattttttcgagctcggtggc cactcactgctggccgtctctctgatcgagcgtctgcgcaagcagggcctgaatctcaac gtaaagactgtattcactgcgcctaccgtgcgtgaaatggccttggctatcagtcaggac aaacacgttctgttccaggtacccgccaaccgcattccagcccattgcacgcaattgacg ccagacatgttgccgctggtggaactgagcgtcgctcagattgaattgatcacctccgcc gttgccggcggagccgccaatatccaggacatctacccgctggcaccgcttcaggacggc atcctgttccattacctgctgaatcgtgagcgcgacgcctacctgatgcgctcgatgatc gagttcgacagccgtgcgcgccttgacgcctttcttgagggcctgcaaacggttatcgac cgccatgacatcctgcgcagctcggtgcattggatcggcctgccgcaagcggtgcaagtg gtgcaccgccaggcgcaattgcctgtccataccctcaccctgacgccggaggaagacgca ctcagtcagctggaccggctaagtgatccaggtcgtctgcgcctggatctgcgacaggcc ccgctgctgctggcctacattgctcgcgacccaaactcggaacgttggctactggcgctg attgatcatcacatgatcagcgaccacgtcaccgtagaactcatactcgaagaaattcgc ctgttgatgcgaggccagagcgcagacctgctgccaccgcagccttaccgggattttgtc gcacagaccctcgccagcccttcaagtgcccacgaagcttacttcacacgccgcctggct gatgttgattcacccaccgctcctttcgaactgctggaagttcagggcgacggcaatgac gtcgaagaggccaaactggcattgaacagtgacctttgcatacgtattcggactcaggcc cgggagcgcggcatgtccccggcggttctgttccatgtcgcctgggcccaggtgatggcc cgttgtaccggtcgcgatgacgtggtgttcggcaccgtggtcaccggccgcctgcaaggt acggccggcgccgagcgggccatgggcatgttcatgaacaccctgccggtccgcgtgcaa ctgaccacacaaggcgcccaggaactggtcatggccacacaccgtgatctcagcgaatta ctgagccacgagcaggcgtcactggccctggcccaacgttgcagtagcgtggccacaggg gtgccgttgttctccagcctgctcaattaccggcaccagggcgaggacagccggttgcaa tggccgggcatgcgcctgctcgacggcaccgagcggaccaactatccgctgtgcttgtcg gtcaacgattacggcagtgagctcgacctgataatacacagcatgcagcccgcaaatccg caacgcctgtgcgccatgatgcagtgcgcgctggagcaactgaccgacgcgctggcgcac acaccgcagatggccgttacgcagctggatgtgctgcctgccgccgagcgcaacctgctg ctggagaccttcaaccagacgcgccaggactacccgacggacctgtgcattcagcacctg ttcgaagcacaggtccgcacacaacctgatgccatcgccgtggctgtccaggggcagcgc ctgagctatgccgacttgaaccgtcaggccaaccgtctcgctcatcacctgatcagcctg ggcattgttccggatgatcgggtggcgatctgtgtcgagcgtggcgtggaaatgatgatc ggcctgctcggtgtgctcaaggcaggggcggcttatgtaccacttgacccggcctatccg gccgagcgcctggcatacatgatcaccgacagccagccagcggcgttgctcactcagcgc ggcttgcaggagcgcttgcccgcattgtccatgccgctggtattgctcgatgacgagcaa taccagggcttggccgagtgtgatgacaacccggtcgtaccgaccctcggcgtgcgcaac ctggcgtatgtgatctacacctcgggctccaccggtaatccgaagggcgtgatgatcgag catcgcggcctggtcaactacagcgtcgatgcggcgcggctgttcgacctgtctcagagc gacacggtgctgcagcagaacaccctgaacttcgacctgtcggtggaagagatcttcccg gcactcctggccggcgcgaccctggcaccaagccgcgagatcttcggcagcgaagggact gaaacccatggcattcaacccaccgtcctgcacctgaccactgcgcactggcatacgctg gttgccgaatggcacaaccagccgcaggctgctgagcaacgtctgcagcatgtgcgtctg atcaacgtcacaggtgacgcattgtcggcgcagaagctcaagctctgggacgaggtgcgc ccggcgcacactcgtctgatcaacacctatgggccgaccgaagcgacggtgtcctgcact gcggcctacgtcagctacgacgctgcggccggcagcgaaggcagcggcaatgcgaccatc ggcaagccgatggccaacacgcgcatttacctgctcgacgctcatcagcagccagtgccg tatggcgtggccggtgaaatctacattggcggcgacggcgtggcacgcggttacctgaac cttgaagaggtcaacgccgagcgcttcctcgctgatccgttcagcgaaagccctgatgcc aggatgtacaaaaccggtgacctggcacgctacatggctgacggccggatcgagtacctg ggccgtaacgatttccaagtcaaggtgcgcggtttccgcatcgaactgggcgaaatcgaa gcccgtctcggcaattgcaaaggggtcaaggaagcggtggtgatcgctcgggaggacaat cccggtgaaaaacgtctcgtggcctatgtggttgcccagccgcaaacccagatcacagcc gctgaactgcgcgccgaactggcaccgcaactggccgagtacatgctgccgagcgcgttc gtgctgcttgatgaactgccgttgacgccgaaccgcaagctcgaccgcaaggccttgccg gctccggctgacgatgcctttgccagccgcgagcacgtggagcctcaaggggctaccgag attgcgctggcgcagatctggcaaaacctgctcgatctggaacgggtgggccgtcatgat cagttctttgaactgggcggccactccttgctggcgatgcgcctgatttcccaggtgcgt catcaattgggcgtcgaacttggtctggctgcactgttcgcccatcccgaactgagtgcc ctggccgtagccatcgctcaggccggacgcagcaaattgccggacatcgtaccggtggca cgcgatcaggcgtggccattgtcattcggccagcaacgtctgtggtttctcgcccagatg gaaggcgccagcgcggcctaccacatacctgccggcctgagcctgcatggcaacctgaat ctcaaggcattgcaacgggcgttggagcgtatcgtggcgcgccacgaaggtttacgcacc acgttcatgcagggcgatgacggacagccggtgcaacgcatcagcccggcggacaccggt ttcaacctgcaaatgcacgatctgcaagggttggcggatgccgaggaaaaacttcaggca ctggccagcgaagagtcgctgcaaagcttcgatctgcaacagggcccgttgattcgtggc cgcctgattcgtatggccgaggaccatcacgtattgttgctgaccctgcaccatatcgtt tccgatggctggtcggttgatgtgctgacccgcgaattgtccgcgctctatgccgcattc agtcaggaccaggacgacccgctggcgccgctggagctgcaatacctggactacgccgtg tggcaacgtcgctggctgagtggcgatgtgctgcaacagcaaagcaatttctggcagcaa accctggcagatgctccggcgttgttgatgttgcccaccgaccgtgcgcgtccggcgctg caggactatgccggtgcagcactgcccgtcgtgttcgacaaagaccttacccgaggtctc aaggcattgagccaacgccgcggcagcaccctgttcatgacggtcatggccgcgtgggcc ggcctgctgggacgcctggctggccaggatgatgtggtcatcggtacgccagtagccaac cgtactcgcagcgaagtcgaagggctggtgggcctgttcgtcaacactctggccatccgc gtcgacctcagtgacaagcccacggcagagacgctgctggcgcgggtcaagcagcagact ctcgatgcccaggcgcatcaggacttgccgttcgaacaagtcgtggaagtcatcaatccg ctacgcagcctgtcccacagcccgattttccaggccatgttgtcgtgggaaaacaacgag gcgtctgatctgacgctcggcgacatgactctgaaaagcatcgaattggccgctgatact gcccaattcgacctgacgctggacatggccgaggtggatgagcaactggtcggcacgctg gagtacgccacagcgttgttcgacgagagcaccatgcggcgctatctgggctacttccag cgtgtgctggaggccatggtcgccgacgaccagcaggtgctggagcacgtagccttgctg ggtgccgacgaacgtgaacatttgctggcaggcctcaacgcaacagaggcgcccttccct caggatcgcacgattcatcagttgttcgaagaaagggttcaggcgcagcccgacgccatc gccgtggccttcggggcgcagcgcttgagctatgccgaattgaaccgtcaggccaaccgt gtggctcaccatctgatcagcctgggaatcaaaccggatgatcgggtggcgatctgcgtc gagcgtggcgtggaaatgctgatcggcgtgctcggtgtgctcaaggccggtgctgcttat gtgccactggatccggcttaccccgccgagcgcctggcctacatgattgaagacagtacg ccgtcggcactgttggcccagcgtgatgtgcaggcgcatctgccgacgctggacttgccg ctggtgctgctcgatgaggatcagcgcaccaccctctccgagcgtggcgacaacccggtg gtggaaacactcggtgcgcacaatctggcgtacgtgatctacacctcgggctccaccggc gtgccgaaaggcgtaatggtcgagcatcgcggattgttcgccgtcagcgcggcgtgggag caactgtacgcactgcacgcgccactcaatcacttgcagatggccgggttttccttcgat gtgttcagcgccgacctgatccgctctctggctttcggcggcacactggtactgtgccca cgcgagacattgatggacccgcctgcgctttaccgcctgttgagcgaggagtcgatcgga tttgcggatttcgtgccagccgtactcaacgcattgctgggctgggtggaagagacgggg cacgacctgtcgttcatgcgcacagtggtctgtggttcggatatctggaccgcgcacagc gcccggcaactgcgcaagctttgtggcgatcacgtgcagatcgtccaggcctacggtgtc actgaagccagtatcgacagcacctgcttcgagttcgaggcaaccagccaggtcgacggg gtcttgccgattggtcgggcattggccaatacgcggatttatctgctcgatgagcttggc caagcggttccgccgggtgtcgcgggcgagctgtatatcggcggcgcgggtattgctcgc ggctatctgaatttgcagcaactgactgccgaacgcttcatggacaaccccttcgtggcg ggcgaacggctgtaccgcagcggcgacatggcgcgctaccgggctgatggcaatatcgaa ttcctcggccgcaacgactcccaggccaagctgcgcgggctgcgtctggagctgggcgaa atcgaagcacgcctggccgaggttgcaggtgtgcgcgaaagcctggtcgtgattcgcgag gacagcggcggcacgccgaaactgatcgcgtattttgtggaatatgccactcgcgacgag tctggccctgccctgaccccgcgcgcgctgcgccagcaactgcaactcaacctgccggaa tacatgatcccggcagcgttcgtgcgcatggccgcattgccgctgagcgccaacggcaaa ctggatcgaagagcgttgcccgagccggatgccgacgccttcgatcagcatgatttcgaa gcagccgatggcccgctggagacggcaatcgccgcaatctgggccgatgtgctgggcgtc gcacaagtcggccgtcatgatgactttttcgcgctcggcggtcattcattgctggtcatg cgcgtactggctcaggttcgtcagcaattgaatctggaggtttcaccgtcagtgtttttc gcggcaccggtgctgcggcagttcgccgagcggctgggcaacacgcaggacaacgctcgc gtggcgatcaagcctgtgcaacgttcgggtgcgctaccgctgtcgtttgcccaacagcgc ctatggttcctcgcgcaactggaaggtggcagcgccgcttaccatattccggcgggactg cgtctgcgtggcaaccttgatcaggcttcgctgcaacgcgcactggaccgtatcgtggcc cgccatgaggcgctgcgcacgacctttgtccaagagcagggacagcctgcggagcagcgt atctctgccgcagaaacaggtttcagactgcaactgcaggtactggccgggcagaccgat gccgaagacaagctgctcgccatcgcggcacaagaggccagcgagcacttcgacctcgtc aatggaccactggtgcgcgggcgtctggtgcgcatggccgatgacgaccacgtgttgctg gtgaccatgcaccacatcgtctccgatggctggtcaaccggggtgttgaatcgcgagctg ggtgccctttacgacgccttccgccagggtgcggatgatccactgccggccttgccagtg caatacgtcgactacgcactgtggcagcgtgactggttgagtggcgacgtgctgcaacaa cagcgtcagtactggcagcaggccctggctggtgcgccggccttgctgaccctgccgacc gaccgaccacgtccggcgcaacaggactacagcgggcagacgctggaactggtgctcgat acacaattgacccgtggcctcaagaccttgagccaacgccacggcagcagtctgttcatg accgtcatgggcgcctgggccgcgctgttgggacggctgtccggtcaggatgacgtggtg atcggtacaccggtggccaaccgtatgagcgccgaggtggagaacctgattggcttcttc gtcaacaccctcgctatacgggtcgacctctcaggcacgccgagcgtcgaagcgctggta cgacaagtcaaacagcgaactctggctgcccaggcaaatcaggacctgccgttcgaacaa gtggttgaagtggttcaaccgcaacgcagcctgtcccacagcccgatttttcaggccatg ctgtcatggcaaaacaacgaggacaccgcgctggtgctcggcgacctgaccctgcaaggc gtcgcagtggccggtgatacggcaaagttcgacttggcgctggacatcggcgaggtggac gggcaactgatcggcacgctggagtacgccacggcactgttcgacgaaagcaccatgcgt cggtatcgaggctacttcctgcgcttgttggaggctatggcggccgatgatcagcaagtg ctggaacaggtaccgttgctcgacactgccgagcgcgagtacctgctgaaggatatcaat gccacagagcgcacctaccctgtcggtcagttgatgcatcgcttgttcgaggcccatgcc gaagctgcaccgcaggcaattgccgtccgccagggtgagcagacactgacctacgctgaa ctcgacagccgcgccaatgccctggctcagcacctgcgcaaacacggtgtgggaccggga acccgggtggcgattctgctggatcgttcggtggaattgctggccagcatgctggccacc ctcaaatgcggcgcggcttatctggcgctggatcgtctggcccctgaagagcgcctgcgc ttcatgctcgaggacagcgaagccatcatgctgctgagccgtagcgacctgacggcacct gacatgacgccaaggctggatctggacacactggagctgtcagcgctgaaccaagagcca gtcgtgcctgcaactgaagtcgcaggcgagacccccgcgtgcatcatctacacctctggc tccaccggtgtgcccaagggcgtgatcgtgacccacaacggcattgtgcggctggttcag gacaacggctactacgacttctccgccgaggaccgtgtggcgttttcgtccaacccggcg ttcgacgccagcactccggaaatctggggtgcattgctcaatggcggccagtcggtgatt atcgagccgcaggtgctgcttgagccggtggccttcgccgccctgctcaagcgccatggt gtaacagccatgatcagctcgaccgccctgttcaacctgtatgccgggttgattcccgag gccctggcaggcctgcgtatgatcatgtgtggcggcgagcgcgctgatccggcctcgttc cgtcgggtccgggagcactccgctcaggtacgcctgttcaacggctatggcccgaccgag ggcaccacctgtgccaccagctacgaaatcttcgatgtactgcctgacaccctcagcctg ccgattggcaagcccaacgccaacgtgcgggtctatgtgcttgacgcccgccgcgagccg gtgccgatgggcgtggtcggcgagatctatatcggtggcacaggcgtcgcactcggctac ctgaaccgcccggagctgaccgctgaacgtttcagcgaagacccgttcagccagcaggcc ggcgcgcgactctatcgcaccggcgacctggcgcgctggttgccggacggtaaccttgaa tacctggcgcgtaacgatgggcaggtcaaggtccgcggcttccgcgtcgagcttggcgaa atcgaaagcgtcctgcatttgtgcgacggcgttcgcaactccgtggtggtggcgcatgaa gccagcccgggtgacacccgtctggtggcttactacaccgtgcatgcgggcgttgatgca cctgatccggaggatctgcgtgcgcaattgagtgccgatctggcggagtacatggttccg agtgtgttcgtacgcctggatgccttgccgctgacgctcaatggcaaggttgatcagaag gcgttaccggtccccgacctgaatgcgatgttcgagcgaacctacgttgcgccggaaggt gccaccgaacaggccctggcggaaatattccaggaactgctgggccttgaacgcgtgggt cgtcatgacggcttcttcgagcttggcggtcattcgctgctggctgcgcaactggtttcc cgtgtgcgtcagcaactgaacggtgacatggcgctgcgccagctgttcaatcacccgacc gtggccgagctggcgaaggtggtcgacggcctgcaaacggtcgattccgacagcatcgaa cccatcgagcgtaacgcgccgctggcactgtccttttcccagcagcgtctatggttcctc gacaggctcgaccctggtgccagcagtgcttaccacatgccgatgtcgctgctgctgcgc ggcgagctggatcaccgcgcgctcaaggctgcgctcgaccgtctggttgcacgtcatgaa agcctgcgcaccaccttcgagctgcacggtgaacagccggtgcaggtcatcgctgcggcg gacagcggtttcgccctggcagaagacgacttgcgctcgcagccttatgaacaggccagc ctcaacgcttcacgcatcgccgacagcgaggccgctgcgccgtttgacctgcgccagggc ccgctgattcgcgggcgtctgctgcgcctggcggatgatgagcacatgttgctgatcacc cagcaccacatcatctccgacggctggtcggtgggggtgctgatcaacgagttcaccgcc ctctaccaggccttcactgagcagcggtcggacccgctgccggccctgtcaatccaatac gccgactacgccgcctggcaacgccgcacctttacaggcgagcgccttgccgagcaggcc gatttctggcgtgagcacctgggtggcgcgccgacgctgctgtcgctgcccaccgaccgg ccacgtccggcggtgcaaagctaccgcggcggcgctgtacccgtgacgatcgacgcagcg cttcatcagcgtctggagcgcttctgccaggcccataacgtcaccttgttcatgggcctg ctcagtgcctggtcggtgcttatggcccgtctgggcaacgaacgcgatgtggtgataggt gtgccgagcgccaaccgtggccgcaccgaaaccgagaacctgatcggtttcttcgtcaac accctggccctgcgcgttgatctgacgcagaacccgagcgtggcgcaactgctggaacag gtccgccagaccacgctggcggccaatgagcatcaggacattccattcgagcaagtgatc gaagccttgcagccgccacgctcgatgagtcatagcccgctgtgtcaggtcgccctgtcg ctggataacaccagcatcggcggcgagttgaagctgccgggccttagcctgcaccccgtg ctacaagcccatgaaaccgcgcagttcgacctgatgctgaccctggctagcgaaaacggc gccctgaacggggtcatcgaatacgccagcgatctcttcgatcgctccaccgtcgagcgt tttgcccagcatttccatacgctgctggaagcgatggtcgaggatgtcgcgcaacctgtg ctcggcctgccgttgctcagcccggcgcagcgcctggcctcgccagcgctactgcagccc aaggcggtattcgcctcggggctgatggtgcatcagcgctttgaacagttcgccgccgcc catccgcagaacatcgcgctggtctttggccggcatgaggtgagctaccaggcgctcaat cgccgagccaaccgcctggcccatgaactactcgcccaaggcgtgcgccccgatgaccgg gtggcgatcctcgcagagcgtggtacgcagatgatctgcgcagtgctggccgtgctcaag tccggtgcggcctacgtaccgctggacccgacttaccccaccgagcgtctcggctacctg ctgacagacagtgcgccggtggcgttgctggcccagtcggcctgccttgacgtgctgccg gcacacagcgtgccggtactgaccctcggcgcggacaacgacagtgccgatttggcagat gaatcactggaccgcaaccctgagcctgctgcgctgggactgtctcgcgagcatttggcg tatgtcatttacacctcagggtcgacaggcctgcccaaaggtgtgctggtcgagcacggc aacgtggcccgcctgttcgacgccaccgccgggcaattcaacttcgggcatgaggatgtc tggacgctgttccactccttcgccttcgacttctcggtctgggaaatctggggcgcgctg tgctacggcggcaaactggtaatcgtcccgagtgaggtggcgcgttcgccggatgacttc tatgcgctggtctgcgagcagcaggtcaccgttctgaaccagacgccaagcgctttccgc cagttcatccaggcccgcgaacgcagcccgcaggagcatgcgctgcgtgaagtggtgttc ggtggtgaggctttggacttccgcagcctgcagccctggaccgcacgcacaccgctgtcg cgtacccgtctggtgaacatgtacgggatcacggaaatcaccgtgcatgccacctactac ccgatcagccagtcggaaatcgacaccgccatgccaagcctgatcggcccggcactggac gacctgtgcctgcgtatcctcgatgactatcagcagccggtaccggtgggcgtcaatggc gagatttatatcggcggcgccggcgttgcccggcattacctgaaccgcacggaactgaat gccgaacgttttattgccgacccctatgcgttgcaaagcggcgcacggctctaccgcacc ggcgacgttgcgcactaccgcagcgacggcggcgtggtctacgtcggccgtaatgactcg caaatcaagattcgcggctttcgtatcgaattgggcgaaatcgaggcgcaattgctcgcc tgccccgacgttcgtgaagcgatggtcatcgtgcgtgaggatcgccccggcgacaaacgc ctggtcgcctacctgattgccgaggacggcgctgctcccgagtcagcgctgctgcgcagc caactggccagcgtgctggccgaacacatgctgcccagtgcctttgtgacccttgaaacc tggccattgaccaccaacggcaagctggaccgtgccgccctgcccgcgccggaccagttc gcgacggtgagtcgtgactacgaagcaccgctaggcgctatcgaaacgaccctggccgct gcctggcaggaattgctcggggttgaacgtgtcggtcgtcaggatcacttcttcgaactg ggtggtcactccttcctcgtcatcagcctgatcgagcgcttgcgtcagatcggcttgttg ctggacgtgagtacggtgttctcggcaccaaccctgcaagccatggccgcggtcctggcg ggcggtactgcggcggaacgggtcgccccggcgaacctgattcccgtcgattgcacggcg ctgaccccggacatgctgccgttggtgaaactgacccggcaggaactggagcatatcgtt gccgatgtgccaggcggcgtcgccaatgttcaggatatctatccactgtcatcgctgcag gaaggcatcctgtttcaccatctgttgcagtcagaaggcgacgcctacctgatgcgcacc ctagcgacgttcgacagccgtgcgttgctcgacaaattcctcggcgcgctgcaagtggtg atcaaccgccacgacatcatgcgcagctccctgcgctggcagggtctgccgcagccggtg caggtggtgcatcgtcaggcacagttgccagtcattcagctcgacaccgcgccgggtgaa gacgccttgcagatgctgcgcgaacgcaccaatacctaccatatgcgcctggacctgcaa caggcaccgctgatagccgcgtatatcacttacgatacccggcaggaaaagtggctgatg gcactgctggaccatcacctgatcagtgacaacgttaccctgcgcctgatcatgggcgag atccaggcagtgatggacggacgcgccgacgccctgccgccatcccagccgtaccgcaac ttcatcgcccgggccgcgtgtgtttcccaggccgaacatgaagcctacttccgtcaactg ctgggcgatgtcgataccaccactgcgccctacggcgtgctcgatgtgcgtggcggcgat gcaacaatcctgcgttcggtgcaggatctgagcgacgatctcagcgcgcggatccacagc accgcacgggcccagggcgtaccaacctcggtgctgttccacgcggcatgggggttggtg gtggccgccaccagcggctgtgacgacgggattttcggtaccgtgctttcgggacgttcc cagggcacctccggcgccaaccatgcgctggggatgttcatcaataccttgccgatgcgt attcgcctgcaacaaaacagcgtgcgcgatatcgttcaggatgcctaccaacagctgagc gggctgctgacccacgagcaggcgcctctggccctggcgcagcgctgcagcgcagtggat gcatcgctgccgatgttcaccgtgatcctcaattgccgtcacggtgatctggtgaacact gccggggaaaacatcgaggacatgggcgaggagcaggaaggtgttcatttcctgggctcc gaaacccgtaccaactacccgatcgaaattgccgtagccaatgaggccaatggcttttcg ctgaccgcgcagtctatagatggcattgatccgcaccggattgccgcctacctcggtcag gcggttgccgagctggtcaacgcccttgagcaggatccggcacgcctggcgagcagtctt gaagtgattccgcaagccgagcggcagctgctgctcaacgacttcaacgacaccgccagc gacttcgcaccggccgtaccgatccatgccttgttcgaagaccaggtccgccgcaatcct gatgccgtagcgctggtctatgaagaccgccaactgagctatcgccagctcaaccgccgc gccaaccacgtggcccggcagttgctgcaactcggtgtgcagccggacgagcgcgtggcc atctgcgccgaacgcagcctggacatgattgtcggcctgctgggcgtgctcaagtccggt gccgcctacgtgccgattgaccctgcccaccctgctgaccgtatggccttcatgctgcag gacagtcagccgcgcgcgctgctgacgcagggcgcgctcagcctgccggtcggcgacacg ccgttgatgctgctggacagcgctgaatcgctgctcgcggcggatgatcaggcgttcgac gccaatcccgtggtcgacggcctgacggcggaaaacctggcctacgtgatctacacctca ggctccaccggccagtcgaaaggtgtcatggtcgagcaccgctcggtgttcaacttctgg aacgtgctgacccgcacgacccatcagcattgcccgacaccggccaccgtggcgctgaat gccggcttcttcttcgacatgtcgatcaaaggcatctcgcaattgttctctggccacaag ctggtgatcatcccgcaactgctgcgtgccaacggcagcgaactgctggacttcctcgaa gcgcatcaggttcatgccttcgactccaccccgtcgcagctcgacaccctgctctcggcc ggtctgctggaacgcagcagctatcagccggtcagcgtgctgctgggtggtgaggcgatc aacgccagcacctgggagaaactgcgtaactgcccgaccatccgcttctacaacatgtat ggcccgaccgagtgcacagtggacgcgaccatcgatctgatccgcgacctgggtgaaaaa ccaagcatcggccggcctattgccaacgtccaggtgcatgttctggatgcgcgtggcgag ccggcaccactgggcgtcgccggggaaattcatatcggcggtagcggtgtggcccgtggc tacctcaaccgtgacgagctgagtgccgagcgtttcatcgttgacccgttctccgatgtc gccaacgcccggctttacaaaaccggcgacctgggtcgctggctggcagacggcacgctg gaatacatgggccgcaacgacttccaggtgaaggttcgcggtttccgtatcgagctgggt gaaatcgaaaacgttctgctggccgtgccgggcattcgcgaggcgatagtgattgcccgc aacgacagccagggtgattcggacagccagcgcctggtcgcttatgtctgtggtgaatcg gtggcagccgaacacttgcgcagcgaattgctcaggcatctgccggagtacatggtgccc agcgctttcgtccagctggacgccctgccgctgaccgccaacggcaaactcgaccgtcgt gcgctgccggcccccggtcaggatgcgttggccagcaaggcttacgaggcgccgcaaggc gaaaccgaagaggccatcgccgagatatggaaagccttgttgcatctggaccaggtaggt cgcaatgacggcttccttgaactgggtggtcattcgttgctcgccgtgcagttgctgtcg cgactgcggcgcaaacttggtacacgaatcaccttgcgtgaactcttcgacgccccgacc gtgcttggcctggcttcactggtcaacgccgcagcgccaggtgaagcacaatcgattccg agggccaatcgctctggccgtctgccgctgtccttttcccagcagcgcttgtggttcctc gatcacctggatcacgccgcgggtgcggcctatcacttgccgatggcgttgcgccttaca gggtcacttgacaccgctgccctggaggcaacgctggatcgcctggttgcccgccacgaa accctgcgcacgcgttttgaactggtggacggtgaaccggtgcagaagatcgccccggcc gatagccgctttccgttgttgaaacaggatctgcgcgacctgtccggtgacgagcgcact tcgaccctggcccgtctggatcaggaaaatgccacgcaactgttcgatctgaccaagggg ccgatgctgcgcgggcatttgctgcgggttgcggatgctgagcatgtgctgttgatcacg ttgcatcacatcgtctccgacggctggtccaacagcgtccttgctcaggaagtgagcgcg ctttacgccgccttcagtcaaggccagaaagacccgctgcccgcgctgccactgcaatac gtggactacgccgcctggcaacggcaatccctcgacggccccgccctgcaggcccagatc gacttctggcgcaagcatctggaaggtgcgccaagtgtgttgaatctgccactggaccgt ccgcgcccggccatccagagctataccggcgggatggtcgagcatgtgttttcgccagca ttgagtgccgacttgcgtgccttcagccaggctcaaggcagcacgccgttcatggttctg ctggcaggatggtcgatgctcatgagccacctgagcgggcagaccgatgtggtggtaggt acgcctgtcgctaaccgccagcatcccgagctggagccaatgatcggcttctttgccaat acgctggcattgcgtgtggcaaccgaccgagagacgcgtttgaacgacatgctcgaccgg atcaagagccttacgctggctgcctacaatcatcaggacttgccgttcgagcaagtggtg agcgccttgcagccaacccgcaacatgagccacagcccgttgttccaggtgatgttgagc ctggataatacgccgccttcgctgttgcaattacctgacctggaagtcgagttgctggac agcgagcatcacaccactcagttcgacctgtcgttgtcactggtggattccagcgaaagc ctgagcggcggcctgcaatactccagcgacctgttcgacaaaaccactgcgcaggccatc atgcagctgtttgcaagggttctggagaacatggtgagcgacgctcggcagtcgattggc caagtgctggacaacacgccagcgctgccgcgttcggcgcataccgcgactatcgctgcg acggtcgaagacgaacagcctgaagccctgccttacgaagcgcccgaaggcgagaccgag atcgccctcgccaacctctggaaagagttgctcaagctggaaaaggtcagtcgccatgac gacttcttcaagctgggcggtatttcgctgatggcggtgcaaatggcctcgcgcctgcgc aaggtgctcggcaaaccgatcgcggtccgcgatctgttcatcgagccgaccattgccggt tttgccagaaccctggacggccaggcacgccccggccagcacagcaacctggtgccggtc cgccgcactggctcgcaaagaccgctgtttctggtgcacccactgggcggcgaagtgcag tacgtgcgcgatctggccgcggcaatcgacccgcaggtgccgctgtatggcttggccgcc agtggtctggcggctggagagacgccgctgtttgaggtgccggccatggctgcgcgttac ctggcggcgattcgccaggtacaaccgaaagggccttaccggatcggcggctggtctgca ggtggtcttatcgcttatgaaatggcccgccagctgcaatccagcggtgaaaaactggag ttcctgggcatcatcgacacctccgcgcgtcttgagcagcaagcgccggaggcattgagc gaaggtcaattcctgatggactggctaccagagcagctcgaccccgaagtattccggcag ctcaccgagctggccggcacggatgccatcgatgaaatgctggcactgtgcatggcacac cgcctgctcccggaggaactgccacaggacgtcgatgccaccttgttacgcagccatctt gctgtggcccatgcaacccatatcgccatcggtaactatgtcagcccgcctgccccactt acggtgacactgtttaccgccagtgcagaggagcgcgacgatccgctgctgggctggacg gccttgctcgattccccggtgaacgttactgagcttcccggcacccacgaaacgctggtc agggcgcctcaggtcagcgcactgggccaggcgatctcccgggcgctgaacaaggagccc aaccaggagccccgcagagaagaggttttacgttcgataaccgcgccagctgagtag

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