Polypterus senegalus (gray bichir): 120516764 Help Entry 120516764         CDS       T08668                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism psex  Polypterus senegalus (gray bichir) Pathway psex04020   Calcium signaling pathway psex04260   Cardiac muscle contraction psex04261   Adrenergic signaling in cardiomyocytes psex04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:psex00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120516764 (ryr2a)    04020 Calcium signaling pathway     120516764 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     120516764 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     120516764 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:psex04040]     120516764 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:psex04990]     120516764 (ryr2a) Ion channels [BR:psex04040]  Voltage-gated cation channels   Ryanodine receptor    120516764 (ryr2a) Domain-containing proteins not elsewhere classified [BR:psex04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    120516764 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  120516764 NCBI-ProteinID:  XP_039594620 LinkDB All DBs Position 16:27065990..27677999 Genome browser AA seq 4997 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGKFMMKTAQGGGHRTLLYGHAVLLRHSYSG MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGNSSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTV PSGEHGEDQRRSVHYEGGAVAIHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS LTEDKGLLLMDKEKADVKSTAFCFRSSKEKLDSGIKKEVDGMGVPEIKYGDSVCYIQHVE TCLWLSYQSVDAKSARMGAIQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFN RFIRGLDTLSKKGKSCCLDLPIESVNLSLQDLIGYFQPPDEHLEHEDKQNRLRALKNRQN LFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQNLICDNLLPGRDLLLQTRLVNHVSSIRPNIFLGISDGS AQYRKWYYELIVDHIESFVMAESTHLRVGWASADGYFPYPGGGEGWGGNGVGDDLYSYGF DGLHLWSGCIARSVNSPNQHLLRDDDVVSCCLDLSAPSISFRINGQPVQGMFENFNAEGF FFPAVSFSAGVKARFLLGGRHGEFKFLPPPGYAPCFEALLPREKMRLEPSREYKQDHGTT RDLLGPTISLNQAAFTPMPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGLV RDDNKRQHPCLVEFSKLPEQECNYNLQMSLETLKTLLALGCHVGIADDHAEEKVIRLNLP SSYELTGGYKPAPMDLSHIKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDIKNK RNPRLVPYALLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARSDTCNVSAERFRI FRAEKTYAVKAGKWYFEFEAVTAGEKRIGWSRPGCLPDKELGSDDQAFVFDGFKAQRWHQ GNEHFGRSWQAGDVVGCMVDLNEHTIIFTLNGEVLLDDSGSELAFKDFEIGEGFIPVCSL GVSEIGRMNFGKNVGTLKYFTICGLQEGYEPFAVNMNRDITMWMSKRLPQFTPVPSRHEH IEVTRIDGTIDSPPCLKVIQRSFGSQNSNTDIVFYRLSMPVECAEGYSRTPGSSLPPSSS YISPKKDLEDFESDSDFEVLMKTAHGHLNSNGPEKEKDSIKDEFNNHKDYTQEKPSRLKQ RFMLKRTKPDYNINHSSARLSEEVLADDRDDYEYLMQTSIYYYSVRIFPGQEPTNVWVGW VTSDFHQHDTSFEMEKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESTSPGQGRNNNGL EIGCLVDTASGLLTFTTNGKEISTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMP LSAALFKSERKNATPQCPPRLHVQFLTPVLWSRVPNDFLKVDVSRVSERHGWQVQCTVPL QFMCLHIPEENRSVDILELTEQEDLLKFHYHTLCLYSAICALGNNRVAHALCSHVDEAQL LHAIENKYMPGLLRTGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDEKKK HGLPGIGLSTSLRPRMQFSSPSFVKINGESFQFSPEFPLETLKTKTIEMLTEAVQEGNLH VRDPVGGSTEFLFVPLIKLFYTLLIMGVFHNGDLKNILRLIEPSVFSEEVVQEYSANPDC DGIKGKLKAEGLGVQGEGISVKVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAV VAFSDDFVASLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKQD CPCPEDIREQLLDFHDDLMTHCGIELDDDRTSDGDTDFTIKGRLLYLVEKVAYLKRKMSD LPKKKKLKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKT YTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRAL GMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENS SVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCPMLVSKGY PDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLA AMGEAIKISEDPARDGPSPTTGSSKTIDAVGEEDDTIHMGNAIMTFYAALIDLLGRCAPE MHLIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFPMPTLAKDGTVVEPDMSAGFCPDHK AAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVL PLLTKCAPLFAGTEPYASLIDSLLHTVYRLSKGCCLTKAQRDSIEECLLAVCGQLRPSMM QHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLF WGIFDALSQKDITFSVKPFIRTYCVKKYEQELFKLALPCLSAVAGALPPDYMESNYVAMM EKQSSMDAEGNFNPQPVDTSNVHIPEKLDYFINKYAEHSHEKWSMEKFANGWIHGEVLCE TSKVHNLLKPYRLLTEKDKEVYRWPIKESLKTMLAWGWSIERIREGDTMSLHNRARRISQ SSQVSVDTSHGYSPRPIDMSNVTLPRELYSMAELLAENYHNIWAKKKKLELETKGGGSHP LLVPYDTLTAKEKSKDREKAQDILKFFQLNGYTVSRGLKELDLDTPSIEKRFAYSFLQQL IRYVDEAHQRMLEVDAGTRTKGEKNPHQQEMKFFGKVVLPLVDQYFKNHRLYFLSTANRP PSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTG LESVKAALRIFFINAAEDLEKTLENLKLGQFAHTRMQPKGVTQIINYTTVALLPVLSSLF EHIGQNLFGEDIILDDVQVSCYRILNSLYGLGTSKSIYVERQRPALGECLAAFAGAFPVS FLEPHLNKYNPYSIYNTKSSRERTVLNLPAQVEDVCISIPFLDKLLEEIMDLAESGVRYT QMPHVMEVILPMLCSYMSHWWEHGPENNPDKMDMCCTALTSDHMNTLLGNILKIIYNNLG IDEGAWMKRLAVFSQPIISKAQPQLLKTHFLPLMEKLKKKAATVLIDEEHLKAEGRGDMS EAELLILDEFTILARDLYAFYPLLIRFVDYNRAKWLKEPNAEAEELFRMVAEVFIFWAKS HNFKREEQNFVVQNEINNMSFLITDTKSKMSKGAVLDQERKKLKRKGDRYSLQTSLIVAA LKRLLPIGLNICAPGDQELIALAKHRFIMKDTEDEVREIIRNNLHLQGKLEDPAIRWQMA LYKDLPNRTEDSSDPQKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVA CFRMAPLYNLPRHRAVNLFIQGYEKSWIETEEHYFEDKLIEDLAKPGEEPVEEDEGVKRI DPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEVKSFEHDIIKDL SNKFVNNVENSLEKEMEKQKLLYQQARLHDRGAAEMVLQMISASKGEMGPMVAATLKLGI AILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEE GSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDY LLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAH SRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGK QMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKH YTQSETEFLLSCAEPDENELLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQT FLELADSVLKYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVV NEGGEKEKMELFVNFCEDTIFEMQLAAQISESDTGERSVNKEDSEKNKPEEDNPENGFFS ITTIRSALLALRYNLMVLMKVLSMKSLKKQMKKIKKMTVKDMIMALVSFYWSILLGLFHF TFSVSRGFFRIMYSTFLGGSLVEGAKKIKVADLLANMPDPTQDGVRGEGEEGERKQSEPS LPSEDLADLAVASDDGDLLSDIFGLDLRREGGQYKLIPHNPNASLSDLITAPSTPVLVTS PELRRRNQGESSKEDEREEKEENKSEPEKAEGEDGEKREKPKVEKPSQKVRKRHSQKSDE IEIQESAFLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSAVTEEK ELMYRSPAEVNPRWSALGSTSHKMVTVHYVLEESSGYMEPTLRILAILHTVISFFCIIGY YCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVK RKVMDKYGEFYGRDRISELLGMDKAALDFSDAQEKKKPKKDSSLSAVLNSIDVKYQIWKL GVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLT VGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDE IEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFI CGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWE FFPAGDCFRKQYEDQLN NT seq 14994 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggcgaggacgaaatccagttcttgcgaactgatgatgaagtg gtgctccagtgttctgccaccatccataaagagcaacagaaactctgtttagctgctgaa ggatttggaaacagactttgcttcctggaatccacttcaaattcaaagaatgtccctccg gatctttcaatttgcacatttgtgctcgagcagtctctctcggtgcgagcccttcaggaa atgctggccaacaccgaggaaaaagctgaagggaaatttatgatgaagactgcacaagga ggaggtcatcgaacacttctctatggacatgctgtattactcaggcattcttacagtgga atgtatctttgttgtttgtccacctcacgctcttcaactgacaaactggctttcgatgta ggactacaagaagatacaacaggtgaggcctgctggtggactattcaccctgcctccaag caaaggtcagaaggtgaaaaagtacgagtgggtgatgaccttatcctagtcagtgtttcc tcggaaagatatctgcatttatcttatgggaacagcagtttgcatgttgatgctgccttt cagcaaactctctggagtgtggcaccgatttgttctggaagtgaagttgcacaagggttc cttattggtggtgatgttttacggttattacatgggcatatggatgaatgcttgaccgtg ccttcaggggagcatggggaagatcagcgaagatcagtccattatgaaggtggagcagta gccatccatgcaagatcattgtggagactggaaactctacgagttgcatggagtggcagt catatacgatggggacaaccctttagactgcgacatgtcacaactggaaagtatctaagt ctgactgaagacaaaggtcttctgcttatggacaaagaaaaagcagatgtgaaatccact gcattctgttttcggtcttccaaggaaaagctagattcaggaataaagaaagaagttgat ggaatgggtgttccagagataaagtatggtgattcagtatgctatattcagcatgtggaa acttgtctgtggctcagttatcagtctgttgatgcaaaatccgcacggatgggagctatt caacgcaaggccataatgcaccatgaaggccacatggatgatgggttaacactgtcacgt tctcaacatgaagagtctcgtacagcacgggttattcgcagcactgtcttcctatttaac agattcatcaggggtcttgataccttgagcaaaaagggcaaatcatgctgcttagatttg ccaatcgagtctgtgaatttgagcctacaagatttaataggctattttcagccacctgat gagcatctagaacatgaagataaacaaaaccgtcttcgggcattaaagaaccgtcaaaat ctcttccaggaagagggtatgataaacctggttcttgaatgtattgaccggttacatgtg tatagcagtgcagcacactttgctgatgtggctggaaaagaagcaggggaagcctggaag tctatactaaactcattatatgagttattagctgcgctgataagaggaaacaggaaaaac tgtgcccaattttcaggttccttggactggctgattagcaggctagagcgattagaagca tcttctggtattttagaagttttacactgtgtccttgttgaaagcccagaagcccttaat attatcaaagaagggcatatcaagtctatcatttctctcttagataaacatggaagaaac cataaggttctggatgtgctatgttccttgtgtgtatgtcatggtgtagctgttagatct aatcaaaacctcatatgtgacaacttacttcctggaagagatcttctactacagacacgc cttgtcaaccatgtgagcagtattcgacctaatatttttctgggcattagtgatggctcg gcacagtaccgaaagtggtactatgagctaattgtggatcatatagaatccttcgtaatg gcggaatcaactcatcttcgtgtcggctgggcatctgcagatgggtattttccataccca ggtggtggtgaaggatggggaggaaatggtgttggagatgacctgtattcatatgggttc gatggtttacatctatggtcaggctgcattgctcggtcagtaaattcacctaatcagcat ttactgagagatgatgatgtggtcagctgttgcctcgatctgagtgctccaagcatctct ttcagaatcaacggccaacctgttcaaggcatgtttgagaatttcaacgccgaaggcttc ttctttccagcagttagcttctccgccggagtaaaagcccgtttccttctaggtggtcgc cacggggagttcaagttccttccaccaccaggctatgctccctgtttcgaagctcttttg cccagagagaaaatgaggttggagcctagtagagaatataaacaagatcatggcacaacc cgagacttgttgggaccaacaatttcccttaatcaagctgcattcacaccaatgcctgtt gacacaagtcagattgtgttgccacctcacttggaacgtataagagaaaagcttgcagaa aatatccatgaactttgggtcatgaacaagattgagcttggctggacatatggactggta agagatgataataaacggcaacatccatgtctggtggagttttccaagttgccagagcaa gagtgtaattacaatttacagatgtcacttgaaactttaaagacgttgctagctttggga tgtcatgtaggaattgctgatgatcatgcagaagaaaaagtaataagactcaatcttccc tcaagttatgagctgacaggtggatacaagccagcacccatggatcttagccatattaag ctgacttcgacccaggaggctatggtggacaagctggcagaaaatgcacacaatgtctgg gctcgagatcgcattcggcaaggttggacttatggaattcaacaggacatcaagaacaaa agaaaccctaggcttgttccatatgctttgctggatgaacgaacaaaaaaatccaataaa gatagtcttcgagaagcagtccgcactctgttgggttatggctacaatttggaggctcca gatcaagaccatgctgcaaggtcagatacctgcaacgtttctgctgagcgcttccggatt ttcagagctgagaagacatacgcagtgaaagctgggaaatggtactttgagtttgaagca gtgactgctggagaaaagcgcattggttggtcaagacctggctgtttaccagataaggaa ctggggtcagatgatcaggcctttgtttttgatggctttaaagctcagagatggcaccaa ggaaatgagcattttggccgttcctggcaggctggggatgttgtgggctgtatggtagac ttaaacgagcataccataatatttaccctgaatggtgaagtccttcttgatgactccgga tcagagcttgccttcaaggactttgaaattggtgaagggtttattcctgtctgtagcctg ggagtttcagagattgggagaatgaattttggcaagaatgttggcacattaaagtatttc accatatgtgggttacaggaaggttatgaaccatttgctgtgaacatgaacagggacatt accatgtggatgagtaagcggctgccacagttcactcctgttccttcaaggcacgagcac attgaggtcacaaggatagatgggacaattgatagtcctccatgtttaaaagtgattcag agatcatttggatcacaaaacagcaacaccgatattgtattttatcgcttaagtatgcct gttgaatgtgcagaggggtattcaaggacaccgggcagtagtttgcccccaagcagcagc tacatttcaccaaagaaagatcttgaagattttgaatctgattctgactttgaagttctt atgaaaactgcacatgggcacttgaattccaatggaccagagaaggaaaaggacagcata aaggatgaattcaacaaccataaagactatacacaggagaaaccttctagacttaaacag aggtttatgttgaaaagaacaaagccagactacaacataaatcactcttcagcccgcctc tcagaagaagtgttagccgatgacagagacgactatgaatacctgatgcagacatcaatc tattactactcagttagaatatttcctggtcaggaacctaccaatgtgtgggttggatgg gttacttctgactttcaccagcatgacacatcctttgaaatggagaaggttcgcacagtg actgttacacttggagatgaaaaaggaaaggtccatgaaagcattaaacgtagtaactgc tacatggtgtgggcaggagaaagtacaagcccaggacaaggtcgcaacaataatggattg gaaataggctgcctagtggatactgccagtggcttgctaacatttacaaccaatgggaaa gagataagcacttactaccaggtggagcccagcacaaaactgtttcctgctgtttttgcc caagctacaagtcctaatgtttttcagtttgaacttggaagaataaaaaatgtcatgcca ctgtctgctgcacttttcaaaagtgaacgtaaaaatgcgacaccccagtgtcctcctcga cttcatgttcaattcttgaccccagtcctgtggagccgagttccaaatgatttcctaaag gtggatgtttcgagagtcagtgaaaggcatggttggcaagtacaatgcacagtgccactt cagttcatgtgccttcacattcctgaagaaaataggtctgttgatatcctagagctcaca gaacaagaggatctattgaaatttcattaccacacattgtgcctgtattctgctatctgt gctcttggaaataacagagttgcccatgcactgtgcagtcatgtggatgaagcacagctc cttcatgctattgaaaataaatatatgcctggtctccttaggacgggctactatgatcta cttattgacattcatctcagtagttacgctacagccagacttatgatgaacaatgaatat attgtacccatgacagaagaaaccaaaagtataactttgttcccagatgagaaaaaaaaa catgggcttccaggcataggcctcagtacatctctaagaccaagaatgcagttttcatct cccagttttgtgaaaattaatggagagtcctttcagttcagtcctgagtttcctttagaa actcttaagactaagactattgaaatgctgacagaagctgtccaagaaggcaatctgcat gtacgggaccctgttgggggtagcacagaatttctttttgtgccgctcatcaagctgttc tacacacttcttataatgggtgtcttccacaatggagatctgaaaaacattctgcgtctg attgagcccagtgtcttctctgaagaggtggtacaagagtattctgccaatcctgactgt gatggcattaaaggaaaattgaaagctgaaggcttgggagtacaaggggaaggcatctct gtaaaagttcctaaagaagggctgcttcagatgaagctaccagagccggtcaaacttcag atgtgtcacctcctgcagtacctgtgtgactgccaagtgcgacacaggattgaggctgtt gtagcattctcagatgattttgttgcaagcctccaggaaaaccagcgtttccgttataat gaagtgatgcaggctctaaatatgtctgcagcactaacagctaggaagacaaaagaattc cgttccccacctcaggaacagattaacatgttgttgaatttcaaagatgataaacaagat tgcccatgtcctgaagatatacgggaacagctattagactttcatgatgacctaatgact cactgtggaattgaactagatgatgatagaactagtgatggagacacagattttacaatt aaaggtagactcctatacttagtggagaaagtggcctatctgaagagaaaaatgtcagat ctaccaaagaagaaaaaattgaaaaagccaagcactcttcagcaattaatatcagaaacc atggtgcgctgggcccaggaatcagtgattgaagacccagaactggtcagagcaatgttt gttctacttcacagacaatacgatggcataggaggtcaggttcgtgctctgcccaaaaca tataccattaattcagtatctgtggaggacacaataaatcttttggcttccttgggacaa atccgatcactgcttagtgttcgtatggggaaagaggaagagaagctaatgatacgtgga cttggagatattatgaataacaaagttttctaccaacacccaaatttaatgagggcattg ggcatgcatgagacagtgatggaggttatggtaaatgtccttggtggaggagagtcaaag gaaattacctttcctaagatggtagccaactgctgccgtttcctgtgctacttctgtcgt ataagtaggcagaaccaaaaggccatgtttgaccacctcagttatttgcttgaaaacagc agtgttggtctcgcatccccttccatgagaggttccactccattggatgttgctgctgca tcagtgatggacaacaatgaacttgccttagccttgagggaaccagacctggagaaggtt gtacagtacttggctggttgtggtttgcaaagctgtcctatgctggtatctaaaggatat ccagatatcggctggaatcctgtagagggagaacgatatctagattttctacgttttgct gtcttctgcaatggagaaagtgtggaagaaaatgctaatgtagtagtaaggttacttatt cggcgaccagaatgtttcggcccagcattacgtggtgaaggaggaaatggtcttttggca gctatgggagaagcaattaagatctcagaagacccagcaagagatgggccttctcctact actggatctagtaaaaccattgatgcagttggtgaagaggatgacactattcacatggga aatgccataatgaccttctatgcagccctaattgacttgcttggtcgctgtgcccctgaa atgcatctcatccatgctgggaaaggtgaagctattaggatacgagctattctccgttct ctgatacctatagaggatcttgaaggcgttatcagcattccatttccaatgccaacatta gccaaagatggtaccgtggtggagcctgatatgtctgctggtttttgtcctgaccataaa gcagcaatggtgctgtttttagatagagtttatggaattgaagaccaaaatttccttttg caccttttggaagttggttttctcccagaccttcgagcagctgcatctttggacacagct gctctcagtgccacggatatggcactggctttaaaccgttatctgtgtactgctgtactg ccactgcttactaagtgtgctccactcttcgctggtacggagccttatgcctccctcatt gactccttacttcatactgtatatagattatccaaaggatgttgtcttaccaaagcacaa agggactctattgaggagtgtttgctggctgtgtgtgggcagctgagaccctcaatgatg cagcatcttctcagaagactggtgtttgatgttccacttttgaatgaacacacaaaaatg ccccttaagttgttgacaaaccattatgagcgttgctggaaatattattgtctacctgga ggatggggaaattttggagctgcatcagaagaagaacttcatttatccagaaagttattt tgggggatttttgatgctttgtcacaaaaggatattacattttctgttaaaccatttata aggacatattgtgtaaagaagtatgaacaagaactgtttaaactggcacttccatgcctc agcgctgtagcaggggctttgccaccagattacatggagtcaaactacgttgccatgatg gagaaacaatcttcaatggatgcggaaggaaacttcaacccacaacctgttgatacctca aatgtgcatatcccagaaaaactggattacttcatcaacaaatatgcagaacattcccat gagaaatggtcaatggaaaagtttgcaaatggctggattcatggcgaggttctttgtgaa accagtaaggtccacaatctgttgaaaccatatagactgcttacagagaaggataaggag gtatatagatggcctattaaggagtctttgaaaacaatgcttgcttggggctggagcatt gaaagaatacgtgaaggggacactatgagcttacataacagagcacggcggatatcacag tccagccaggtttctgtagataccagtcatggttatagtccccgacctattgacatgagt aatgtcacactgcctcgggagctttattcaatggcagaattgcttgccgagaactaccac aacatctgggccaaaaagaaaaagctggaattggaaaccaaaggaggaggaagtcatcct ctactagtgccatatgacaccttaacagccaaagaaaaatccaaagacagagaaaaagca caggacatcctaaagttttttcagctaaacggatatactgtttccagaggtttaaaggaa ctggatttagatactccttcgatagaaaaacgttttgcttacagtttccttcagcaactc attagatacgtggatgaggcccatcagcgtatgctggaagttgatgctggaactcgaacc aaaggagaaaaaaatcctcaccagcaagaaatgaagttttttggaaaggttgttctgccc ttagtagatcagtatttcaaaaatcatcgtctttacttcctttccactgcaaatcggcct cctagcagtggtggtcatgcatctaacaaggaaaaagagatggttaccagcctattctgc aaacttggagtacttgtgagacataggatatcattgtttgggaatgatgcaacatctata gtgaattgccttcatatattgggccagactctggatgccaggacagtgatgaagacaggg cttgaatccgttaaggcagcattgaggatttttttcataaatgctgcagaagatttggag aagacactggaaaatctgaaactgggtcagtttgcacataccaggatgcaacccaaagga gtcacccaaatcatcaactacacaacggttgctcttctgccagtcttgtcttctcttttt gagcacatcgggcaaaatctttttggagaagatattatattggatgatgttcaagtgtct tgctatagaattcttaacagcttgtatggattgggtactagcaaaagcatttatgtggaa agacagaggcctgctttgggtgaatgtctcgctgcctttgcaggtgcctttcctgtgtca tttttggaacctcatctaaacaaatacaatccttactccatctacaatacaaagtcctca agagaaagaacagttcttaacttgccagcccaggttgaagatgtatgtataagcattcct ttcttggacaaactgcttgaagaaataatggaccttgctgaatctggggtacgatataca cagatgccacatgtgatggaggttatattgccaatgctttgtagttatatgtctcattgg tgggaacatggacctgaaaacaacccagacaaaatggacatgtgctgcactgctttgacg tccgatcacatgaatacattgttaggaaatatcctgaaaatcatttacaataatcttggt attgatgaaggtgcttggatgaaacgattagcagtgttctcacaaccaatcataagcaag gcacagccacaacttctcaaaacccactttttgccacttatggagaagctaaagaaaaaa gcagcaacagtgcttatagatgaggagcacctgaaggcagaaggcagaggagacatgtct gaagcggaactccttattcttgatgaattcactatactagcccgtgacctctatgccttt tatcctctacttattagatttgtagattataacagagcaaagtggctgaaagagccaaat gcagaggcagaagaattatttcgtatggttgcagaagtcttcatattctgggcaaaatct cataatttcaaaagggaggagcagaactttgtggttcagaatgagatcaacaacatgtca tttctaattactgataccaaatcaaaaatgtcaaagggtgctgttttggatcaagagaga aaaaagttaaagagaaaaggagacagatattcattgcaaacatctcttattgtagctgca ttaaaaaggcttctcccaattggtttaaatatatgtgcacctggagatcaagaattaatt gctttggcaaagcataggttcattatgaaggacacagaagatgaagtcagggaaataatt cgtaataaccttcacctacaaggaaaactggaagaccctgctattcggtggcaaatggct ctttataaagatttaccaaatagaacagaagattcttcagatccacagaaaacagtggag cgtgttttagacatagcaaatgtgctgtttcatctggaacaggtagagcatccacaaagg agtaagaaagctgtctggcataagttactgtccaaacaaagaaaaagagcagttgtggca tgttttagaatggctccattatataatttaccgaggcaccgagctgtaaacctctttatt caaggatatgaaaagtcctggattgaaacagaagagcattattttgaagacaaattaata gaagacttagcgaaaccaggagaggaacctgttgaggaagatgaaggagtgaagcgcatt gatccattacaccagctcattctcctctttagcaggactgctctaacagaaaagtgtaag ctggaagaagattttctgtatatggcctatgctgacattatggcaaagagttgccacgat gaagaagacgatgatggagaagaagtaaaaagctttgaacacgatattatcaaagattta agcaacaaatttgtcaacaacgtggaaaactctctggaaaaagaaatggagaagcagaaa cttttataccagcaagcaagactacacgaccgtggagcagctgaaatggttttgcagatg atcagtgccagcaaaggtgaaatgggtccaatggtggctgctacattaaaactcggaatt gccattttaaatggaggaaattctacagtacaacagaaaatgctcgactatctaaaggac aagaaggatgtgggattctttcaaagtctagcgggtcttatgcagtcatgcagtgttcta gacctcaatgcatttgaaaggcaaaataaggcagaaggtcttgggatggtgacagaagaa ggatcagtcatcactcatgagcgtggagaaaaagtgatgcaggatgatgaatttacctgt gacctttttcgctttcttcagttgctctgcgaaggacacaactcagactttcagaattat ttaaggactcaaactggaaacaatacaactgtcaatatcataatatctactgttgactac ctcctgagggttcaggaatcaatcagtgacttctattggtattactctggaaaagatgtc attgatgagcaggggcaacgcaatttctccaaagcaattaacgtagccaaacaggtgttc aataccctcacggaatatattcaggggccatgcacaggaaatcagcagagccttgcacac agcaggttgtgggatgcagtggttggatttcttcatgtgtttgcacacatgcaaatgaag ctgtctcaggattccagtcaaatagaattgctgaaagaattaatggatctgcaaaaggat atggtagtaatgttgctttccatgcttgaaggaaacgtcgttaacgggaccattggcaaa cagatggttgacatgctggtagaatcttccaacaatgtagaaatgattctcaagtttttt gacatgtttcttaaattgaaagatttgacatcctctgatgcttttaaagagtatgatccg gatggtaaaggagttatatcaaaaagggactttcataaagctatggaaagccacaagcac tatacacagtcagaaacagagtttctgttgtcttgtgctgaacctgatgaaaatgaacta ctagattatgaggaatttgttaagaggttccatgaacctgcaaaagacattggctttaat gtggctgtcttattgactaatctttctgaacatatgccccatgattctcggcttcagact tttctggaattggcagacagtgtccttaaatattttcaacctttcctgggtcgtattgaa atcatgggcagtgcaaaacgtattgagcgagtctattttgaaatcagtgaatccagtcgg acacaatgggagaaacctcaggtgaaggagtcaaaaaggcagtttatatttgatgttgtg aatgaaggaggagaaaaagaaaagatggagctctttgtgaacttttgcgaggatacaatt tttgaaatgcaattagcagcacagatatcagaatcagatacaggagagagatctgtgaat aaggaggacagtgaaaaaaacaaacctgaagaagataatcctgaaaacggattcttctct attaccaccatcagatcagcacttttagcattaaggtacaatttgatggtgcttatgaag gtgctttctatgaaaagccttaaaaagcagatgaagaagattaagaagatgactgtgaaa gacatgatcatggctttagtctctttctactggagcattttattgggactttttcatttc acatttagtgtatcacgtggcttctttcgtatcatgtatagtacattccttggaggaagt ttggtagaaggagccaaaaaaattaaagtggctgatcttttagcaaacatgcctgatccc acccaagatggggttcgtggagaaggtgaagaaggtgagaggaagcagtctgaaccatca ttgccttctgaagatctggccgatttagctgttgcttctgatgatggtgaccttctgtca gacatttttggattagatttaaggcgagaaggaggacagtataaactaatcccacataat cctaatgctagtctgagtgacttaattactgcaccctctacgcctgttttggtaacctca cctgagctgcgaagacgaaatcagggggaatcaagcaaagaagatgagagagaagagaaa gaagaaaataagtcagaacctgaaaaagcagagggggaagatggagaaaaaagagaaaag ccaaaagtagagaaacccagtcagaaggttagaaagcgtcattcacagaagtcagatgaa attgaaattcaagaatcagcatttttgaagaagatcattgcataccagcgaaaattgctt aactactttgcacgaaatttttacaatatgcggatgctggctctgtttgtggcctttgct atcaacttcattctgcttttttacaaggtctccacctcatcagcagtgacagaagagaag gagcttatgtatagaagccctgcagaagtaaatccacgatggagtgccttaggaagcaca tcccataaaatggtgactgtgcactatgtattagaggaaagcagtggctacatggagccc acattaagaattcttgccattctgcatacagttatttcatttttctgcattataggctat tactgtttaaaagtacctttagtcatcttcaaacgtgaaaaggaagttgctcggaaactg gagtttgatggactttacatcactgagcagccttcagaagatgacatcaaaggacagtgg gatagacttgtaattaatacacagtcattcccaaataactactgggacaaatttgtgaaa agaaaggttatggataaatatggagaattctatggacgtgatagaattagtgaattgcta ggaatggataaagcagctcttgattttagtgatgctcaggagaaaaagaaaccaaagaaa gacagttcactgtcagctgtgttgaactcaattgatgttaaatatcaaatctggaagcta ggtgttgtttttacagataattcctttctttatcttgcctggtatatgactatgtccatt ttgggacactacaataactttttctttgctgctcatctcctggatatagccatgggattt aaaacattacggactatattgtcttcagttactcacaacgggaagcagcttgtattgaca gttggactcctggctgttgttgtttacctatatactgtggtagcattcaacttttttcgc aaattttataacaaaagtgaagatggagacactcccgacatgaagtgtgatgatatgcta acatgttacatgtttcacatgtacgtgggagttcgcgctggaggaggaattggtgatgaa atagaagatccagctggagatgaatacgaaatttatcgtattatttttgacatcaccttt ttcttcttcgtaattgttattctgttggctatcattcaaggtttaataattgatgccttt ggtgaactgcgtgaccagcaagaacaggtgaaggaagatatggagactaaatgcttcatc tgtgggattgggaatgactactttgatacagtgccccatggctttgaaacacacactctg caggagcacaacttggcaaactatctatttttcttgatgtatcttatcaacaaagatgaa acagagcacacaggccaggaatcatatgtttggaaaatgtatcaggaacgctgctgggag ttcttcccagctggagactgctttcgcaaacaatatgaagaccagctcaattga

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