Polypterus senegalus (gray bichir): 120518470 Help Entry 120518470         CDS       T08668                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism psex  Polypterus senegalus (gray bichir) Pathway psex04020   Calcium signaling pathway psex04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:psex00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120518470 (ryr3)    04020 Calcium signaling pathway     120518470 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:psex04040]     120518470 (ryr3) Ion channels [BR:psex04040]  Voltage-gated cation channels   Ryanodine receptor    120518470 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  120518470 NCBI-ProteinID:  XP_039597199 LinkDB All DBs Position 18:complement(68062853..68602586) Genome browser AA seq 4904 aa AA seqDB search MAEGAEAEDEIQFLRTDDEVVLQCVANIQKDHKKFCLSVEGLGNRLCFLELTSEAKRIPP DLCICNFVLEQSLSVRALQEMLANTGENASEGPRDLDKWASQGGGHRTLLYGHAILLRHS FSGMYLTCLTTSRSLTDKLAFDVGLQEDSIGEACWWTIHPASKQRSEGEKVRIGDDLILV SVSSERYLHLSISNGSIQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVMRLFHGHDEIL TIPSSPKSEDQYRIVNYEAGSAGARARSLWRVEPLRISWSGSYIRWGQPFRLRHITTGQY LALVDRTLVLHDREKADTESTAFCFRASKEKIESSPKRDVEGMGVAEIKYGDSICIVMHV ASGLWLSYQAPDAKSARLGPLKRRAILHQEGHMDDGLILQRCQHEESRAARIIRNTTKLF SQFIRDLDNLSGKNRTYIALPIEEVLQTLNDLITYFQPPEEELEHEEKQNKLRSLKNRQN LFKDEGMLTLVSNCIDRLNVYNSAAHFGEYAGEEAGSAWKDILNLLYELLASLIRGNRNN CTQFSNNLDWLVSKLDRLESSSGILEVLYCILIESPEALNIIQKGHIKSIISLLDKHGRN HKVLDVLCSLCVCNGVAVRANQNLICDQLLPRRDLLLQTRLVNDVTSMRPNIFLGISEGS AQYKKWYYELMIDQVDPFVTNEPSHLRVGWATTEGYAPYPGGGEGWGGNGVGDDLYSYGF DGLHLWSGRVPRTVASINQHLLTSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGL FFPVVSFSAGVKVRFLQGGRHGDFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDYDGV RDLLGTMQFLSQASFIPVPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVVQVNMNAEEDLKKMKLP KNYMMSNGYKPSPLDLSEVKLIPAQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSK RNPRLVPYALLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQESAGQAVERLSIDKIRFF RVEKTYAVKTGKWYFEFEAVSGGDMRVGWARPGCRPDVELGLDNQAFVFDGSRGHRLHQG SSFFGRTWQAGDVVGCMIDLQDKSMIFTLNGEILITNKGSELCFADFEVEDGFIPVCSLG LSQIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFINVPKEHPHI EVTRIDGTVESPPCLKVTHKTFGTQNSNADMVYCRLSMPVEFHSSFRSGTAMDSDGIQED DSQKTKQRFPLKSQKQVEESSSRRIEFGHITAYYYSVRVFAGQDPSCVWVGWVTPDYHFY SNCFDLNRNRTVTVTLGDERGRVHESVKRSNCYMVWGGDISSLQGSSRNNVDIEIGCHID LATGYVSFTANGKDLGTSYQVEPNTKLFPAVFVQPTSPNLFQFELGKLKNVMPLSAAIFK SEHRNPVPQCPPRLDVQTITPVLWSRMPNVFLKVEAARVSERHGWVVQCLEPLQMMALHI PEENRCVDILELSEQEGLMKFHYHTLKLYCALCALGNNRVAHALCSHVDQSQLLYTIDNQ YLPGMLRQGFYDLLISIHLETAKEARLMMNNEFIIPVTDETRSIKLFPDDSKKHSLPGVG LSTSLKPRLSFSPPCFITTNREQQLHSPQIPLDILKEKAISMLTEAVQGGGHHIRDPVGG CVEFQFVPILKLIGTLLIMGVLSDDDVKQILLMIDPCVFGDQKEEEEQEVKAKEEVTSTE EKAVEAGEEEAKESKQPMNGLLEKHLPESVKRQMCELLHYFCDCELRHRTEAIVSFSDSF VSKLQFNQKFRYNELMVALNMSAALTARKTREFRSPPQEQINMLLNFKLGEDCPCPEEIR EELYEFHDDLLLHCGIPLEEEEEEEQDTSIRGRLMSLVYKIKGAPKKQEEEPAETEQAAP TTLKELISQTMVSWAQESHIQDPELVRVMFSLLRRQYDSIGELLRALRKAYSISAVSVQD TINLLASLGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVM VNVLGGDKSQEIAFPKMVASCCRFLCYFCRISRQNQKSMFDHLSYLLENSSVGLASPSMR GSTPLDVAAASVMDNNGLALALEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEG ERYLSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGSGLLGAMKEAIKISE TPALDLPSTTSGVRRDPSGEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLINTGKGEA LRIRAILRSLVPMEDLVGIISIPLKMPTVNKDGTINEPDMSATFCPDHKAPMVLFLDRVY GVEDQCFLLHLLEVGFLPDLRASASLDTEALSTTEIALAMNRYICSAVLPLLTRCAPQFA GTEHYAALIDSILHTIYRLSKGRSLTKAQRDAIEECLLSICRYLRPSMLQQLLRRLVFDV PLLNEYCKMPLKLLTIHYEQSWKYYCLPSGWGSYGMASEEEVLLTKKLFWGIFDSLSQKS LSLLQKYDRELFKMAMPCLSAISGALPPDYVDASITTTLEKQTSVDAEGNFDPKPISTAN ISLPEKLEYIANKYAEHCHDKWASEKVALGWKFGEVMDEKIKTHPLLKPYKSLAEKEREI YRWPVKESLKSMLAMGWNIERTKEGEAMFQQRESEKLRKISQSSQGNGYTPCPLDMSNVV LSRELQAMVEVVAENYHNIWAKKKKMELGSRGGGSHPLLVPYDTLTAKEKARDREKAQEL FRFLQINGYAITRGLKDMEQDASSMEKRFAFKFLKKVLKYVDSAQEFIAHLEAIVSSGKA DKSPHEQEIKFFAKVLLPLIDQYFKNHCLYFLSSPIKTLSSSGYASNKEKEMVTSLFCKL AALVRHRISLFGSDSTTMVSCLHILARTLDTRTVMKSGSELVKAGLRTFFESAAEDLEKT LENLKLGKFTHSRTQMKGVSQNINYTTVALLPVLTSLFEHITQHHFGADLILDDVQVSCY RILCSLYSLGTGKNIYVERQRPALGECLATLAGAMPVAFLEPHLNMHNPRSVFNTKTPRE RTILGMPDTVEEMCPEMPRLDGLMKDINDMAESGARYTEMPHVIEVILPMLCNYLSYWWE KGPDNITESSGPCCTMVTSEHLSVILGNILKILNNNLGIDEASWMKRIAVYAQPIISKAR PDLLKSHFLPTLEKLKKKTVKVVAEEEMLKADSKSDTQEAELLILDEFAVLCRDLYSFYP MLIRYVDNNRSRWLKEPDSDSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFL TGDSKSKMSKSMLLKTGGQDQERKRTRRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQ ELISLAKFRYGLKDTDDEVKDHIRQNLHLREKSEDPAVRWQMNLYKDVVVKSEEPADPEH TVNRVQRISAAVYHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHKNNN YFLSSYQHIWLEKVLEKTDYDSLVFTLTKPQKKVEEEEEEEITKQPDPLHQLILHFSRNA LTERSSLEEDPLYIAYADMMAKSCQGEEEEEEEGKEKTFEEKEMEKQKTLYQQARLHERG AAEMVLQTISASKGRMGPMVVSTLKLGIAVLNGGNVVVQQKMLDYLKEKRDAGFFKSLSG LMQSCSVLDLNAFERQNKAEGLGMVTEEGSMIVRERGEKVLQNDEFTRDLFRFLQLLCEG HNNDFQNFLRTQTGNTTTINIIISTVDYLLRLQESISDFYWYYSGKDVIDEPGQRNFSKA LGVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDASQIELLK ELLDLQQDMVVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTSS DAFKEYDPDGKGVISKKEFQKAMESQKQYTQSEIEFLLSCAEADENDMFSYKEFVDRFHE PAKDIGFNVAVLLTNLSEHMPHDSRLSSFLELAESVLSYFEPYLGRIEIMGGAKRIERVY FEISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEP DAAERPEEEEDEPHSLLEELGSEEEEEANLESSSAFTIACVSMKKNFANFMHLLTFKNIR KQYRKFKKMTIKEMVKVFFSFFWMIFVGLFHFIFTLVWGLIHIVWSSMFGGGLVEGAKNI KVTDILGNMPDPTQFGIHGDILEAEKGDSSESTTTSDLVQLAKGEKAEPDLMSELLGIGP KKEGHSKHSPEPGLGDISEIIGTDTPSSLVSAVHQKQLAQETDITKEAETEVKSEAEKAD TEDGEKKDKAKEEEPPELVVEEKKIRRRRHGQKQEETDAFMANFLAGLEVYQTKMLNYLA RNFYNLRLLALFVAFAINFILLFYKVTEDPFDFDEVDEDSDLWNGDEEEEDEGGMVYFVL QESTGYMAPTLRFLAVIHTIISFLCVIGYYCLKVPLVVFKREKEIARKLEFDGLYITEQP SDDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNP TEETAPKEATLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHL LDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPD MKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQ GLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLM YLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14715 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtgctgaagcggaggatgaaatccagttcttacgaactgatgatgaagtg gtactacaatgtgttgccaatatccagaaagaccacaaaaaattctgcttatcggttgaa ggacttgggaaccgtctgtgcttcttagaattaacgtcagaggcgaagagaatcccacca gacctatgtatctgcaattttgtgcttgaacagtccctgtcggtcagagccctgcaggag atgctggctaacaccggggaaaatgccagcgaagggcccagagacctggacaaatgggcc tctcagggaggtggacataggacacttctttatggtcatgcaattcttctccgacactca tttagtggaatgtatttaacatgcttgactacatcaaggtctctgacagataaacttgct tttgatgtgggattgcaagaagattcaataggtgaagcttgctggtggaccattcatcca gcatccaaacagagatctgaaggagagaaggtgcgcatcggggatgaccttattctagtg agcgtttcctctgagaggtatctgcatctctcaatatccaatggcagtattcaggtagat gcatctttcatgcaaactctatggaatgtgcaccccacctgttctggaagtagcgtggaa gaaggttatttgcttggtgggcatgtgatgcgtctctttcatggtcatgatgagattctg accatcccatcatctcctaagagtgaagatcagtataggatagtaaattatgaagctgga agtgctggtgctcgagcaagatctttatggagggttgaaccacttcgcataagttggagt ggaagctatattcggtggggtcagcctttccgcctgcgacacattacaacggggcaatat ctagcattggtggaccgaactctggttcttcatgacagagaaaaggcggacactgaatct acagccttctgctttagagcatcaaaggaaaaaattgaatccagtccaaaaagagatgtt gaaggcatgggagtagcagaaattaaatatggagattccatttgtattgttatgcatgtt gcttctggcctatggctgtcctaccaagctccagatgccaaatcagctcgacttggaccc ctcaagcgaagggctatacttcaccaagaaggccacatggatgatggattgatattgcaa cgctgccagcatgaagagtctagagctgccaggatcatccgcaacacaacaaagcttttc agtcagtttatcagggatctagataacctgagtggaaagaaccgtacctacattgccctg cctattgaggaggttctgcagaccctgaacgacctaatcacttacttccagcctccggag gaagagttggaacatgaggaaaaacagaacaagctgcgctctctaaaaaacagacaaaat ctctttaaggatgagggaatgttgactttggtttcaaactgcattgaccggctcaacgtc tacaacagtgctgctcattttggggagtatgctggagaggaagctggctctgcatggaaa gacattctgaacctactctatgagttgcttgcttcccttatccgtggaaacagaaataat tgcacgcaattctccaataatcttgactggctagttagtaaactagacaggttggaatct tcatcaggtattcttgaagttttgtactgtattctcattgaaagcccagaagctctcaac attatccaaaaaggacatatcaagtccatcatctctctcttggataaacatggtcggaac cacaaggtattggatgtcttatgctctctttgtgtttgcaatggcgtggcggtgagagcc aaccaaaacctgatatgcgaccaattgctgccacgtagagatttgcttcttcaaacccgt ctggtaaacgacgtcaccagcatgaggcccaacattttcttgggaattagtgagggatct gcccagtataaaaagtggtactacgaactgatgattgaccaggtggatccttttgtgacc aatgagccttctcatttacgtgttggctgggcaaccactgaaggatacgctccataccct ggaggtggcgagggctggggaggcaacggtgttggagatgatctctactcttatggcttt gatggccttcatctctggtcaggtcgtgtcccaagaactgtggcctccataaatcagcat ttattgacttcagatgatgttgtcagttgttgccttgatctgggagcacctagcatctcg tttcgcatcaacggacagccagtgcagggcatgtttgaaaacttcaacacggatggcctt ttcttccctgtagtgagcttctctgcaggagtcaaggtgcgcttcctgcaaggaggccgt catggagacttcaagttcctccctcctgctggctatgccccatgctatgaagctcttctg cccaaggaaaaaatgcgagtggagccagtgaaggaatacaagcgagactatgatggtgtg cgcgatctgctgggcaccatgcagttcctttctcaggcctccttcatccctgtgccagtt gagaccagtcagattgtcatgcctccacacctggaaaaggtccgagacaaattagctgag aacatccatgagctgtggggtatgaataagatcgaactggggtggacctatggcaaggta cgagatgacaacaaaaggcagcatccctgtctggtagatttctctaaattacctgaaact gaaaaaaattacaacctccagatgtcaacagaaactctcaaaaccttgctagcgttgggc tgccatgtagttcaagtgaatatgaatgcagaagaagatctgaaaaaaatgaaacttcca aaaaactacatgatgtcaaatggatacaagccctctccactggatctttctgaggtgaag ttaattccagcccaggaagttttggttgataaacttgcagagaatgctcataatgtgtgg gcaaaggaccgaattaaacaaggatggacctatggcattcagcaggatctgaagagcaaa agaaatcctcgtttggtgccatatgctttattggatgagcgcactaagaaatccaacaga gacagcctccgtgaggctatccggaccctgattgggtacggatacaatattgaacctcct gaccaagagagtgcaggccaggctgtggaaagactgagcattgataagatacgtttcttc cgtgtggaaaaaacctatgcagttaagactggaaaatggtattttgagtttgaggccgtg agtggtggggacatgcgtgtgggctgggcccggccaggatgcagaccagatgtggagctg ggactggacaaccaggcttttgtctttgatggatcccggggtcaccgtttacaccaagga agcagcttttttggtaggacatggcaagcaggtgatgttgtgggatgcatgattgacctg caagacaaatcaatgatcttcacattgaatggtgaaattctgattactaataaaggctca gaactctgctttgctgattttgaggttgaagatggttttattccagtatgcagcttgggt ctgtcccagattggccgcatgaaccttgggaaggatgctagcacttttaaatattataca atgtgtggccttcaagaaggctttgagccttttgctgtcaacatgaaccgggatgttgca atgtggtttagcaaacgcctgccaacctttatcaatgtgccaaaagaacatccccatatt gaggtcaccagaattgatggcactgttgaaagtcctccatgtctcaaagtgacacataag acttttggaacacaaaacagcaatgcagacatggtctactgtcgtctaagcatgcctgtg gagtttcattcgtctttccgaagtggtactgccatggattcagatggaattcaagaagac gattcacaaaaaacaaagcaaaggtttccactcaaatctcaaaaacaagttgaagaaagt tcttcacgaagaattgaattcggacatatcactgcgtattactactcagtgcgagtgttt gctggacaagatccctcatgtgtgtgggttggctgggttaccccagattaccatttctat agcaactgctttgacctcaataggaaccgtactgtcactgtcacccttggagatgagaga ggcagagttcatgaaagtgtcaagcgtagcaattgctacatggtatggggtggagatatc agcagcctccagggatcaagtcgcaacaatgtggacattgaaattgggtgtcatattgac ttggccactggctatgtgtccttcactgcaaatggaaaggatctgggcacatcctaccag gttgaaccaaataccaaactgttccccgcagtttttgttcagcccaccagcccaaacctt tttcagtttgaacttggaaagttaaagaatgtcatgcctctgtcagctgccatttttaag agtgaacaccgaaacccagttccacagtgtccaccacgtcttgatgttcagaccatcact ccagtgctatggagcaggatgccaaatgtcttcctaaaggtggaggcagcacgagtgagc gagcgtcatggctgggttgtgcagtgtcttgagcccttgcagatgatggctttacatatc ccagaagaaaacaggtgtgtggatatcttggagctttctgaacaagaaggtctgatgaag ttccactaccatacactgaagctgtactgtgcactgtgtgctttgggcaataatcgagtt gcccatgcactctgcagccatgttgaccagtcacaactcctatatacaattgacaaccag tacttaccaggaatgctgcgtcaaggcttttatgatcttttgatcagtatccatttggag acagcaaaggaagctcggctaatgatgaacaatgagtttatcattccagttacagacgaa accaggagtatcaagcttttcccagatgactctaaaaagcactctttgcctggagtaggc ctaagcacatctcttaagcctcgcctcagcttttctcccccgtgctttatcacaacaaac agggaacagcagctgcacagcccacagattcctttggatatcctgaaggagaaagcaatt agcatgctcaccgaggcagtgcaaggaggtggccaccatatcagagaccctgtgggagga tgtgtagagttccagtttgtgccaatactgaagctgattggcacactgcttatcatgggt gtcttgagtgatgatgatgtaaagcagattttgctcatgatcgacccttgtgtgtttggg gatcagaaggaggaggaagagcaggaagtgaaagcaaaggaggaagtcaccagcacagaa gagaaagcagtggaggcaggagaagaggaggccaaagaaagcaaacagccaatgaatggc ctgctagagaagcatctacctgagtcagtaaagcggcagatgtgcgaactgcttcactac ttctgtgactgtgaattgaggcaccgaactgaagcaattgtctccttctcagacagtttt gtgtctaagctacagtttaatcagaaattccgctacaacgagctgatggttgctttgaac atgtcggctgctttgacagccaggaagaccagggagtttcgctcacccccacaggagcag atcaacatgttgttgaacttcaaacttggagaagactgtccatgtccagaagaaattcgg gaggagctgtatgaatttcatgatgacctgttactgcactgtggaatccccttagaagaa gaggaggaagaggaacaagacacatctattagaggaagattgatgtcattagtgtacaaa atcaaaggtgcccctaagaaacaggaagaagagccagcagagaccgaacaagcagctcct acaacccttaaagagctgatatctcaaaccatggtcagctgggcacaggagtcccacatc caggacccagagctagtgcgggtcatgtttagcctcctccgtcgacagtatgacagcatt ggtgagcttctgagagccctgaggaaggcttactccattagtgcagtctcagtccaggac accatcaaccttttggcttcactggggcaaatcaggtccctgcttagtgtcaggatggga aaagaggaggagaagctgatgattgatggattaggggatatcatgaataataaggtgttc taccagcaccccaacctaatgagagtattgggcatgcatgaaaccgttatggaagtcatg gtgaatgtactaggaggtgacaaatctcaggagattgcttttccaaagatggttgcaagc tgctgccgcttcttgtgctacttctgccgcattagtcgccagaatcagaagtccatgttt gaccatttgagctatctgttggaaaacagcagtgttggactggcttctccatccatgagg gggtccactccccttgatgtagctgcggcctcagtaatggataacaatggtcttgccctg gccttggaggagcctgatcttgaaaaggttgtcacttatttggcaggctgtggcctgcag agctgtcctatgctcctagcgaagggataccctgacattgggtggaatccaattgaaggc gaacgctatctgtccttcctgaggtttgccgtgtttgtgaacggtgaaagcgtagaggaa aattccagtgtagtggtaaagctgctcatccgtcgcccagaatgttttggcccagctctc agaggagaaggtggcagtggtctgcttggagccatgaaagaagctatcaagatatctgag accccagccctcgatctcccaagcacaacttctggtgtccgtcgagacccgtctggagaa gaagaggaagagattgttcatatgggcaatgccatcatgtctttctactctgcactaatc gatctgctaggacgctgtgctcctgaaatgcatctgatcaacaccggcaaaggtgaagcc ttaaggatcagggcaattctacgttctcttgttccaatggaggacctggtggggatcatc agtataccactcaagatgccaactgtaaataaagatggcactattaatgagcctgatatg tctgccactttctgtcctgatcacaaagctcccatggtgctgttcctggaccgtgtctat ggtgttgaggaccaatgcttcttgctgcacctgctggaggttggcttcctgcctgaccta agggcctcagcttcacttgacactgaggcactaagcaccactgaaattgcccttgccatg aatcgatacatctgctcagcagtactccctctgctcacccgctgtgcccctcagtttgct ggtactgagcactatgctgctctcattgactctatcctacatacaatctaccgtttgtct aaagggcgatccctcaccaaggcacagagagatgccattgaagagtgtttgctgtccatt tgtcgttacttacggccatccatgctgcagcagcttctgcgacgccttgtttttgatgtg cctctgctgaatgagtattgcaagatgcccctgaagctcctcaccattcactatgaacag agctggaagtactactgcttgccctccgggtggggaagctatggcatggcttctgaagaa gaggtactcctcaccaagaaactgttctggggcatctttgattcactgtcccaaaagtcc ctgtctcttctgcagaagtatgatcgcgagctcttcaaaatggccatgccctgcctcagt gcaatttcaggagcgttgcctcctgactatgtggatgccagcattaccacaacattggaa aaacaaacatctgtggatgcagagggcaactttgaccccaaacccatcagtactgccaat atttccttaccagaaaaactggaatatattgccaataaatatgctgagcactgtcatgac aagtgggcttctgaaaaggtggcacttggatggaaatttggggaggtcatggatgagaag atcaagactcatcctttgttgaagccttacaagtccctggccgagaaggagcgagagatt taccgctggcctgttaaagagtctctgaagagtatgctggcaatgggatggaacattgaa aggaccaaagagggtgaagccatgtttcagcagcgggaaagtgagaaattgcgcaagata tcccagtcttcccagggaaatggctatactccatgcccacttgacatgagtaatgtggtt ctgtctcgagagcttcaggcaatggtggaggttgtggctgaaaattaccataacatctgg gcaaaaaagaaaaaaatggaattgggaagcagaggtggaggaagccatcctttgctggtt ccatatgataccctaactgctaaggagaaggcccgggatcgagagaaagctcaggagtta ttccgcttcctccaaatcaatggctatgcgataacaagaggcctaaaggatatggagcag gatgcttcgtccatggaaaaaagatttgcttttaaatttctgaagaaggtacttaagtat gtggactctgctcaagaattcatcgctcacttagaggcaattgttagcagtgggaaagct gacaagtcacctcatgaacaggagatcaagttctttgcgaaggttctccttccactgatt gaccagtactttaagaatcattgtctgtatttcttgtcatctcctatcaaaactctaagc agcagtgggtatgcttccaacaaggagaaggagatggtgaccagcttgttctgtaagctg gcagcccttgtccggcatcggatttctctctttggaagtgactcaaccaccatggtcagc tgcttgcatatcttggctcgcactctggacacaagaacagtgatgaagtcgggctccgaa ctcgtcaaagctggtctacggaccttctttgaaagtgcagcagaagacctggagaaaacg ttggaaaacctgaagctggggaagtttactcattcacggactcagatgaaaggcgtgtcg cagaacatcaactacaccactgttgctttactgccagttctcacgtctctgtttgaacac atcacccagcatcactttggagctgatctcattttggatgatgtccaggtctcctgttac agaatactatgcagcttatactctttaggaactggaaagaacatctatgtggagaggcag cgtccagctcttggagaatgtttagctactcttgctggggccatgcccgttgctttcctt gagcctcatctgaatatgcacaatccacgctctgtcttcaatacaaagacacccagagaa agaaccattttaggtatgccagacacagttgaagagatgtgtcctgaaatgcccagactg gatggtttaatgaaggacatcaatgatatggctgagtctggtgcacgctacacagaaatg ccccatgtcatcgaggtcatactacccatgctgtgtaattacttatcttactggtgggag aaggggcctgacaacattacagaaagcagtggcccgtgctgcactatggtgacatctgaa cacctcagtgttattcttgggaatattcttaaaatcttgaacaataaccttgggattgat gaggcctcctggatgaagagaattgcagtgtacgctcaaccaattattagcaaggctcga cctgacttgctgaagtctcacttcctcccaacattagagaagctgaagaagaagacagta aaggttgtagctgaagaggaaatgctcaaagcagacagcaaaagtgatacccaggaggca gagctgcttatcctcgatgagtttgcagtactctgccgtgacctctatagcttctatcct atgctcatccgttatgttgacaacaacaggtccagatggctgaaagaacctgatagtgac tctaatgagctcttccgcatggtggctgagatctttatcctctggtgtaaatcacataac tttaaaagagaggagcagaactttgttgttcagaatgaaatcaacaacttgtcttttctt acgggggacagcaagagcaagatgtccaagtccatgctcttaaagacaggaggccaagat caagaaagaaagaggacgaggcgccgtggggaattctattccatccagacctcactgatt gttgcagctctcaaaaagatgttgcccattggtctgaatatgtgcactccaggagatcag gagctgatatcgctggccaaattcagatatggactgaaggatacagatgatgaggttaag gaccatattcgacaaaatctgcacttgcgagaaaagtctgaagatccagcagtacgatgg caaatgaacctttataaagatgttgtggtgaagagtgaagagcctgcagacccagaacac acagtcaacagggtgcagagaatttcggctgctgtctaccacttggagcaggttgagcag cctttaaggtccaagaaggcagtgtggcacaagcttctatctaagcagcgtaagcgagca gtggttgcatgcttcaggatggcacctctctacaaccttccaagacacaaaaataacaat tacttcctgagctcctaccaacatatttggctggaaaaggtgcttgagaaaacagactat gacagtctggtcttcaccttgacgaaaccacagaagaaggtcgaggaggaggaagaagaa gaaattactaagcaacctgatcccctgcaccaactcattctccatttcagtcgcaacgca cttacagagagaagctccctggaggaagaccccttgtacattgcttatgcggacatgatg gctaagagctgccaaggagaggaagaggaggaagaggaaggaaaagagaagacttttgag gaaaaggaaatggagaagcagaagaccctgtatcagcaagccagactacatgagcgtgga gctgctgagatggtgcttcagactatcagtgccagcaaaggtcgaatgggacccatggtt gtgtccactctgaagcttggaattgctgttctgaatggtggcaatgttgtagttcagcag aaaatgttagactatttgaaggagaaaagggatgctggatttttcaagagcttatcagga cttatgcaatcttgcagtgttctggacttgaatgcttttgaaagacagaacaaagcagaa ggcttggggatggtaacagaggaggggtctatgatcgtgcgtgagaggggcgaaaaggtc ctgcagaatgatgagttcacccgggatctgtttaggtttttgcagctgctctgtgagggt cacaataatgatttccagaatttcctacgcactcagacgggcaacaccaccactatcaac ataatcatcagcactgtcgattaccttctgaggcttcaagaatccatcagtgacttttat tggtattattcaggcaaggatgtgattgatgagcctgggcaacgcaatttctcaaaagct ttgggtgtcgccaaacaaatctttaactctcttactgagtacattcagggcccctgtatt ggcaatcaacaaagtcttgcacacagcaggctctgggatgcagtggttggctttcttcat gtctttgctaacatgcagatgaagctctcccaggatgccagccagattgagcttcttaag gaactgctggatctgcagcaggatatggtggtaatgatgttgtcactactggaaggtaat gttgtaaatggaacaattggcaagcagatggttgataccctggtagaatcatctagcaat gttgaaatgatcctgaaattttttgatatgttcctcaagttgaaagacctaacctcttct gatgcattcaaggagtatgatcctgatggaaagggagtcatctccaagaaagagtttcag aaagctatggaaagccaaaagcagtacactcaatcagaaattgaattcttgttatcatgt gcagaggctgatgagaatgacatgtttagctataaagagtttgtagatcgtttccatgag cctgctaaggatattggctttaatgtagcagtcttgctaactaatctgtcagagcacatg ccccacgactcgcggctcagttctttcttagaactggcagaaagtgtcctcagttacttt gagccctacctaggccgcatcgaaatcatgggaggagcaaagcgcattgaaagagtgtac tttgagatcagtgagtccagcaggacccagtgggagaagccacaagtcaaggagtccaag cggcagtttatctttgatgttgtcaatgaaggtggggagagtgaaaagatggagctcttt gtgaacttttgtgaagacaccatttttgaaatgcagctggcttctcagatttctgaacct gatgctgctgaaaggcctgaggaggaagaggatgagccacacagcctcctggaggaactg ggatcagaagaggaagaggaggcaaatttggaatcttcatctgccttcaccattgcctgt gtctccatgaagaaaaactttgccaacttcatgcatctcctcacattcaaaaatatccga aagcagtacaggaaatttaaaaagatgacaataaaagaaatggtcaaagtcttcttctca ttcttctggatgatatttgttggcctcttccattttatcttcaccctggtgtggggtctg atccatattgtgtggagctctatgtttgggggtggcttagttgaaggtgcaaagaacatt aaagtgactgatattttaggaaacatgcctgaccccacccagtttggcatccatggtgac atccttgaagctgaaaagggtgacagcagtgaatcgaccaccacctctgaccttgtacaa ttagcaaaaggagagaaagctgagccagatctgatgtcagaactactaggcattggccca aagaaggaaggccactctaaacacagcccagagcctggtttaggtgacatctctgaaata attggcacagacactccatcatctttagtaagtgcagtgcatcaaaagcaactagcccag gaaacagatatcaccaaggaagctgaaactgaagtcaaatcagaagcagaaaaggcagac actgaggatggtgagaaaaaggataaagccaaggaagaggagccaccagagctggtggtg gaggagaagaagatccgaagaagacgacatggccagaagcaggaagagactgatgctttc atggctaatttcctggctggcctggaggtgtatcagactaagatgctgaattacctggca cgcaatttctacaacctgagacttctcgctctctttgtggccttcgccatcaacttcatc ctcctcttctacaaggtcactgaggacccctttgactttgatgaagtggatgaagactct gatctatggaatggagacgaggaggaggaggatgaaggaggaatggtttactttgttttg caagagagtacgggttacatggcgcctacgctccgattcctggctgtgattcacaccatc atttccttcttgtgtgttattgggtactactgccttaaggtgcctctggttgtgttcaaa cgtgaaaaggaaattgccagaaagttggagtttgatggcctctacataactgaacaaccg tcagatgatgacatcaagggacagtgggaccggctggtgattaacactccatctttccct aacaactactgggacaagtttgtgaaacgtaaggtcattaacaaatatggggatctctat ggagctgagagaattgctgaactcttgggtttggacaaaagtgctctggacttcaaccca acagaagagactgcccccaaagaagccacactggtgtcatggttgagctctattgacatg aaataccacatatggaaactgggagtcgtctttactgacaactccttcctttacctggcc tggtacaccaccatgtctattttgggccactacaacaacttcttctttgccgctcacttg cttgatattgccatgggctttaagacattgagaaccatcctgtcatctgtaactcacaat ggaaaacagctggtcctgactgtgggtcttctggccgtcgtcgtgtatctctacacagtg gttgcgtttaactttttccgcaaattctacaacaagagcgaggatgaggatgagccagac atgaagtgtgatgacatgatgacgtgctacctcttccacatgtacgtgggcgtgagagcc ggaggaggcattggtgatgagattgaagacccagctggtgacccctatgagatgtaccgt attgtctttgacatcacatttttcttcttcgtcattgtcatcttgctcgccatcatccag ggtctcatcattgatgcatttggtgagctcagagatcagcaggagcaagtaagggaggat atggagaccaaatgcttcatttgtggaattggaaatgattactttgacacaacgccacat ggctttgaaactcacaccttgcaagaacacaacctggccaactacttgttcttccttatg tacctcattaacaaagatgagacggagcacacaggtcaggaatcctatgtctggaaaatg taccaggaacgctgttgggacttcttccctgctggagattgcttccgcaaacaatatgag gatcaactgggttaa

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