KEGG   Phocoena sinus (vaquita): 116740954
Entry
116740954         CDS       T07759                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
psiu  Phocoena sinus (vaquita)
Pathway
psiu00562  Inositol phosphate metabolism
psiu01100  Metabolic pathways
psiu04015  Rap1 signaling pathway
psiu04020  Calcium signaling pathway
psiu04022  cGMP-PKG signaling pathway
psiu04062  Chemokine signaling pathway
psiu04070  Phosphatidylinositol signaling system
psiu04071  Sphingolipid signaling pathway
psiu04072  Phospholipase D signaling pathway
psiu04081  Hormone signaling
psiu04082  Neuroactive ligand signaling
psiu04261  Adrenergic signaling in cardiomyocytes
psiu04270  Vascular smooth muscle contraction
psiu04310  Wnt signaling pathway
psiu04371  Apelin signaling pathway
psiu04540  Gap junction
psiu04611  Platelet activation
psiu04613  Neutrophil extracellular trap formation
psiu04621  NOD-like receptor signaling pathway
psiu04713  Circadian entrainment
psiu04720  Long-term potentiation
psiu04723  Retrograde endocannabinoid signaling
psiu04724  Glutamatergic synapse
psiu04725  Cholinergic synapse
psiu04726  Serotonergic synapse
psiu04728  Dopaminergic synapse
psiu04730  Long-term depression
psiu04742  Taste transduction
psiu04750  Inflammatory mediator regulation of TRP channels
psiu04911  Insulin secretion
psiu04912  GnRH signaling pathway
psiu04915  Estrogen signaling pathway
psiu04916  Melanogenesis
psiu04918  Thyroid hormone synthesis
psiu04919  Thyroid hormone signaling pathway
psiu04921  Oxytocin signaling pathway
psiu04922  Glucagon signaling pathway
psiu04924  Renin secretion
psiu04925  Aldosterone synthesis and secretion
psiu04926  Relaxin signaling pathway
psiu04927  Cortisol synthesis and secretion
psiu04928  Parathyroid hormone synthesis, secretion and action
psiu04929  GnRH secretion
psiu04933  AGE-RAGE signaling pathway in diabetic complications
psiu04934  Cushing syndrome
psiu04935  Growth hormone synthesis, secretion and action
psiu04961  Endocrine and other factor-regulated calcium reabsorption
psiu04970  Salivary secretion
psiu04971  Gastric acid secretion
psiu04972  Pancreatic secretion
psiu04973  Carbohydrate digestion and absorption
psiu05010  Alzheimer disease
psiu05016  Huntington disease
psiu05017  Spinocerebellar ataxia
psiu05022  Pathways of neurodegeneration - multiple diseases
psiu05142  Chagas disease
psiu05143  African trypanosomiasis
psiu05146  Amoebiasis
psiu05163  Human cytomegalovirus infection
psiu05200  Pathways in cancer
psiu05415  Diabetic cardiomyopathy
psiu05417  Lipid and atherosclerosis
Module
psiu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:psiu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    116740954 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    116740954 (PLCB4)
   04310 Wnt signaling pathway
    116740954 (PLCB4)
   04371 Apelin signaling pathway
    116740954 (PLCB4)
   04020 Calcium signaling pathway
    116740954 (PLCB4)
   04070 Phosphatidylinositol signaling system
    116740954 (PLCB4)
   04072 Phospholipase D signaling pathway
    116740954 (PLCB4)
   04071 Sphingolipid signaling pathway
    116740954 (PLCB4)
   04022 cGMP-PKG signaling pathway
    116740954 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    116740954 (PLCB4)
   04081 Hormone signaling
    116740954 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    116740954 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    116740954 (PLCB4)
   04613 Neutrophil extracellular trap formation
    116740954 (PLCB4)
   04621 NOD-like receptor signaling pathway
    116740954 (PLCB4)
   04062 Chemokine signaling pathway
    116740954 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    116740954 (PLCB4)
   04922 Glucagon signaling pathway
    116740954 (PLCB4)
   04929 GnRH secretion
    116740954 (PLCB4)
   04912 GnRH signaling pathway
    116740954 (PLCB4)
   04915 Estrogen signaling pathway
    116740954 (PLCB4)
   04921 Oxytocin signaling pathway
    116740954 (PLCB4)
   04926 Relaxin signaling pathway
    116740954 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    116740954 (PLCB4)
   04918 Thyroid hormone synthesis
    116740954 (PLCB4)
   04919 Thyroid hormone signaling pathway
    116740954 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    116740954 (PLCB4)
   04916 Melanogenesis
    116740954 (PLCB4)
   04924 Renin secretion
    116740954 (PLCB4)
   04925 Aldosterone synthesis and secretion
    116740954 (PLCB4)
   04927 Cortisol synthesis and secretion
    116740954 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    116740954 (PLCB4)
   04270 Vascular smooth muscle contraction
    116740954 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    116740954 (PLCB4)
   04971 Gastric acid secretion
    116740954 (PLCB4)
   04972 Pancreatic secretion
    116740954 (PLCB4)
   04973 Carbohydrate digestion and absorption
    116740954 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    116740954 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    116740954 (PLCB4)
   04725 Cholinergic synapse
    116740954 (PLCB4)
   04728 Dopaminergic synapse
    116740954 (PLCB4)
   04726 Serotonergic synapse
    116740954 (PLCB4)
   04720 Long-term potentiation
    116740954 (PLCB4)
   04730 Long-term depression
    116740954 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    116740954 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    116740954 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    116740954 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    116740954 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116740954 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    116740954 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    116740954 (PLCB4)
   05142 Chagas disease
    116740954 (PLCB4)
   05143 African trypanosomiasis
    116740954 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116740954 (PLCB4)
   05016 Huntington disease
    116740954 (PLCB4)
   05017 Spinocerebellar ataxia
    116740954 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    116740954 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    116740954 (PLCB4)
   05415 Diabetic cardiomyopathy
    116740954 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    116740954 (PLCB4)
   04934 Cushing syndrome
    116740954 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:psiu04131]
    116740954 (PLCB4)
Enzymes [BR:psiu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     116740954 (PLCB4)
Membrane trafficking [BR:psiu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    116740954 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    116740954 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 116740954
NCBI-ProteinID: XP_032462969
Ensembl: ENSPSNG00000007109
LinkDB
Position
15:36034667..36308407
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAIGKSENDLEGRVVCVCSGTDLVNISFTYMVAENSE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDLKKKGQISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANSVKKASD
DLEHENNKKGLVTIEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRLAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKASVTPQ
SSSELRPTTTAALGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDLHLSQQCELLKKLLVNAHEQQTLQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCV
KLQDAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcgtttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggacaagttcta
gaatgttctctcatcaacagtgttcgactgggagccacaccaaaggatcccaaaattttg
gctgctcttgaagctattggaaagtcagaaaatgacctggaagggcgggtagtttgtgtc
tgcagtggtacagatctggtgaacatcagtttcacatacatggtggctgaaaattcagaa
gtaactaagcaatgggtcgaaggcctgagatccatcatacacaacttcagggccaacaat
gtcagtcccatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattaccagaacctttgcatcggggaagacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgaa
cctgcagcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattc
ccattttatgatactaaaagggcaatgcagatcattgagatgtatgagcctgatgaagac
ttgaagaaaaaaggccaaatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctagatcgcctagagctttaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcagacagtttggtgggaag
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaagaaccaataataactcatggaaaagcaatgtgc
acagatatactttttaaggatgttattcaagccatcaaggaaactgcatttgtcacatct
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcccttgaatcacat
ccactggaaccaggcagacctttgccatccccaaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagcttgaagctttgaaaagtatg
atggaagcaggagaatccgctgccccagtgagcatcttagaggatgataatgaagaggaa
atagaaagtgctgagcaagaggaagaagctcaccctgaatataaatatggaaatgaactt
tctgcagacgacttgggtcacaaggaagctattgccaatagtgttaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactatagaagatgagcaggcatgg
atggcatcttataaatatgtaggcgccaccactaatatccatccatatttgtccacaatg
atcaactatgcacagcccgtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattataacatgtcttcttttaatgagtcagttggtctaggctacttgaagacacatgcg
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgagacggcccgatcgaacatttgat
cccttctctgagacgcctgttgatggggttattgcagccacttgctcggtgcaggtcata
tcaggtcagttcttatcagataaaaaaattggcacatatgtagaagtggatatgtatggg
ttgcccaccgacactatccggaaggaattccgaacacgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtatttcggaaggtgatcctccccgacctggca
gtcttgagacttgcagtgtatgatgacaacaacaagctgattggccagaggattctgcca
ctggatggcctccaagcaggctatcgacacatttctcttcgaaatgagggaaataaacct
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccagatgagagctatgggcattgaaaccagtgacatcgccgacgtgcccagtgac
acgtcaaagaatgacaagaaagggaaagccaacacagcgaaagcaagtgtgacccctcag
agcagctcagagctcaggcctaccaccacggccgccctgggagctggcctggaggccaag
aaaggtattgaactgatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctcaattctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagctacattgcacacaagttgacaaaattgtggcgcagtat
gacaaggagaagtcaactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaagaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaggagatcgtggcgcagcacacaaaagagtggtcagacatgatc
aacactcacagtgcagaggagcaggagatccgggatctgcacctcagccagcagtgcgag
ctactcaaaaagctcctggtcaacgcccacgagcagcagaccctgcagttgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagacaaatctatcaagaataaagcagaacgggaaaggcgggtcagg
gaattaaacagcagcaacactaaaaagtttctggaagaaagaaagcgactcgcaatgaag
cagtccaaagaaatggaccagttgaaaaaagtccagcttgagcacctcgaattcctagag
aaacagaacgaacagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagttgtgtg
aaactccaggacgcaaactga

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