KEGG   Phocoena sinus (vaquita): 116741676
Entry
116741676         CDS       T07759                                 
Symbol
CHUK
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
psiu  Phocoena sinus (vaquita)
Pathway
psiu01523  Antifolate resistance
psiu04010  MAPK signaling pathway
psiu04014  Ras signaling pathway
psiu04062  Chemokine signaling pathway
psiu04064  NF-kappa B signaling pathway
psiu04068  FoxO signaling pathway
psiu04150  mTOR signaling pathway
psiu04151  PI3K-Akt signaling pathway
psiu04210  Apoptosis
psiu04380  Osteoclast differentiation
psiu04620  Toll-like receptor signaling pathway
psiu04621  NOD-like receptor signaling pathway
psiu04622  RIG-I-like receptor signaling pathway
psiu04623  Cytosolic DNA-sensing pathway
psiu04625  C-type lectin receptor signaling pathway
psiu04657  IL-17 signaling pathway
psiu04658  Th1 and Th2 cell differentiation
psiu04659  Th17 cell differentiation
psiu04660  T cell receptor signaling pathway
psiu04662  B cell receptor signaling pathway
psiu04668  TNF signaling pathway
psiu04920  Adipocytokine signaling pathway
psiu04936  Alcoholic liver disease
psiu05010  Alzheimer disease
psiu05132  Salmonella infection
psiu05135  Yersinia infection
psiu05142  Chagas disease
psiu05145  Toxoplasmosis
psiu05160  Hepatitis C
psiu05161  Hepatitis B
psiu05162  Measles
psiu05163  Human cytomegalovirus infection
psiu05164  Influenza A
psiu05165  Human papillomavirus infection
psiu05166  Human T-cell leukemia virus 1 infection
psiu05167  Kaposi sarcoma-associated herpesvirus infection
psiu05168  Herpes simplex virus 1 infection
psiu05169  Epstein-Barr virus infection
psiu05170  Human immunodeficiency virus 1 infection
psiu05171  Coronavirus disease - COVID-19
psiu05200  Pathways in cancer
psiu05208  Chemical carcinogenesis - reactive oxygen species
psiu05212  Pancreatic cancer
psiu05215  Prostate cancer
psiu05220  Chronic myeloid leukemia
psiu05221  Acute myeloid leukemia
psiu05222  Small cell lung cancer
psiu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
psiu05417  Lipid and atherosclerosis
psiu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:psiu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    116741676 (CHUK)
   04014 Ras signaling pathway
    116741676 (CHUK)
   04064 NF-kappa B signaling pathway
    116741676 (CHUK)
   04668 TNF signaling pathway
    116741676 (CHUK)
   04068 FoxO signaling pathway
    116741676 (CHUK)
   04151 PI3K-Akt signaling pathway
    116741676 (CHUK)
   04150 mTOR signaling pathway
    116741676 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    116741676 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    116741676 (CHUK)
   04621 NOD-like receptor signaling pathway
    116741676 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    116741676 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    116741676 (CHUK)
   04625 C-type lectin receptor signaling pathway
    116741676 (CHUK)
   04660 T cell receptor signaling pathway
    116741676 (CHUK)
   04658 Th1 and Th2 cell differentiation
    116741676 (CHUK)
   04659 Th17 cell differentiation
    116741676 (CHUK)
   04657 IL-17 signaling pathway
    116741676 (CHUK)
   04662 B cell receptor signaling pathway
    116741676 (CHUK)
   04062 Chemokine signaling pathway
    116741676 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    116741676 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    116741676 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116741676 (CHUK)
   05208 Chemical carcinogenesis - reactive oxygen species
    116741676 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    116741676 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    116741676 (CHUK)
   05221 Acute myeloid leukemia
    116741676 (CHUK)
   05220 Chronic myeloid leukemia
    116741676 (CHUK)
   05215 Prostate cancer
    116741676 (CHUK)
   05222 Small cell lung cancer
    116741676 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    116741676 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    116741676 (CHUK)
   05161 Hepatitis B
    116741676 (CHUK)
   05160 Hepatitis C
    116741676 (CHUK)
   05171 Coronavirus disease - COVID-19
    116741676 (CHUK)
   05164 Influenza A
    116741676 (CHUK)
   05162 Measles
    116741676 (CHUK)
   05168 Herpes simplex virus 1 infection
    116741676 (CHUK)
   05163 Human cytomegalovirus infection
    116741676 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116741676 (CHUK)
   05169 Epstein-Barr virus infection
    116741676 (CHUK)
   05165 Human papillomavirus infection
    116741676 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    116741676 (CHUK)
   05135 Yersinia infection
    116741676 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    116741676 (CHUK)
   05142 Chagas disease
    116741676 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116741676 (CHUK)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    116741676 (CHUK)
   05418 Fluid shear stress and atherosclerosis
    116741676 (CHUK)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    116741676 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    116741676 (CHUK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:psiu01001]
    116741676 (CHUK)
Enzymes [BR:psiu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     116741676 (CHUK)
Protein kinases [BR:psiu01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   116741676 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 116741676
NCBI-ProteinID: XP_032464482
Ensembl: ENSPSNG00000011567
UniProt: A0A8C9E302
LinkDB
Position
16:complement(56902542..56937580)
AA seq 744 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKVAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPIDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTCSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEMALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGVTPQASAWLPTTSAEREHPLSCVVTPHDGETLAQIIEENLNCLGHLS
TIMHEANEKQGNSMMNLDWSWLTE
NT seq 2235 nt   +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
ctgggcaccggcgggttcgggaatgtttgcctgtaccaacatcgggaacttgatctcaaa
gtagcaattaagtcttgtcgcttggagctaagcaccaaaaacagagaacggtggtgccat
gaaatccagatcatgaagaagttgaaccacgccaatgttgtaaaggcctgtgatgttcct
gaggaattgaattttttgattaatgatgtgcctcttctagcaatggaatattgttctgga
ggagatctccggaagctactcaacaaaccagaaaattgctgtggacttaaagaaagccag
atactttctttactgagtgatataggatctgggatacgatatttgcatgaaaacaaaatt
atacatcgtgatctaaaacctgaaaacatagttcttcaggatgttggtggaaagattatg
cataaaataattgatttaggatatgccaaagatgttgatcaaggaagtctgtgtacatct
tttgtgggaacattgcaatatctggccccagagctctttgagaataagccttacacagcc
actgttgattattggagctttgggaccatggtgtttgagtgtattgctgggtataggcct
tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaggatccaaag
tgtatatttgcatgcgaagagatgacaggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttaatagtagaacccatggaaaactggctacagttgatgcta
aactgggatcctcagcagagaggaggacctattgatcttactttgaagcagccaagatgt
tttgtattaatggatcacattctgaatttgaagatagtacacatcctaaatatgacttct
gcaaagatcatttcttttctgttaccacctgatgaaagtcttcattcactacagtctcgt
attgagcgtgaaactggaataaatacttgttctcaagagcttctttcagagacgggaatt
tctttggatcctcggaaaccagcctctcagtgtgttttggatggagttaggggctgtgat
agctatatggtttatttgtttgataaaagtaagactgtatatgaaggaccatttgcttcc
agaagtttatctgactgtgtaaattatattgtacaggacagcaaaatacagcttccaatt
atacagctgcgtaaagtatgggccgaagcagtgcactatgtgtctgggctaaaagaagac
tacagcaggctctttcagggacagagagcagcaatgttaagtcttcttagatataatgct
aacttgacaaaaatgaagaacactttaatctcagcatctcagcaactgaaagctaaattg
gagttttttcacaaaagcattcagcttgacttggaaagatatagtgagcagatgacttat
gggatatcctcagaaaaaatgttaaaagcatggaaagaaatggaagaaaaggctatccac
tatgctgaggtgggtgtcattggatacctggaggatcagataatgtccctgcacactgaa
atcatggagctacagaagagcccctatggacgacgtcagggagacttgatggaatctctg
gaacagcgtgccattgatctatataagcagttaaagcacagaccttcagatcactcctac
agcgacagcacggagatggtgaaaatcattgtgcatactgtgcagagtcaggaccgggtt
ctcaaggagctgttcggtcatttgagcaagttgttgggctgtaagcagaagattattgat
ctactgcccaaggtggaaatggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagaggcagaaagaaatatggcatctccttaaaattgcctgtacacag
agctctgctcggtcccttgtaggatccagtctagaaggtgtaacccctcaggcatcagca
tggctgcccacaacttcagcagaacgtgaacatcctctgtcatgcgtggtaactcctcac
gatggggagactttagcacaaataatagaagaaaatttgaactgtcttggccatttaagc
actattatgcatgaagcaaatgagaaacagggcaacagtatgatgaatcttgattggagt
tggttaacagaatga

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