KEGG   Phocoena sinus (vaquita): 116747370
Entry
116747370         CDS       T07759                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
psiu  Phocoena sinus (vaquita)
Pathway
psiu01521  EGFR tyrosine kinase inhibitor resistance
psiu01522  Endocrine resistance
psiu04010  MAPK signaling pathway
psiu04012  ErbB signaling pathway
psiu04068  FoxO signaling pathway
psiu04270  Vascular smooth muscle contraction
psiu04650  Natural killer cell mediated cytotoxicity
psiu04720  Long-term potentiation
psiu04726  Serotonergic synapse
psiu04730  Long-term depression
psiu04810  Regulation of actin cytoskeleton
psiu04910  Insulin signaling pathway
psiu04914  Progesterone-mediated oocyte maturation
psiu04928  Parathyroid hormone synthesis, secretion and action
psiu05010  Alzheimer disease
psiu05022  Pathways of neurodegeneration - multiple diseases
psiu05034  Alcoholism
psiu05160  Hepatitis C
psiu05161  Hepatitis B
psiu05200  Pathways in cancer
psiu05205  Proteoglycans in cancer
psiu05208  Chemical carcinogenesis - reactive oxygen species
psiu05210  Colorectal cancer
psiu05211  Renal cell carcinoma
psiu05212  Pancreatic cancer
psiu05213  Endometrial cancer
psiu05214  Glioma
psiu05215  Prostate cancer
psiu05218  Melanoma
psiu05219  Bladder cancer
psiu05220  Chronic myeloid leukemia
psiu05221  Acute myeloid leukemia
psiu05223  Non-small cell lung cancer
psiu05224  Breast cancer
psiu05225  Hepatocellular carcinoma
psiu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:psiu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    116747370 (ARAF)
   04012 ErbB signaling pathway
    116747370 (ARAF)
   04068 FoxO signaling pathway
    116747370 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    116747370 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    116747370 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116747370 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    116747370 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    116747370 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    116747370 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    116747370 (ARAF)
   04720 Long-term potentiation
    116747370 (ARAF)
   04730 Long-term depression
    116747370 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116747370 (ARAF)
   05205 Proteoglycans in cancer
    116747370 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    116747370 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116747370 (ARAF)
   05212 Pancreatic cancer
    116747370 (ARAF)
   05225 Hepatocellular carcinoma
    116747370 (ARAF)
   05226 Gastric cancer
    116747370 (ARAF)
   05214 Glioma
    116747370 (ARAF)
   05221 Acute myeloid leukemia
    116747370 (ARAF)
   05220 Chronic myeloid leukemia
    116747370 (ARAF)
   05218 Melanoma
    116747370 (ARAF)
   05211 Renal cell carcinoma
    116747370 (ARAF)
   05219 Bladder cancer
    116747370 (ARAF)
   05215 Prostate cancer
    116747370 (ARAF)
   05213 Endometrial cancer
    116747370 (ARAF)
   05224 Breast cancer
    116747370 (ARAF)
   05223 Non-small cell lung cancer
    116747370 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    116747370 (ARAF)
   05160 Hepatitis C
    116747370 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116747370 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    116747370 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    116747370 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116747370 (ARAF)
   01522 Endocrine resistance
    116747370 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:psiu01001]
    116747370 (ARAF)
Enzymes [BR:psiu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     116747370 (ARAF)
Protein kinases [BR:psiu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   116747370 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 116747370
NCBI-ProteinID: XP_032475265
Ensembl: ENSPSNG00000020741
LinkDB
Position
X:42496519..42506872
AA seq 644 aa
MPPARNRRSGLTRGAPWHLPSPTLARLDKVLGSMEPPRGPPANGAEPSRAVGTVKVYLPN
KQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELI
VEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDM
STNRRQFYHSVQDLCGGSRQHEAPSNRPLNEPLTPQGPSLSPASSCTQHRDPKHFPFPAP
ANAPLQRIRSTSTPNVHMVSTTAPMDSGLIQLPAQSFNTDAAGNRGGGDGTPRGSPSPAS
MSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFG
TVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIIT
QWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLT
VKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYEL
MTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQ
ILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
NT seq 1935 nt   +upstreamnt  +downstreamnt
atgccccccgcccggaaccggaggagtggtttgacccggggagccccatggcacctgccc
agccccaccttagcccgtcttgacaaagtcctaggctccatggagccaccacggggcccc
cctgccaacggggccgaaccatcccgggcggtgggcaccgtcaaagtgtacctgcccaac
aagcaacgcacggtggtgactgtccgggatggcatgagtgtctacgactctttagacaag
gccctcaaggtgcggggactcaatcaggattgctgtgtggtctaccggctcatcaagggt
cgaaagacagtcaccgcctgggacacagccattgcacccctggatggcgaggagctcatt
gtggaggtcctcgaagacgtccccctgaccatgcacaattttgtacggaagacgttcttc
agcctggccttttgtgacttctgccttaagtttctgttccatggcttccgctgccaaacc
tgtggatacaagttccaccagcattgttcctccaaggtccccacagtctgtgttgacatg
agtaccaaccgccgacagttctaccacagtgtccaggatttgtgcggaggctccagacag
catgaggctccctcgaaccgccccctgaatgagccactcacccctcagggtcccagcctt
tcccctgccagctcctgcacccagcaccgcgatcccaagcacttccccttccctgccccg
gccaacgcccccctccagcgcatccgctccacatccacccccaacgtccacatggtcagc
accacggcccccatggactccggcctcatccagctccctgcccagagtttcaacactgac
gctgccgggaatagaggtggtggcgatggaaccccccgggggagccccagcccagccagc
atgtcctcggggaggaagtccccacattccaagtccccatcagagcagcgggagcggaag
tccttggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggctattac
tgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcgtttggg
accgtgtttcgtgggcggtggcacggcgatgtggccgtgaaggtgctcaaggtggcccaa
cccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaagacacgt
cacgtcaacatcttgctgttcatgggcttcatgacccggccgggatttgctatcatcaca
cagtggtgcgagggctccagcctctaccaccacctgcacgtggccgacacacgcttcgac
atggtccagctcattgatgtggcccggcagactgcccagggcatggactacctccatgcc
aagaacatcatccaccgagatctcaagtctaacaacatcttcctacacgaggggctcacg
gtgaagatcggggacttcggcctggccacagtgaagacgcggtggagtggggcccagcct
ttggagcagccctcgggctctgtgctatggatggcagctgaggtgatccgtatgcaggac
ccgaacccctacagcttccagtcggatgtctacgcctatggggttgtgctctatgagctc
atgaccggctcgctgccttacagccacattggcagccgtgaccagattatctttatggtg
ggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaaggccatg
aggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttcccccag
atcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagtgcctcc
gaaccctccttgcaccgtacccaggctgatgagttgcctgcctgcctactcagcgcagcc
cgccttgtgccttag

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