Phocoena sinus (vaquita): 116747589
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Entry
116747589 CDS
T07759
Symbol
MAP2K1
Name
(RefSeq) LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
psiu
Phocoena sinus (vaquita)
Pathway
psiu01521
EGFR tyrosine kinase inhibitor resistance
psiu01522
Endocrine resistance
psiu04010
MAPK signaling pathway
psiu04012
ErbB signaling pathway
psiu04014
Ras signaling pathway
psiu04015
Rap1 signaling pathway
psiu04022
cGMP-PKG signaling pathway
psiu04024
cAMP signaling pathway
psiu04062
Chemokine signaling pathway
psiu04066
HIF-1 signaling pathway
psiu04068
FoxO signaling pathway
psiu04071
Sphingolipid signaling pathway
psiu04072
Phospholipase D signaling pathway
psiu04114
Oocyte meiosis
psiu04140
Autophagy - animal
psiu04148
Efferocytosis
psiu04150
mTOR signaling pathway
psiu04151
PI3K-Akt signaling pathway
psiu04210
Apoptosis
psiu04218
Cellular senescence
psiu04270
Vascular smooth muscle contraction
psiu04370
VEGF signaling pathway
psiu04371
Apelin signaling pathway
psiu04380
Osteoclast differentiation
psiu04510
Focal adhesion
psiu04540
Gap junction
psiu04550
Signaling pathways regulating pluripotency of stem cells
psiu04613
Neutrophil extracellular trap formation
psiu04620
Toll-like receptor signaling pathway
psiu04650
Natural killer cell mediated cytotoxicity
psiu04660
T cell receptor signaling pathway
psiu04662
B cell receptor signaling pathway
psiu04664
Fc epsilon RI signaling pathway
psiu04666
Fc gamma R-mediated phagocytosis
psiu04668
TNF signaling pathway
psiu04720
Long-term potentiation
psiu04722
Neurotrophin signaling pathway
psiu04725
Cholinergic synapse
psiu04726
Serotonergic synapse
psiu04730
Long-term depression
psiu04810
Regulation of actin cytoskeleton
psiu04910
Insulin signaling pathway
psiu04912
GnRH signaling pathway
psiu04914
Progesterone-mediated oocyte maturation
psiu04915
Estrogen signaling pathway
psiu04916
Melanogenesis
psiu04917
Prolactin signaling pathway
psiu04919
Thyroid hormone signaling pathway
psiu04921
Oxytocin signaling pathway
psiu04926
Relaxin signaling pathway
psiu04928
Parathyroid hormone synthesis, secretion and action
psiu04929
GnRH secretion
psiu04934
Cushing syndrome
psiu04935
Growth hormone synthesis, secretion and action
psiu05010
Alzheimer disease
psiu05022
Pathways of neurodegeneration - multiple diseases
psiu05034
Alcoholism
psiu05132
Salmonella infection
psiu05135
Yersinia infection
psiu05160
Hepatitis C
psiu05161
Hepatitis B
psiu05163
Human cytomegalovirus infection
psiu05164
Influenza A
psiu05165
Human papillomavirus infection
psiu05166
Human T-cell leukemia virus 1 infection
psiu05167
Kaposi sarcoma-associated herpesvirus infection
psiu05170
Human immunodeficiency virus 1 infection
psiu05200
Pathways in cancer
psiu05205
Proteoglycans in cancer
psiu05206
MicroRNAs in cancer
psiu05207
Chemical carcinogenesis - receptor activation
psiu05208
Chemical carcinogenesis - reactive oxygen species
psiu05210
Colorectal cancer
psiu05211
Renal cell carcinoma
psiu05212
Pancreatic cancer
psiu05213
Endometrial cancer
psiu05214
Glioma
psiu05215
Prostate cancer
psiu05216
Thyroid cancer
psiu05218
Melanoma
psiu05219
Bladder cancer
psiu05220
Chronic myeloid leukemia
psiu05221
Acute myeloid leukemia
psiu05223
Non-small cell lung cancer
psiu05224
Breast cancer
psiu05225
Hepatocellular carcinoma
psiu05226
Gastric cancer
psiu05230
Central carbon metabolism in cancer
psiu05231
Choline metabolism in cancer
psiu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
psiu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
116747589 (MAP2K1)
04012 ErbB signaling pathway
116747589 (MAP2K1)
04014 Ras signaling pathway
116747589 (MAP2K1)
04015 Rap1 signaling pathway
116747589 (MAP2K1)
04370 VEGF signaling pathway
116747589 (MAP2K1)
04371 Apelin signaling pathway
116747589 (MAP2K1)
04668 TNF signaling pathway
116747589 (MAP2K1)
04066 HIF-1 signaling pathway
116747589 (MAP2K1)
04068 FoxO signaling pathway
116747589 (MAP2K1)
04072 Phospholipase D signaling pathway
116747589 (MAP2K1)
04071 Sphingolipid signaling pathway
116747589 (MAP2K1)
04024 cAMP signaling pathway
116747589 (MAP2K1)
04022 cGMP-PKG signaling pathway
116747589 (MAP2K1)
04151 PI3K-Akt signaling pathway
116747589 (MAP2K1)
04150 mTOR signaling pathway
116747589 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
116747589 (MAP2K1)
04148 Efferocytosis
116747589 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
116747589 (MAP2K1)
04210 Apoptosis
116747589 (MAP2K1)
04218 Cellular senescence
116747589 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
116747589 (MAP2K1)
04540 Gap junction
116747589 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
116747589 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
116747589 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
116747589 (MAP2K1)
04620 Toll-like receptor signaling pathway
116747589 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
116747589 (MAP2K1)
04660 T cell receptor signaling pathway
116747589 (MAP2K1)
04662 B cell receptor signaling pathway
116747589 (MAP2K1)
04664 Fc epsilon RI signaling pathway
116747589 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
116747589 (MAP2K1)
04062 Chemokine signaling pathway
116747589 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
116747589 (MAP2K1)
04929 GnRH secretion
116747589 (MAP2K1)
04912 GnRH signaling pathway
116747589 (MAP2K1)
04915 Estrogen signaling pathway
116747589 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
116747589 (MAP2K1)
04917 Prolactin signaling pathway
116747589 (MAP2K1)
04921 Oxytocin signaling pathway
116747589 (MAP2K1)
04926 Relaxin signaling pathway
116747589 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
116747589 (MAP2K1)
04919 Thyroid hormone signaling pathway
116747589 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
116747589 (MAP2K1)
04916 Melanogenesis
116747589 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
116747589 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
116747589 (MAP2K1)
04726 Serotonergic synapse
116747589 (MAP2K1)
04720 Long-term potentiation
116747589 (MAP2K1)
04730 Long-term depression
116747589 (MAP2K1)
04722 Neurotrophin signaling pathway
116747589 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
116747589 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
116747589 (MAP2K1)
05206 MicroRNAs in cancer
116747589 (MAP2K1)
05205 Proteoglycans in cancer
116747589 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
116747589 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
116747589 (MAP2K1)
05230 Central carbon metabolism in cancer
116747589 (MAP2K1)
05231 Choline metabolism in cancer
116747589 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
116747589 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
116747589 (MAP2K1)
05212 Pancreatic cancer
116747589 (MAP2K1)
05225 Hepatocellular carcinoma
116747589 (MAP2K1)
05226 Gastric cancer
116747589 (MAP2K1)
05214 Glioma
116747589 (MAP2K1)
05216 Thyroid cancer
116747589 (MAP2K1)
05221 Acute myeloid leukemia
116747589 (MAP2K1)
05220 Chronic myeloid leukemia
116747589 (MAP2K1)
05218 Melanoma
116747589 (MAP2K1)
05211 Renal cell carcinoma
116747589 (MAP2K1)
05219 Bladder cancer
116747589 (MAP2K1)
05215 Prostate cancer
116747589 (MAP2K1)
05213 Endometrial cancer
116747589 (MAP2K1)
05224 Breast cancer
116747589 (MAP2K1)
05223 Non-small cell lung cancer
116747589 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
116747589 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
116747589 (MAP2K1)
05161 Hepatitis B
116747589 (MAP2K1)
05160 Hepatitis C
116747589 (MAP2K1)
05164 Influenza A
116747589 (MAP2K1)
05163 Human cytomegalovirus infection
116747589 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
116747589 (MAP2K1)
05165 Human papillomavirus infection
116747589 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
116747589 (MAP2K1)
05135 Yersinia infection
116747589 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
116747589 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
116747589 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
116747589 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
116747589 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
116747589 (MAP2K1)
01522 Endocrine resistance
116747589 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
psiu01001
]
116747589 (MAP2K1)
Enzymes [BR:
psiu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
116747589 (MAP2K1)
Protein kinases [BR:
psiu01001
]
Serine/threonine kinases: STE group
STE7 family
116747589 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
Motif
Other DBs
NCBI-GeneID:
116747589
NCBI-ProteinID:
XP_032475869
Ensembl:
ENSPSNG00000002407
UniProt:
A0A8C9B7K5
LinkDB
All DBs
Position
2:complement(68857799..68937944)
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELVFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHVAGI
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcaaaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgccttgaggccttccttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggtgctggcaatggaggt
gtggtgttcaaggtctcccacaagccatccggtctggttatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatacgggagctgcaggttctacatgag
tgcaactccccttacattgtgggcttctacggtgcattctacagtgatggcgagatcagt
atctgcatggagcatatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcataagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggct
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctggtgtttgggtgccaggtggag
ggagatgcggctgagacaccgccccggccaaggactcccggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaattgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaagaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccacgtggctggtatctaa
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integrated database retrieval system
