Phocoena sinus (vaquita): 116748590 Help Entry 116748590         CDS       T07759                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism psiu  Phocoena sinus (vaquita) Pathway psiu04020   Calcium signaling pathway psiu04371   Apelin signaling pathway psiu04713   Circadian entrainment psiu04921   Oxytocin signaling pathway psiu04970   Salivary secretion psiu05010   Alzheimer disease psiu05012   Parkinson disease psiu05020   Prion disease psiu05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:psiu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116748590 (RYR3)    04020 Calcium signaling pathway     116748590 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     116748590 (RYR3)   09154 Digestive system    04970 Salivary secretion     116748590 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     116748590 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     116748590 (RYR3)    05012 Parkinson disease     116748590 (RYR3)    05020 Prion disease     116748590 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     116748590 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:psiu04040]     116748590 (RYR3) Ion channels [BR:psiu04040]  Voltage-gated cation channels   Ryanodine receptor    116748590 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  116748590 NCBI-ProteinID:  XP_032477612 Ensembl:  ENSPSNG00000005763 LinkDB All DBs Position 2:100302435..100702341 Genome browser AA seq 5219 aa AA seqDB search MQPEHHTMHGAALITKVQNGSSANFQTPPAAFGDFSLHVDSSSGVPENLLPGSTAQFLGG GSHGLKPSSLTPFLSEVQVPLAKSCDDTGELETVAPDIRELPLTDHLPSRLYSGRRSTMR QRYKGLAEKRKKESGYVVEEHTCPAEGPADDSLCCHLRPESGKEFSTLAVHQSPGETCTQ RPSLEIPIIWIRVLVAYSFLLRLTNRSDPLFLLTFMIFIQQASVACWPRESFANDPERRG RAKVPLAINSEMAKTDTPVLGLGGRGCKLEPDGDPALKGYKVNREELRETMDIEPGLEIS GSSTPRIQMSVLLKVCGDNSCCLERRQVRAATPDGVCSQVSTEHTVPDSMWKNAKVFGEG LLCHLRQEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCVCNFVL EQSLSVRALQEMLANTGEHGGEGAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRSQT DKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSVSNGN IQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTDQNDSQHRRLY YEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRGK SDTKSTAFSFEHQREIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIASGLWVTYKAQD AKTSRLGPVKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTALFSQFVSGNSRTAA PVTLPIEEVLQTLHDLIAYFQPPEEEMQHENRQNKLRSLKNRQNLFKEEGMLALVLNCID RLNIYNSIAHFTGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLD RLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGV AVRANQNLICDNLLPQRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVD PFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVAS INQHLLKSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVSFSAGVKVRFL MGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGTTQFLSQASFI PCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSK LPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLRKVKLPKNYMMSNGYKPAPLDL SDVKLLPPQEMLVDKLAENAHNVWAKDRIRQGWTYGIQQDLKNKRNPRLVPYALLDERTK KSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSYAVRSGKWYFE FEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGC MINLDDASMIFTLNGELLITNKGSELAFADYEIDNGFVPICSLGLSQIGRMNLGMDASTF KFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQIEVVRIDGTMDSPPCLK VIHKTFGTQNGNATMIYCRLSVPVECHSSFSHSPCPDGDAFQKRKQMQEILSHTTTQCYY AIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMV WGGDVVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPNTKVFPAVFLQ PTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPSSFLKV EMERVSDRHGWVVQCLEPLQMMALYIPEENRCVDILELCEKEDLMWFHYHTLRLYSALCA LGNSRVAYALCSHVDLSQLFYAIDNKYLPGFLRSGFYDLLISIHLASAKERKLMMKNEYI IPITSSTRKIHLYPDESKRHGLPGVGPRTCLKPGFRFSPACFVMTNEEHQKQSPEIPLEL LKTKALSMLTEAVRCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVRQILLVI DPSVFGEHSGDTQDGAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLPESVKLQMCEL LSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTREFRSPP QEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEAEEEDTSWTGKFRAL VYKIKGSSKPEKERPTEEEERCPTTLKELISQTMICWAQEDQIQDAELVRMMFNLLRRQY DSIGELLQALRKTYTISQASVSDTVSLLAALGQIRCLLSVRMGKEEELLMINGLGDIMNN KVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYFCRISRQNQKA MFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCG LQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGP ALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSSEDHEDEEGVVHMGNAIMSFYS ALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSE PDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAV LALNRYICSAVLPLLTRCAPLFAGTEHYSSLIDSTLQTIYRLSKGRSLTKAQRDTIEECL LAICNHLRPSMLQQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLA VEDELHLTEKIFWGILDSLSHKRYDPDLFRMALPCLSAIAGALPPDYLDTRISATLEKQI SVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKYGISLDENVKT HPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALFQQRENEKLRSVSQA TQGNSYSPAPLDLSNVVLSRELQGMVEVIAENYHNIWAKKKKLELESKGGGSHPLLVPYD TLTAKEKFRDREKAQDLFKFLQVNGIVVSRGVKDMGLDASSMEKRFAYKFLKKILKYVDS AQEFIVHLETIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSG YASHKEKEMVASLFCKLAALVRHRISLFGNDSTTMVSCLHILAQTLDTRTVMKSGSELVK AGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILKSIFEHMAQ HQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPT LDCYNPLSVFNAKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAESGARYTEMPHV IEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIINNNLGIDEAS WMKRIAVYAQPIIGKARADLLRSHFIPTLEKLKKKAVKTVQEEEQLKADSKGDAQEAELL ILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKR EEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKRTKRRGDLYSIQTSLIVAA LKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLWNNLHLQEKSDDPAVKWQLN LYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVAC FRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEAEETEKQP DPLHQIILHFSRNALTERSKLEDDPLYTSYASMMAKSCQSGEDEEGEEDKEKTFEEKEME KQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDY LKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDE FTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSG KDVIDESGQHNFSKALAVTKQIFNSLTEYIQGPCVGNQQSLAHSRLWDAVVGFLHVFANM QMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMIL KFFDMFLKLKDLTGSDAFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADE NDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLTYFEPYLG RIEIMGEAKKIERVYFEISESSRTQWEKPQVKESKQQFIFDVVNEGGEQEKMELFVNFCE DTIFEMQLASQISESDSADRPEEEEEENEDSSYTLEVEGEEDDKSFECASAFAVACASVK RNVANFLKRATLKNLKKQCRKVKKMTLKELVKVFFSFFWTLFVGLFHLLFAILGGIFQIL WSTVFGGGLIEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVPEPGIATELVHFVKG ERGDADIMSDLFGLQSKKEGGLKHGPEVGLGDLSEITGKDEPPTLESTVREKRKAQAAET KAAHEAKGKVESEKADTEDGEKEDTAKEEQAEAGWADATKRKKRWCGQKIEKPEAFMASF FKGLEIYQTKLLHYLARNFYNLRLLALFVAFAINFILLFYKVTEEPLEEETEDIANLWNS FNDEEEEEAVVFFVLQESTGYMAPTLRALAVIHTIISLVCVVGYYCLKVPLVVFKREKEI ARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERI AELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTM SVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNF FRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETH TLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 15660 nt NT seq  +upstreamnt  +downstreamnt atgcagccggaacatcatacgatgcacggggccgccctgataacaaaggtccaaaatggc agcagtgctaactttcaaacccctcctgctgcctttggggacttcagcctacatgttgac agttcatctggggttcctgaaaatctgttacccggcagcacagcacagttcctgggggga ggcagccatggcctgaagccgagctctctcacaccctttctttctgaggtgcaggttccc ttggcaaagtcctgtgatgacactggagaactggaaaccgtggctcctgacatcagggag ctgccactgaccgatcatcttcctagtcgcctgtactcagggagaaggagtaccatgagg caacgttataaaggcctagcagaaaagagaaaaaaggaatcaggctatgttgtagaggag cacacctgccctgccgaggggcccgcagatgacagcctttgttgtcacctccgacctgag tctggaaaggagttctccaccctcgctgtgcatcagtcacctggggagacctgcacccag cgcccttccctagagattcccatcatttggatccgggtactcgtggcctacagcttttta ctccgattgaccaaccgttctgacccactgtttcttctcaccttcatgattttcattcaa caagcctctgtggcatgttggccacgtgagtcctttgcgaatgacccagagagaagaggg agagccaaggtgcctctggccatcaactccgagatggcgaaaacggacactccagtcctt gggctgggaggcagggggtgtaaacttgaaccagatggggatcctgccctcaaggggtac aaagtcaaccgagaggagctgagagagaccatggatatagagcctggactggagatttcc gggtcaagcactccaaggatccagatgtctgtcttattgaaggtttgtggagataatagc tgctgtctggagcgaaggcaggtacgggctgccacgccagatggtgtctgtagccaggtc agcacggagcatacggttccagacagcatgtggaaaaatgcgaaagtgtttggagaaggc ctcctctgtcacctccggcaggaagatgaagtggtcctccagtgcatcgccaacattcac aaggaacagaggaagttctgcctggcagctgagggacttgggaatcgcctgtgcttcttg gaacccacttcagaagccaagtatgttcctccagatctctgcgtctgcaattttgtactg gaacagtccctctctgtcagagccctacaggaaatgcttgccaacacaggtgaacatggc ggcgaaggggctgcacaagggggtggccacaggaccctgctgtacggccacgcgattctc ctgcggcactccttcagcggaatgtatctaacatgtttgactacatcaagatcccagaca gataaacttgcctttgatgtaggtctacgggaacatgccacaggagaagcctgttggtgg accatacatcccgcttccaagcagaggtctgagggagaaaaggttcgaattggtgatgac ctcatccttgtcagcgtatcctctgaaagataccttcatctctcagtatcaaatggtaac atacaagtggatgcctcctttatgcaaacactctggaatgtacatcctacgtgctcggga agtagcatcgaagaaggatacctacttggtgggcatgtagtacgtcttttccatggtcac gatgagtgtttgacaataccatctacagaccagaatgattcccagcacaggaggttatac tacgaagctgggggagctggcacgagagccagatctctgtggagagtggaaccccttcgg ataagttggagtggcagtaacatcagatggggccaggctttccgacttcggcatctcacc acaggccactacctggccttgacagaggaccaaggccttatactgcaagaccggggaaaa tcagacaccaagtccacagccttctctttcgagcatcaaagggaaatcaaggagaaactg gattccagtcacaagcgagatatagagggcatgggagtcccagaaatcaagtacggagac tctgtctgctttgtccaacatatagccagtggtctctgggtgacctacaaagcacaagat gccaagacatcccgcctgggacctgtgaaaagaaaggtcatactccatcaggaaggccac atggatgacgggttaacactgcagagatgccagcatgaggagtcccaggctgcccggatc atccggaacacgaccgctttattcagccagtttgtaagtggaaacagccgcacagcagcc cctgtcaccctgccgatagaagaggtcctgcagaccttacacgacttgatcgcctacttc cagcccccggaggaggagatgcagcatgagaacaggcagaacaagctccgctcactcaaa aacagacagaatcttttcaaggaagagggaatgttggcccttgtgttaaactgcattgat cgcttaaatatctacaatagcatagcacacttcacagggattgccagggaggagagtggg atggcctggaaagaaattctgaacctcctctacaaattgctggctgctctcattcgtgga aacagaaacaattgcgctcaattctccaataaccttgattggctaatcagcaaattggac agactagaatcttcctcaggtatcttggaagttttgcactgcatcctgattgaaagccca gaagccttaaacctgatagcagaaggccacatcaagtcaatcatctccctgttggataag cacgggcgaaatcacaaggttctggacgtgctgtgttccctctgtctctgcaatggggtc gcagtgagagccaaccagaatctgatctgtgacaacttgctgccccagagaaacctgctc ctgcagacgcggctcattaacgatgtgacaagtattcggccaaacatcttcctgggagtc gctgagggttcagcacagtacaagaagtggtacttcgagctaatcatcgaccaggtggac cccttcctcacagcagagcccacacacctgcgggtgggctgggcctcttcctcaggctat gccccataccccggaggcggagaaggatgggggggcaacggtgttggcgatgacctgtac tcctacggctttgacggacttcacctttggtcaggccgcatacccagagccgtggcctcc atcaaccagcacctcctgaagtcggacgatgtggtgagctgttgcctggacctcggagca cccagcatctctttccgcatcaacgggcagcctgtgcaggggatgtttgagaacttcaac acagatgggctcttcttccctgtggtgagcttttcagcaggtgtcaaagtacgtttcctg atggggggacgtcacggagaatttaagttcctgcctccctctggctatgccccttgctac gaagccttacttccaaaagaaaagatgagattggagcccgtcaaagagtataaacgtgat gctgaaggtgttcgagatctgctgggtaccacccagttcctctcccaagcttctttcatt ccgtgccccatagataccagtcaggttgttttaccacctcacctagagaagatccgagac aggctggctgaaaacatccacgagctttggggaatgaataaaatagagcttggctggact tttggcaagatacgggatgacaacaaaagacaacacccctgccttgttgagttttcaaag ctacctgaaactgagaagaattataacctacaaatgtcaactgaaaccttaaaaaccctc ctggccctggggtgccacatcgctcacgttaacccagctgctgaggaggatctcaggaag gtcaagttgcccaaaaactacatgatgtccaatggctataagccagcccctttggatttg tctgatgtgaagctgttacctcctcaagaaatgttagtggataagcttgcagaaaatgca cacaatgtttgggcaaaagacagaataagacaaggatggacctatggcattcaacaggat ttaaagaacaaaagaaatccccgtctggtgccgtatgcattattggatgagcgtaccaag aagtcaaatagggatagccttcgtgaagctgttcggacttttgttggctatggctataac attgagccatcagaccaagaactagccgacccagctgtggagaaagtcagcatagacaag atccgctttttccgggtagagcgctcttatgcagtgagatctggaaagtggtattttgag tttgaggtagtgaccggaggagacatgcgtgtcggctgggccaggccaggctgtcggcct gacgttgagctgggggccgatgaccaagcctttgtgtttgaaggcagcaggggccagcgt tggcatcaagggagtgggtattttggacggacctggcagccaggagatgtggttggatgt atgattaacctggatgatgcttcaatgatcttcacgctgaatggggagttgctgatcacc aacaaaggctctgagcttgccttcgctgactacgagatcgacaatggctttgtgcccata tgctctctgggcctgtctcagatcggccgcatgaatctcgggatggacgccagcaccttc aagttttataccatgtgcggcctccaagagggctttgagccttttgctgtcaacatgaac cgcgacgtggccatgtggttcagcaagcgcctcccaacatttgtcaacgtgcccaaggat catccacagatagaggtggtgaggatcgatggcaccatggacagccctccgtgcctcaag gtgatccacaagacgttcggcacgcagaacggcaatgccaccatgatctactgccgcctc agcgtgccggtggagtgccactcctccttcagtcacagcccatgtccggacggtgacgct ttccagaaaaggaaacagatgcaagaaatactctctcatacaacaacacagtgctactac gcaattcgcatctttgctggacaggacccctcctgcgtctgggtcggatgggtgactccc gactatcatttgtacagtgaaaagtttgacttgaataaaaactgtaccgtgactgttact ctgggggacgaaagaggccgggtccacgaaagtgtgaagcgcagcaactgctacatggtc tggggtggggacgtcgtggccacgtcccaaagagcaagtcgcagcaacgtggacctagag atcggctgcctcgtggatctggcaatgggcatgttgtccttctcggccaacgggagggaa ctcggcacctgctaccaggtggagcccaataccaaggtgtttccagcggtcttcctgcag cctacaagcacctctttgtttcagtttgaacttgggaagctgaagaacgccatgcccctg tcggcagccatatttaagagtgaagagaaaaaccccgtcccgcagtgcccaccacggctg gacgtccaaaccatccagcccgtcctctggagccgtatgcccagcagcttcctgaaggtg gagatggagcgggtgagcgaccgccatggctgggtggtgcagtgcctggagcctctacag atgatggcgctctacatccccgaggagaacaggtgtgtggacatcctggagctctgcgag aaggaggacctcatgtggttccattaccacacactgagactctacagcgccttgtgcgcc ctgggaaacagccgggtggcttacgccctgtgcagccacgtggacctctcccagctcttc tatgccattgacaacaagtacctccccggcttcctgcgctccggcttctatgaccttctc atcagcatccacctggccagcgctaaggagaggaagctgatgatgaagaatgagtacatc atccccatcaccagcagcaccaggaaaatccacctgtacccggacgagtccaagaggcat gggctccctggggtgggcccgagaacatgcctcaagccagggttcaggttctcccccgcc tgcttcgtcatgaccaacgaggaacaccagaagcagagccccgagattcccttggagctt ctcaagacgaaggcgctgagcatgctgacggaggcagtgcggtgcagtggggctcacatc cgggaccccgtcggggggtccgtggagttccagttcgtgcctgtgctgaaactcatcgga accctgctggtcatgggggtgtttgacgatgacgatgttcggcagatcctccttgtcatc gacccctccgtgtttggggagcacagtggggacacacaggacggagcagagaaggaggag gtgacccaggtggaggagaaggctgtggaggctggggaaaaggccagcaaggaggctccc gtcaaaggcttgttgcagacccgattaccggagtccgtcaagctgcagatgtgtgagctc ctcagctatctctgtgactgtgagctgcaacaccgggtggaggccatcgtggcctttggc gacatttatgtctccaagctccaggcgaatcagaagttccgctacaacgaactcatgcag gccctgaacatgtctgcggccctgactgctcggaagaccagggagttccgctcacccccg caggagcagatcaacatgcttcttaactttcaactgggggagaactgcccgtgcccagaa gagatccgggaggagctgtatgacttccacgaggaccttctcattcactgcggggttccc ctggaggaagaggaagcggaagaggaggacacctcctggactggaaaattccgtgccttg gtgtataaaatcaaaggctcttccaagccagagaaggagcggccgacagaggaggaggag agatgccctacgacactgaaggagctcatctcacagaccatgatctgctgggcccaggag gaccagatccaggatgcagagctggttcggatgatgttcaacctcctgcggaggcagtac gacagcatcggggagctgctgcaggcgctgcggaagacttacaccatcagccaggcctct gtgagcgacaccgtcagcctgctggctgccctgggccagattcgctgcctgcttagtgtc cggatgggcaaggaggaggagctgctcatgatcaacgggctgggagacataatgaacaac aaggtgttttaccagcaccccaacctcatgcgagtcctcggcatgcacgagacagtcatg gaggtgatggtgaacgtgctgggtgcagagaaatctcagattgcctttccaaagatggtt gctagctgttgccgcttcctgtgctatttctgtcgaattagccgacaaaatcagaaggcc atgtttgagcatctcagttacctgctggagaatagcagtgttggcctagcctccccgtcc atgagaggatccaccccgctggacgtggctgcttcctctgtgatggacaacaatgagtta gcgctgggcttagaggaaccagacctcgagaaggtggtgacctacttggcaggctgtggc ctacagagctgccccatgcttctggccaaaggataccctgatgtcggctggaaccccatt gaaggggagcgctacctgtccttcctgaggtttgccgtcttcgtgaacagtgaaagtgtg gaagaaaacgccagcgtcgtggtcaagctgctcatcagacgccccgagtgcttcggcccg gccctgcggggtgaaggaggaaatggtctattggcggccatgcaaggcgccattaagatc tccgagaacccagccctcgacctcccctcgcaggggtacaagagagaagtcagctcggag gaccatgaagacgaagaaggggtcgtgcacatgggcaatgcaattatgtcattttattcg gctcttatagatctgctgggccgctgtgctcctgaaatgcaccttatccagacaggaaag ggggaagccatccggatcaggtccatcctgcgctccctggtccccaccgaggacttggtt ggaatcatcagcatccccttgaaactgccctccctgaacaaagatggatcagtcagcgaa ccagatatggcggccaacttctgccccgaccacaaggcacccatggtgctgttcttggac cgtgtttatggtataaaggatcaaactttcctgctccacttgttggaagttggattttta cctgacttaagagcctctgcctctttagatacagtctccctaagcaccaccgaggccgtg ctggcactgaacaggtacatatgttctgccgtgctcccgcttctcacaagatgcgcccct ctctttgctggaacagagcactattcctctttgatcgactctacactgcagacgatatac aggctttccaagggccgttccctcaccaaagctcagagggacaccatagaggagtgtttg ctggccatttgcaatcacttgaggccttccatgttacagcaactcctgcgacgtctagtt tttgatgtgccgcaactcagtgaatactgcaaaatgcctctgaagcttctgacaaatcac tacgaacagtgctggaagtattactgtctgccgtcaggctgggggagctacggtctggct gtggaggatgagctgcatctgacagagaagatcttctgggggattcttgactccctttcc cataagaggtatgacccagatcttttccgaatggccctgccctgtctcagtgctatagct ggggccttgccaccagactatttagataccagaatctcagccacattggagaaacagatc tcagtggatgcagatggcaactttgaccccaagcctatcaacaccatgaatttctccttg cctgaaaagttggaatacatcgtcaccaagtatgctgagcactcgcatgataaatgggcc tgtgataagagtcagaatggatggaaatacggaatttccctggatgaaaatgtgaagacc catccattgatcaggcctttcaagacattaacagagaaggagaaggaaatttatcgctgg cctgccagagagtccctgaaaaccatgctggctgtgggctggacggtagagaggaccaaa gaaggagaagccctatttcaacagcgggaaaatgagaagcttcgaagcgtgtcccaggcc acccagggcaacagctacagccctgctcccctggatctctccaatgttgtgctgtccaga gagctccaggggatggtggaggtgatagctgagaactatcacaatatctgggccaagaag aagaagctggagctggagagcaaaggtggcggcagtcaccctcttttggtaccgtatgac accttgaccgccaaggaaaagttcagggaccgggagaaggcccaggacctgttcaagttc ctccaagtgaacggcattgtggtttctagaggtgtcaaggatatggggctggatgcctcc tccatggaaaagaggtttgcctataagtttttgaagaagatcctgaaatatgttgattct gctcaagagtttatcgtccatttggaaaccattgtcagcagtgggaaaactgaaaagtct ccccatgaccaggagatcaagttctttgccaaagttcttctcccactggttgaccagtac tttaccaatcaccgcctctacttcctctcgtcccctctgaagccccttagcagcagcggg tatgcctctcataaggagaaagaaatggtggccagcctgttctgcaaactcgctgctctt gttcgacataggatttccctctttgggaacgattctactacaatggtgagctgtcttcac atcttagctcagacacttgacacaaggacagtcatgaagtcaggctcagagctggtgaag gccgggttacgagcattctttgaaaatgcagccgaagacttagagaagacttcagaaaac ctgaagctcggcaagtttacccattccagaacgcagattaaaggcgtctctcagaatata aactacaccacggtggccctgctgcccatcctgaagtccatctttgagcacatggctcag catcagttcggggtggatttactcttgggtgacgtgcagatttcatgctaccatatactg tgcagcctctactcccttgggacaggaaagaacatctatgttgaaaggcaacgtcctgcc ctcggagaatgcctggcctcactggcagctgccataccagtggccttcctggagcccacc cttgactgctacaacccactctcagtcttcaacgccaaaacccccagggagaggtctatt ctggggatgccagacacggtggaggagatgtgccctgacatcccccagctggaaggcctg atgaaggaaatcaacgacctggccgagtcaggggcccggtacacggagatgccccacgtc atcgaggtgatcttacccatgctctgcaactacctgtcctactggtgggagcgggggccc gagcacctgccccccagcacagggccctggtgcaccaaggtcacctctgaacacctcagc gtcatcctgggcaacattctgaaaatcatcaacaacaacctgggcatcgatgaggcctcc tggatgaagcgcattgcagtgtatgcccagccaatcatcggcaaagccagggcggacctg ctaagaagccacttcatcccaactctggagaagctgaagaagaaggctgtgaagaccgtg caggaagaggagcagctgaaagccgacagcaaaggggacgcccaggaggcagagctcctc attctggatgagtttgccgtcctctgcagagacctctatgccttctaccccatgctgatc cgctacgtggacaacaacagatctaactggctcaaaagccccgatgctgactctgaccag ctcttccgcatggtggcagaggtcttcatcctgtggtgtaaatctcacaacttcaagagg gaagagcaaaattttgtgattcagaacgaaattaataatttggcatttttaactggagac agcaaaagcaagatgtcaaaagccatgcaagtaaagtctggaggacaggaccaggagagg aagaggacgaagcggaggggggacctgtattccatccagacctccctcatcgtggctgca ctcaagaaaatgctgcccattggtttgaatatgtgcaccccaggcgatcaggagctgatc tccctcgcaaaatcacggtacagctataaggacacagacgaagaggtgaaggagcatctg tggaataacttgcacttgcaggaaaagtccgatgacccagctgtaaagtggcaactgaac ctatacaaggatgttttgaagagtgaagaaccttccaacccagaaaagacagtggagcgt gtgcagagaatttcagcagctgtcttccacctagagcaggtggaacagcctttgaggtcc aagaaggcggtctggcacaaactgctatcaaagcagcggaaacgggcagtggtggcctgt ttcaggatggcccctctctacaacctgcccaggcaccgctctattaacctcttcctccat ggctatcagagattttggatagaaacagaggagtattcctttgaagagaaactagtacag gatttggctaaatctcccaaggtggaagaagaagaggcggaggagacagaaaagcagcca gacccacttcatcagatcatactccactttagccgcaatgctctcacagagaggagcaaa ctggaagacgaccctttgtacacctcctatgccagcatgatggccaagagttgtcagagt ggggaagacgaagaaggggaggaagacaaggaaaaaacgtttgaagagaaagaaatggaa aagcagaaaaccctctatcagcaagcgcggctgcatgagcgtggagccgcagagatggtc cttcagatgataagcgccagcaaaggtgagatgagccccatggtggtggagactctgaag ctggggatcgccattctgaatgggggcaacgctggcgtgcagcagaaaatgctagattac ctaaaggagaaaaaggatgctgggttctttcaaagcctttctggtcttatgcagtcttgc agtgtccttgatttgaatgcatttgagaggcagaataaagctgaaggcctggggatggtt actgaggaaggaacactcatcgttcgtgagcgtggtgaaaaagtactccagaatgatgag tttacacgagatctctttagattcctacagttactttgtgaaggacataacagtgatttc cagaacttcctgcggactcagatgggcaacaccaccaccgtgaacgtcatcatcagtact gtggactacctcctgcgtctgcaggaatcaatcagtgacttctactggtattattcaggg aaggacgtcattgatgaatctggacagcacaatttttccaaagccctggcggtcaccaag cagattttcaattctcttacggaatatatccagggcccctgcgttgggaaccagcagagc ctcgctcacagtaggctatgggatgcagtggtcggcttcctccacgtatttgctaacatg cagatgaaactctctcaggattccagtcagatcgagctgctgaaggaactcttggatctc cttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtggtaaatggaact attggcaagcagatggttgacacactggtagagtcctctaccaatgtagaaatgatcttg aaattctttgacatgttcttgaaacttaaagacttaaccggctcagacgccttcaaagaa tatgaccccgatgggaaagggatcatctccaaaaaggaattccagaaggccatggaaggg caaaaacagtacacgcagtcggagattgactttctcctttcgtgcgcagaagcggatgag aatgacatgtttaattacgttgactttgtagaccggttccacgagccggccaaggacata gggtttaacgtggcggtgttattgacaaacctctccgaacatatgccaaacgattctcgc cttaagtgtctgttggacccagccgaaagcgtactcacttactttgaaccgtacctagga cgcattgagatcatgggtgaggccaagaaaattgagcgtgtttattttgagatcagtgag tccagtcgaactcagtgggagaagccccaggtgaaggagtctaagcagcagttcatcttt gatgtcgtcaacgaaggcggagagcaagagaagatggagctgttcgtgaacttctgtgaa gacaccatctttgagatgcagttagcatcacagatctcagaatcggactcagccgacagg ccggaagaggaggaggaagaaaatgaagactcttcctacacgttagaagttgagggtgaa gaggacgacaagtcttttgagtgtgcctctgcgtttgccgtggcctgtgcctcagtgaag agaaacgtggccaactttctgaagagggccaccctgaagaacctcaagaagcagtgtagg aaggtaaagaagatgactctgaaggagctggtgaaggtgttcttctctttcttctggact ttgttcgtggggctcttccacttgctcttcgccatactgggaggaatctttcagattctc tggagcacagtgtttggagggggcctcatagaaggcgcaaagaacatcagagtcacaaag atcctgggtgacatgcctgacccaacccaatttggtatccacgatgatgcgatggaggct gagagggcagaagtgcccgagccaggtatcgccacggaactcgtgcacttcgtaaagggg gagaggggagatgcggatatcatgtcagatctctttggactccagtcaaagaaagaaggt ggcttaaagcatgggcctgaagtgggtttgggtgacctctctgagattactggcaaggat gaaccccccacgttagagagtactgtacgggagaaaaggaaagcacaggcagcagagacg aaagcagctcatgaagccaaaggaaaagtggagtctgagaaggcagacacggaagatggg gagaaagaggacacagccaaagaagagcaggccgaggccgggtgggcggatgcgaccaaa aggaagaagcgatggtgtggccagaaaattgagaagcctgaagccttcatggccagtttc tttaaagggctggaaatctatcagaccaagctgctgcactacctggccaggaatttctac aacctgaggctccttgctctgtttgtagccttcgctatcaacttcatcctgctcttttac aaggtcaccgaggaacctttagaagaagagacagaagacattgcaaacctgtggaattcc tttaatgatgaggaagaggaagaagcagtggtattctttgtcctgcaggagagcactgga tatatggcgccaacattgcgagccctggccgttatccacaccatcatttctttagtctgc gtggtgggctattactgcctgaaggttcctttggtggtattcaaaagagaaaaagaaatt gccaggaagctggagtttgatggcctgtatatcaccgaacagccttctgaagatgacatc aaggggcaatgggatcgcttggtaatcaacacaccatcttttcctaataactactgggac aagtttgtaaagagaaaggtgatcaacaagtatggagatctctacggagcagaacgcatt gctgaactcctggggttggacaaaaatgccctcgactttagcccagtagaagagaccaaa gcagaggcagcctccctggtgtcatggctaagttccatcgacatgaagtaccatatctgg aagctgggagttgtttttactgacaattcctttctctacctcgcctggtacacgaccatg tcagtcctgggccactacaacaacttcttcttcgctgctcatctgctggatatcgcgatg ggcttcaagactctgaggactattctgtcatctgtcactcacaatggcaaacagttggtc ctgactgtcggtctcctggccgtggtggtttacctctataccgtggtggcgttcaacttc ttccgcaagttctacaacaaaagtgaagacgacgatgagcccgacatgaagtgtgatgac atgatgacgtgttacctgttccacatgtatgtgggagtgagagctggaggtggcattggc gatgaaattgaagaccccgctggggacccgtacgaaatgtaccgcatcgtctttgacatt acattcttcttctttgtcattgtcatcctgctggccatcatccaaggtcttattattgat gcttttggggagctgagagaccagcaggaacaagtacgagaggatatggagactaaatgt ttcatctgtgggatcggcaatgactactttgacacgacccctcatggctttgaaacacac accttacaagagcacaacttagccaactacttgttcttcctgatgtatttgattaataaa gatgaaacagagcacacaggtcaggaatcttatgtctggaagatgtaccaagaaaggtgt tgggatttcttccctgctggtgactgcttccggaaacagtacgaagatcagcttggataa

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