Phocoena sinus (vaquita): 116752059
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Entry
116752059 CDS
T07759
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
psiu
Phocoena sinus (vaquita)
Pathway
psiu00310
Lysine degradation
psiu01100
Metabolic pathways
psiu05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
psiu00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
116752059 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
116752059 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
psiu03036
]
116752059 (DOT1L)
Enzymes [BR:
psiu01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
116752059 (DOT1L)
Chromosome and associated proteins [BR:
psiu03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
116752059 (DOT1L)
HMT complexes
Dot1-containing complex
116752059 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
116752059
NCBI-ProteinID:
XP_032484547
Ensembl:
ENSPSNG00000016605
LinkDB
All DBs
Position
3:1587646..1645047
Genome browser
AA seq
1730 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKTAMPADTPMDSGAEEEKAGATTVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTT
NPERKPKKTQSALDLLHAQTVSRAASPSPQGAPYQLPPSTQRRPPEQLLLAPAPPALHRL
LESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNARLLGAVQQLFGHCQAQKEEIKRLF
QQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLRLLKARCEEL
KLDWSTLSLEGLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDD
ALSLHLRGKGGLGRELEAEPGRPHLELDCARFSLPHLSNMSPELSMNGHAAGYELCGALS
RPSPKQNTPQYLASPLDQEVVPCTPNHSGRPRLEKLSGLALPDYTRLSPAKLVLRRHLSQ
DHTANSRATASELHSRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPAALQMTGEKGSE
KREQAGPVVCLQGLKERTYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEK
VRSTPSPVPQARESSSTLEKQMGAGTHGSGCSAAGSRSLALAPAGFAYAGSVAISGALAG
SPAPLVSGAEPPTLDESSSSGSLFATVGSRSSTPQHPPLLAQPRNCGSASPAPQLCASPR
LGAQGPLPDTSKGDLPSEAGFSDPESEAKRRIVFTISAGSSSAKQSPSSKHSPLSSGARG
DGGQSHGQDSRKRGRRKRAAAGTPGFSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSN
INQPLEITAISSPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSED
EPSSARIERKIATISLESKSPPKTLENGGGLAGRKVSASEPVNSSKWKSTFSPISDLGLA
KAADSPLQAASALSHNSLFAFRPGLEEPGAADAKLAAHPRKSFPGALPGAGGLSPSSHPA
SSFALGGGLAADLSLHSFSDGASLSHKAPEAAGLGTPLSFPGPRGKEGGAADPGPFVNKR
QLDGLAPKGEGGPPVCGPADKASATHGKAGKGRDREPDVKNGHNLFMAAAAAAAAAAAAP
PGGLLSGPGLAPAASSAGGTAPSVQTHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLF
SSVPAAGLVHVSTAATRLTNSHAMGSFSSGVAGGAVGGAFNHAVPPASAHPFGASFGSGA
ACRSATLSLTPLQAVASTPASSFQAPPPAEPRPPPPPPHLGRPPPGPPALHAPPPPNAAL
PPPPALLPANSEPVLLQNLASLPANQAFLPASSAASVPPANASLSIKLASLPHKVSRPSF
TVHHPPLPGLALAQAAPVIPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq
5193 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggctgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atccggtgggtctgtgaagaaatcccagatctcaagctcgctatggagaattatgtttta
atcgactacgacaccaaaagcttcgaaagcatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacgcagcccatgaagctgaacaca
cggccgtccacggggctcctgcgccacatcctgcagcaggtctacaaccactcggtgacc
gaccccgagaaactcaacaactatgagcccttctccccggaggtgtacggggagacttcc
ttcgacctggtcgcccagatgatcgacgagatcaagatgaccgaagacgacctgtttgtg
gacctgggtagcggagtgggccaggttgtgctgcaggtcgctgcggctaccaactgcaaa
catcactatggtgtcgagaaagctgacatcccggccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagaga
ggagatttcctctcagaggagtggagagagcggatcgccaacacgagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggttcgcaaacatg
aaggaaggtggcagaattgtgtcctcgaagccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgcctctaaaa
ggctcggtgtcgtggacggggaagccggtgtcttactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacgaccacccccaccaaggtgccc
gagagcaagacggccatgcccgccgacacccccatggactctggtgctgaggaagagaaa
gccggggcaaccactgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggccggccggaagcgcggacgtcccaagaagatgagcaccacc
aaccctgagcgcaagcccaagaagacccagagcgcactggacctgctgcatgcccagacc
gtgtcgcgggcggcgtcgccctcgccgcagggcgccccctatcagctacctcccagcacg
cagcgacgcccccctgagcagctgctgctggcgcccgccccgcctgccctacaccggctg
ctagaatccttcaagattcagtacctacagttcctggcgtacacaaagacccctcagtac
aaggccaacctgcagcagctgctggaccaggagaaggagaagaacgcccggttgctgggc
gccgtgcagcagctgttcggccactgccaagctcagaaggaggagatcaagaggcttttc
cagcagaaactggatgagctgggagtgaaggcgctgacctacaacgacctgatccaagcg
cagaaggagatctcagctcataaccagcagctgagggagcagacggagcagctggagaag
ggcaaccgggagctgaggagccagagcctgcggctgctcaaggcacggtgcgaggagctg
aagctggactggtccacgctgtcccttgagggcctgctgaaggagaagcaggccctgaag
agccagatctcggagaagcagaggcactgcctggagctgcagatcagcattgtggagctg
gagaagagccagaggcagcaggagctcctgcagctcaagtcctgcgtgccgcccgacgac
gccctgtccctgcacctgcgcgggaagggtggcctgggccgagagctggaggccgagccc
ggccggccacacctggagctggactgtgccaggttctccctgccccacttgagcaacatg
agcccggagctgtccatgaacggccacgcggccggctatgagctctgcggcgcgctgagc
cggccctcgcccaagcagaacaccccccagtacctggcctcccccctggaccaggaggtc
gtgccctgcaccccgaaccacagtggccggccgaggctcgagaagttgtccggcctggcc
ctgcccgactacaccaggctctccccggccaagctggtgctgcggcgccacctgagccaa
gaccacacagccaacagcagggcgaccgccagcgagctgcactcacgagctgagcatgcc
aaggagaacggcctcccgtaccagagccccggcatcgccaacggcatcaaactgagccca
caggaccctcggccctcgtcccctgcggccttgcagatgacgggagagaagggcagtgag
aagcgggagcaggctggcccggtggtgtgtctgcagggtttgaaggagcgcacctacgcc
agcagtggggaggccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcct
agcaagctgccagtcagcatccctctggccagcgtggtgctgcccagccgcgccgagaag
gtgagaagcacccccagccccgtgccacaggcccgagagtcctcgtccacactggagaag
cagatgggtgctggcacccacggctccgggtgcagtgctgctgggagcagaagcctcgcc
ctggcccctgcaggctttgcctacgccggctcagtggccatcagtggggccctggcaggc
agcccggcaccactcgtctctggagccgagccccccaccctggacgagtcctccagctcc
ggaagcctctttgccactgtggggtcccgcagctccacccctcagcacccccccctgctg
gcgcagcctcgcaactgcggctcggcctcgccggccccccagctctgcgccagtccccgg
cttggcgcccagggcccgctccccgacaccagcaaaggagacctgccctctgaggccggc
ttctcggatcccgagagtgaagccaagagaaggatcgtcttcaccatctcggccggctct
agcagcgccaaacagtcaccttccagcaagcacagccctctgtcctcgggcgcccgcggt
gacggcggccagagccacgggcaggacagccgcaagaggggcaggaggaagcgggcagcg
gcggggacccccggcttcagctcgggcgtgtcccccaagcgccgggccctgccgtccgtc
gccggcctcttcacccagtcttcagggtcccccctgaacctcaactccatggtcagcaac
atcaaccagcccttggaaatcacggccatctcgtcccccgagagttccctgaagagctcg
cctgtcccttaccaggacaacgaccagccgcccgtgctcaagaaggaaaagcccctgagc
cagaccaacggggcccactattccccgctgacctcggatgaggagcagggctctgaggac
gagcccagcagtgccagaattgagagaaaaattgcaaccatctccttagaaagcaaatct
cctccgaaaaccttggaaaatgggggcggcctggcgggaaggaaggtgtcggccagcgag
ccggtcaacagcagcaagtggaagtccaccttctcgcccatctccgacctcggcctggcc
aaggcagccgacagcccgctgcaggccgcctccgctctgagccacaactccctgttcgct
ttccggcccggcctggaggaacctggcgcggctgacgccaagctggctgcccaccccagg
aagagcttcccaggcgcgctgccgggggcgggcgggctgagccccagcagccatcccgcc
agcagcttcgccctgggcgggggcctggcggctgacctcagtttacacagcttcagcgat
ggtgcttctctctcccacaaggcccccgaggcggccggcctgggcacccccctgagcttt
cccggcccgcggggcaaggagggcggcgccgcagaccccggccccttcgtgaacaagagg
cagctggacggactggccccgaagggcgaggggggcccacctgtgtgcggacccgcggac
aaggcctcagcgacgcacggcaaggcgggcaagggccgtgaccgcgagcccgatgtcaag
aacggccacaacctcttcatggccgctgctgctgctgccgccgctgccgccgccgccccc
cccgggggcctcctcagcggcccgggccttgccccggcggcgtcctcggcagggggcacg
gccccgtccgtccagacccaccgccccttcctgggcgccttcgcccccggcccgcagttc
gcactgggccccatgtccctgcaggccaacctgggcccgtccgtgctgcagtccctgttc
agctccgtgcccgccgccggcctggtgcacgtctcaaccgctgccaccagactgaccaac
tcgcacgccatgggcagcttctcctccggggtggccggcggtgcagtcggaggtgccttt
aaccacgcggtgcctcccgcctccgctcatccgtttggagccagtttcggcagtggggct
gcatgtcgcagcgccacgctgagcctaaccccgctgcaggcggtggccagcaccccggcc
tcttcctttcaggccccgccccctgcggagccgaggccgcccccgccccctccgcacctg
ggccggccccctccggggccgcccgccctccacgccccgccccctcctaacgccgccttg
cctccgccccccgcgctgctcccggctaactctgagcccgtgctcctgcagaacctcgcg
tccctcccagctaaccaagctttcttacctgcctcctctgctgcctctgtgccgcctgct
aacgcctctctgtccatcaagctcgcctcacttccgcacaaggtgtcccgcccctccttc
acggtgcaccacccgcccctgcccgggctggccctggcccaggccgcgcccgtgatcccg
caggccagctccacggggccgcccgccgtgtgggtttcccttggcatgccacctccgtat
gccgcgcgccttgcgggggttaagccgcgataa
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