KEGG   Phocoena sinus (vaquita): 116752990
Entry
116752990         CDS       T07759                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
psiu  Phocoena sinus (vaquita)
Pathway
psiu00562  Inositol phosphate metabolism
psiu01100  Metabolic pathways
psiu01521  EGFR tyrosine kinase inhibitor resistance
psiu01522  Endocrine resistance
psiu01524  Platinum drug resistance
psiu04012  ErbB signaling pathway
psiu04014  Ras signaling pathway
psiu04015  Rap1 signaling pathway
psiu04024  cAMP signaling pathway
psiu04062  Chemokine signaling pathway
psiu04066  HIF-1 signaling pathway
psiu04068  FoxO signaling pathway
psiu04070  Phosphatidylinositol signaling system
psiu04071  Sphingolipid signaling pathway
psiu04072  Phospholipase D signaling pathway
psiu04081  Hormone signaling
psiu04140  Autophagy - animal
psiu04150  mTOR signaling pathway
psiu04151  PI3K-Akt signaling pathway
psiu04152  AMPK signaling pathway
psiu04210  Apoptosis
psiu04211  Longevity regulating pathway
psiu04213  Longevity regulating pathway - multiple species
psiu04218  Cellular senescence
psiu04360  Axon guidance
psiu04370  VEGF signaling pathway
psiu04380  Osteoclast differentiation
psiu04510  Focal adhesion
psiu04550  Signaling pathways regulating pluripotency of stem cells
psiu04611  Platelet activation
psiu04613  Neutrophil extracellular trap formation
psiu04620  Toll-like receptor signaling pathway
psiu04625  C-type lectin receptor signaling pathway
psiu04630  JAK-STAT signaling pathway
psiu04650  Natural killer cell mediated cytotoxicity
psiu04660  T cell receptor signaling pathway
psiu04662  B cell receptor signaling pathway
psiu04664  Fc epsilon RI signaling pathway
psiu04666  Fc gamma R-mediated phagocytosis
psiu04668  TNF signaling pathway
psiu04670  Leukocyte transendothelial migration
psiu04722  Neurotrophin signaling pathway
psiu04725  Cholinergic synapse
psiu04750  Inflammatory mediator regulation of TRP channels
psiu04810  Regulation of actin cytoskeleton
psiu04910  Insulin signaling pathway
psiu04914  Progesterone-mediated oocyte maturation
psiu04915  Estrogen signaling pathway
psiu04917  Prolactin signaling pathway
psiu04919  Thyroid hormone signaling pathway
psiu04923  Regulation of lipolysis in adipocytes
psiu04926  Relaxin signaling pathway
psiu04929  GnRH secretion
psiu04930  Type II diabetes mellitus
psiu04931  Insulin resistance
psiu04932  Non-alcoholic fatty liver disease
psiu04933  AGE-RAGE signaling pathway in diabetic complications
psiu04935  Growth hormone synthesis, secretion and action
psiu04960  Aldosterone-regulated sodium reabsorption
psiu04973  Carbohydrate digestion and absorption
psiu05010  Alzheimer disease
psiu05017  Spinocerebellar ataxia
psiu05020  Prion disease
psiu05100  Bacterial invasion of epithelial cells
psiu05132  Salmonella infection
psiu05135  Yersinia infection
psiu05142  Chagas disease
psiu05146  Amoebiasis
psiu05160  Hepatitis C
psiu05161  Hepatitis B
psiu05162  Measles
psiu05163  Human cytomegalovirus infection
psiu05164  Influenza A
psiu05165  Human papillomavirus infection
psiu05166  Human T-cell leukemia virus 1 infection
psiu05167  Kaposi sarcoma-associated herpesvirus infection
psiu05168  Herpes simplex virus 1 infection
psiu05169  Epstein-Barr virus infection
psiu05170  Human immunodeficiency virus 1 infection
psiu05171  Coronavirus disease - COVID-19
psiu05200  Pathways in cancer
psiu05203  Viral carcinogenesis
psiu05205  Proteoglycans in cancer
psiu05206  MicroRNAs in cancer
psiu05207  Chemical carcinogenesis - receptor activation
psiu05208  Chemical carcinogenesis - reactive oxygen species
psiu05210  Colorectal cancer
psiu05211  Renal cell carcinoma
psiu05212  Pancreatic cancer
psiu05213  Endometrial cancer
psiu05214  Glioma
psiu05215  Prostate cancer
psiu05218  Melanoma
psiu05220  Chronic myeloid leukemia
psiu05221  Acute myeloid leukemia
psiu05222  Small cell lung cancer
psiu05223  Non-small cell lung cancer
psiu05224  Breast cancer
psiu05225  Hepatocellular carcinoma
psiu05226  Gastric cancer
psiu05230  Central carbon metabolism in cancer
psiu05231  Choline metabolism in cancer
psiu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
psiu05415  Diabetic cardiomyopathy
psiu05417  Lipid and atherosclerosis
psiu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:psiu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    116752990 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    116752990 (PIK3CA)
   04014 Ras signaling pathway
    116752990 (PIK3CA)
   04015 Rap1 signaling pathway
    116752990 (PIK3CA)
   04370 VEGF signaling pathway
    116752990 (PIK3CA)
   04630 JAK-STAT signaling pathway
    116752990 (PIK3CA)
   04668 TNF signaling pathway
    116752990 (PIK3CA)
   04066 HIF-1 signaling pathway
    116752990 (PIK3CA)
   04068 FoxO signaling pathway
    116752990 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    116752990 (PIK3CA)
   04072 Phospholipase D signaling pathway
    116752990 (PIK3CA)
   04071 Sphingolipid signaling pathway
    116752990 (PIK3CA)
   04024 cAMP signaling pathway
    116752990 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    116752990 (PIK3CA)
   04152 AMPK signaling pathway
    116752990 (PIK3CA)
   04150 mTOR signaling pathway
    116752990 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    116752990 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    116752990 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    116752990 (PIK3CA)
   04218 Cellular senescence
    116752990 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    116752990 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    116752990 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    116752990 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    116752990 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    116752990 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    116752990 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    116752990 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    116752990 (PIK3CA)
   04660 T cell receptor signaling pathway
    116752990 (PIK3CA)
   04662 B cell receptor signaling pathway
    116752990 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    116752990 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    116752990 (PIK3CA)
   04670 Leukocyte transendothelial migration
    116752990 (PIK3CA)
   04062 Chemokine signaling pathway
    116752990 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116752990 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    116752990 (PIK3CA)
   04929 GnRH secretion
    116752990 (PIK3CA)
   04915 Estrogen signaling pathway
    116752990 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    116752990 (PIK3CA)
   04917 Prolactin signaling pathway
    116752990 (PIK3CA)
   04926 Relaxin signaling pathway
    116752990 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    116752990 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    116752990 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    116752990 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    116752990 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    116752990 (PIK3CA)
   04722 Neurotrophin signaling pathway
    116752990 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    116752990 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    116752990 (PIK3CA)
   04380 Osteoclast differentiation
    116752990 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    116752990 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    116752990 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116752990 (PIK3CA)
   05206 MicroRNAs in cancer
    116752990 (PIK3CA)
   05205 Proteoglycans in cancer
    116752990 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    116752990 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    116752990 (PIK3CA)
   05203 Viral carcinogenesis
    116752990 (PIK3CA)
   05230 Central carbon metabolism in cancer
    116752990 (PIK3CA)
   05231 Choline metabolism in cancer
    116752990 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    116752990 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116752990 (PIK3CA)
   05212 Pancreatic cancer
    116752990 (PIK3CA)
   05225 Hepatocellular carcinoma
    116752990 (PIK3CA)
   05226 Gastric cancer
    116752990 (PIK3CA)
   05214 Glioma
    116752990 (PIK3CA)
   05221 Acute myeloid leukemia
    116752990 (PIK3CA)
   05220 Chronic myeloid leukemia
    116752990 (PIK3CA)
   05218 Melanoma
    116752990 (PIK3CA)
   05211 Renal cell carcinoma
    116752990 (PIK3CA)
   05215 Prostate cancer
    116752990 (PIK3CA)
   05213 Endometrial cancer
    116752990 (PIK3CA)
   05224 Breast cancer
    116752990 (PIK3CA)
   05222 Small cell lung cancer
    116752990 (PIK3CA)
   05223 Non-small cell lung cancer
    116752990 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    116752990 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    116752990 (PIK3CA)
   05161 Hepatitis B
    116752990 (PIK3CA)
   05160 Hepatitis C
    116752990 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    116752990 (PIK3CA)
   05164 Influenza A
    116752990 (PIK3CA)
   05162 Measles
    116752990 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    116752990 (PIK3CA)
   05163 Human cytomegalovirus infection
    116752990 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116752990 (PIK3CA)
   05169 Epstein-Barr virus infection
    116752990 (PIK3CA)
   05165 Human papillomavirus infection
    116752990 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    116752990 (PIK3CA)
   05135 Yersinia infection
    116752990 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    116752990 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    116752990 (PIK3CA)
   05142 Chagas disease
    116752990 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116752990 (PIK3CA)
   05017 Spinocerebellar ataxia
    116752990 (PIK3CA)
   05020 Prion disease
    116752990 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    116752990 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    116752990 (PIK3CA)
   05415 Diabetic cardiomyopathy
    116752990 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    116752990 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    116752990 (PIK3CA)
   04931 Insulin resistance
    116752990 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    116752990 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116752990 (PIK3CA)
   01524 Platinum drug resistance
    116752990 (PIK3CA)
   01522 Endocrine resistance
    116752990 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:psiu04131]
    116752990 (PIK3CA)
Enzymes [BR:psiu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     116752990 (PIK3CA)
Membrane trafficking [BR:psiu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    116752990 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 116752990
NCBI-ProteinID: XP_032486213
Ensembl: ENSPSNG00000000243
UniProt: A0A8C9AXI3
LinkDB
Position
4:56648964..56761263
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatctcaattcaccgcat
agtagagcaatgtacgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaagaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgacgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctactctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcacttagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttctatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttggagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggag
ctactggactgcaattacccagatcctatggttcgaggttttgctgttcgatgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctacttgtgaggtttttactcaaaaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatttgaag
cacctgaataggcaggttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaaatttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacagggctttctgtcgcctctaaaccctgctcatcag
ctgggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacgacaagatatgctaacacttcagattattcgtattatg
gaaaatatatggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtcc
attggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt
cagtgtaaaggaggcctgaaaggtgccctgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaagggagaaatatatgatgcagccatcgatctatttacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagagcgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacagtcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaggaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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