Piliocolobus tephrosceles (Ugandan red Colobus): 111520206
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Entry
111520206 CDS
T07491
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
pteh
Piliocolobus tephrosceles (Ugandan red Colobus)
Pathway
pteh05012
Parkinson disease
pteh05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
pteh00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
111520206 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
111520206 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pteh01001
]
111520206 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pteh04131
]
111520206 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
pteh04147
]
111520206 (LRRK2)
Enzymes [BR:
pteh01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
111520206 (LRRK2)
Protein kinases [BR:
pteh01001
]
Serine/threonine kinases: TKL group
LRRK family
111520206 (LRRK2)
Membrane trafficking [BR:
pteh04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
111520206 (LRRK2)
Exosome [BR:
pteh04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
111520206 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
COR
LRR_4
Ras
LRR_14
LRR_9
LRR_13
WDR55
Arf
Beta-prop_EML_2
Ank_2
Beta-prop_RSE1_2nd
WD40_CDC20-Fz
LRR_NXF1-5
nSTAND3
Beta-prop_BBS7
T2SSE
AAA_22
ABC_tran
G-alpha
AAA_7
Kdo
LRR_6
WD40_like
PduV-EutP
GTP_EFTU
NACHT
AAA_16
MMR_HSR1
TrwB_AAD_bind
cobW
MobB
Septin
WD40_Prp19
TsaE
AAA_29
FtsK_SpoIIIE
ResIII
TniB
AAA_23
SRPRB
WD40_WDHD1_1st
ARM_LIN_2nd
Motif
Other DBs
NCBI-GeneID:
111520206
NCBI-ProteinID:
XP_023038548
Ensembl:
ENSPTEG00000020229
UniProt:
A0A8C9HDR1
LinkDB
All DBs
Position
10:36987541..37134346
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPGTMQSLMGPQDVGNDWEVLGVHQLILK
MLTVHNASVNLSMIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
RYPENTALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEVKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSPDTM
AAVVPKIITVMKSHETSLPVQLEALRAILHFIVPGMPEESREDTESHRKLNMVKKQCFKN
DIHKPVLAALNRFIGNPGIQKCGLKVIYSIAHFADALEVLSLEGAMDSVLHTLQMYPDDQ
EIQCLGLSLIGSLITKKNLCIGTGHLLAKILASSLYRFKDVAEVQTEGFQTILAILKLSA
SFSKLLVHYSFDLVIFHQISSNIVEQKDQQFLNLCCKCFAKVAMDDDLKNVMLERACDQN
NSIMVECLLLLGADANQAKDGTSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
RMVTRYQMKSAMEEGAASGSDGNFFEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSSSLGPILDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLVSEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCVANLDVSRNDIGPSVVLDPAV
KCSTLKQFNLSYNQLSSVPENLADVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
ISSLSENFLEACPKVESFNARMNFLAAMPFLPPSMTSLKLSQNKFTCIPEAILNLPHLRS
LDMSSNDIQRLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
RGKRKRDLVLNVWDFAGREEFYSTHPHFITQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDQKRLLQLVREN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
HPKGIISRRDVEKFLSKKRRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDKHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELVCLTRHILLPKNVIVECMVATHH
NSRNTSIWLGCGHTDRGQLSFLDLNTEGYTSEEVAESRILCLALVHLPVQKESWIVSGTQ
SGTLLVINTEDGKKRHTLEKMTDSITCLYCNSFSKQSKQKNFLLVGTADGNLAIFEDKTV
KLEGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
SQLFSYAAFSDSNIVTVVVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLREVMVKV
NKESKHKMSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRIIYNFCDSVRVMMT
AQLGSLKNVMLVLGYNRKSTEGTQRQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
MRGTSIE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggctagtggcagctgtcaggggtgcgaggaggacgaggaaactctgaagaagttgata
gtcaggctgaacaatgtccaggaaggtaaacagatagaaacgctggtccaaatcctggag
gatctgctggtgttcacgtactccgagcacgcctccaagttatttcaaggcaaaaatatc
catgtgcctctgttgatcgtcttggactcgtatatgagagtcgcgagtgtgcagcaggtg
ggttggtcacttctctgcaaattaatagaaatctgtccaggtacaatgcaaagcttaatg
ggaccccaggatgttggaaatgattgggaagtccttggtgttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtaaacttgtcaatgattggactgaagaccttagat
ctcctcctaacttcaggtaaaatcaccttactgatattggatgaagaaagtgatattttc
atgttaatttttgacgccatgcactcatttccagccaatgatgaagtccagaaacttgga
tgcaaagctttacatgtgctgtttgagagagtctcagaggagcaactgactgaatttgtt
gagaacaaagattatatgatactgttaagtgcgttaacaaattttaaagatgaagaggaa
attgtacttcatgtgctgcattgtttacattccctagcgattccttgcaataatgtggaa
gtcctcatgagtggcaatgtcaggtgttataatattgtggtggaagctatgaaagcattc
cctatcagtgaaaaaattcaagaagtgagttgctgtttgctccataggcttacattaggt
aatttttttaatatcctcgtattaaacgaagtccatgaatttgtggtgaaagctgttcag
cggtacccagagaacacagcattacagatctcagcgctcagctgtttggccctcctcact
gagaccattttcttaaatcaagatttagaggaaaagaatgagaatcaagagaatgatgat
gagggcgaagaagttaaattgttttggctggaagcctgttacaaagcattaacgtggcat
agaaagaacaagcatgtgcaggaggctgcatgctgggcactaaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccatttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcaaaggaagttttccaggcatctgctaat
gcattgtcaactctcttagaacaaaatgttaatttcagaaaaatcctgttatcaaaagga
atatacctgaatgttttggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagcaacacttccccggatacaatg
gcagcagtggtccccaaaataataacagttatgaaaagtcatgagacatcattaccagtg
cagctggaggcgcttcgagctattttacattttatagtgccaggcatgccagaagaatcc
agggaggatacagaatctcatcgtaagctaaatatggttaaaaaacagtgtttcaagaat
gatattcacaaacctgtcctagcagctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttattctattgcacattttgctgatgcattagaggtgtta
tccctggaaggtgctatggattcagtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatccttgattacaaagaagaatttatgc
ataggaactggacatctgctggcaaaaattctggcttccagcttataccgatttaaggat
gttgctgaagtacagactgaaggatttcagacaatcttagcaatcctcaaattgtcagca
tctttttctaagctgctggtgcattattcgtttgacttagtaatattccatcaaatatct
tccaatatcgtggaacaaaaggatcaacagtttctaaacctctgttgcaagtgttttgca
aaagtagctatggatgatgacttaaaaaatgtgatgctagagagagcgtgtgatcagaat
aacagcatcatggttgaatgcttgcttctattgggagcagatgccaatcaagcaaaggac
ggaacttctttaatttgtcaggtatgtgagaaagagagcagtcccaaattggtggaactc
ttattgaatagtggatctcgtgaacaagatgtacgaaaagcgctgacgataagcattggg
aaaggcgacagccagattatcagcttgctcttaaggaggctggccctggacgtggccaac
aatagcatttgcctcggagggttttgtataggaaaagtcgaaccttcttggcttggtcct
ttatttccagataagacttctaatttaaggaaacaaacaaatatagcatctacactagca
agaatggtgaccagatatcagatgaaaagtgccatggaagaaggagcagcctcaggcagt
gatggaaatttttttgaagatgtgctgtctaaatttgatgaatggacctttattcctgac
tcttctatggacagtgtcttcgctcaaagtgatgatctagatagtgaaggaagcgaaggc
tcatttcttgtgaaaaagaaatcaaattcaattagtgtaggagaattttaccgagatgcc
gtattacagcgttgctcaccaaatttgcaaaggcattccagttccttggggcccattttg
gatcatgaagatttactgaggagaaaaagaaaaatattatcttcagatgattcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttctctggtttctgag
agagagtatattacatcactagacctttcagcaaatgaactaagagatattgatgcccta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacagctatgtgaaactctgaagagtttgacacatttg
gacttgcacagtaataaatttacatcatttccttcttacttgttgaaaatgagttgtgtt
gctaaccttgatgtctctcgaaatgacattggaccctcagtggttttagatcctgcagtg
aaatgttcaactctgaaacagtttaacctgtcatataaccagctgtcttctgttcctgag
aaccttgctgatgtggtagagaaactggagcagctcattttagaaggaaataaaatatca
gggatatgctcccccttgagactgaaggaactgaagattttaaaccttagtaaaaaccac
atttcatccctatcagagaactttcttgaagcttgtcctaaagtggagagtttcaatgcc
agaatgaattttcttgctgctatgcctttcttgcctccttccatgacaagcctaaaatta
tctcaaaacaaatttacatgtattccagaagcaattttaaatcttccacacttgcggtct
ttagatatgagcagcaatgatattcaacgtctaccaggtcctgcacactggaaatctttg
aacttaagggaactcttatttagccataatcaaatcagcatcttggacttgagtgaaaaa
gcatatttatggtctagagtagagaaactgcatctttctcacaataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttacaacttggaa
ctaagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcgtcttaactttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccctataaccgaatgaaacttatgattgtt
ggaaatactgggagtggtaaaaccaccttattgcagcaattaatgaaaaccaagaaatca
gatcttggaatgcaaagtgccacagttggcatagatgtgaaagactggcctatccaaata
agaggcaaaagaaagagagatctcgttctgaatgtgtgggattttgcaggtcgtgaggaa
ttctatagtactcatcctcattttataacgcagcgagcattgtaccttgctgtctatgac
ctcagcaaaggacaggctgaagttgatgccatgaagccttggctcttcaatataaaggct
cgcgcttcttcttcccctgtgattctcgttggcacacatttggatgtttctgatgagaag
cagcgcaaagcctgcataagtaaaatcaccaaggaactcctgaataagcgagggttccct
gctatacgagattaccactttgtgaatgccaccgaggaatctgatgctttggcaaaactt
cggaaaaccatcataaacgagagccttaatttcaagatccgagatcagcctgttgttgga
cagctgattccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccaattgaatttcctgtaattgaccagaaacgattattacaactagtgagagaaaat
cagttgcagttagatgaaaatgagcttcctcacgcagttcactttctaaatgaatcagga
gtccttcttcattttcaagacccagcactgcagttaagtgacttgtattttgtggaaccc
aaatggctttgtaaaatcatggcacagattttgacagtgaaagtggaaggttgtccaaaa
caccctaagggaattatttcacgtagagacgtggaaaaatttctttcgaagaaaaggaga
tttccaaagaactacatgtcacagtactttaagctcctagaaaaattccagattgctttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcatccgactatatgaaatgccttatttc
ccaatgggattctggtcgaggttaatcaatcgattacttgagatttcaccttacatgctt
tcagggagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctactta
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaagcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaggaatggtttcctgggttgctggagattgatatt
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaggaaggagatctctta
gtaaatccagatcaaccaaggctcaccattccaatatctcagattgcccctgacttgatt
ttggctgacctgcctagaaatattatgttgaataatgatgagctggaatttgaacaagct
ccagagtttctcctaggtgatggcagttttggatcagtttatcgagcagcctatgaagga
gaagaagtggctgtgaagatttttaataaacacacatcacttaggctgttaagacaagag
ctggtggtgctttgccacctccaccaccccagtttgatctctttgctggcagctggtatt
cgtccccggatgttggtgatggagttagcctccaagggttccttggatcgcctgcttcag
caggacaaagccagcctcactagaaccctacagcacaggattgcactccatgtggctgat
ggtttgagatacctccactcagccatgattatataccgagatttgaagccccacaatgtg
ctgcttttcacactgtatcccaatgctgccatcattgcaaagattgctgactacggcatt
gctcagtactgctgtagaatggggataaaaacgtcagagggcacaccagggtttcgtgca
cctgaagttgccagaggaaatgtcatttataatcaacaagctgatgtttattcatttggt
ttgctactctatgacattttgacaactggaggtagaatagtagagggtttgaagtttcca
aatgagtttgatgaattggcaatacaaggaaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggttgaaaaattaattacaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgaattagtctgtctg
acgagacacattttattacctaaaaacgtaattgttgaatgcatggttgctacacatcac
aacagcaggaatacaagcatttggctgggctgtgggcacaccgacagaggacagctatca
tttcttgacttaaatactgaaggatacacttctgaggaagttgctgagagtagaatattg
tgcttagccttggtgcatcttcctgttcaaaaagaaagctggattgtgtctgggacacag
tctggtactctcctggtcatcaataccgaagatgggaaaaagagacataccctagaaaag
atgactgattccatcacttgtttgtattgcaattccttttccaagcaaagcaaacaaaaa
aattttcttttggttggaaccgctgatggcaatttagcaatttttgaagataagactgtt
aagcttgaaggagctgctcctttgaagatactaaatataggaaatgtcagtactccattg
atgtgtttgagtgaatccacaaattcaacagaaagaaatgtaatgtggggaggatgtggc
acaaagattttctccttttctaatgatttcaccattcagaaactcattgagacaagaaca
agccaactgttttcttatgcagctttcagtgattccaacatcgtaacagtggtggtagac
actgctctctatattgctaagaaaaatagccctgttgtggaagtgtgggataagaaaact
gaaaaactctgcgaactaatagactgtgtgcactttttaagggaggtaatggtaaaagta
aacaaggaatcaaaacacaaaatgtcttattctgggagagtgaaagctctctgccttcag
aagaacactgctctttggataggaactggaggaggccatattttactcctggatctttca
actcgtcgagttatacgtataatttacaacttttgtgattcggtcagagtcatgatgaca
gcacagctagggagccttaaaaatgtcatgctggtattgggctataaccggaaaagtact
gaaggtacacaacggcagaaagagatacagtcttgcttgactgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacacattgaagtgagaaaagaattagctgaaaaa
atgagaggaacatctattgaataa
DBGET
integrated database retrieval system
