KEGG   Piliocolobus tephrosceles (Ugandan red Colobus): 111523340
Entry
111523340         CDS       T07491                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pteh  Piliocolobus tephrosceles (Ugandan red Colobus)
Pathway
pteh00562  Inositol phosphate metabolism
pteh01100  Metabolic pathways
pteh01521  EGFR tyrosine kinase inhibitor resistance
pteh01522  Endocrine resistance
pteh01524  Platinum drug resistance
pteh04012  ErbB signaling pathway
pteh04014  Ras signaling pathway
pteh04015  Rap1 signaling pathway
pteh04024  cAMP signaling pathway
pteh04062  Chemokine signaling pathway
pteh04066  HIF-1 signaling pathway
pteh04068  FoxO signaling pathway
pteh04070  Phosphatidylinositol signaling system
pteh04071  Sphingolipid signaling pathway
pteh04072  Phospholipase D signaling pathway
pteh04081  Hormone signaling
pteh04140  Autophagy - animal
pteh04150  mTOR signaling pathway
pteh04151  PI3K-Akt signaling pathway
pteh04152  AMPK signaling pathway
pteh04210  Apoptosis
pteh04211  Longevity regulating pathway
pteh04213  Longevity regulating pathway - multiple species
pteh04218  Cellular senescence
pteh04360  Axon guidance
pteh04370  VEGF signaling pathway
pteh04380  Osteoclast differentiation
pteh04510  Focal adhesion
pteh04550  Signaling pathways regulating pluripotency of stem cells
pteh04611  Platelet activation
pteh04613  Neutrophil extracellular trap formation
pteh04620  Toll-like receptor signaling pathway
pteh04625  C-type lectin receptor signaling pathway
pteh04630  JAK-STAT signaling pathway
pteh04650  Natural killer cell mediated cytotoxicity
pteh04660  T cell receptor signaling pathway
pteh04662  B cell receptor signaling pathway
pteh04664  Fc epsilon RI signaling pathway
pteh04666  Fc gamma R-mediated phagocytosis
pteh04668  TNF signaling pathway
pteh04670  Leukocyte transendothelial migration
pteh04722  Neurotrophin signaling pathway
pteh04725  Cholinergic synapse
pteh04750  Inflammatory mediator regulation of TRP channels
pteh04810  Regulation of actin cytoskeleton
pteh04910  Insulin signaling pathway
pteh04914  Progesterone-mediated oocyte maturation
pteh04915  Estrogen signaling pathway
pteh04917  Prolactin signaling pathway
pteh04919  Thyroid hormone signaling pathway
pteh04923  Regulation of lipolysis in adipocytes
pteh04926  Relaxin signaling pathway
pteh04929  GnRH secretion
pteh04930  Type II diabetes mellitus
pteh04931  Insulin resistance
pteh04932  Non-alcoholic fatty liver disease
pteh04933  AGE-RAGE signaling pathway in diabetic complications
pteh04935  Growth hormone synthesis, secretion and action
pteh04960  Aldosterone-regulated sodium reabsorption
pteh04973  Carbohydrate digestion and absorption
pteh05010  Alzheimer disease
pteh05017  Spinocerebellar ataxia
pteh05020  Prion disease
pteh05100  Bacterial invasion of epithelial cells
pteh05132  Salmonella infection
pteh05135  Yersinia infection
pteh05142  Chagas disease
pteh05146  Amoebiasis
pteh05160  Hepatitis C
pteh05161  Hepatitis B
pteh05162  Measles
pteh05163  Human cytomegalovirus infection
pteh05164  Influenza A
pteh05165  Human papillomavirus infection
pteh05166  Human T-cell leukemia virus 1 infection
pteh05167  Kaposi sarcoma-associated herpesvirus infection
pteh05168  Herpes simplex virus 1 infection
pteh05169  Epstein-Barr virus infection
pteh05170  Human immunodeficiency virus 1 infection
pteh05171  Coronavirus disease - COVID-19
pteh05200  Pathways in cancer
pteh05203  Viral carcinogenesis
pteh05205  Proteoglycans in cancer
pteh05206  MicroRNAs in cancer
pteh05207  Chemical carcinogenesis - receptor activation
pteh05208  Chemical carcinogenesis - reactive oxygen species
pteh05210  Colorectal cancer
pteh05211  Renal cell carcinoma
pteh05212  Pancreatic cancer
pteh05213  Endometrial cancer
pteh05214  Glioma
pteh05215  Prostate cancer
pteh05218  Melanoma
pteh05220  Chronic myeloid leukemia
pteh05221  Acute myeloid leukemia
pteh05222  Small cell lung cancer
pteh05223  Non-small cell lung cancer
pteh05224  Breast cancer
pteh05225  Hepatocellular carcinoma
pteh05226  Gastric cancer
pteh05230  Central carbon metabolism in cancer
pteh05231  Choline metabolism in cancer
pteh05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pteh05415  Diabetic cardiomyopathy
pteh05417  Lipid and atherosclerosis
pteh05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pteh00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    111523340 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    111523340 (PIK3CB)
   04014 Ras signaling pathway
    111523340 (PIK3CB)
   04015 Rap1 signaling pathway
    111523340 (PIK3CB)
   04370 VEGF signaling pathway
    111523340 (PIK3CB)
   04630 JAK-STAT signaling pathway
    111523340 (PIK3CB)
   04668 TNF signaling pathway
    111523340 (PIK3CB)
   04066 HIF-1 signaling pathway
    111523340 (PIK3CB)
   04068 FoxO signaling pathway
    111523340 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    111523340 (PIK3CB)
   04072 Phospholipase D signaling pathway
    111523340 (PIK3CB)
   04071 Sphingolipid signaling pathway
    111523340 (PIK3CB)
   04024 cAMP signaling pathway
    111523340 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    111523340 (PIK3CB)
   04152 AMPK signaling pathway
    111523340 (PIK3CB)
   04150 mTOR signaling pathway
    111523340 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    111523340 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    111523340 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    111523340 (PIK3CB)
   04218 Cellular senescence
    111523340 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    111523340 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    111523340 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    111523340 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    111523340 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    111523340 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    111523340 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    111523340 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    111523340 (PIK3CB)
   04660 T cell receptor signaling pathway
    111523340 (PIK3CB)
   04662 B cell receptor signaling pathway
    111523340 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    111523340 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    111523340 (PIK3CB)
   04670 Leukocyte transendothelial migration
    111523340 (PIK3CB)
   04062 Chemokine signaling pathway
    111523340 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    111523340 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    111523340 (PIK3CB)
   04929 GnRH secretion
    111523340 (PIK3CB)
   04915 Estrogen signaling pathway
    111523340 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    111523340 (PIK3CB)
   04917 Prolactin signaling pathway
    111523340 (PIK3CB)
   04926 Relaxin signaling pathway
    111523340 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    111523340 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    111523340 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    111523340 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    111523340 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    111523340 (PIK3CB)
   04722 Neurotrophin signaling pathway
    111523340 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    111523340 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    111523340 (PIK3CB)
   04380 Osteoclast differentiation
    111523340 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    111523340 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    111523340 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    111523340 (PIK3CB)
   05206 MicroRNAs in cancer
    111523340 (PIK3CB)
   05205 Proteoglycans in cancer
    111523340 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    111523340 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    111523340 (PIK3CB)
   05203 Viral carcinogenesis
    111523340 (PIK3CB)
   05230 Central carbon metabolism in cancer
    111523340 (PIK3CB)
   05231 Choline metabolism in cancer
    111523340 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    111523340 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    111523340 (PIK3CB)
   05212 Pancreatic cancer
    111523340 (PIK3CB)
   05225 Hepatocellular carcinoma
    111523340 (PIK3CB)
   05226 Gastric cancer
    111523340 (PIK3CB)
   05214 Glioma
    111523340 (PIK3CB)
   05221 Acute myeloid leukemia
    111523340 (PIK3CB)
   05220 Chronic myeloid leukemia
    111523340 (PIK3CB)
   05218 Melanoma
    111523340 (PIK3CB)
   05211 Renal cell carcinoma
    111523340 (PIK3CB)
   05215 Prostate cancer
    111523340 (PIK3CB)
   05213 Endometrial cancer
    111523340 (PIK3CB)
   05224 Breast cancer
    111523340 (PIK3CB)
   05222 Small cell lung cancer
    111523340 (PIK3CB)
   05223 Non-small cell lung cancer
    111523340 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    111523340 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    111523340 (PIK3CB)
   05161 Hepatitis B
    111523340 (PIK3CB)
   05160 Hepatitis C
    111523340 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    111523340 (PIK3CB)
   05164 Influenza A
    111523340 (PIK3CB)
   05162 Measles
    111523340 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    111523340 (PIK3CB)
   05163 Human cytomegalovirus infection
    111523340 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    111523340 (PIK3CB)
   05169 Epstein-Barr virus infection
    111523340 (PIK3CB)
   05165 Human papillomavirus infection
    111523340 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    111523340 (PIK3CB)
   05135 Yersinia infection
    111523340 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    111523340 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    111523340 (PIK3CB)
   05142 Chagas disease
    111523340 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    111523340 (PIK3CB)
   05017 Spinocerebellar ataxia
    111523340 (PIK3CB)
   05020 Prion disease
    111523340 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    111523340 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    111523340 (PIK3CB)
   05415 Diabetic cardiomyopathy
    111523340 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    111523340 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    111523340 (PIK3CB)
   04931 Insulin resistance
    111523340 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    111523340 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    111523340 (PIK3CB)
   01524 Platinum drug resistance
    111523340 (PIK3CB)
   01522 Endocrine resistance
    111523340 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pteh04131]
    111523340 (PIK3CB)
Enzymes [BR:pteh01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     111523340 (PIK3CB)
Membrane trafficking [BR:pteh04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    111523340 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 111523340
NCBI-ProteinID: XP_023043606
Ensembl: ENSPTEG00000005183
LinkDB
Position
2:complement(161033727..161222589)
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAIHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAIYAVLDKVKTKKSTKNI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIMLHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaaccagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagtgaggaaaagatc
ctgtcacttgtgggattgtcttggatggactggctgaaacaaacatatccaccggagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcattgtagct
attcattttgaaaactgccaggatgtgtttagctttcaagtatctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagtgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccgaaactgtgtaatgaacaggaccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatcggaattcatctaaccttcctcttccattaccaccaaagaaaacg
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaaccattgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctatttatgctgttttggataaagtaaaaacgaagaaatcaacgaaaaatatt
aatccctctaaatatcagaccatcagaaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatgttacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatattaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcactgccaaaattactactgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcagtatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagttaaacagagccaaagggaaggag
gccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccagatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgacggcatgggaatctcttc
atcactctctttgcgctgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacaatatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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