KEGG   Piliocolobus tephrosceles (Ugandan red Colobus): 111546452
Entry
111546452         CDS       T07491                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pteh  Piliocolobus tephrosceles (Ugandan red Colobus)
Pathway
pteh00562  Inositol phosphate metabolism
pteh01100  Metabolic pathways
pteh04015  Rap1 signaling pathway
pteh04020  Calcium signaling pathway
pteh04022  cGMP-PKG signaling pathway
pteh04062  Chemokine signaling pathway
pteh04070  Phosphatidylinositol signaling system
pteh04071  Sphingolipid signaling pathway
pteh04072  Phospholipase D signaling pathway
pteh04081  Hormone signaling
pteh04082  Neuroactive ligand signaling
pteh04261  Adrenergic signaling in cardiomyocytes
pteh04270  Vascular smooth muscle contraction
pteh04310  Wnt signaling pathway
pteh04371  Apelin signaling pathway
pteh04540  Gap junction
pteh04611  Platelet activation
pteh04613  Neutrophil extracellular trap formation
pteh04621  NOD-like receptor signaling pathway
pteh04713  Circadian entrainment
pteh04720  Long-term potentiation
pteh04723  Retrograde endocannabinoid signaling
pteh04724  Glutamatergic synapse
pteh04725  Cholinergic synapse
pteh04726  Serotonergic synapse
pteh04728  Dopaminergic synapse
pteh04730  Long-term depression
pteh04742  Taste transduction
pteh04750  Inflammatory mediator regulation of TRP channels
pteh04911  Insulin secretion
pteh04912  GnRH signaling pathway
pteh04915  Estrogen signaling pathway
pteh04916  Melanogenesis
pteh04918  Thyroid hormone synthesis
pteh04919  Thyroid hormone signaling pathway
pteh04921  Oxytocin signaling pathway
pteh04922  Glucagon signaling pathway
pteh04924  Renin secretion
pteh04925  Aldosterone synthesis and secretion
pteh04926  Relaxin signaling pathway
pteh04927  Cortisol synthesis and secretion
pteh04928  Parathyroid hormone synthesis, secretion and action
pteh04929  GnRH secretion
pteh04933  AGE-RAGE signaling pathway in diabetic complications
pteh04934  Cushing syndrome
pteh04935  Growth hormone synthesis, secretion and action
pteh04961  Endocrine and other factor-regulated calcium reabsorption
pteh04970  Salivary secretion
pteh04971  Gastric acid secretion
pteh04972  Pancreatic secretion
pteh04973  Carbohydrate digestion and absorption
pteh05010  Alzheimer disease
pteh05016  Huntington disease
pteh05017  Spinocerebellar ataxia
pteh05022  Pathways of neurodegeneration - multiple diseases
pteh05142  Chagas disease
pteh05143  African trypanosomiasis
pteh05146  Amoebiasis
pteh05163  Human cytomegalovirus infection
pteh05200  Pathways in cancer
pteh05415  Diabetic cardiomyopathy
pteh05417  Lipid and atherosclerosis
Module
pteh_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pteh00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    111546452 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    111546452 (PLCB1)
   04310 Wnt signaling pathway
    111546452 (PLCB1)
   04371 Apelin signaling pathway
    111546452 (PLCB1)
   04020 Calcium signaling pathway
    111546452 (PLCB1)
   04070 Phosphatidylinositol signaling system
    111546452 (PLCB1)
   04072 Phospholipase D signaling pathway
    111546452 (PLCB1)
   04071 Sphingolipid signaling pathway
    111546452 (PLCB1)
   04022 cGMP-PKG signaling pathway
    111546452 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    111546452 (PLCB1)
   04081 Hormone signaling
    111546452 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    111546452 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    111546452 (PLCB1)
   04613 Neutrophil extracellular trap formation
    111546452 (PLCB1)
   04621 NOD-like receptor signaling pathway
    111546452 (PLCB1)
   04062 Chemokine signaling pathway
    111546452 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    111546452 (PLCB1)
   04922 Glucagon signaling pathway
    111546452 (PLCB1)
   04929 GnRH secretion
    111546452 (PLCB1)
   04912 GnRH signaling pathway
    111546452 (PLCB1)
   04915 Estrogen signaling pathway
    111546452 (PLCB1)
   04921 Oxytocin signaling pathway
    111546452 (PLCB1)
   04926 Relaxin signaling pathway
    111546452 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    111546452 (PLCB1)
   04918 Thyroid hormone synthesis
    111546452 (PLCB1)
   04919 Thyroid hormone signaling pathway
    111546452 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    111546452 (PLCB1)
   04916 Melanogenesis
    111546452 (PLCB1)
   04924 Renin secretion
    111546452 (PLCB1)
   04925 Aldosterone synthesis and secretion
    111546452 (PLCB1)
   04927 Cortisol synthesis and secretion
    111546452 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    111546452 (PLCB1)
   04270 Vascular smooth muscle contraction
    111546452 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    111546452 (PLCB1)
   04971 Gastric acid secretion
    111546452 (PLCB1)
   04972 Pancreatic secretion
    111546452 (PLCB1)
   04973 Carbohydrate digestion and absorption
    111546452 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    111546452 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    111546452 (PLCB1)
   04725 Cholinergic synapse
    111546452 (PLCB1)
   04728 Dopaminergic synapse
    111546452 (PLCB1)
   04726 Serotonergic synapse
    111546452 (PLCB1)
   04720 Long-term potentiation
    111546452 (PLCB1)
   04730 Long-term depression
    111546452 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    111546452 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    111546452 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    111546452 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    111546452 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    111546452 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    111546452 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    111546452 (PLCB1)
   05142 Chagas disease
    111546452 (PLCB1)
   05143 African trypanosomiasis
    111546452 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    111546452 (PLCB1)
   05016 Huntington disease
    111546452 (PLCB1)
   05017 Spinocerebellar ataxia
    111546452 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    111546452 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    111546452 (PLCB1)
   05415 Diabetic cardiomyopathy
    111546452 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    111546452 (PLCB1)
   04934 Cushing syndrome
    111546452 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pteh04131]
    111546452 (PLCB1)
Enzymes [BR:pteh01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     111546452 (PLCB1)
Membrane trafficking [BR:pteh04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    111546452 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    111546452 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 111546452
NCBI-ProteinID: XP_023073636
Ensembl: ENSPTEG00000003409
UniProt: A0A8C9GD93
LinkDB
Position
20:complement(53248396..54032993)
AA seq 1173 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTCSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSETPSEVRTTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KGEGSSSFLSETCHEDPSVSPNFTPPNPQALKW
NT seq 3522 nt   +upstreamnt  +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactcaactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctactggatctcagccttgtcaaagatgccagatgtgggagacatgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcag
cgcatgatcacagtggtgtatggacctgacctcgtgaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgc
cctcgacctgaaattgataacatcttttcagaatttggtgccaaaagcaaaccatatctt
accgttgaccagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaa
atactttatccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
aacaacagcctcgccaaaaaaggacaaatatcagtggatgggttcatgcgctatctgagt
ggagaagaaaacggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactg
gctggaaactcctctgttgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
gagctggactgctggaagggacgaactgcagaagaggagcctgtcatcacccatggcttc
accatgacaactgaaatatctttcaaggaagtgatagaagcaatagcggagtgtgcattt
aagacttcaccatttccaattctcctttcatttgagaaccatgtggattccccaaagcag
caagccaagatggcggagtactgccgactgatctttggggatgcccttctcatggagccc
ctggaaaaatatccactggaatctggagttcctcttccaagccctatggatttaatgtat
aaaattttggtgaaaaataagaagaaatcacacaagtcatccgaaggaagtggcaaaaag
aagctctcagaacaagcctccaacacctgcagcgactcctccagcatgtttgagccttca
tccccaggagccggagaagctgatacggaaagtgacgacgatgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggaccgctggaagtgaggctatggccacagaagaaatg
tctaacctggtgaactacattcagccggtcaagtttgagtcatttgaaatttcaaaaaaa
agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcacc
aaatctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacacgtgtggattcatccaactatatgcctcagctcttctggaatgcaggttgtcag
atggtggcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtat
gaatacaatggaaagagtggctatagactgaagccggagttcatgaggaggcccgacaag
cattttgatccatttactgaaggcatcgtagatgggatagtggcaaacacgttgtctgtt
aagattatttcaggtcagtttctttctgataagaaagtcgggacttatgtggaagtggat
atgtttggtttgcctgtggatacaaggaggaaggcatttaagaccaagacatcccaagga
aatgctgtgaatcctgtctgggaagaagaacctattgtgttcaaaaaggtggttcttcct
actctggcctgtttgagaatagcagtttatgaagaaggaggtaaattcattggccaccgt
atcttgccagtgcaagccattcggccaggctatcactatatatgtctaaggaatgaaagg
aaccagcctctgacgctgcctgctgtctttgtctacatagaagtgaaagactatgtgcca
gacacatatgcagatgtcattgaagctttatcaaacccaatccggtatgtgaacctgatg
gagcagagagctaagcaattggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggagaaacaccatcagagactccaagtgaagtgagaacgactccagcc
gaaaatggggtgaatcacactacatccctgacacccaagccaccctcccaggctctccac
agccaaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gtcttaacagaagtggaagcacagaccattgaagagctaaagcaacagaaatcgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggtaaagagacaccacaagaaa
accactgaccttatcaaagaacacactaccaagtataatgaaattcagaatgactacttg
agaaggagagcagctttggaaaagtccgccaaaaaggacagtaagaaaaaatcggaaccc
agcagccctgatcatggttcctcaacgattgagcaagacctcgctgccctggatgctgaa
atgacccaaaaattaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgg
caagaacagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
aagttgacagatgtcgcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatc
tgtgagaaagaaaagaaagaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagctaagtctaaagacaaaagtcagatggaagaggagaagacagagatgatccgg
tcatatatccaggaagtggtgcagtacatcaagaggctagaagaggcacaaagtaaacgg
caagaaaaactcgtagagaaacacaaggaaatacgtcagcagatcctggatgaaaagccc
aagggggaaggttcctcctcattcttgtcggaaacttgccatgaggatccctctgtttcc
cccaactttactccccccaaccctcaagctctcaagtggtga

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