| Entry |  | 
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| Symbol | PLCB1
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| Name | (RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
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| KO |  | 
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| Organism | pteh  Piliocolobus tephrosceles (Ugandan red Colobus)
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| Pathway | | pteh04070 | Phosphatidylinositol signaling system | 
 | pteh04261 | Adrenergic signaling in cardiomyocytes | 
 | pteh04613 | Neutrophil extracellular trap formation | 
 | pteh04621 | NOD-like receptor signaling pathway | 
 | pteh04723 | Retrograde endocannabinoid signaling | 
 | pteh04750 | Inflammatory mediator regulation of TRP channels | 
 | pteh04925 | Aldosterone synthesis and secretion | 
 | pteh04928 | Parathyroid hormone synthesis, secretion and action | 
 | pteh04933 | AGE-RAGE signaling pathway in diabetic complications | 
 | pteh04935 | Growth hormone synthesis, secretion and action | 
 | pteh04961 | Endocrine and other factor-regulated calcium reabsorption | 
 | pteh04973 | Carbohydrate digestion and absorption | 
 | pteh05022 | Pathways of neurodegeneration - multiple diseases | 
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| Module | | pteh_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 | 
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| Brite | KEGG Orthology (KO) [BR:pteh00001]09100 Metabolism
 09101 Carbohydrate metabolism
 00562 Inositol phosphate metabolism
 111546452 (PLCB1)
 09130 Environmental Information Processing
 09132 Signal transduction
 04015 Rap1 signaling pathway
 111546452 (PLCB1)
 04310 Wnt signaling pathway
 111546452 (PLCB1)
 04371 Apelin signaling pathway
 111546452 (PLCB1)
 04020 Calcium signaling pathway
 111546452 (PLCB1)
 04070 Phosphatidylinositol signaling system
 111546452 (PLCB1)
 04072 Phospholipase D signaling pathway
 111546452 (PLCB1)
 04071 Sphingolipid signaling pathway
 111546452 (PLCB1)
 04022 cGMP-PKG signaling pathway
 111546452 (PLCB1)
 09133 Signaling molecules and interaction
 04082 Neuroactive ligand signaling
 111546452 (PLCB1)
 04081 Hormone signaling
 111546452 (PLCB1)
 09140 Cellular Processes
 09144 Cellular community - eukaryotes
 04540 Gap junction
 111546452 (PLCB1)
 09150 Organismal Systems
 09151 Immune system
 04611 Platelet activation
 111546452 (PLCB1)
 04613 Neutrophil extracellular trap formation
 111546452 (PLCB1)
 04621 NOD-like receptor signaling pathway
 111546452 (PLCB1)
 04062 Chemokine signaling pathway
 111546452 (PLCB1)
 09152 Endocrine system
 04911 Insulin secretion
 111546452 (PLCB1)
 04922 Glucagon signaling pathway
 111546452 (PLCB1)
 04929 GnRH secretion
 111546452 (PLCB1)
 04912 GnRH signaling pathway
 111546452 (PLCB1)
 04915 Estrogen signaling pathway
 111546452 (PLCB1)
 04921 Oxytocin signaling pathway
 111546452 (PLCB1)
 04926 Relaxin signaling pathway
 111546452 (PLCB1)
 04935 Growth hormone synthesis, secretion and action
 111546452 (PLCB1)
 04918 Thyroid hormone synthesis
 111546452 (PLCB1)
 04919 Thyroid hormone signaling pathway
 111546452 (PLCB1)
 04928 Parathyroid hormone synthesis, secretion and action
 111546452 (PLCB1)
 04916 Melanogenesis
 111546452 (PLCB1)
 04924 Renin secretion
 111546452 (PLCB1)
 04925 Aldosterone synthesis and secretion
 111546452 (PLCB1)
 04927 Cortisol synthesis and secretion
 111546452 (PLCB1)
 09153 Circulatory system
 04261 Adrenergic signaling in cardiomyocytes
 111546452 (PLCB1)
 04270 Vascular smooth muscle contraction
 111546452 (PLCB1)
 09154 Digestive system
 04970 Salivary secretion
 111546452 (PLCB1)
 04971 Gastric acid secretion
 111546452 (PLCB1)
 04972 Pancreatic secretion
 111546452 (PLCB1)
 04973 Carbohydrate digestion and absorption
 111546452 (PLCB1)
 09155 Excretory system
 04961 Endocrine and other factor-regulated calcium reabsorption
 111546452 (PLCB1)
 09156 Nervous system
 04724 Glutamatergic synapse
 111546452 (PLCB1)
 04725 Cholinergic synapse
 111546452 (PLCB1)
 04728 Dopaminergic synapse
 111546452 (PLCB1)
 04726 Serotonergic synapse
 111546452 (PLCB1)
 04720 Long-term potentiation
 111546452 (PLCB1)
 04730 Long-term depression
 111546452 (PLCB1)
 04723 Retrograde endocannabinoid signaling
 111546452 (PLCB1)
 09157 Sensory system
 04742 Taste transduction
 111546452 (PLCB1)
 04750 Inflammatory mediator regulation of TRP channels
 111546452 (PLCB1)
 09159 Environmental adaptation
 04713 Circadian entrainment
 111546452 (PLCB1)
 09160 Human Diseases
 09161 Cancer: overview
 05200 Pathways in cancer
 111546452 (PLCB1)
 09172 Infectious disease: viral
 05163 Human cytomegalovirus infection
 111546452 (PLCB1)
 09174 Infectious disease: parasitic
 05146 Amoebiasis
 111546452 (PLCB1)
 05142 Chagas disease
 111546452 (PLCB1)
 05143 African trypanosomiasis
 111546452 (PLCB1)
 09164 Neurodegenerative disease
 05010 Alzheimer disease
 111546452 (PLCB1)
 05016 Huntington disease
 111546452 (PLCB1)
 05017 Spinocerebellar ataxia
 111546452 (PLCB1)
 05022 Pathways of neurodegeneration - multiple diseases
 111546452 (PLCB1)
 09166 Cardiovascular disease
 05417 Lipid and atherosclerosis
 111546452 (PLCB1)
 05415 Diabetic cardiomyopathy
 111546452 (PLCB1)
 09167 Endocrine and metabolic disease
 04933 AGE-RAGE signaling pathway in diabetic complications
 111546452 (PLCB1)
 04934 Cushing syndrome
 111546452 (PLCB1)
 09180 Brite Hierarchies
 09182 Protein families: genetic information processing
 04131 Membrane trafficking [BR:pteh04131]
 111546452 (PLCB1)
 Enzymes [BR:pteh01000]
 3. Hydrolases
 3.1  Acting on ester bonds
 3.1.4  Phosphoric-diester hydrolases
 3.1.4.11  phosphoinositide phospholipase C
 111546452 (PLCB1)
 Membrane trafficking [BR:pteh04131]
 Exocytosis
 Calcium ion-dependent exocytosis
 Phospholipases
 111546452 (PLCB1)
 Endocytosis
 Macropinocytosis
 Phospholipase C
 111546452 (PLCB1)
 
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| SSDB |  | 
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| Motif |  | 
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| Other DBs |  | 
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| LinkDB |  | 
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| Position | 20:complement(53248396..54032993)
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| AA seq | 1173 aa MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
 KLSEQASNTCSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
 EADPGETPSETPSEVRTTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
 KGEGSSSFLSETCHEDPSVSPNFTPPNPQALKW
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| NT seq | 3522 nt   +upstreamnt  +downstreamntatggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
 agcctcaagaagggcaccaaattcgtcaagtgggatgatgactcaactattgttactcca
 attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
 acggagctactggatctcagccttgtcaaagatgccagatgtgggagacatgccaaagct
 cccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcag
 cgcatgatcacagtggtgtatggacctgacctcgtgaacatctcccatttgaatctcgtg
 gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
 ctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
 ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
 gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
 tcaatacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgc
 cctcgacctgaaattgataacatcttttcagaatttggtgccaaaagcaaaccatatctt
 accgttgaccagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaa
 atactttatccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
 aacaacagcctcgccaaaaaaggacaaatatcagtggatgggttcatgcgctatctgagt
 ggagaagaaaacggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
 cccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactg
 gctggaaactcctctgttgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
 gagctggactgctggaagggacgaactgcagaagaggagcctgtcatcacccatggcttc
 accatgacaactgaaatatctttcaaggaagtgatagaagcaatagcggagtgtgcattt
 aagacttcaccatttccaattctcctttcatttgagaaccatgtggattccccaaagcag
 caagccaagatggcggagtactgccgactgatctttggggatgcccttctcatggagccc
 ctggaaaaatatccactggaatctggagttcctcttccaagccctatggatttaatgtat
 aaaattttggtgaaaaataagaagaaatcacacaagtcatccgaaggaagtggcaaaaag
 aagctctcagaacaagcctccaacacctgcagcgactcctccagcatgtttgagccttca
 tccccaggagccggagaagctgatacggaaagtgacgacgatgatgatgatgatgactgt
 aaaaaatcttcaatggatgaggggaccgctggaagtgaggctatggccacagaagaaatg
 tctaacctggtgaactacattcagccggtcaagtttgagtcatttgaaatttcaaaaaaa
 agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcacc
 aaatctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
 ggaacacgtgtggattcatccaactatatgcctcagctcttctggaatgcaggttgtcag
 atggtggcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtat
 gaatacaatggaaagagtggctatagactgaagccggagttcatgaggaggcccgacaag
 cattttgatccatttactgaaggcatcgtagatgggatagtggcaaacacgttgtctgtt
 aagattatttcaggtcagtttctttctgataagaaagtcgggacttatgtggaagtggat
 atgtttggtttgcctgtggatacaaggaggaaggcatttaagaccaagacatcccaagga
 aatgctgtgaatcctgtctgggaagaagaacctattgtgttcaaaaaggtggttcttcct
 actctggcctgtttgagaatagcagtttatgaagaaggaggtaaattcattggccaccgt
 atcttgccagtgcaagccattcggccaggctatcactatatatgtctaaggaatgaaagg
 aaccagcctctgacgctgcctgctgtctttgtctacatagaagtgaaagactatgtgcca
 gacacatatgcagatgtcattgaagctttatcaaacccaatccggtatgtgaacctgatg
 gagcagagagctaagcaattggctgctttgacactggaagatgaagaagaagtaaagaaa
 gaggctgatcctggagaaacaccatcagagactccaagtgaagtgagaacgactccagcc
 gaaaatggggtgaatcacactacatccctgacacccaagccaccctcccaggctctccac
 agccaaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
 gtcttaacagaagtggaagcacagaccattgaagagctaaagcaacagaaatcgtttgtg
 aaacttcaaaagaagcactacaaagaaatgaaagacctggtaaagagacaccacaagaaa
 accactgaccttatcaaagaacacactaccaagtataatgaaattcagaatgactacttg
 agaaggagagcagctttggaaaagtccgccaaaaaggacagtaagaaaaaatcggaaccc
 agcagccctgatcatggttcctcaacgattgagcaagacctcgctgccctggatgctgaa
 atgacccaaaaattaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgg
 caagaacagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
 aagttgacagatgtcgcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatc
 tgtgagaaagaaaagaaagaattaaagaagaaaatggataaaaagaggcaggagaagata
 acagaagctaagtctaaagacaaaagtcagatggaagaggagaagacagagatgatccgg
 tcatatatccaggaagtggtgcagtacatcaagaggctagaagaggcacaaagtaaacgg
 caagaaaaactcgtagagaaacacaaggaaatacgtcagcagatcctggatgaaaagccc
 aagggggaaggttcctcctcattcttgtcggaaacttgccatgaggatccctctgtttcc
 cccaactttactccccccaaccctcaagctctcaagtggtga
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