KEGG   Panthera tigris altaica (Amur tiger): 102950077
Entry
102950077         CDS       T02988                                 
Symbol
ATF4
Name
(RefSeq) activating transcription factor 4
  KO
K04374  cyclic AMP-dependent transcription factor ATF-4
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg04010  MAPK signaling pathway
ptg04022  cGMP-PKG signaling pathway
ptg04137  Mitophagy - animal
ptg04141  Protein processing in endoplasmic reticulum
ptg04151  PI3K-Akt signaling pathway
ptg04210  Apoptosis
ptg04211  Longevity regulating pathway
ptg04261  Adrenergic signaling in cardiomyocytes
ptg04668  TNF signaling pathway
ptg04720  Long-term potentiation
ptg04722  Neurotrophin signaling pathway
ptg04725  Cholinergic synapse
ptg04728  Dopaminergic synapse
ptg04911  Insulin secretion
ptg04912  GnRH signaling pathway
ptg04915  Estrogen signaling pathway
ptg04918  Thyroid hormone synthesis
ptg04922  Glucagon signaling pathway
ptg04925  Aldosterone synthesis and secretion
ptg04926  Relaxin signaling pathway
ptg04927  Cortisol synthesis and secretion
ptg04928  Parathyroid hormone synthesis, secretion and action
ptg04932  Non-alcoholic fatty liver disease
ptg04934  Cushing syndrome
ptg04935  Growth hormone synthesis, secretion and action
ptg05010  Alzheimer disease
ptg05012  Parkinson disease
ptg05014  Amyotrophic lateral sclerosis
ptg05020  Prion disease
ptg05022  Pathways of neurodegeneration - multiple diseases
ptg05030  Cocaine addiction
ptg05031  Amphetamine addiction
ptg05034  Alcoholism
ptg05161  Hepatitis B
ptg05163  Human cytomegalovirus infection
ptg05166  Human T-cell leukemia virus 1 infection
ptg05203  Viral carcinogenesis
ptg05207  Chemical carcinogenesis - receptor activation
ptg05215  Prostate cancer
ptg05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    102950077 (ATF4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102950077 (ATF4)
   04668 TNF signaling pathway
    102950077 (ATF4)
   04022 cGMP-PKG signaling pathway
    102950077 (ATF4)
   04151 PI3K-Akt signaling pathway
    102950077 (ATF4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    102950077 (ATF4)
  09143 Cell growth and death
   04210 Apoptosis
    102950077 (ATF4)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    102950077 (ATF4)
   04922 Glucagon signaling pathway
    102950077 (ATF4)
   04912 GnRH signaling pathway
    102950077 (ATF4)
   04915 Estrogen signaling pathway
    102950077 (ATF4)
   04926 Relaxin signaling pathway
    102950077 (ATF4)
   04935 Growth hormone synthesis, secretion and action
    102950077 (ATF4)
   04918 Thyroid hormone synthesis
    102950077 (ATF4)
   04928 Parathyroid hormone synthesis, secretion and action
    102950077 (ATF4)
   04925 Aldosterone synthesis and secretion
    102950077 (ATF4)
   04927 Cortisol synthesis and secretion
    102950077 (ATF4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102950077 (ATF4)
  09156 Nervous system
   04725 Cholinergic synapse
    102950077 (ATF4)
   04728 Dopaminergic synapse
    102950077 (ATF4)
   04720 Long-term potentiation
    102950077 (ATF4)
   04722 Neurotrophin signaling pathway
    102950077 (ATF4)
  09149 Aging
   04211 Longevity regulating pathway
    102950077 (ATF4)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    102950077 (ATF4)
   05203 Viral carcinogenesis
    102950077 (ATF4)
  09162 Cancer: specific types
   05215 Prostate cancer
    102950077 (ATF4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102950077 (ATF4)
   05161 Hepatitis B
    102950077 (ATF4)
   05163 Human cytomegalovirus infection
    102950077 (ATF4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102950077 (ATF4)
   05012 Parkinson disease
    102950077 (ATF4)
   05014 Amyotrophic lateral sclerosis
    102950077 (ATF4)
   05020 Prion disease
    102950077 (ATF4)
   05022 Pathways of neurodegeneration - multiple diseases
    102950077 (ATF4)
  09165 Substance dependence
   05030 Cocaine addiction
    102950077 (ATF4)
   05031 Amphetamine addiction
    102950077 (ATF4)
   05034 Alcoholism
    102950077 (ATF4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102950077 (ATF4)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    102950077 (ATF4)
   04934 Cushing syndrome
    102950077 (ATF4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:ptg03000]
    102950077 (ATF4)
Transcription factors [BR:ptg03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    102950077 (ATF4)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 DUF4407 MCU KIF21A Asd-4 AAA_13 Nop53 bZIP_Maf DUF3450 Laminin_II OVT1
Other DBs
NCBI-GeneID: 102950077
NCBI-ProteinID: XP_007079479
UniProt: A0A8C9MAY1
LinkDB
Position
Un
AA seq 352 aa
MAEMMSFLSSEVLGGDLMSPFDQSGLGAEVSLGLLDDYLEVAKHFKPHGFSSDKAKAGSS
EWLAADGLVSASDNGKEDAFSGTDWMVEKMDLKEFDFDSLFNIDDLETMPDELLATLDDT
CDLFDPLVQETNKEPPQTMNPIGHLPESLPKTDQVAPYAFLQPLSLSPGALSSTPDHSFS
LELGSEVDISEGDRKPDSTAYILMIPQCIKEEDAPSDNDSGICMSPESYLGSPQHSPSTA
RGSPSKSQLSPCNLCGSARPKPYDPPGEKTAAKVKVEKLDKKLKKMEQNKTAATRYRQKK
RAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKAREKKRVP
NT seq 1059 nt   +upstreamnt  +downstreamnt
atggccgagatgatgagcttcctgagcagcgaggtgttggggggggacttgatgtccccc
ttcgaccagtcgggtttgggggctgaagtaagcctaggtctcttagacgattacctggag
gtggccaagcacttcaaacctcatgggttctccagcgacaaggctaaggcgggctcctcc
gaatggctggctgcggatgggttggtcagtgcctcagacaacggcaaggaggatgccttc
tccgggacagattggatggtggagaaaatggatctgaaggagtttgattttgattctctg
ttcaatatagatgacctggaaaccatgccagatgagcttttggccactttggatgacaca
tgtgatctctttgaccccctagtccaggagacgaataaggagcccccccagaccatgaac
ccaattggccatctcccagaaagtttacccaaaacagaccaggttgccccttatgccttc
ctgcaacctctttctctctccccaggggccctttcctccactccagatcattcctttagt
ttagagctaggcagtgaggtggatatctctgaaggagatagaaagccagactctactgct
tacattctcatgatcccacagtgcataaaggaggaggatgccccgtcagataatgatagt
ggcatctgtatgagtcctgagtcctatctggggtccccccagcatagcccctcgactgca
aggggctctccaagtaagagccagctgtctccatgtaacctctgtggttctgcccgcccc
aaaccctacgatccccctggagagaaaacggcagcaaaagtaaaggtggagaagttggat
aagaagctgaaaaaaatggagcagaacaagacagcagccactaggtaccgccagaagaag
agggcggagcaagaggcccttactggcgagtgtaaagagctagaaaagaagaatgaggct
ctgaaagagagggcagactctttggccaaggagatacaatacctgaaagatttgatagaa
gaggtccgaaaggccagggagaagaaaagggtcccctag

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