Panthera tigris altaica (Amur tiger): 102950748
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Entry
102950748 CDS
T02988
Symbol
SOS2
Name
(RefSeq) SOS Ras/Rho guanine nucleotide exchange factor 2
KO
K03099
son of sevenless
Organism
ptg
Panthera tigris altaica (Amur tiger)
Pathway
ptg01521
EGFR tyrosine kinase inhibitor resistance
ptg01522
Endocrine resistance
ptg04010
MAPK signaling pathway
ptg04012
ErbB signaling pathway
ptg04014
Ras signaling pathway
ptg04062
Chemokine signaling pathway
ptg04068
FoxO signaling pathway
ptg04072
Phospholipase D signaling pathway
ptg04150
mTOR signaling pathway
ptg04151
PI3K-Akt signaling pathway
ptg04510
Focal adhesion
ptg04540
Gap junction
ptg04630
JAK-STAT signaling pathway
ptg04650
Natural killer cell mediated cytotoxicity
ptg04660
T cell receptor signaling pathway
ptg04662
B cell receptor signaling pathway
ptg04664
Fc epsilon RI signaling pathway
ptg04714
Thermogenesis
ptg04722
Neurotrophin signaling pathway
ptg04810
Regulation of actin cytoskeleton
ptg04910
Insulin signaling pathway
ptg04912
GnRH signaling pathway
ptg04915
Estrogen signaling pathway
ptg04917
Prolactin signaling pathway
ptg04926
Relaxin signaling pathway
ptg04935
Growth hormone synthesis, secretion and action
ptg05034
Alcoholism
ptg05160
Hepatitis C
ptg05161
Hepatitis B
ptg05163
Human cytomegalovirus infection
ptg05165
Human papillomavirus infection
ptg05200
Pathways in cancer
ptg05205
Proteoglycans in cancer
ptg05206
MicroRNAs in cancer
ptg05207
Chemical carcinogenesis - receptor activation
ptg05208
Chemical carcinogenesis - reactive oxygen species
ptg05210
Colorectal cancer
ptg05211
Renal cell carcinoma
ptg05213
Endometrial cancer
ptg05214
Glioma
ptg05215
Prostate cancer
ptg05220
Chronic myeloid leukemia
ptg05221
Acute myeloid leukemia
ptg05223
Non-small cell lung cancer
ptg05224
Breast cancer
ptg05225
Hepatocellular carcinoma
ptg05226
Gastric cancer
ptg05231
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
ptg00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
102950748 (SOS2)
04012 ErbB signaling pathway
102950748 (SOS2)
04014 Ras signaling pathway
102950748 (SOS2)
04630 JAK-STAT signaling pathway
102950748 (SOS2)
04068 FoxO signaling pathway
102950748 (SOS2)
04072 Phospholipase D signaling pathway
102950748 (SOS2)
04151 PI3K-Akt signaling pathway
102950748 (SOS2)
04150 mTOR signaling pathway
102950748 (SOS2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
102950748 (SOS2)
04540 Gap junction
102950748 (SOS2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
102950748 (SOS2)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
102950748 (SOS2)
04660 T cell receptor signaling pathway
102950748 (SOS2)
04662 B cell receptor signaling pathway
102950748 (SOS2)
04664 Fc epsilon RI signaling pathway
102950748 (SOS2)
04062 Chemokine signaling pathway
102950748 (SOS2)
09152 Endocrine system
04910 Insulin signaling pathway
102950748 (SOS2)
04912 GnRH signaling pathway
102950748 (SOS2)
04915 Estrogen signaling pathway
102950748 (SOS2)
04917 Prolactin signaling pathway
102950748 (SOS2)
04926 Relaxin signaling pathway
102950748 (SOS2)
04935 Growth hormone synthesis, secretion and action
102950748 (SOS2)
09156 Nervous system
04722 Neurotrophin signaling pathway
102950748 (SOS2)
09159 Environmental adaptation
04714 Thermogenesis
102950748 (SOS2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102950748 (SOS2)
05206 MicroRNAs in cancer
102950748 (SOS2)
05205 Proteoglycans in cancer
102950748 (SOS2)
05207 Chemical carcinogenesis - receptor activation
102950748 (SOS2)
05208 Chemical carcinogenesis - reactive oxygen species
102950748 (SOS2)
05231 Choline metabolism in cancer
102950748 (SOS2)
09162 Cancer: specific types
05210 Colorectal cancer
102950748 (SOS2)
05225 Hepatocellular carcinoma
102950748 (SOS2)
05226 Gastric cancer
102950748 (SOS2)
05214 Glioma
102950748 (SOS2)
05221 Acute myeloid leukemia
102950748 (SOS2)
05220 Chronic myeloid leukemia
102950748 (SOS2)
05211 Renal cell carcinoma
102950748 (SOS2)
05215 Prostate cancer
102950748 (SOS2)
05213 Endometrial cancer
102950748 (SOS2)
05224 Breast cancer
102950748 (SOS2)
05223 Non-small cell lung cancer
102950748 (SOS2)
09172 Infectious disease: viral
05161 Hepatitis B
102950748 (SOS2)
05160 Hepatitis C
102950748 (SOS2)
05163 Human cytomegalovirus infection
102950748 (SOS2)
05165 Human papillomavirus infection
102950748 (SOS2)
09165 Substance dependence
05034 Alcoholism
102950748 (SOS2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
102950748 (SOS2)
01522 Endocrine resistance
102950748 (SOS2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
RasGEF
RasGEF_N
RhoGEF
SOS1_NGEF_PH
PH
RHG20_PH
PH_19
PH_10
IQ_SEC7_PH
PH_13
Motif
Other DBs
NCBI-GeneID:
102950748
NCBI-ProteinID:
XP_007097663
LinkDB
All DBs
Position
Un
AA seq
1354 aa
AA seq
DB search
MWGGSHFCLPSSEITTQMPVETRQCRPRRVAPSQAGLSWEGREKGAFVLDTVQEQVHPNL
SANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRK
RRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEIS
QQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELN
MIIKVFREAFLSDRKLFKPSDIERIFSNISDIHELTVKLLGLIEDTVEMTDDSSPHPLAG
SCFEDLAEEQAFDPYETLSQDILSPKFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLP
RLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRP
GDPICPFYNRHLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERH
IFLFDGLMISCKPNHSQSRLPGYSSAEYRLKEKFVMRKIQICDKEDTCECKHAFEIVSKD
ENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVK
DSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQEL
LSLLIERFEIPEPEPTEADKLAVEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHH
FYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPP
IEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPN
LLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNS
VSVYRLDHTFEALQERKRRILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKT
EEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGSA
SEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTP
LEREPYKISFSRIAETDLESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIF
APVLLPHSKSFFSSCGSLHKLNEEPLIPPPLPPRKKFDHDASNSKGNTKSDDDPPAIPPR
QPPPPKVKPRVPAPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPP
LGHLHRDPEWLRDVSTCPNSPNTPPSTPSPRVPRRCYALSSSHNNLAHPQAPPVPPRQNS
SPHLPKLPPKTYKRELSHPPSYRLPLLENAETPQ
NT seq
4065 nt
NT seq
+upstream
nt +downstream
nt
atgtggggtggatcacatttctgtttgcctagctcagagatcacaactcagatgcctgta
gagactaggcagtgtcgtcctcgaagagtggcaccgagtcaggcaggattgtcttgggaa
ggtcgagagaagggagcgttcgtgttagacacagttcaggagcaagtacatcccaatctc
tcagctaatgaagagtctctctattatattgaagagctgatttttcagctgcttaataaa
ttatgcatggctcagccaaggactgttcaagatgtggaggaacgtgttcagaagaccttt
cctcatccaattgacaagtgggctattgctgatgcacaatctgccatagaaaaacgaaaa
cgaagaaatcctctcttactgcctgtggacaaaatccatccttcattgaaggaggtttta
gggtacaaagtggactatcatgtatccctgtatattgtggctgtactagagtatatctca
gctgatattttgaagttggctggtaattatgtttttaatatccgacattatgaaatatcc
cagcaggacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcag
gatgacataggtttggtttctctctgtgaagatgaaccgagttcttcaggtgaattaaac
tactatgaccttgtcagaactgaaattgcagaagaaaggcagtatctacgggaattaaac
atgattataaaagtgtttcgagaagctttcctttctgacagaaagctatttaaaccttct
gatattgaaaggattttcagtaacatttcagatatacatgaattgaccgtgaaacttcta
ggtcttattgaagacacagttgaaatgactgatgacagcagccctcatccattagctggc
agctgttttgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacag
gatattctgtctccaaaatttaatgagcatttcagtaagttgatggccagacctgcagtg
gctctacactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttcca
cgccttatgctggtgcctgtatatcattgttggcactattttgaattattaaagcaattg
aaagcatgtagtgaagagcaggaagacagagaatgtttgaaccaagctattactgctctt
atgaatctccaaggtagtatggaccgaatttacaagcagtattcacctagacgccgacct
ggggatcctatttgccctttttataatcgtcacttaagaagcaagcatctggctattaaa
aaaatgaatgaaattcagaagaacatagatggatgggaaggcaaagatattggacagtgt
tgtaatgaattcattatggaaggtccattgacacgaattggtgctaaacatgaacggcat
atttttctctttgatggcttaatgattagctgtaagcccaatcatagccagtcacgcctt
ccaggttacagtagtgcagaatacagattaaaagaaaaatttgtcatgaggaaaatacaa
atatgtgataaagaagatacctgtgagtgtaaacatgcttttgaaatagtatccaaagat
gaaaacagcataatatttgctgctaagtctgctgaagagaaaaataattggatggccgca
cttatttctcttcactaccgtagtacactagatcgaatgctagattcagtgttactgaaa
gaagaaaatgagcagccattgagattaccaagtcctgaagtgtatcgttttgtggtaaaa
gactctgaggaaaacattgtttttgaagacaacttgcaaagtagaagtggaattcccatc
attaaaggaggaactgtggtgaaattaattgaaaggttaacatatcatatgtatgcagat
cccaattttgtccgtacttttcttactacataccgttcattttgtaaaccacaggaatta
ctaagcttactgattgaacgatttgaaattccagagccagaacctactgaagcagataaa
ttggcagtagagaaaggcgaacagccaatcagtgcagaccttaaaaggtttcgcaaggaa
tatgtccaaccagtacaacttaggatcttaaatgtgtttcggcactgggttgaacatcat
ttttatgactttgaaagagatttggagttgcttgagagactagaatccttcatttcaagt
gtaagagggaaagctatgaagaagtgggtagagtcaattgctaagatcatcaagaggaag
aaacaagctcaggcaaatggaataagccataatattacctttgagagtccacctccacca
attgaatggcatattagcagaccaggacagtttgaaacatttgatcttatgacacttcat
ccaatagaaattgcacgtcagctgacacttttggaatctgatctctacaggaaagtccag
ccttctgaacttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaat
ttattaaaaatgattcgccataccacaaatctcaccctctggtttgaaaagtgcattgtg
gaagcagaaaattttgaggaacgggtggcagtactaagtagaattatagaaattctgcaa
gtttttcaagatttgaataatttcaatggtgtactggagatagtcagtgcagtaaattca
gtgtcagtgtacagactagaccatacttttgaggcattgcaggaaagaaaaaggagaatt
ttggatgaagctgtggaattaagtcaagatcactttaaaaaatatctagtaaaacttaag
tcaatcaatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaaaact
gaagaagggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaag
aggaggaaagtagctgaaattactggagaaattcagcagtatcagaatcaaccttactgt
ttacggatagaaccagaaatgaggagattctttgaaaaccttaaccccatgggaagtgct
tctgaaaaggagtttacagattatttgttcaataaatcactagaaattgaaccccgaaac
tgcaaacagccacctcgatttcctaggaaatcaactttctccttaaaatctcctggaata
aggcctaatacaggccgacatggctctacctcaggcactttacgaggtcatccaacacca
ttagaaagagaaccatataagataagctttagtcggattgctgaaactgatcttgaatca
actgtgtcagcaccaacctctccaaatacgccatctactccaccggtatctgcttcttca
gaccttagtgtgtttttagatgtggatctcaacagttcctgtggcagcaatagcatcttt
gctccagtcctcttgccacattcaaagtctttcttcagttcatgtggtagtttacataaa
ctaaatgaagagccactgattcctcctccacttcctcctcgaaaaaagtttgatcacgat
gcttcaaattccaagggaaatacgaaatctgatgatgacccccctgctattccaccaaga
caacctcctcctccaaaggtaaaacccagagttcctgctcctactggtgcatttgacggg
cctctgcatagtccacctccaccaccgccgagagatcctcttcctgatacccctccacca
gttccccttcggcctccagaacactttataaactgtccatttaatcttcagccacctcca
ctaggacatcttcacagagatccagagtggctcagagacgttagtacctgtccaaattca
ccaaatactcctcctagcacaccctctccaagagtaccacgtcgatgctatgcgctcagt
tccagtcacaataaccttgctcatcctcaagctccccctgttccaccaaggcagaattca
agccctcacctaccaaaactgccaccaaagacttataaacgggagctttcacacccccca
tcgtacagactgcctttgctagaaaatgcagaaactcctcaatga
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integrated database retrieval system
